Volume 101 Number 8
Published online 13 October 2009 (1225 - 1490)
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The Big What If Challenge #4: CGH/CNV
What if you could gain a clear view of the genomic aberrations that matter?
What if you could win a SurePrint G3 CNV or Custom CGH Microarray Kit
just by solving a puzzle? Test your wits against Agilent's monthly genomics
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Visit http://links.ealert.nature.com/ctt?kn=52&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
now to win!
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British Journal of Cancer publishes high quality original papers and
reviews that make a significant contribution to increasing
understanding of the causes of cancer and to improving the treatment
and survival of patients.
Visit the journal online at http://links.ealert.nature.com/ctt?kn=59&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0 to view the
latest research and access selected articles FREE of charge.
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British Journal of Cancer has an impact factor of 4.846*
2008 Journal Citation Reports (Thomson Reuters, 2009)
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MINIREVIEW
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Imaging metastatic bone disease from carcinoma of the prostate
C Messiou, G Cook and N M deSouza
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=109&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
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CLINICAL STUDIES
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Open-label, clinical phase I studies of tasquinimod in patients with castration-resistant prostate cancer
O Bratt, M Haggman, G Ahlgren, O Nordle, A Bjork and J-E Damber
Abstract: http://links.ealert.nature.com/ctt?kn=108&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=107&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Weekly administration of sagopilone (ZK-EPO), a fully synthetic epothilone, in patients with refractory solid tumours: results of a phase I trial
D Arnold, W Voigt, P Kiewe, C Behrmann, S Lindemann, S Reif, H Wiesinger, M Giurescu, E Thiel and H-J Schmoll
Abstract: http://links.ealert.nature.com/ctt?kn=114&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=113&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Phase II trial of short-term neoadjuvant docetaxel and complete androgen blockade in high-risk prostate cancer
B Mellado, A Font, A Alcaraz, L A Aparicio, F J G Veiga, J Areal, E Gallardo, N Hannaoui, J R M Lorenzo, A Sousa, P L Fernandez and P Gascon
Abstract: http://links.ealert.nature.com/ctt?kn=112&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=111&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Nuclear receptor co-activators and HER-2/neu are upregulated in breast cancer patients during neo-adjuvant treatment with aromatase inhibitors
M Hauglid Flageng, L L Haugan Moi, J M Dixon, J Geisler, E A Lien, W R Miller, P E Lonning and G Mellgren
Abstract: http://links.ealert.nature.com/ctt?kn=138&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=140&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Phase II study of cetuximab in combination with cisplatin and docetaxel in patients with untreated advanced gastric or gastro-oesophageal junction adenocarcinoma (DOCETUX study)
C Pinto, F Di Fabio, C Barone, S Siena, A Falcone, S Cascinu, F L Rojas Llimpe, G Stella, G Schinzari, S Artale, V Mutri, S Giaquinta, L Giannetta, A Bardelli and A A Martoni
Abstract: http://links.ealert.nature.com/ctt?kn=21&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=24&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Evaluation of bowel cancer registration data in England, 1996-2004
A M Jones, E Morris, J Thomas, D Forman, J Melia and S M Moss
Abstract: http://links.ealert.nature.com/ctt?kn=23&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Cutoff value determines the performance of a semi-quantitative immunochemical faecal occult blood test in a colorectal cancer screening programme
L G M van Rossum, A F van Rijn, R J F Laheij, M G H van Oijen, P Fockens, J B M J Jansen, A L M Verbeek and E Dekker
Abstract: http://links.ealert.nature.com/ctt?kn=26&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis
O Fluge, K Gravdal, E Carlsen, B Vonen, K Kjellevold, S Refsum, R Lilleng, T J Eide, T B Halvorsen, K M Tveit, A P Otte, L A Akslen and O Dahl for the Norwegian Gastrointestinal Cancer Group
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
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TRANSLATIONAL THERAPEUTICS
