October 2009 Volume 15 Number 10, pp 1095 - 1228
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2009 Lasker Medical Research Awards
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This year, the Lasker Foundation honors the contributions of John Gurdon, Shinya Yamanaka, Brian Druker, Nicholas Lydon and Charles Sawyers.
Read a series of freely available commentaries written by the winners in celebration of the Award.
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NATURE MEDICINE PODCAST
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See-through science
Biologists look to create translucent tissue-and they're testing it on a common grocery item. Plus, experts are developing a propaganda index for peer-reviewed articles.
http://links.ealert.nature.com/ctt?kn=16&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
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EDITORIAL
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The twain shall meet p1095
doi:10.1038/nm1009-1095
Announcing an initiative to connect commercially oriented academics with their local business community.
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NEWS
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Large trial to examine parasites' influence on global killers p1097
Cassandra Willyard
doi:10.1038/nm1009-1097
http://links.ealert.nature.com/ctt?kn=127&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Survey of medical centers points to funding gaps p1098
Erica Westly
doi:10.1038/nm1009-1098a
http://links.ealert.nature.com/ctt?kn=122&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Infections linked to prostate cancer p1098
Vicki Brower
doi:10.1038/nm1009-1098b
http://links.ealert.nature.com/ctt?kn=137&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Value of health interventions underestimated by governments p1099
Nayanah Siva
doi:10.1038/nm1009-1099a
http://links.ealert.nature.com/ctt?kn=132&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Closing Army pathology lab bristles at replacement attempt p1099
Erica Westly
doi:10.1038/nm1009-1099b
http://links.ealert.nature.com/ctt?kn=153&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Harvard Medical School rescinds controversial media rules p1100
Mike May
doi:10.1038/nm1009-1100a
http://links.ealert.nature.com/ctt?kn=152&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
'Propaganda index' proposed for medical literature pp1100 - 1101
Nicola Jones
doi:10.1038/nm1009-1100b
http://links.ealert.nature.com/ctt?kn=157&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Analysis of retractions puts spotlight on academia p1101
Nicola Jones
doi:10.1038/nm1009-1101
http://links.ealert.nature.com/ctt?kn=155&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
News in brief pp1102 - 1103
doi:10.1038/nm1009-1102
http://links.ealert.nature.com/ctt?kn=42&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Straight talk with...Christopher Murray pp1104 - 1105
Charlotte Schubert
doi:10.1038/nm1009-1104
Abstract: http://links.ealert.nature.com/ctt?kn=168&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
The most transparent research pp1106 - 1109
Melinda Wenner
doi:10.1038/nm1009-1106
Abstract: http://links.ealert.nature.com/ctt?kn=169&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
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CORRESPONDENCE
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CCL3L1 and HIV/AIDS susceptibility pp1110 - 1112
Thomas J Urban et al.
doi:10.1038/nm1009-1110
http://links.ealert.nature.com/ctt?kn=34&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
CCL3L1 and HIV/AIDS susceptibility pp1112 - 1115
Tanmoy Bhattacharya et al.
doi:10.1038/nm1009-1112
http://links.ealert.nature.com/ctt?kn=19&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Experimental aspects of copy number variant assays at CCL3L1 pp1115 - 1117
Sarah F Field et al.
doi:10.1038/nm1009-1115
http://links.ealert.nature.com/ctt?kn=12&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Reply to: "CCL3L1 and HIV/AIDS susceptibility" and "Experimental aspects of copy number variant assays at CCL3L1" pp1117 - 1120
Weijing He et al.
doi:10.1038/nm1009-1117
http://links.ealert.nature.com/ctt?kn=9&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
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BOOK REVIEW
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Smallpox outfoxed p1121
Ellen G Strauss reviews Smallpox-The Death of a Disease: The Inside Story of Eradicating a Worldwide Killer by D.A. Henderson
doi:10.1038/nm1009-1121
http://links.ealert.nature.com/ctt?kn=7&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
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NEWS AND VIEWS
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Gateway to the diseased brain pp1123 - 1124
Federico Mingozzi and Katherine A High
doi:10.1038/nm1009-1123
The blood-brain barrier constitutes a major obstacle to effective treatment of diseases affecting the central nervous system. A new strategy to target specifically the endothelium of diseased brain may allow the development of more effective gene-based therapies (pages 1215-1218).
