Signaling Gateway - 16 October 2009
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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CHEMOTHERAPY: IMATINIB IS ABL TO PRESERVE FERTILITY
Pharmaceutical inhibition of a c-Abl-TAp63 signaling pathway protects
female mice from chemotherapy-induced infertility.
Original research paper: Nature Medicine 15, 1179-1185 (2009)
http://links.ealert.nature.com/ctt?kn=24&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
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Molecule Pages
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SKAP-HOM
http://links.ealert.nature.com/ctt?kn=7&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
SKAP-HOM is a multifunctional signaling molecule belonging to the
group of cytosolic adaptor proteins. In macrophages, SKAP-HOM becomes
tyrosine phosphorylated after external ligation of integrins by
fibronectin or ICAM-1. Dephosphorylation of SKAP-HOM by the protein
tyrosine phosphatase YopH, a virulence factor of the bacterium
Yersinia enterocolitica, could be one mechanism by which
Y. enterocolitica infection alters macrophage function and inhibits
phagocytosis.
search the molecule pages
http://links.ealert.nature.com/ctt?kn=6&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
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Selected Updates
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TOLERANCE: SIRT1 KEEPS ESCAPEES QUIET
Sirtuin 1 (SIRT1), a type III histone deacetylase, maintains anergy
in T cells by inhibiting acetylation of JUN, a component of the
activator protein 1 (AP1) transcription factor.
Original research paper: J. Clin. Invest. 1 September 2009
(DOI 10.1172/JCI38902)
http://links.ealert.nature.com/ctt?kn=10&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
TUMORIGENESIS: NO FRILLS ATTACHED
Primary cilia can have either an oncogenic or a tumor-suppressive
role in modulating oncogenic hedgehog (HH) signaling depending on the
nature of the activating mutation in the HH pathway.
Original research paper: Nature Med. 15, 1062-1065 (2009)
http://links.ealert.nature.com/ctt?kn=8&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
NEURODEGENERATIVE DISORDERS: A BIOMARKER AND A TARGET FOR
PROGRESSIVE MS
A signaling pathway involving Toll-like receptor 2 (TLR2) and
poly(ADP-ribose) polymerase 1 (PARP1) is a potential therapeutic
target for secondary progressive multiple sclerosis (SPMS).
Original research paper: Nature Immunol. 10, 958-964 (2009)
http://links.ealert.nature.com/ctt?kn=2&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=1&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=4&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
SPATIOTEMPORAL CONTROL OF CELL SIGNALLING USING A LIGHT-SWITCHABLE
PROTEIN INTERACTION
Nature 461, 999-1001 (2009)
http://links.ealert.nature.com/ctt?kn=16&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
IN VIVO RNAi SCREENING IDENTIFIES REGULATORS OF ACTIN DYNAMICS AS KEY
DETERMINANTS OF LYMPHOMA PROGRESSION
Nature Genetics 41, 1133-1137 (2009)
http://links.ealert.nature.com/ctt?kn=29&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
THE EXECUTION OF THE TRANSCRIPTIONAL AXIS MUTANT P53, E2F1 AND ID4
PROMOTES TUMOR NEO-ANGIOGENESIS
Nature Structural & Molecular Biology 16, 1086-1093 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
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Signaling News
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NATURE CHEMICAL BIOLOGY PRIMER: KINASE INHIBITORS
http://links.ealert.nature.com/ctt?kn=17&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
Since the discovery that the activity of glycogen phosphorylase is
regulated by the addition and removal of a phosphate group,
reversible phosphorylation has come to be recognized as the major
signaling mechanism of the cell. Intensive pharmaceutical,
biotechnology and academic research efforts have focused on
discovering small-molecule kinase inhibitors, resulting in 11
inhibitors approved for clinical use so far. This free Primer from
Nature Chemical Biology highlights the four different mechanisms
employed by kinase inhibitors.
More news
http://links.ealert.nature.com/ctt?kn=14&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
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Gateway Updates
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LIPIDOMICS GATEWAY - OCTOBER UPDATE
http://links.ealert.nature.com/ctt?kn=18&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
The Lipidomics Gateway is a free, comprehensive website for
researchers interested in lipid biology.
This month's update features "Lipid signaling: S1P's nuclear program"
and "Membrane curvature: Bending begets binding".
Sign up here to receive the monthly update alert for the
Lipidomics Gateway.
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Job of the Week
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Career Development Postdoctoral Fellowship
Employer: Medical Research Council
Location: Dundee, Scotland, UK
http://links.ealert.nature.com/ctt?kn=31&m=34247260&r=MTc2ODc4NDI0MAS2&b=2&j=NTk0ODk2NTkS1&mt=1&rt=0
A Career Development Postdoctoral Fellowship is available in
Dr. Gopal Sapkota's laboratory at the MRC Protein Phosphorylation
Unit to undertake multidisciplinary research on TGF-beta signaling
networks. Studies in the laboratory focus on the molecular mechanisms
by which novel Smad-interacting proteins affect the function of Smad
proteins and TGF-beta signaling in cancer cells.
More Jobs:
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To advertise a job in this spot, please contact Naturejobs.
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