October 2009 Volume 27 Number 10, pp 869 - 958
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EDITORIAL
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The twain shall meet p869
doi:10.1038/nbt1009-869
Announcing an initiative to connect commercially oriented academics with their local business community.
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NEWS
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Expanded access rules pose quandary for drug developers pp871 - 872
George S Mack
doi:10.1038/nbt1009-871
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FDA penalizes trial misconduct p872
Catherine Shaffer
doi:10.1038/nbt1009-872
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Test tube meat on the menu? p873
Jeffrey L Fox
doi:10.1038/nbt1009-873
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Europe plans for drug-making plants p874
Wendy Wolfson
doi:10.1038/nbt1009-874a
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Pfizer lured to Sweden p874
Susan Aldridge
doi:10.1038/nbt1009-874b
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Spotlight focuses on protein-misfolding therapies p874
Mark Ratner
doi:10.1038/nbt1009-874c
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Regulation of consumer genomic tests remains in limbo pp875 - 877
Malorye Allison
doi:10.1038/nbt1009-875
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Golden Triangle taps Boston p877
Susan Aldridge
doi:10.1038/nbt1009-877a
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Fits and starts for Geron p877
Laura DeFrancesco
doi:10.1038/nbt1009-877b
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Firms seek new models to access public equity pp878 - 879
Peter Mitchell
doi:10.1038/nbt1009-878
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Sanofi's Shantha boost p879
Killugudi Jayaraman
doi:10.1038/nbt1009-879a
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Gulf beckons biotech p879
Hayley Birch
doi:10.1038/nbt1009-879b
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NEWS FEATURE
Under wraps pp880 - 882
Emily Waltz
doi:10.1038/nbt1009-880
Are the crop industry's strong-arm tactics and close-fisted attitude to sharing seeds holding back independent research and undermining public acceptance of transgenic crops? Emily Waltz investigates.
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BIOENTREPRENEUR
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BUILDING A BUSINESS
Credibility: your most important asset
Douglas MacDougall and Jennifer Conrad
doi:10.1038/bioe.2009.8
Without credibility, everything you say to investors, potential partners or even your employees can be questioned. Here's how to build and retain it.
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OPINION AND COMMENT
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CORRESPONDENCE
Is it virtuous to be virtual? The VC viewpoint pp886 - 888
Justin Chakma, Jeff L Calcagno, Ali Behbahani and Shawn Mojtahedian
doi:10.1038/nbt1009-886
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The power of social networking in medicine pp888 - 890
Catherine A Brownstein et al.
doi:10.1038/nbt1009-888
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Creating a mouse academic research commons pp890 - 891
David Einhorn and Rita Heimes
doi:10.1038/nbt1009-890
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Cofactor-mediated protein promiscuity p892
Jordan D Dimitrov and Tchavdar L Vassilev
doi:10.1038/nbt1009-892a
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Healthcare-biotech symbiosis pp892 - 893
Kamran Ahmed and Hutan Ashrafian
doi:10.1038/nbt1009-892b
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Improved genome annotation for Zymomonas mobilis pp893 - 894
Shihui Yang et al.
doi:10.1038/nbt1009-893
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FEATURES
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Can web 2.0 reboot clinical trials? pp895 - 902
Malorye Allison
doi:10.1038/nbt1009-895
Dozens of companies are trying to leverage social networking and other software tools to accelerate trials and reduce their cost.
http://links.ealert.nature.com/ctt?kn=76&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
PATENTS
Legal uncertainty in the area of genetic diagnostic testing pp903 - 909
Isabelle Huys, Nele Berthels, Gert Matthijs and Geertrui Van Overwalle
doi:10.1038/nbt1009-903
A patent landscape analysis of 22 common genetic diagnostic tests shows substantially fewer claims on genes per se than initially suggested but raises questions of legal uncertainty as to the claims' scope.
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Recent patent applications in RNA interference p910
doi:10.1038/nbt1009-910
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NEWS AND VIEWS
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siRNA delivery not Toll-free pp911 - 912
Michael P Gantier and Bryan R G Williams
doi:10.1038/nbt1009-911
Activating the tumor-associated immune system with an siRNA conjugated to a Toll-like receptor 9 ligand is a promising anticancer strategy.
