15 October 2009 Volume 461 Number 7266, pp 847 - 1018
Visit Nature online to browse the journal.
Now available at http://links.ealert.nature.com/ctt?kn=234&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Please note that you need to be a subscriber to enjoy full text
access to Nature online. To purchase a subscription, please visit:
http://links.ealert.nature.com/ctt?kn=101&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.com/ctt?kn=53&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
NPG Asia Materials will begin publishing review articles from October.
3 Review Articles will be published soon on the following fields
1. Carbon Nanomaterials (by T.Ando of Tokyo Institute of Technology)
2. LCD (by K-H Kim and J-K Song of Samsung Electronics Company Ltd)
3. Optics & Photonics (by Y.Koike and M.Asai of Keio University)
Register now for the free NPG Asia Materials email alerts
so you are the first to know when the review articles appear!
http://links.ealert.nature.com/ctt?kn=75&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
=====================================================================
=========================== ADVERTISEMENT ===========================
Introducing: The MassARRAY(R) Compact 96
Get the results you need in a fraction of the time of other techniques
Fast and accurate genetic analysis across a range of applications - at
a price you can afford. The MassARRAY(R) Compact 96 System provides
unmatched speed and performance in a simple bench-top platform, giving
you data in days, instead of weeks or months. Learn more...
http://links.ealert.nature.com/ctt?kn=50&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
=====================================================================
=========================== ADVERTISEMENT ===========================
Nature News Special: Neuroscience
Researchers are using every technique available to gain new insights
into neuroscience and, in particular, the human brain. This week?s
Neuroscience themed issue of Nature showcases and analyzes some of
these advances.
Nature Insight Neurotechniques
New techniques are markedly altering the landscape of experimental
neuroscience and redefining the questions that can be asked. These
new Methods are yielding insights into a diverse range of topics.
To explore these new techniques access selected content free online.
http://links.ealert.nature.com/ctt?kn=203&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
=====================================================================
----------------------
EDITORIALS
----------------------
Psychology: a reality check p847
If clinical psychology in the United States wants to remain viable and
relevant in today's health systems, it needs to publicly embrace science.
doi:10.1038/461847a
http://links.ealert.nature.com/ctt?kn=104&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Windfall warning pp847-848
Without forward planning, the billions of dollars in the US stimulus
package will go to long-term waste.
doi:10.1038/461847b
http://links.ealert.nature.com/ctt?kn=115&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Caught on camera p848
What to do when you are interviewed for an unscientific documentary.
doi:10.1038/461848a
http://links.ealert.nature.com/ctt?kn=112&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
Biology: Copy bat p850
doi:10.1038/461850a
http://links.ealert.nature.com/ctt?kn=77&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Atmospheric science: Monsoon madness p850
doi:10.1038/461850b
http://links.ealert.nature.com/ctt?kn=82&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Physics: Holy yocto! p850
doi:10.1038/461850c
http://links.ealert.nature.com/ctt?kn=88&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Structural biology: DNA first responder p850
doi:10.1038/461850d
http://links.ealert.nature.com/ctt?kn=93&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Biogeochemistry: Preindustrial carbon p850
doi:10.1038/461850e
http://links.ealert.nature.com/ctt?kn=140&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Virology: Infectious fatigue pp850-851
doi:10.1038/461850f
http://links.ealert.nature.com/ctt?kn=110&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Genomics: Human genome in 3D p851
doi:10.1038/461851a
http://links.ealert.nature.com/ctt?kn=123&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Astrophysics: Merge, no surge p851
doi:10.1038/461851b
http://links.ealert.nature.com/ctt?kn=118&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Biology: When colonies collide p851
doi:10.1038/461851c
http://links.ealert.nature.com/ctt?kn=136&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Stem-cell biology: Chemical reset p851
doi:10.1038/461851d
http://links.ealert.nature.com/ctt?kn=130&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------
JOURNAL CLUB
----------------------
Journal club p851
Sam Wang
doi:10.1038/461851e
http://links.ealert.nature.com/ctt?kn=48&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------
NEWS
----------------------
News briefing: 15 October 2009 pp852-853
The week in science
doi:10.1038/461852a
http://links.ealert.nature.com/ctt?kn=215&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Japan to slash huge grant scheme pp854-855
Upstart government brings fresh priorities to science.
