Signaling Gateway - 28 August 2009
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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SENESCENCE: DNA DAMAGE RESPONSE TRIGGERS CYTOKINE PRODUCTION
Severe genotoxic stress induces senescence and stimulates the DNA
damage response pathway to induce secretion of inflammatory
cytokines.
Original research paper: Nature Cell Biology 11, 973-979 (2009)
http://links.ealert.nature.com/ctt?kn=23&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
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Molecule Pages
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CLEC5A
http://links.ealert.nature.com/ctt?kn=7&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
CLEC5A (C-type lectin 5A) is a type 2 transmembrane protein with an
extracellular C-type lectin-like domain. It associates in the plasma
membrane with the adaptor protein Dap12. Signaling through this
complex stimulates osteoclastogenesis and bone remodeling. CLEC5A is
a receptor for Dengue virus on the surface of macrophages and this
interaction triggers the release of proinflammatory cytokines.
Also published this week:
CLEC-1
http://links.ealert.nature.com/ctt?kn=10&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
Search the molecule pages
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Selected Updates
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Cell signalling: Telomerase gets Wnt talking
The telomerase reverse transcriptase (TERT) subunit of telomerase
interacts with the ATP-dependent chromatin remodeling factor BRG1 at
specific sites in Wnt-dependent target genes to regulate
Wnt–beta-catenin-mediated transcription.
Original research paper: Nature 460, 66-72 (2009)
http://links.ealert.nature.com/ctt?kn=2&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
METASTASIS: T-ALL ORDER
The chemokine receptor CCR7 is necessary for infiltration of T-cell
acute lymphoblastic leukemia (T-ALL) cells into the central nervous
system (CNS), suggesting that pharmacological inhibition of CCR7
might help reduce CNS relapse.
Original research paper: Nature 459, 1000-1004 (2009)
http://links.ealert.nature.com/ctt?kn=1&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
EVOLUTION: PROTEIN KINASES MIX IT UP
High-throughput mass spectrometry of the phosphoproteomes of three
yeast species that are separated by 400-600 million years of
evolution - Saccharomyces cerevisiae, Candida albicans and
Schizosaccharomyces pombe - has revealed the rate at which
kinase-substrate interactions change.
Original research paper: PLoS Biol. 7, e1000134 (2009)
http://links.ealert.nature.com/ctt?kn=4&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=16&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=15&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
LINKING THE p53 TUMOUR SUPPRESSOR PATHWAY TO SOMATIC CELL
REPROGRAMMING
Nature 460, 1140-1144 (2009)
http://links.ealert.nature.com/ctt?kn=18&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
A MOUSE MODEL OF ATR-SECKEL SHOWS EMBRYONIC REPLICATIVE STRESS AND
ACCELERATED AGING
Nature Genetics 41, 891-898 (2009)
http://links.ealert.nature.com/ctt?kn=28&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
AVID INTERACTIONS UNDERLIE THE LYS63-LINKED POLYUBIQUITIN BINDING
SPECIFICITIES OBSERVED FOR UBA DOMAINS
Nature Structural & Molecular Biology 16, 883-889 (2009)
http://links.ealert.nature.com/ctt?kn=32&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
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Signaling News
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DNA SWAP COULD AVOID INHERITED DISEASES
http://links.ealert.nature.com/ctt?kn=33&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
Mutations in mitochondrial DNA are linked to a variety of diseases,
including diabetes, mitochondrial myopathies and Leigh syndrome.
In experiments in rhesus macaques, US researchers transferred DNA
from the nucleus of one egg into the empty nucleus of another egg
without carrying over any mitochondrial DNA in the process. This
technique may help mothers avoid passing on mitochondrial DNA
mutations to their offspring.
More news
http://links.ealert.nature.com/ctt?kn=13&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - AUGUST UPDATE
http://links.ealert.nature.com/ctt?kn=24&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update includes "Profiling proteoglycans: RIP them out"
and "Tumor suppression: Glycosyltransferases loom LARGE".
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://links.ealert.nature.com/ctt?kn=37&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
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Job of the Week
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Postdoctoral Fellow
Employer: Novo Nordisk Center for Protein Research
Location: University of Copenhagen, Denmark
http://links.ealert.nature.com/ctt?kn=30&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
A postdoctoral position is available at the Novo Nordisk Center for
Protein Research to study the mechanisms regulating the development
of hepatic steatosis. The project involves the use of state of the
art mass spectrometry to analyze protein posttranslational
modifications involved in the development of fatty liver associated
to the metabolic syndrome. Proteomic methodology will be applied to
globally assess posttranslational modifications and a systems biology
approach used to analyze these and other complex data sets.
More Jobs:
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To advertise a job in this spot, please contact Naturejobs.
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