Signaling Gateway - 4 September 2009
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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GTPASE ACTIVATION AT THE LEADING EDGE: ADVANCING TECHNOLOGIES
The use of 'computational multiplexing' and a photoactivatable
version of Rac1 has revealed that RhoA is activated concomitantly to
cell advancement, that Rac1 and Cdc42 activation is delayed compared
to that of RhoA, and that Rac1 inhibits RhoA.
Original research paper: Nature 461, 104-108 (2009)
http://links.ealert.nature.com/ctt?kn=42&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
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Molecule Pages
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RhoA
http://links.ealert.nature.com/ctt?kn=40&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
RhoA is a prototypical member of the Rho subfamily of Ras-related
small GTP-binding proteins. RhoA, along with other Rho-subfamily
members, plays pivotal roles in cellular activities, including
cell-cycle progression, cytokinesis, vesicle trafficking and cell
adhesion. Aberrant regulation of RhoA activity can contribute to
cancer-cell phenotypes, although RhoA mutational activation has not
been reported.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=38&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
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Selected Updates
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SMALL RNAS: P53 MAKES MICRORNAS MATURE
Wild-type p53 increases the post-transcriptional maturation of
microRNAs (miRNAs) that have growth-suppressive functions, whereas
mutant p53 interferes with miRNA processing.
Original research paper: Nature 460, 529-533 (2009)
http://links.ealert.nature.com/ctt?kn=36&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
NEURODEGENERATIVE DISEASE: AVOIDING BAD COMPLEMENT IN ALZHEIMER'S
DISEASE
Inhibition of the receptor for the pro-inflammatory complement factor
C5a (C5aR) reduces the neuropathology and rescues cognitive deficits
in two mouse models of Alzheimer's disease.
Original research paper: J. Immunol. 183, 1375-1383 (2009)
http://links.ealert.nature.com/ctt?kn=34&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
OBESITY: A TWO-PRONGED ATTACK
A single peptide that targets the glucagon receptor and glucagon-like
peptide 1 receptor - two key pathways in glucose homeostasis - might
provide a novel therapeutic strategy for obesity.
Original research paper: Nature Chem. Biol. 13 Jul 2009
(DOI 10.1038/nchembio.209)
http://links.ealert.nature.com/ctt?kn=32&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=29&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=27&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
ANTIOXIDANT AND ONCOGENE RESCUE OF METABOLIC DEFECTS CAUSED BY LOSS
OF MATRIX ATTACHMENT
Nature 461, 109-113 (2009)
http://links.ealert.nature.com/ctt?kn=53&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
MUTATIONS IN INPP5E, ENCODING INOSITOL POLYPHOSPHATE-5-PHOSPHATASE E,
LINK PHOSPHATIDYL INOSITOL SIGNALING TO THE CILIOPATHIES
Nature Genetics 41, 1032-1036 (2009)
http://links.ealert.nature.com/ctt?kn=55&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
CABIN 1 RESTRAINS p53 ACTIVITY ON CHROMATIN
Nature Structural & Molecular Biology 16, 910-915 (2009)
http://links.ealert.nature.com/ctt?kn=35&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
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Signaling News
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BIOGPS SPOTLIGHT ON THE SIGNALING GATEWAY
http://links.ealert.nature.com/ctt?kn=17&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
BioGPS is a gene portal that offers users the ability to customize
gene annotation reports by drawing content from multiple online
databases. BioGPS now provides a 'Nature Databases' layout that
enables users to visualize Molecule Pages side-by-side with pathways
in the NCI-Nature Pathway Interaction Database. This week, the BioGPS
blog features an interview with the editors of the Signaling Gateway.
More news
http://links.ealert.nature.com/ctt?kn=56&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
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Gateway Updates
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THE CELL MIGRATION GATEWAY - SEPTEMBER UPDATE
http://links.ealert.nature.com/ctt?kn=46&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's update features "Focal adhesion assembly: New
relationships from an siRNA screen".
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
http://links.ealert.nature.com/ctt?kn=37&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
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Job of the Week
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Tenure-Track Faculty Positions
Employer: Yeshiva University
Location: New York City, New York, USA
http://links.ealert.nature.com/ctt?kn=9&m=33990449&r=MTc2ODc4NDI0MAS2&b=2&j=NTc1NzI0MzgS1&mt=1&rt=0
The Albert Einstein College of Medicine at Yeshiva University is
seeking to fill multiple tenure-track faculty positions in the newly
formed Department of Systems and Computational Biology. Candidates
should have expertise in a physical, mathematical or computational
field with experience in applying these skills to a biological or
biomedical area. Areas of interest include modeling cellular
processes, pathway analysis, and functional proteomics and genomics.
More Jobs:
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To advertise a job in this spot, please contact Naturejobs.
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