October 2009 Volume 6 Number 10
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EDITORIAL
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The wrong end of the scope
Stephen B. Hanauer
p559 | doi:10.1038/nrgastro.2009.164
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RESEARCH HIGHLIGHTS
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IBD: Risk of IBD increases after Salmonella or Campylobacter gastroenteritis
p561 | doi:10.1038/nrgastro.2009.152
http://links.ealert.nature.com/ctt?kn=56&m=34089817&r=MTc2OTYyOTQ2MwS2&b=2&j=NTg3MjEwNTES1&mt=1&rt=0
Esophagus: Longitudinal esophageal muscle dysfunction reported in
eosinophilic esophagitis
p562 | doi:10.1038/nrgastro.2009.155
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Cancer: Asbestos exposure linked to digestive cancer
p562 | doi:10.1038/nrgastro.2009.156
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Cancer: Diabetes therapies affect pancreatic cancer risk
p563 | doi:10.1038/nrgastro.2009.151
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Chronic hepatitis C progression
p563 | doi:10.1038/nrgastro.2009.153
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Infectious disease: Typhoid vaccine effective
p563 | doi:10.1038/nrgastro.2009.154
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Surgery: Glycemic control after bariatric surgery
p564 | doi:10.1038/nrgastro.2009.157
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Endoscopy: Capsule endoscopy: a new technique for colon cancer screening?
p564 | doi:10.1038/nrgastro.2009.158
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NEWS AND VIEWS
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Hepatitis: Monitoring drug therapy for hepatitis B-a global challenge?
Tin Nguyen and Stephen Locarnini
p565 | doi:10.1038/nrgastro.2009.160
A new study has found undetectable serum levels of HBV DNA at week 24 of
treatment to be the strongest predictor of optimal outcomes for patients
with chronic HBV infection. Although this finding is not surprising, it
has important implications for those patients on antiviral therapy who
do not achieve a favorable response.
http://links.ealert.nature.com/ctt?kn=7&m=34089817&r=MTc2OTYyOTQ2MwS2&b=2&j=NTg3MjEwNTES1&mt=1&rt=0
Colorectal cancer: What do studies of diet patterns tell us?
Marjorie L. McCullough
p567 | doi:10.1038/nrgastro.2009.159
Among the challenges of studying the contribution of individual dietary
factors to cancer risk is the interwoven nature of diet-dietary factors
are often correlated and eating patterns are complex. A large, prospective
epidemiological study of diet patterns used cluster analyses to
demonstrate the benefit of a fruit and vegetable diet to colorectal
cancer risk.
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Colorectal cancer: Management of small polyps detected by CT colonography
Perry J. Pickhardt
p568 | doi:10.1038/nrgastro.2009.161
A recent survey of patients, primary physicians and gastroenterologists
found that an overwhelming majority prefer endoscopic polypectomy for
small polyps detected by screening CT colonography. These hypothetical
results, however, strongly contradict results in actual clinical practice.
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Hepatitis C: CIFN for re-treatment of PEG-IFN plus RBV nonresponders?
Christian Trepo and Pierre Pradat
p570 | doi:10.1038/nrgastro.2009.145
The current re-treatment options available to patients with chronic
hepatitis C who fail to respond to treatment with pegylated interferon
plus ribavirin are limited. Findings from a large, multicenter study
suggest that re-treatment with consensus interferon plus ribavirin
should now be considered for compliant, motivated nonresponders.
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Surgery: A midline or transverse abdominal incision?
Henrik Kehlet
p571 | doi:10.1038/nrgastro.2009.150
Whether a midline or transverse incision is used in abdominal surgery
depends mainly on the disease, anatomy and potential effects on wound
healing, pain and postoperative complications. Decisions can, however,
be based on a surgeon's experience and preference, as the procedures'
respective benefits remain to be clearly delineated.
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REVIEWS
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The clinical use of HVPG measurements in chronic liver disease
Jaime Bosch, Juan G. Abraldes, Annalisa Berzigotti and Juan Carlos
Garcia-Pagan
Published online: 01 September 2009
p573 | doi:10.1038/nrgastro.2009.149
Hepatic venous pressure gradient (HVPG) is the most useful parameter
for the assessment of patients with cirrhosis. HVPG provides diagnostic
and prognostic information in several clinical scenarios: treatment of
portal hypertension, surgery for hepatocellular carcinoma, treatment
of HCV-related or HBV-related cirrhosis, and outcome of recurrent HCV
infection after liver transplantation.