David Cyranoski
doi:10.1038/461854a
http://links.ealert.nature.com/ctt?kn=144&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Cancer metastasis scrutinized pp854-855
Researchers shift focus to catch secondary tumours.
Elie Dolgin
doi:10.1038/461854b
http://links.ealert.nature.com/ctt?kn=147&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Fusion delays sow concern p855
Construction on ITER won't begin until 2010.
Geoff Brumfiel
doi:10.1038/461855a
http://links.ealert.nature.com/ctt?kn=150&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Where the US stimulus money is going pp856-857
How agencies have carved up their windfall.
doi:10.1038/461856a
http://links.ealert.nature.com/ctt?kn=153&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Key protein-design papers challenged p859
Chemists question stability of proteins from 2003 Nature study.
Erika Check Hayden
doi:10.1038/461859a
http://links.ealert.nature.com/ctt?kn=32&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Structural biology bags chemistry prize p860
Chemistry Nobel for trio who described the ribosome.
Richard Van Noorden
doi:10.1038/461860a
http://links.ealert.nature.com/ctt?kn=30&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Impact theory under fire once more p861
Archaeologists fail to find evidence for comet explosion.
Rex Dalton
doi:10.1038/461861a
http://links.ealert.nature.com/ctt?kn=36&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------
NEWS FEATURES
----------------------
Neuroscience: Small, furry … and smart pp862-864
Researchers have engineered more than 30 strains of 'smart mice',
revealing possible ways to boost human brains. But, as Jonah Lehrer
finds, cognitive enhancement may come at a cost.
Jonah Lehrer
doi:10.1038/461862a
http://links.ealert.nature.com/ctt?kn=34&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Neuroscience: Opening up brain surgery pp866-868
Neurosurgeons have unparalleled access to the human brain. Now they
are teaming up with basic researchers to work out what makes it
unique, finds Alison Abbott.
doi:10.1038/461866a
http://links.ealert.nature.com/ctt?kn=38&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Seismology: Shaking up earthquake theory pp870-872
Geological faults are not behaving as scientists once expected.
Glennda Chui reports on efforts to forge a new understanding of quake behaviour.
doi:10.1038/461870a
http://links.ealert.nature.com/ctt?kn=13&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------
CORRESPONDENCE
----------------------
OPINION
Pakistan: basic education essential to underpin reforms p874
Muhammad Naim Siddiqi, Abdul Wahab Yousafzai and Raza Ur Rahman
doi:10.1038/461874a
http://links.ealert.nature.com/ctt?kn=44&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Pakistan: cash infusion of limited use to universities p874
Pervez Hoodbhoy
doi:10.1038/461874b
http://links.ealert.nature.com/ctt?kn=46&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Pakistan: sense of urgency powered education reforms p874
Atta ur Rahman
doi:10.1038/461874c
http://links.ealert.nature.com/ctt?kn=40&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Battlefield: hitting the supporters of biotechnology p875
Jens A. Katzek
doi:10.1038/461875a
http://links.ealert.nature.com/ctt?kn=42&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Battlefield: useful debate needs caution and civility p875
Allison A. Snow
doi:10.1038/461875b
http://links.ealert.nature.com/ctt?kn=66&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Commercial pressure quelling creation of new microscopes p875
Brad Amos
doi:10.1038/461875c
http://links.ealert.nature.com/ctt?kn=64&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------
OPINION
----------------------
Is the stimulus working for you? pp876-878
More money for science is always good. Or is it? Six experts tell
Nature what concerns them most about the US stimulus spending and
suggest ways to ensure that it benefits research and society in
the long term.
doi:10.1038/461876a
http://links.ealert.nature.com/ctt?kn=62&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Massively collaborative mathematics pp879-881
The 'Polymath Project' proved that many minds can work together to
solve difficult mathematical problems. Timothy Gowers and
Michael Nielsen reflect on the lessons learned for open-source science.