http://links.ealert.nature.com/ctt?kn=4&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Preserving fertility during cancer treatment pp1124 - 1125
Teresa K Woodruff
doi:10.1038/nm1009-1124
Imatinib (trade name Gleevec) preserves fertility in female mice treated with the common chemotherapeutic agent cisplatin. Imatinib seems to block an apoptotic pathway activated by cisplatin in ovarian germ cells (pages 1179-1185). The findings could lead to new ways to protect germ cells from the damaging effects of cancer treatment.
http://links.ealert.nature.com/ctt?kn=72&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Epilepsy: synapses stuck in childhood pp1126 - 1127
Matteo Caleo
doi:10.1038/nm1009-1126
Mouse experiments show how mutation of a gene involved in human epilepsy causes hyperexcitability of the neuronal network (pages 1208-1214). The mutations interfere with the maturation of excitatory synapses during postnatal development.
http://links.ealert.nature.com/ctt?kn=73&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Gene copy number: learning to count past two pp1127 - 1129
Sadeep Shrestha, Jianming Tang and Richard A Kaslow
doi:10.1038/nm1009-1127
The number of copies of the gene encoding a ligand for an HIV co-receptor have been found to influence the susceptibility to HIV infection and AIDS progression. New studies dispute this conclusion. The studies are contested by the authors of the original findings, and highlight the inherent difficulties in accurately measuring gene copy numbers (pages 1110-1112, 1112-1115, 1115-1117 and 1117-1120).
http://links.ealert.nature.com/ctt?kn=17&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
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COMMUNITY CORNER
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Biomarkers for Alzheimer's disease: the dilemma of silent disease p1130
doi:10.1038/nm1009-1130
http://links.ealert.nature.com/ctt?kn=77&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
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BETWEEN BEDSIDE AND BENCH
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Bleeding in the brain
Hemorrhages in the brain are responsible for about 15% of strokes and are particularly difficult to treat. Costantino Iadecola assesses a new clinical study that may change the view of why a common form of hemorrhage, subarachnoid hemorrhage, often leads to death. Massive brain lesions often develop days after the initial event, a dangerous complication previously attributed to vasospasm, narrowing of the arteries. The study suggests that these lesions may instead by caused by neuronal depolarization, extending in waves across the brain. Gregory del Zoppo explores the connection between deposition of toxic amyloid-beta peptides in the brain and hemorrhage. He discusses studies suggesting that the peptides inactivate proteins in the blood that can stop hemorrhage.
Bleeding in the brain: Killer waves of depolarization in subarachnoid bleed pp1131 - 1132
Costantino Iadecola
doi:10.1038/nm1009-1131
http://links.ealert.nature.com/ctt?kn=79&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Bleeding in the brain: Amyloid-beta may keep clots away pp1132 - 1133
Gregory J del Zoppo
doi:10.1038/nm1009-1132
http://links.ealert.nature.com/ctt?kn=45&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Research Highlights pp1134 - 1135
doi:10.1038/nm1009-1134
http://links.ealert.nature.com/ctt?kn=51&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
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COMMENTARIES
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2009 Albert Lasker Medical Research Awards
Lasker Awards and papal portraiture: turning fields upside down pp1137 - 1140
Joseph L Goldstein
doi:10.1038/nm1009-1137
http://links.ealert.nature.com/ctt?kn=48&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
2009 Albert Lasker Medical Research Awards
Nuclear reprogramming in eggs pp1141 - 1144
John Gurdon
doi:10.1038/nm1009-1141
http://links.ealert.nature.com/ctt?kn=55&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
2009 Albert Lasker Medical Research Awards
Ekiden to iPS Cells pp1145 - 1148
Shinya Yamanaka
doi:10.1038/nm1009-1145
http://links.ealert.nature.com/ctt?kn=52&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
2009 Albert Lasker Medical Research Awards
Perspectives on the development of imatinib and the future of cancer research pp1149 - 1152
Brian J Druker
doi:10.1038/nm1009-1149
http://links.ealert.nature.com/ctt?kn=144&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
2009 Albert Lasker Medical Research Awards
Attacking cancer at its foundation pp1153 - 1157
Nicholas Lydon
doi:10.1038/nm1009-1153
http://links.ealert.nature.com/ctt?kn=140&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
2009 Albert Lasker Medical Research Awards
Shifting paradigms: the seeds of oncogene addiction pp1158 - 1161
Charles L Sawyers
doi:10.1038/nm1009-1158
http://links.ealert.nature.com/ctt?kn=136&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
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Autoimmune disease: Treating MS with hypertension drugs
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ARTICLES
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An integrin alphavbeta3-c-Src oncogenic unit promotes anchorage-independence and tumor progression pp1163 - 1169
Jay S Desgrosellier et al.
