Signaling Gateway - 18 September 2009
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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P53 RESPONSES: AXIN' ARREST FOR DEATH
The scaffold protein Axin interacts with either Tip60 or Pirh2 to
promote p53-mediated apoptosis or cell-cycle arrest following DNA
damage.
Original research paper: Nature Cell Biology 11, 1128-1134 (2009)
http://links.ealert.nature.com/ctt?kn=20&m=34049365&r=MTc2ODc4NDI0MAS2&b=2&j=NTgxNDg4OTIS1&mt=1&rt=0
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Selected Updates
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PHAGOCYTOSIS: DON'T EAT THE HSCS
Acute myeloid leukemia stem cells transiently upregulate CD47 in
order to evade macrophage-mediated killing and protect themselves
from phagocytosis.
Original research paper: Cell 138, 271–285 (2009)
http://links.ealert.nature.com/ctt?kn=6&m=34049365&r=MTc2ODc4NDI0MAS2&b=2&j=NTgxNDg4OTIS1&mt=1&rt=0
METASTASIS: ROUTE MASTER
Activation of the Wnt pathway in lung adenocarcinoma cells enhances
their ability to metastasize to the brain and bone.
Original research paper: Cell 138, 51–62 (2009)
http://links.ealert.nature.com/ctt?kn=5&m=34049365&r=MTc2ODc4NDI0MAS2&b=2&j=NTgxNDg4OTIS1&mt=1&rt=0
AGEING: SECRETS OF A LONG LIFE
Caloric restriction and inhibition of mTOR signaling have both been
shown to extend lifespan in animal models.
Original research paper: Science 325, 201–204 (2009)
http://links.ealert.nature.com/ctt?kn=9&m=34049365&r=MTc2ODc4NDI0MAS2&b=2&j=NTgxNDg4OTIS1&mt=1&rt=0
More Updates:
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Research Library
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http://links.ealert.nature.com/ctt?kn=2&m=34049365&r=MTc2ODc4NDI0MAS2&b=2&j=NTgxNDg4OTIS1&mt=1&rt=0
RESPONSE AND RESISTANCE TO MEK INHIBITION IN LEUKAEMIAS INITIATED BY
HYPERACTIVE RAS
Nature 461, 411-414 (2009)
http://links.ealert.nature.com/ctt?kn=13&m=34049365&r=MTc2ODc4NDI0MAS2&b=2&j=NTgxNDg4OTIS1&mt=1&rt=0
A CRUCIAL ROLE FOR ADIPOSE TISSUE p53 IN THE REGULATION OF INSULIN
RESISTANCE
Nature Medicine 15, 1082-1087 (2009)
http://links.ealert.nature.com/ctt?kn=26&m=34049365&r=MTc2ODc4NDI0MAS2&b=2&j=NTgxNDg4OTIS1&mt=1&rt=0
SYNTHETIC PARTIAL AGONISTS REVEAL KEY STEPS IN IP3 RECEPTOR
ACTIVATION
Nature Chemical Biology 5, 631-639 (2009)
http://links.ealert.nature.com/ctt?kn=14&m=34049365&r=MTc2ODc4NDI0MAS2&b=2&j=NTgxNDg4OTIS1&mt=1&rt=0
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Signaling News
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PUBLICATION BIAS CONTINUES DESPITE CLINICAL-TRIAL REGISTRATION
http://links.ealert.nature.com/ctt?kn=10&m=34049365&r=MTc2ODc4NDI0MAS2&b=2&j=NTgxNDg4OTIS1&mt=1&rt=0
The publicly available ClinicalTrials.gov registry was established in
2000 by the US National Institutes of Health to address the problem
that drug trial sponsors often fail to publish studies with negative
results. However, two new studies have found that fewer than half of
published clinical trials are adequately registered, and, on the
other hand, fewer than half of registered trials are ever published
in peer-reviewed journals.
More news
http://links.ealert.nature.com/ctt?kn=1&m=34049365&r=MTc2ODc4NDI0MAS2&b=2&j=NTgxNDg4OTIS1&mt=1&rt=0
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - SEPTEMBER UPDATE
http://links.ealert.nature.com/ctt?kn=21&m=34049365&r=MTc2ODc4NDI0MAS2&b=2&j=NTgxNDg4OTIS1&mt=1&rt=0
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update includes "Cardiac muscle: Sweet heartbeats" and
"H. pylori infection: Sugar wars".
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://links.ealert.nature.com/ctt?kn=34&m=34049365&r=MTc2ODc4NDI0MAS2&b=2&j=NTgxNDg4OTIS1&mt=1&rt=0
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Job of the Week
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Postdoctoral position
Employer: University of Crete, School of Medicine
Location: Crete, Greece
http://links.ealert.nature.com/ctt?kn=28&m=34049365&r=MTc2ODc4NDI0MAS2&b=2&j=NTgxNDg4OTIS1&mt=1&rt=0
A two-year postdoctoral position is available in the laboratory of
Dr. Christos Tsatsanis in the Department of Laboratory Medicine at the
University of Crete. A highly motivated individual is sought to
investigate the role of microRNAs and signaling molecules in innate
immune responses. Candidates must have a PhD and previous experience
with basic molecular biology methods, cell culture and in vivo models
of inflammatory diseases.
More Jobs:
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To advertise a job in this spot, please contact Naturejobs.
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