Signaling Gateway - 7 August 2009
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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ONCOGENESIS: THE MANY FACES OF C-CBL
Mutations in the E3 ubiquitin ligase C-CBL that unmask its oncogenic
potential have been detected in patients with myelodysplastic
syndromes.
Original research paper: Nature advance online publication,
20 July 2009
http://links.ealert.nature.com/ctt?kn=17&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
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Molecule Pages
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Hippocalcin
http://links.ealert.nature.com/ctt?kn=58&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
Hippocalcin (Hpca) is a Ca2+-binding protein of the neuronal calcium
sensor (NCS) protein family that is predominantly expressed in the
hippocampus. Hpca may act as a multifunctional modulator in
Ca2+-signaling pathways. Hpca is involved in the activity-dependent
activation of the MAPK pathway through interactions with
mixed-lineage kinases, or by regulating ERK signaling with subsequent
activation of cAMP-response element-binding protein (CREB).
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=41&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
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Selected Updates
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CELL SIGNALLING: TIME FOR WORK?
A fluorescent bioprobe reveals the spatiotemporal activation of the
small GTPase Cdc42 in developing Drosophila melanogaster embryos.
Original research paper: Science 324, 1338-1340 (2009)
http://links.ealert.nature.com/ctt?kn=55&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
TUMORIGENESIS: CONE CELLS SET THE STAGE
The loss of the tumor suppressor retinoblastoma protein (RB) in eye
cone cells suppresses cell death and promotes cell survival, leading
to the development of the cancer retinoblastoma.
Original research paper: Cell 137, 1018–1031 (2009)
http://links.ealert.nature.com/ctt?kn=7&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
ANTICANCER DRUGS: MICRORNA SUPPRESSES LIVER CANCER
Reinstating the expression of miR-26a, a microRNA that is
specifically downregulated in liver cancer cells, suppresses tumor
progression by repressing cyclin D2 and cyclin E2.
Original research paper: Cell 137, 1005–1017 (2009)
http://links.ealert.nature.com/ctt?kn=43&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=54&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=15&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
MIR-145 AND MIR-143 REGULATE SMOOTH MUSCLE CELL FATE AND PLASTICITY
Nature 460, 705-710 (2009)
http://links.ealert.nature.com/ctt?kn=27&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
PERSISTENT DNA DAMAGE SIGNALLING TRIGGERS SENESCENCE-ASSOCIATED
INFLAMMATORY CYTOKINE SECRETION
Nature Cell Biology 11, 973-979 (2009)
http://links.ealert.nature.com/ctt?kn=25&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
CA2+ AND CALMODULIN INITIATE ALL FORMS OF ENDOCYTOSIS DURING
DEPOLARIZATION AT A NERVE TERMINAL
Nature Neuroscience 12, 1003-1010 (2009)
http://links.ealert.nature.com/ctt?kn=34&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
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Signaling News
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GRANT SCORES LEAVE APPLICANTS IN LIMBO
http://links.ealert.nature.com/ctt?kn=23&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
Applicants for the coveted Challenge Grants issued by the US National
Institutes of Health (NIH) as part of the American Recovery and
Reinvestment Act learned the peer-review scores for their proposals
late last month. However, they received little in the way of
certainty over whether those scores will translate into money come
September, when the NIH will announce which grants it plans to fund.
The NIH director's office will fund only about 1% of the
applications.
More news
http://links.ealert.nature.com/ctt?kn=26&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
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Gateway Updates
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LIPIDOMICS GATEWAY - AUGUST UPDATE
http://links.ealert.nature.com/ctt?kn=21&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
The Lipidomics Gateway is a free, comprehensive website for
researchers interested in lipid biology.
This month's update features "Targeted lipidomics: Planned discovery"
and "Macrophage lipid droplets: Inert? Eicosa' not!"
Sign up here to receive the monthly update alert for the
Lipidomics Gateway.
http://links.ealert.nature.com/ctt?kn=44&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
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Job of the Week
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Postdoctoral position
Employer: Ulm University Hospital
Location: Ulm, Germany
http://links.ealert.nature.com/ctt?kn=28&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
Ulm University invites applications for a postdoctoral researcher in
the field of cancer stem cells and apoptosis. The successful
candidate will study apoptotic pathways in cancer stem cells derived
from malignant brain tumors, with the aim to identify key molecules
for the development of new cancer therapeutics and novel prognostic
biomarkers.
More Jobs:
http://links.ealert.nature.com/ctt?kn=14&m=33823990&r=MTc2ODc4NDI0MAS2&b=2&j=NTUyNDQwNTkS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
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