Timothy Gowers and Michael Nielsen
doi:10.1038/461879a
http://links.ealert.nature.com/ctt?kn=60&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Stitching science together p881
Google Wave is the kind of open-source online collaboration tool that
should drive scientists to wire their research and publications into
an interactive data web, says Cameron Neylon.
Cameron Neylon
doi:10.1038/461881a
http://links.ealert.nature.com/ctt?kn=58&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------
BOOKS AND ARTS
----------------------
Art history's window onto the mind pp882-883
Neuroscientists should worry less about testing abstract qualities
such as beauty, and work with art historians towards a concrete
understanding of types of viewing, argues Martin Kemp.
Martin Kemp
doi:10.1038/461882a
http://links.ealert.nature.com/ctt?kn=8&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
In Retrospect: Brodmann's brain map p884
A classic neurology text written 100 years ago still provides the core
principles for linking the anatomy of the cerebral cortex to its
functions today, explains Jacopo Annese.
Jacopo Annese reviews Localisation in the Cerebral Cortex
by Korbinian Brodmann
doi:10.1038/461884a
http://links.ealert.nature.com/ctt?kn=10&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Q&A: The space entrepreneur p885
After completing simultaneous doctorates in physics and chemistry,
Harry Kloor became a space-exploration consultant and film-maker.
As his three-dimensional animated feature Quantum Quest — made
with real footage from the Cassini spacecraft — is previewed in
New York, Kloor shares his thoughts on manned space flight and
the use of prizes to motivate adventurous science.
Jascha Hoffman reviews Quantum Quest: A Cassini Space Odyssey
doi:10.1038/461885a
http://links.ealert.nature.com/ctt?kn=2&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Behavioural neurobiology: Chemical love pp887-888
Male and female fruitflies use pheromones to flaunt their species
identity and gender as they court amid other fruitfly species. The
grammar of this chemical language is surprisingly sophisticated.
Nicolas Gompel and Benjamin Prud'homme
doi:10.1038/461887a
http://links.ealert.nature.com/ctt?kn=4&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Condensed-matter physics: Wien route to monopoles pp888-889
Determining the magnetic charge of monopoles in a crystalline host
seemed a mountain too high for physicists to climb. An experiment
based on Wien's theory of electrolytes has now measured its value.
Shivaji Sondhi
doi:10.1038/461888a
http://links.ealert.nature.com/ctt?kn=7&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Neuroscience: The inside story on place cells pp889-890
Neurons known as place cells encode spatial information that is
needed to guide an animal's movement. Nearly 40 years after these
cells were discovered, neuroscience gets a look at their internal
dynamics.
Douglas Nitz
doi:10.1038/461889a
http://links.ealert.nature.com/ctt?kn=27&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Analytical chemistry: The matrix neutralized pp890-891
Many of the best methods available for monitoring biological binding
events can't be used in a diverse range of clinical samples. An
ultrasensitive assay based on magnetic signals overcomes this problem.
Ilia Fishbein and Robert J. Levy
doi:10.1038/461890a
http://links.ealert.nature.com/ctt?kn=18&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Stem cells: A fateful age gap pp891-892
When a stem cell divides, one sister cell differentiates and the
other retains its stem-cell identity. Differences in the age of
an organelle -- the centriole -- inherited at cell division may
determine these differing fates.
Tim Stearns
doi:10.1038/461891a
http://links.ealert.nature.com/ctt?kn=16&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
50 & 100 years ago p892
doi:10.1038/461892b
http://links.ealert.nature.com/ctt?kn=295&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Materials science: Quasicrystals from nanocrystals pp892-893
Quasicrystals have a host of unusual physical properties. These
intermediates between amorphous solids and regular crystalline
materials can now be made to self-assemble from nanoparticles.