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Snapshots of kinase activities pp912 - 913
Javier Munoz and Albert J R Heck
doi:10.1038/nbt1009-912
A mass spectrometry-based strategy facilitates sensitive and rapid detection of kinase activities in small amounts of cell lysate.
http://links.ealert.nature.com/ctt?kn=2&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
Stem cell biology meets p53 pp914 - 915
Anna M Puzio-Kuter and Arnold J Levine
doi:10.1038/nbt1009-914
Often called "the guardian of the genome," p53 may also be the guardian of stable development.
http://links.ealert.nature.com/ctt?kn=5&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
Cancer's insatiable appetite pp916 - 917
Jason W Locasale, Lewis C Cantley and Matthew G Vander Heiden
doi:10.1038/nbt1009-916
Seemingly unrelated mutations that drive cancer share the ability to promote nutrient uptake and metabolism conducive to cell growth.
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Introducing the acetylome pp917 - 919
Karen T Smith and Jerry L Workman
doi:10.1038/nbt1009-917
Mass spectrometry reveals protein acetylation to be as widespread as phosphorylation.
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RESEARCH HIGHLIGHTS
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Research highlights p920
Kathy Aschheim, Markus Elsner, Peter Hare and Craig Mak
doi:10.1038/nbt1009-920
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COMPUTATIONAL BIOLOGY
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PRIMER
How to visually interpret biological data using networks pp921 - 924
Daniele Merico, David Gfeller and Gary D Bader
doi:10.1038/nbt.1567
Networks in biology can appear complex and difficult to decipher. We illustrate how to interpret biological networks with the help of frequently used visualization and analysis patterns.
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RESEARCH
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ARTICLES
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses pp925 - 932
Marcin Kortylewski et al.
doi:10.1038/nbt.1564
Tumors generate microenvironments that actively suppress the body's anti-tumor immune response. Kortylewski et al. restore immunity by delivering an siRNA against Stat3, a regulator of immune suppression, to myeloid and B cells using a CpG oligonucleotide that targets toll-like receptor 9.
Abstract: http://links.ealert.nature.com/ctt?kn=152&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=29&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
Sensitive multiplexed analysis of kinase activities and activity-based kinase identification pp933 - 940
Kazuishi Kubota et al.
doi:10.1038/nbt.1566
Kubota et al. describe a sensitive mass spectrometric method for generating signatures of kinase activity characteristic of specific cell types. They also identify kinases responsible for phosphorylating substrates of interest.
Abstract: http://links.ealert.nature.com/ctt?kn=156&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=4&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
LETTERS
Induction of protein-protein interactions in live cells using light pp941 - 945
Masayuki Yazawa, Amir M Sadaghiani, Brian Hsueh and Ricardo E Dolmetsch
doi:10.1038/nbt.1569
Controlling protein-protein interaction with high temporal and spatial resolution is essential for understanding many cellular processes. Yazawa et al. present genetically encoded tags that can induce protein dimer formation upon stimulation with blue light.
Abstract: http://links.ealert.nature.com/ctt?kn=155&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=38&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
Automated design of synthetic ribosome binding sites to control protein expression pp946 - 950
Howard M Salis, Ethan A Mirsky and Christopher A Voigt
doi:10.1038/nbt.1568
Salis et al. design precisely tuned ribosome binding sites that allow rational control over the rate of protein translation. This technology should facilitate the design of synthetic genetic circuits and metabolic pathways.
Abstract: http://links.ealert.nature.com/ctt?kn=151&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=130&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
A proteomics approach to discovering natural products and their biosynthetic pathways pp951 - 956
Stefanie B Bumpus et al.
doi:10.1038/nbt.1565
Nonribosomal peptides and polyketides constitute a large fraction of antibiotic, antitumor and immunosuppressant drugs. Bumpus et al. present a proteomic strategy to identify new natural products and their biosynthetic pathways.
Abstract: http://links.ealert.nature.com/ctt?kn=150&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=139&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
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ERRATA
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Erratum: Sanofi Aventis grooms its ranks for biotech partnering p957
Nuala Moran
doi:10.1038/nbt1009-957a
http://links.ealert.nature.com/ctt?kn=137&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
Erratum: Diagnostics firms face new patent claim worries p957
Malorye Allison
doi:10.1038/nbt1009-957b
http://links.ealert.nature.com/ctt?kn=134&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
Erratum: Novo awaits green light for diabetes drug p957
Mike May
doi:10.1038/nbt1009-957c
http://links.ealert.nature.com/ctt?kn=144&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
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CAREERS AND RECRUITMENT
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PEOPLE
People p958
doi:10.1038/nbt1009-958
http://links.ealert.nature.com/ctt?kn=146&m=34209474&r=MTc3MTg2NzE2NgS2&b=2&j=NTkzMzkzODcS1&mt=1&rt=0
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