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Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells
D L Roberts, K J Williams, R L Cowen, M Barathova, A J Eustace, S Brittain-Dissont, M J Tilby, D G Pearson, C J Ottley, I J Stratford and C Dive
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=115&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Cytokeratins 18 and 8 are poor prognostic markers in patients with squamous cell carcinoma of the oesophagus
T Makino, M Yamasaki, A Takeno, M Shirakawa, H Miyata, S Takiguchi, K Nakajima, Y Fujiwara, T Nishida, N Matsuura, M Mori and Y Doki
Abstract: http://links.ealert.nature.com/ctt?kn=125&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=126&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Synergistic anti-cancer effects of immunotoxin and cyclosporin in vitro and in vivo
Y Andersson, O Engebraaten and O Fodstad
Abstract: http://links.ealert.nature.com/ctt?kn=123&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=124&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Glucocorticoid therapy and risk of bladder cancer
K Dietrich, A Schned, J Fortuny, J Heaney, C Marsit, K T Kelsey and M R Karagas
Abstract: http://links.ealert.nature.com/ctt?kn=121&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=122&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Human leukocyte antigen class I expression is an independent prognostic factor in advanced ovarian cancer resistant to first-line platinum chemotherapy
M Shehata, A Mukherjee, S Deen, A Al-Attar, L G Durrant and S Chan
Abstract: http://links.ealert.nature.com/ctt?kn=119&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=120&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Vaccination with Mage-b DNA induces CD8 T-cell responses at young but not old age in mice with metastatic breast cancer
F Castro, B Leal, A Denny, R Bahar, S Lampkin, R Reddick, S Lu and C Gravekamp
Abstract: http://links.ealert.nature.com/ctt?kn=116&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=118&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
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MOLECULAR DIAGNOSTICS
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Molecular characteristics of screen-detected vs symptomatic breast cancers and their impact on survival
S J Dawson, S W Duffy, F M Blows, K E Driver, E Provenzano, J LeQuesne, D C Greenberg, P Pharoah, C Caldas and G C Wishart
Abstract: http://links.ealert.nature.com/ctt?kn=141&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=142&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Human papilloma virus is associated with breast cancer
B Heng, W K Glenn, Y Ye, B Tran, W Delprado, L Lutze-Mann, N J Whitaker and J S Lawson
Abstract: http://links.ealert.nature.com/ctt?kn=143&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=133&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Koilocytes indicate a role for human papilloma virus in breast cancer
J S Lawson, W K Glenn, B Heng, Y Ye, B Tran, L Lutze-Mann and N J Whitaker
Abstract: http://links.ealert.nature.com/ctt?kn=134&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=136&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Gene expression profile and response to trastuzumab-docetaxel-based treatment in breast carcinoma
F Vegran, R Boidot, B Coudert, P Fumoleau, L Arnould, J Garnier, S Causeret, J Fraise, D Dembele and S Lizard-Nacol
Abstract: http://links.ealert.nature.com/ctt?kn=137&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=129&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells
S Semba, Y Kodama, K Ohnuma, E Mizuuchi, R Masuda, M Yashiro, K Hirakawa and H Yokozaki
Abstract: http://links.ealert.nature.com/ctt?kn=130&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=132&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells
K Ueno, S Hazama, S Mitomori, M Nishioka, Y Suehiro, H Hirata, M Oka, K Imai, R Dahiya and Y Hinoda
Abstract: http://links.ealert.nature.com/ctt?kn=87&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=88&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
CD8+ lymphocytes/[thinsp]tumour-budding index: an independent prognostic factor representing a /`pro-/anti-tumour/' approach to tumour host interaction in colorectal cancer
A Lugli, E Karamitopoulou, I Panayiotides, P Karakitsos, G Rallis, G Peros, G Iezzi, G Spagnoli, M Bihl, L Terracciano and I Zlobec
Abstract: http://links.ealert.nature.com/ctt?kn=84&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=85&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Inflammation and tissue repair markers distinguish the nodular sclerosis and mixed cellularity subtypes of classical Hodgkin's lymphoma