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=34089817&r=MTc2OTYyOTQ2MwS2&b=2&j=NTg3MjEwNTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=71&m=34089817&r=MTc2OTYyOTQ2MwS2&b=2&j=NTg3MjEwNTES1&mt=1&rt=0
Pathophysiology, diagnosis and management of postoperative dumping
syndrome
Jan Tack, Joris Arts, Philip Caenepeel, Dominiek De Wulf and Raf Bisschops
Published online: 01 September 2009
p583 | doi:10.1038/nrgastro.2009.148
The signs and symptoms of dumping syndrome, a well-established complication
of gastric and esophageal surgery, result from rapid gastric emptying
and the delivery of large particles of poorly digested food to the small
bowel. These symptoms, which can be classed as early or late, their
pathophysiological basis, and the treatment options available to patients
with dumping syndrome are outlined in this article.
Abstract: http://links.ealert.nature.com/ctt?kn=80&m=34089817&r=MTc2OTYyOTQ2MwS2&b=2&j=NTg3MjEwNTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=34089817&r=MTc2OTYyOTQ2MwS2&b=2&j=NTg3MjEwNTES1&mt=1&rt=0
Advances in sexually transmitted infections of the gastrointestinal tract
Siew C. Ng and Brian Gazzard
Published online: 25 August 2009
p592 | doi:10.1038/nrgastro.2009.143
The gastrointestinal mucosa is an important target of many sexually
transmitted infections-it is a site for HIV entry, replication and
destruction of CD4+ T cells, and provides a niche for other sexually
transmitted pathogens. This Review discusses the pathogenesis and
gastrointestinal complications of HIV infection and summarizes advances
in our understanding of other sexually transmitted infections of the
gastrointestinal system.
Abstract: http://links.ealert.nature.com/ctt?kn=78&m=34089817&r=MTc2OTYyOTQ2MwS2&b=2&j=NTg3MjEwNTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=62&m=34089817&r=MTc2OTYyOTQ2MwS2&b=2&j=NTg3MjEwNTES1&mt=1&rt=0
Systemic amyloidosis and the gastrointestinal tract
Prayman T. Sattianayagam, Philip N. Hawkins and Julian D. Gillmore
Published online: 01 September 2009
p608 | doi:10.1038/nrgastro.2009.147
Systemic amyloidosis is characterized by the extracellular deposition
of protein in an abnormal and insoluble form. Involvement of the
gastrointestinal tract is very common but is often subclinical. This
Review describes the gastrointestinal manifestations of systemic
amyloidosis and discusses available methods for the diagnosis and
treatment of systemic amyloidosis and its gastrointestinal consequences.
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=34089817&r=MTc2OTYyOTQ2MwS2&b=2&j=NTg3MjEwNTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=47&m=34089817&r=MTc2OTYyOTQ2MwS2&b=2&j=NTg3MjEwNTES1&mt=1&rt=0
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CASE STUDY
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A case of complete resolution of gastric varices
Vanessa Tieu, George Behrens, Hector Ferral, Stanley M. Cohen and
Joseph Ahn
p618 | doi:10.1038/nrgastro.2009.144
This article considers the case of a 49-year-old woman with a history
of hepatitis C and peptic ulcer disease who presented with massive
hematemesis. She was diagnosed with gastric variceal hemorrhage and
splenic vein thrombosis. The patient underwent splenic artery
embolization and balloon-occluded retrograde transvenous obliteration
of gastric varices. By 30 months post-treatment no evidence of gastric
varices or splenic vein thrombosis remained.
Abstract: http://links.ealert.nature.com/ctt?kn=85&m=34089817&r=MTc2OTYyOTQ2MwS2&b=2&j=NTg3MjEwNTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=34089817&r=MTc2OTYyOTQ2MwS2&b=2&j=NTg3MjEwNTES1&mt=1&rt=0
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