November 2009 Volume 6 Number 11
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NEW from Nature Reviews Cardiology: Molecular Imaging Series
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Reviews and Perspective articles from leading specialists in
cardiovascular imaging.
The Molecular Imaging Series covers every aspect of the visualization
of physiological and pathophysiological processes at the cellular and
molecular levels. With each issue of Nature Reviews Cardiology until
spring 2010, a molecular-imaging-focused paper will be published in
print and added to our online article series.
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EDITORIAL
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The CVD paradox: mortality vs prevalence
Valentin Fuster and Bryony M. Mearns
p669 | doi:10.1038/nrcardio.2009.187
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RESEARCH HIGHLIGHTS
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Arrhythmias: Antiarrhythmic drugs in the treatment of ARVC
p671 | doi:10.1038/nrcardio.2009.166
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Is a reduced SBP target warranted?
p672 | doi:10.1038/nrcardio.2009.150
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Surgery: Long-term success of CABG in Kawasaki disease
p672 | doi:10.1038/nrcardio.2009.152
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CORRECTION
Imaging outcomes in cardiovascular clinical trials
p672 | doi:10.1038/nrcardio.2009.186
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Endoscopic catheter ablation of AF
p673 | doi:10.1038/nrcardio.2009.151
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Hypertension: Sildenafil reduces pulmonary hypertension in HF
p673 | doi:10.1038/nrcardio.2009.167
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Stroke: Stroke prevention in patients with AF
p673 | doi:10.1038/nrcardio.2009.168
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Thrombosis: New-generation combined oral contraceptives linked to raised
risk of thrombosis
p674 | doi:10.1038/nrcardio.2009.169
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Coronary artery disease: Myocardial bridge: a 'double-edged sword' in
atherosclerosis
p674 | doi:10.1038/nrcardio.2009.170
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NEWS AND VIEWS
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Interventional cardiology: Renal artery stenting-which patients will
benefit?
Nicholas J. Ruggiero and Michael R. Jaff
p675 | doi:10.1038/nrcardio.2009.173
The role of endovascular therapy in patients with renal artery stenosis
continues to be very controversial. Two reports have added notable
findings to the growing body of evidence on this subject. The
investigators of these studies aimed to clarify which patients, if any,
would benefit from renal artery stent placement.
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Coronary artery disease: High field strength coronary MRA-ready for
prime time?
Reza Nezafat and Warren J. Manning
p676 | doi:10.1038/nrcardio.2009.184
Yang and colleagues report on their single-center experience with
high-field coronary MRA using a new MR contrast agent. Data on 30
patients were compared with conventional X-ray angiography. Their new
coronary MRA approach seems favourable when compared with previous
MRA methods.
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Arrhythmias: Unexplained sudden cardiac death-back to clinical evaluation
Silvia G. Priori
p678 | doi:10.1038/nrcardio.2009.174
The diagnosis of unexplained cardiac arrest could soon become obsolete,
as so-called molecular autopsy can now be used to identify its underlying
causes. The current view of this subject is discussed, and some personal
opinions are presented on the assessment of survivors of sudden cardiac
arrest and relatives of individuals who do not survive.
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Pharmacotherapy: Cardiovascular effects of aldosterone blockade in CKD
Bertram Pitt
p679 | doi:10.1038/nrcardio.2009.175
The results of the CRIB-2 trial, which show that the mineralocorticoid
receptor blocker (MRB) spironolactone improves left ventricular mass
and aortic stiffness in patients with early stage chronic kidney disease
(CKD), provide impetus for large-scale clinical trials to evaluate the
effects of this strategy on clinical outcomes. The optimum choice of MRB
and its dose, however, remain uncertain given the potential risk of
hyperkalemia in patients with CKD.
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REVIEWS
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Calcification in atherosclerosis
Nikolaos Alexopoulos and Paolo Raggi
Published online: 29 September 2009
p681 | doi:10.1038/nrcardio.2009.165
The extent of coronary calcification is thought to reflect the total
coronary atherosclerotic burden. In this Review, Drs. Alexopoulos and
Raggi discuss the current uncertainty about the role of coronary artery
calcium in various disease states, the utility of calcium screening and
current recommendations on its use.
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=34306271&r=MTc2NDI1MzEzNAS2&b=2&j=NTk4NTM0NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=34306271&r=MTc2NDI1MzEzNAS2&b=2&j=NTk4NTM0NDIS1&mt=1&rt=0
Prevention and treatment of rheumatic heart disease in the developing world
Andrew C. Steer and Jonathan R. Carapetis
Published online: 15 September 2009
p689 | doi:10.1038/nrcardio.2009.162
Rheumatic heart disease is a substantial global health problem that
particularly affects developing countries. In this article, Andrew Steer
and Jonathan Carapetis review the pathophysiology and epidemiology of
this disease and discuss strategies for diagnosis, prevention, and
treatment. They also emphasize the importance of secondary prophylaxis
programs and highlight the potential for vaccine development.
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=34306271&r=MTc2NDI1MzEzNAS2&b=2&j=NTk4NTM0NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=34306271&r=MTc2NDI1MzEzNAS2&b=2&j=NTk4NTM0NDIS1&mt=1&rt=0
Article series: Molecular Imaging
Applications of cardiac multidetector CT beyond coronary angiography
Karl H. Schuleri, Richard T. George and Albert C. Lardo
p699 | doi:10.1038/nrcardio.2009.172
In the past 5 years, technological advances in multidetector CT imaging
have enabled the development of complementary myocardial applications
beyond coronary imaging. In this Review, the authors describe these
advances and discuss the clinical potential of such imaging for a broad
range of applications.
Abstract: http://links.ealert.nature.com/ctt?kn=76&m=34306271&r=MTc2NDI1MzEzNAS2&b=2&j=NTk4NTM0NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=62&m=34306271&r=MTc2NDI1MzEzNAS2&b=2&j=NTk4NTM0NDIS1&mt=1&rt=0
Socioeconomic status and cardiovascular disease: risks and implications
for care
Alexander M. Clark, Marie DesMeules, Wei Luo, Amanda S. Duncan and
Andy Wielgosz
Published online: 22 September 2009
p712 | doi:10.1038/nrcardio.2009.163
Patients of low socioeconomic status (SES) with cardiovascular disease
are a highly vulnerable, but often under-served, population. In high
income countries in particular, these individuals develop cardiovascular
disease younger, have more risk factors, and are less likely to benefit
from treatment than are patients of higher socioeconomic status. In this
Review, Clark et al. examine how socioeconomic status is linked to adverse
cardiovascular outcomes and what clinicians can do to address inequalities.
Abstract: http://links.ealert.nature.com/ctt?kn=78&m=34306271&r=MTc2NDI1MzEzNAS2&b=2&j=NTk4NTM0NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=85&m=34306271&r=MTc2NDI1MzEzNAS2&b=2&j=NTk4NTM0NDIS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
National policies and strategies for noncommunicable diseases
Shanthi Mendis and Valentin Fuster
p723 | doi:10.1038/nrcardio.2009.171
In this Perspectives article, the authors discuss the need for national
policies to add ress the global problem of noncommunicable diseases.
They present their views on the benefits of national policies and the
processes involved in developing and implementing such policies.
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=34306271&r=MTc2NDI1MzEzNAS2&b=2&j=NTk4NTM0NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=84&m=34306271&r=MTc2NDI1MzEzNAS2&b=2&j=NTk4NTM0NDIS1&mt=1&rt=0
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