November 2009 Volume 7 Number 11
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This month's FEATURED article:
Structural biology of the chaperone-usher pathway of pilus biogenesis
Gabriel Waksman and Scott J. Hultgren
p765 | doi:10.1038/nrmicro2220
http://links.ealert.nature.com/ctt?kn=54&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
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In this issue
p757 | doi:10.1038/nrmicro2258
http://links.ealert.nature.com/ctt?kn=34&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Editorial: Giving microbial diversity a home
David Emerson and Willie Wilson
p758 | doi:10.1038/nrmicro2246
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=36&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Bacterial physiology: Mirror signal, manoeuvre
p759 | doi:10.1038/nrmicro2250
http://links.ealert.nature.com/ctt?kn=48&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Fungal physiology: Stressed fungi are not highly sprung
p760 | doi:10.1038/nrmicro2247
http://links.ealert.nature.com/ctt?kn=50&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Bacterial pathogenesis: A 'hijacked' regulatory mechanism
p760 | doi:10.1038/nrmicro2252
http://links.ealert.nature.com/ctt?kn=46&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Symbiosis: A partnership cast in iron
p760 | doi:10.1038/nrmicro2255
http://links.ealert.nature.com/ctt?kn=7&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
IN BRIEF
Environmental microbiology | Techniques & applications | Structural biology
p761 | doi:10.1038/nrmicro2256
http://links.ealert.nature.com/ctt?kn=82&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Bacterial immune evasion: An evasive surface
p762 | doi:10.1038/nrmicro2251
http://links.ealert.nature.com/ctt?kn=15&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Fungal physiology: Candida puts RNA at the tip
p762 | doi:10.1038/nrmicro2254
http://links.ealert.nature.com/ctt?kn=17&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
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NEWS AND ANALYSIS
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GENOME WATCH
Unity in diversity: lessons from Candida
Christiane Hertz-Fowler and Arnab Pain
p763 | doi:10.1038/nrmicro2253
http://links.ealert.nature.com/ctt?kn=22&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
DISEASE WATCH
In the News
p764 | doi:10.1038/nrmicro2257
http://links.ealert.nature.com/ctt?kn=20&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
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REVIEWS
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Structural biology of the chaperone-usher pathway of pilus biogenesis
Gabriel Waksman and Scott J. Hultgren
p765 | doi:10.1038/nrmicro2220
Chaperone-usher pili are assembled and secreted by a periplasmic
chaperone and a dimeric outer-membrane usher complex. Gabriel Waksman
and Scott Hultgren review the structural information that has been
gathered over the past decade on the various players that participate
in P and type 1 pilus biogenesis.
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
The trypanosome flagellar pocket
Mark C. Field and Mark Carrington
p775 | doi:10.1038/nrmicro2221
The flagellar pocket of Trypanosoma brucei is a small invagination in
the plasma membrane where the flagellum exits the cytoplasm. In this
Review, Mark Field and Mark Carrington highlight the importance of this
complex organelle for cell polarity, cell division, protein trafficking
and immune evasion.
Abstract: http://links.ealert.nature.com/ctt?kn=83&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=29&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
The evolutionary conundrum of pathogen mimicry
Nels C. Elde and Harmit S. Malik
p787 | doi:10.1038/nrmicro2222
A diverse range of pathogens produce molecules that mimic host cell
components to subvert host cell functions. Elde and Malik highlight
the various types of mimicry used by pathogens and the measures that
host cells use to counteract the mimics' effects.
Abstract: http://links.ealert.nature.com/ctt?kn=84&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Understanding HIV-1 latency provides clues for the eradication of
long-term reservoirs
Mayte Coiras, Maria Rosa Lopez-Huertas, Mayte Perez-Olmeda and
Jose Alcami
p798 | doi:10.1038/nrmicro2223
Latent HIV-1 reservoirs, in which the viral genome becomes permanently
integrated into the host chromosome, are established early during primary
infection and pose a substantial obstacle to the eradication of HIV-1
infection. Here, Jose Alcami and colleagues discuss the mechanisms that
are associated with HIV-1 latency and outline strategies for targeting
HIV-1 reservoirs.
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Humans and evolutionary and ecological forces shaped the phylogeography
of recently emerged diseases
Paul S. Keim and David M. Wagner
p813 | doi:10.1038/nrmicro2219
Infectious diseases emerge and spread around the globe. Using the
distribution, establishment and spread of anthrax, plague and tularaemia
as examples, Keim and Wagner describe the factors that determine the
phylogeography of emerging diseases.
Abstract: http://links.ealert.nature.com/ctt?kn=87&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=57&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
Metabolism, cell growth and the bacterial cell cycle
Jue D. Wang and Petra A. Levin
p822 | doi:10.1038/nrmicro2202
The mechanisms by which bacteria alter the dynamics of their cell cycle
to accommodate changes in nutrient availability have puzzled microbiologists
for nearly 50 years. In this Opinion article, Wang and Levin summarize
efforts to examine the links between nutrient availability, metabolic status,
cell division and cell growth.
Abstract: http://links.ealert.nature.com/ctt?kn=88&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
OPINION
Explaining microbial population genomics through phage predation
Francisco Rodriguez-Valera, Ana-Belen Martin-Cuadrado, Beltran Rodriguez-Brito,
Lejla Pasic, T. Frede Thingstad, Forest Rohwer and Alex Mira
p828 | doi:10.1038/nrmicro2235
Not all isolates of a species contain the same set of genes. In this
Opinion article, Rodriguez-Valera and colleagues propose the constant-diversity
model to account for these differences. In this model, predation by phages
promotes bacterial diversity and allows more efficient use of the nutrients
in the environment.
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=65&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
Erratum: The biology and future prospects of antivirulence therapies
Lynette Cegelski, Garland R. Marshall, Gary R. Eldridge and Scott J. Hultgren
p836 | doi:10.1038/nrmicro2244
http://links.ealert.nature.com/ctt?kn=77&m=34245824&r=MTc2NzM1ODUwNgS2&b=2&j=NTk0ODMyMzIS1&mt=1&rt=0
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