Alfons van Blaaderen
doi:10.1038/461892a
http://links.ealert.nature.com/ctt?kn=306&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Obituary: Norman E. Borlaug (1914-2009) p894
Plant scientist who transformed global food production.
M. S. Swaminathan
doi:10.1038/461894a
http://links.ealert.nature.com/ctt?kn=300&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------
NEWS AND VIEWS Q&A
----------------------
Neuroscience: Alzheimer's disease pp895-897
The neurodegenerative disorder Alzheimer's disease is becoming more
prevalent in ageing populations worldwide. The identification of
effective treatments will require a better understanding of the
physiological mechanisms involved, and innovative approaches to
drug development and evaluation.
Lennart Mucke
doi:10.1038/461895a
http://links.ealert.nature.com/ctt?kn=311&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------
INSIGHT
----------------------
EDITORIAL
Neurotechniques p899
Noah Gray and Tanguy Chouard
doi:10.1038/461899a
http://links.ealert.nature.com/ctt?kn=308&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
REVIEW ARTICLE
Molecular genetics and imaging technologies for circuit-based
neuroanatomy pp900-907
Benjamin R. Arenkiel and Michael D. Ehlers
doi:10.1038/nature08536
Abstract: http://links.ealert.nature.com/ctt?kn=289&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=273&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Neuroscience in the era of functional genomics and systems biology
pp908-915
Daniel H. Geschwind and Genevieve Konopka
doi:10.1038/nature08537
Abstract: http://links.ealert.nature.com/ctt?kn=297&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=283&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
pp916-922
Richard J. Perrin, Anne M. Fagan and David M. Holtzman
doi:10.1038/nature08538
Abstract: http://links.ealert.nature.com/ctt?kn=292&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=285&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Reverse engineering the mouse brain pp923-929
Daniel H. O'Connor, Daniel Huber and Karel Svoboda
doi:10.1038/nature08539
Abstract: http://links.ealert.nature.com/ctt?kn=294&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=259&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Electrophysiology in the age of light pp930-939
Massimo Scanziani and Michael Hausser
doi:10.1038/nature08540
Abstract: http://links.ealert.nature.com/ctt?kn=303&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=255&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
It has never been as easy to make discoveries beyond the
boundaries of current knowledge.
Carl Zeiss works together with researchers around the world to
develop systems that open up new perspectives in the life sciences.
Find out more about ELYRA, LSM 780 and VivaTome - three unique
new vehicles to take you to new dimensions. http://links.ealert.nature.com/ctt?kn=67&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
=====================================================================
----------------------
ARTICLES
----------------------
Intracellular dynamics of hippocampal place cells during virtual
navigation pp941-946
As we navigate, spatial information is encoded in both rate and temporal
codes by place cells located in the hippocampus. To investigate the
origin of these codes, the intracellular dynamics of place cells are now
measured in vivo in awake mice navigating a virtual-reality environment.
Three subthreshold signatures of place fields are identified that
underlie the primary features of place-cell rate and temporal codes.
Christopher D. Harvey, Forrest Collman, Daniel A. Dombeck and David W. Tank
doi:10.1038/nature08499
Abstract: http://links.ealert.nature.com/ctt?kn=305&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=252&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Asymmetric centrosome inheritance maintains neural progenitors in the
neocortex pp947-955
Radial glia progenitors divide asymmetrically in the ventricular zone
(VZ) of the developing neocortex to produce both self-renewing radial
glia and differentiating cells. The latter will then leave the VZ
whereas the renewing radial glia progenitors stay to divide further,
but the mechanisms underlying these differences in behaviour are
unclear. Asymmetric inheritance of centrosomes is now shown to regulate
the differential behaviour of renewing progenitors in the embryonic
mouse neocortex.