doi:10.1038/nm.2009
Abstract: http://links.ealert.nature.com/ctt?kn=158&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=124&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors pp1170 - 1178
Francois Ghiringhelli et al.
doi:10.1038/nm.2028
Dying tumor cells release ATP, which activates the NLRP3 inflammasome in dendritic cells, enabling the secretion of interleukin-1beta and the subsequent priming of tumor-specific interferon-gamma-producing T lymphocytes.
Abstract: http://links.ealert.nature.com/ctt?kn=159&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=100&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death pp1179 - 1185
Stefania Gonfloni et al.
doi:10.1038/nm.2033
Chemotherapy often leads to premature death of oocytes, and thus infertility, in young individuals with cancer. Here, Stefania Gonfloni and her colleagues show that chemotherapy-induced activation of the kinase c-Abl is responsible for this oocyte failure and that, in vivo, the c-Abl inhibitor imatinib prevents this effect (pages 1124-1125).
Abstract: http://links.ealert.nature.com/ctt?kn=160&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
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Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis pp1186 - 1194
Torsten K Roepke et al.
doi:10.1038/nm.2029
Torsten Roepke et al. show that the potassium channel subunit KCNE2-which previously has been most recognized for its role in controlling electrical activity in the heart-is important for normal thyroid function. KCNE2, together with its partner KCNQ1, is expressed in both mouse and human thyroid epithelial cells, and Kcne2 deficiency in mice leads to a constellation of defects resulting from decreased thyroid hormone biosynthesis. These results suggest new genetic links between thyroid and heart function.
Abstract: http://links.ealert.nature.com/ctt?kn=108&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=94&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake pp1195 - 1201
Leona Plum et al.
doi:10.1038/nm.2026
Insulin action in the brain is known to inhibit food intake. Now Leona Plum and her colleagues show that in hypothalamic neurons insulin inhibits FoxO1-mediated transcriptional repression of Cpe, a gene that encodes a carboxypeptidase that is required for proper processing of key anorexigenic neuropeptides. The team also found that this pathway is disturbed in states of diet-induced obesity, suggesting that obesity-induced insulin resistance may affect obesity even further.
Abstract: http://links.ealert.nature.com/ctt?kn=116&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=92&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly pp1202 - 1207
Masami Yamada et al.
doi:10.1038/nm.2023
Lissencephaly is a developmental brain disorder caused by mutations in LIS1 and characterized by impaired neuronal migration. Inhibiting calpain prevents LIS1 degradation in heterozygous mice and rescues the defective neuronal migration in utero.
Abstract: http://links.ealert.nature.com/ctt?kn=118&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=184&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy pp1208 - 1214
Yu-Dong Zhou et al.
doi:10.1038/nm.2019
LGI1, a gene linked to epilepsy in humans, promotes disease by impairing the maturation of glutamatergic circuits in the mouse brain.
Abstract: http://links.ealert.nature.com/ctt?kn=119&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
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LETTER
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Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy pp1215 - 1218
Yong Hong Chen, Michael Chang and Beverly L Davidson
doi:10.1038/nm.2025
Abstract: http://links.ealert.nature.com/ctt?kn=120&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
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TECHNICAL REPORTS
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Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging pp1219 - 1223
Benjamin J Vakoc et al.
doi:10.1038/nm.1971
Abstract: http://links.ealert.nature.com/ctt?kn=111&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=174&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Development of universal antidotes to control aptamer activity pp1224 - 1228
Sabah Oney et al.
doi:10.1038/nm.1990
Abstract: http://links.ealert.nature.com/ctt?kn=112&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=165&m=34149776&r=MTc2NTQyNDEzOQS2&b=2&j=NTkxNDEwNzAS1&mt=1&rt=0
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