A Birgersdotter, K R N Baumforth, A Porwit, J Sjoberg, W Wei, M Bjorkholm, P G Murray and I Ernberg
Abstract: http://links.ealert.nature.com/ctt?kn=79&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=80&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling
V Zismanov, M Lishner, S Tartakover-Matalon, J Radnay, H Shapiro and L Drucker
Abstract: http://links.ealert.nature.com/ctt?kn=77&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
DKC1 overexpression associated with prostate cancer progression
P Sieron, C Hader, J Hatina, R Engers, A Wlazlinski, M Muller and W A Schulz
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma
J-J Patard, N Rioux-Leclercq, D Masson, S Zerrouki, F Jouan, N Collet, C Dubourg, B Lobel, M Denis and P Fergelot
Abstract: http://links.ealert.nature.com/ctt?kn=98&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=99&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas
M Murase, M Kano, T Tsukahara, A Takahashi, T Torigoe, S Kawaguchi, S Kimura, T Wada, Y Uchihashi, T Kondo, T Yamashita and N Sato
Abstract: http://links.ealert.nature.com/ctt?kn=103&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=105&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Overexpression of FOXG1 contributes to TGF-[beta] resistance through inhibition of p21WAF1/CIP1 expression in ovarian cancer
D W Chan, V W S Liu, R M Y To, P M Chiu, W Y W Lee, K M Yao, A N Y Cheung and H Y S Ngan
Abstract: http://links.ealert.nature.com/ctt?kn=106&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=92&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma
V Koljonen, H Kukko, E Pukkala, R Sankila, T Bohling, E Tukiainen, H Sihto and H Joensuu
Abstract: http://links.ealert.nature.com/ctt?kn=93&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=94&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
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GENETICS AND GENOMICS
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NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma
R J Flockhart, J L Armstrong, N J Reynolds and P E Lovat
Abstract: http://links.ealert.nature.com/ctt?kn=95&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=96&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
O M Sinilnikova, A C Antoniou, J Simard, S Healey, M Leone, D Sinnett, A B Spurdle, J Beesley, X Chen, kConFab8, M H Greene, J T Loud, F Lejbkowicz, G Rennert, S Dishon, I L Andrulis, OCGN11, S M Domchek, K L Nathanson, S Manoukian, P Radice, I Konstantopoulou, I Blanco, A L Laborde, M Duran, A Osorio, J Benitez, U Hamann, F B L Hogervorst, T A M van Os, H J P Gille, HEBON23, S Peock, M Cook, C Luccarini, D G Evans, F Lalloo, R Eeles, G Pichert, R Davidson, T Cole, J Cook, J Paterson, C Brewer, EMBRACE3, D J Hughes, I Coupier, S Giraud, F Coulet, C Colas, F Soubrier, E Rouleau, I Bieche, R Lidereau, L Demange, C Nogues, H T Lynch, GEMO1242, R K Schmutzler, B Versmold, C Engel, A Meindl, N Arnold, C Sutter, H Deissler, D Schaefer, U G Froster, GC-HBOC4344454647484950, K Aittomaki, H Nevanlinna, L McGuffog, D F Easton, G Chenevix-Trench and D Stoppa-Lyonnet on behalf of the Consortium of Investigators of Modifiers of BRCA1/2
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis
J M Cunningham, R A Vierkant, T A Sellers, C Phelan, D N Rider, M Liebow, J Schildkraut, A Berchuck, F J Couch, X Wang, B L Fridley, Ovarian Cancer Association Consortium, A Gentry-Maharaj, U Menon, E Hogdall, S Kjaer, A Whittemore, R DiCioccio, H Song, S A Gayther, S J Ramus, P D P Pharaoh and E L Goode
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=38&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Gene expression profiling integrated into network modelling reveals heterogeneity in the mechanisms of BRCA1 tumorigenesis
R Fernandez-Ramires, X Sole, L De Cecco, G Llort, A Cazorla, N Bonifaci, M J Garcia, T Caldes, I Blanco, M Gariboldi, M A Pierotti, M A Pujana, J Benitez and A Osorio
Abstract: http://links.ealert.nature.com/ctt?kn=35&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
GATA factors in human neuroblastoma: distinctive expression patterns in clinical subtypes
V Hoene, M Fischer, A Ivanova, T Wallach, F Berthold and C Dame
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=36&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
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LETTER TO THE EDITOR
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The mysterious steps in carcinogenesis: addendum
D Brash and J Cairns
http://links.ealert.nature.com/ctt?kn=41&m=34219085&r=MTc2MDAwMTgxNgS2&b=2&j=NTkzNzg4MDUS1&mt=1&rt=0
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