Xiaoqun Wang et al.
doi:10.1038/nature08435
Abstract: http://links.ealert.nature.com/ctt?kn=298&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=124&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
----------------------------------------------------------------------
Introducing Nature India
http://links.ealert.nature.com/ctt?kn=169&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Nature India is dedicated to highlighting the best research being
produced in India in science and clinical medicine.
Latest Research Highlights
http://links.ealert.nature.com/ctt?kn=313&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
* Cancer terminators
http://links.ealert.nature.com/ctt?kn=109&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
* No side effect painkillers
http://links.ealert.nature.com/ctt?kn=21&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Always keep up-to-date! Sign up to Nature India e-alerts.
http://links.ealert.nature.com/ctt?kn=271&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------------------------------------------------------
=====================================================================
----------------------
LETTERS
----------------------
Measurement of the charge and current of magnetic monopoles in spin ice
pp956-959
Magnetic counterparts to electric charges and currents have proved elusive.
However, it was recently proposed that magnetic charges can exist in a
certain type of material termed 'spin ice'. Here, experimental measurements
prove that magnetic charges can indeed exist in such a material and have
measurable currents, thus establishing an instance of perfect symmetry
between electricity and magnetism.
S. T. Bramwell et al.
doi:10.1038/nature08500
Abstract: http://links.ealert.nature.com/ctt?kn=301&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=119&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Cooper pair splitter realized in a two-quantum-dot Y-junction pp960-963
One of the most counterintuitive fundamental properties of quantum
mechanics is non-locality, which manifests itself as correlations between
spatially separated parts of a quantum system. Although experimental
tests of non-locality (Bell inequalities) have been successfully
conducted with pairwise entangled photons, similar demonstrations using
electrons have so far not been possible. The realization of a Y-shaped
tunable Cooper pair splitter, to split entangled electrons on demand,
brings this one step closer.
L. Hofstetter, S. Csonka, J. Nygard and C. Schonenberger
doi:10.1038/nature08432
Abstract: http://links.ealert.nature.com/ctt?kn=310&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=129&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Quasicrystalline order in self-assembled binary nanoparticle superlattices
pp964-967
Quasicrystals are ordered structures that lack any translational symmetry,
challenging the classic conception of ordered solids as periodic
structures. So far, they have been reported in certain systems and can,
for example, form from intermetallic compounds and organic dendrimers.
Here it is shown that colloidal inorganic nanoparticles from several
materials can self-assemble into binary aperiodic superlattices with
quasicrystalline order.
Dmitri V. Talapin et al.
doi:10.1038/nature08439
Abstract: http://links.ealert.nature.com/ctt?kn=312&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=71&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Scaleable catalytic asymmetric Strecker syntheses of unnatural
[alpha]-amino acids pp968-970
Efficient methods for the synthesis of enantioenriched [alpha]-amino
acids -- the building blocks of proteins -- have been developed, but
it remains a challenge to obtain non-natural amino acids. A new
catalytic asymmetric method is now reported for the syntheses of
highly enantiomerically enriched non-natural amino acids using a
simple and robust chiral amido-thiourea catalyst. The method also
uses a safer source of cyanide.
Stephan J. Zuend, Matthew P. Coughlin, Mathieu P. Lalonde
and Eric N. Jacobsen
doi:10.1038/nature08484
Abstract: http://links.ealert.nature.com/ctt?kn=307&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Extensive dynamic thinning on the margins of the Greenland and
Antarctic ice sheets pp971-975
Mass loss from the glaciers along the margins of the Greenland and
Antarctic ice sheets is increasingly contributing to sea level rise.
However, ice loss as a result of accelerated flow, known as dynamic
thinning, is so poorly understood that its potential future contribution
to sea level remains unpredictable. Here, high-resolution laser
altimetry is used to map changes along these ocean margins; the results
show that dynamic thinning is more important and extensive than
previously thought.
Hamish D. Pritchard, Robert J. Arthern, David G. Vaughan and Laura A. Edwards
doi:10.1038/nature08471
Abstract: http://links.ealert.nature.com/ctt?kn=239&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=89&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Ammonia oxidation kinetics determine niche separation of nitrifying
Archaea and Bacteria pp976-979
Ammonia oxidation is carried out by both Bacteria and Archaea.
Oligotrophic ammonia oxidation kinetics and cellular characteristics
of a mesophilic crenarchaeon found in the open ocean are now reported;
its remarkably high specific affinity for reduced nitrogen suggests
that certain ammonia-oxidizing Archaea could successfully compete with
heterotrophic bacterioplankton and phytoplankton. Thus, ammonia
oxidation may be more prevalent in the marine nitrogen cycle than is
currently accounted for.
Willm Martens-Habbena et al.
doi:10.1038/nature08465
Abstract: http://links.ealert.nature.com/ctt?kn=241&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=204&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Cheater-resistance is not futile pp980-982
Individuals in cooperative social systems can cheat the system by
reaping the benefits of cooperation without incurring the costs. Here,
the presence of a cheater in a population of randomly mutated social
amoebae is shown to select for mutations that confer resistance to
cheating in the rest of the population. This cheater-resistance can
be a noble strategy because the resister strain does not necessarily
exploit other strains, preserving cooperative behaviour.
Anupama Khare et al.
doi:10.1038/nature08472
Abstract: http://links.ealert.nature.com/ctt?kn=242&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=196&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
An anatomical signature for literacy pp983-986
Unlike language, a uniquely human ability which children naturally
develop, reading is a learnt skill that requires tuition and practice.
Learning to read is likely to involve structural brain changes, but
these are nearly impossible to isolate in children owing to other
concurrent changes. A population of former Colombian guerrillas
learning to read as adults is now studied, using structural brain
scans to compare changes in the brains of these late-literates with
those of illiterates.
Manuel Carreiras et al.
doi:10.1038/nature08461
Abstract: http://links.ealert.nature.com/ctt?kn=243&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=200&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Specialized cells tag sexual and species identity in Drosophila melanogaster
pp987-991
Many organisms use chemical signals to indicate species and sex. Cuticular
hydrocarbon signals are used by insects, including Drosophila melanogaster,
to distinguish conspecific individuals from others, and they also
contribute to courtship and mating interactions. Direct evidence is now
provided that a single compound is used to communicate female identity
among D. melanogaster, and to define a reproductive isolation barrier
between D. melanogaster and sibling species.
Jean-Christophe Billeter et al.
doi:10.1038/nature08495
Abstract: http://links.ealert.nature.com/ctt?kn=235&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=221&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
A secreted complement-control-related protein ensures acetylcholine
receptor clustering pp992-996
For efficient neurotransmission at chemical synapses to occur, there
must be spatial congruence between the presynaptic area where synaptic
vesicles fuse and the postsynaptic area where neurotransmitter receptors
concentrate. An extracellular scaffold is now described that is
necessary for the clustering of acetylcholine receptors at neuromuscular
junctions in the nematode Caenorhabditis elegans; it involves the
protein LEV-9, the function of which relies on complement control
protein domains.
Marie Gendrel, Georgia Rapti, Janet E. Richmond and Jean-Louis Bessereau
doi:10.1038/nature08430
Abstract: http://links.ealert.nature.com/ctt?kn=236&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=218&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Spatiotemporal control of cell signalling using a light-switchable
protein interaction pp997-1001
The use of light to precisely control cellular behaviour is a challenge
that has only recently begun to be addressed. Here, a genetically
encoded light-control system is demonstrated in mammalian cells. Based
on a reversible protein-protein interaction from the phytochrome
signalling network of Arabidopsis thaliana, the system is used to
reversibly translocate activators of the Rho-family GTPases to the
plasma membrane with high temporal and spatial resolution.
Anselm Levskaya, Orion D. Weiner, Wendell A. Lim and Christopher A. Voigt
doi:10.1038/nature08446
Abstract: http://links.ealert.nature.com/ctt?kn=237&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=178&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Integrin-linked kinase is an adaptor with essential functions during
mouse development pp1002-1006
Integrin-linked kinase (Ilk) is a multifunctional protein that binds
[beta]-integrin cytoplasmic domains and regulates actin dynamics
through the recruitment of actin binding regulatory proteins such
as [alpha]- and [beta]-parvin. In mice, genetic evidence is now
provided that the kinase activity of Ilk is not essential for
mammalian development but that an interaction between Ilk and
[alpha]-parvin is critical for kidney development.
Anika Lange et al.
doi:10.1038/nature08468
Abstract: http://links.ealert.nature.com/ctt?kn=238&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=174&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
DNA demethylation in hormone-induced transcriptional derepression
pp1007-1012
Gene regulation is known to be affected by epigenetic modifications
at the histone level in response to extracellular signals; however,
the effect of modifications at the DNA level, and especially active
DNA demethylation, are not well understood. Here, DNA
methylation/demethylation is found to be hormonally switched in
order to control the transcription of the cytochrome p450 27B1 gene.
Mi-Sun Kim et al.
doi:10.1038/nature08456
Abstract: http://links.ealert.nature.com/ctt?kn=245&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=172&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
Careers Q&A
Krzysztof Matyjaszewski p1015
A chemist at Carnegie Mellon University in Pittsburgh, Pennsylvania,
Matyjaszewski is the winner of this year's Presidential Green
Chemistry Challenge academic award.
Paul Smaglik
doi:10.1038/nj7266-1015a
http://links.ealert.nature.com/ctt?kn=146&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Postdoc journal
Heart matters p1015
Leaving academia for the freelance world has its rewards.
Joanne Isaac
doi:10.1038/nj7266-1015b
http://links.ealert.nature.com/ctt?kn=159&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
In Brief
Call for cluster funding p1015
Regional innovation could create research jobs in the United States.
doi:10.1038/nj7266-1015c
http://links.ealert.nature.com/ctt?kn=157&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
In Brief
Psychology overhaul p1015
More robust science training recommended for clinical psychologists.
doi:10.1038/nj7266-1015d
http://links.ealert.nature.com/ctt?kn=167&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
In Brief
Genomics gets a boost p1015
US$45 million will support tool development.
doi:10.1038/nj7266-1015e
http://links.ealert.nature.com/ctt?kn=164&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------
FUTURES
----------------------
Escapism p1018
Where there's a will...
Nick Mamatas
doi:10.1038/4611018a
http://links.ealert.nature.com/ctt?kn=190&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
14 October 2009
Effector T cell interactions with meningeal vascular structures in
nascent autoimmune CNS lesions
Ingo Bartholomäus et al.
doi:10.1038/nature08478
Abstract: http://links.ealert.nature.com/ctt?kn=182&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=182&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Human DNA methylomes at base resolution show widespread epigenomic
differences
Ryan Lister et al.
doi:10.1038/nature08514
Abstract: http://links.ealert.nature.com/ctt?kn=274&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=274&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Fractional quantum Hall effect and insulating phase of Dirac electrons
in graphene
Xu Du et al.
doi:10.1038/nature08522
Abstract: http://links.ealert.nature.com/ctt?kn=280&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=280&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
11 October 2009
SSB protein diffusion on single-stranded DNA stimulates RecA filament
formation
Rahul Roy, Alexander G. Kozlov, Timothy M. Lohman and Taekjip Ha
doi:10.1038/nature08442
Abstract: http://links.ealert.nature.com/ctt?kn=286&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=286&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Nature Methods is 5 years old!!!
To celebrate the 5-year anniversary of the Nature Methods launch,
the October 2009 issue will contain a special feature highlighting
critical method developments and their importance in biological
research.
Visit:
http://links.ealert.nature.com/ctt?kn=247&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
=====================================================================
You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=52&m=34222600&r=MjA1NTkxMDA2MAS2&b=2&j=NTkzOTkzNTAS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2009 Nature Publishing Group
=====================================================================
