Signaling Gateway - 14 August 2009
http://links.ealert.nature.com/ctt?kn=39&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=37&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
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In Signaling Update this week:
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Featured Article
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GPCR SUBUNITS: SEPARATE BUT NOT EQUAL
A functional complementation assay reveals that maximal
heterotrimeric G-protein activation is achieved by agonist binding
to one subunit of a dopamine D2 receptor dimer.
Original research paper: Nature Chemical Biology advance online
publication, 2 August 2009
http://links.ealert.nature.com/ctt?kn=15&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
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Molecule Pages
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Nup98
http://links.ealert.nature.com/ctt?kn=24&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
Nup98 is a 98 kDa protein of the nuclear pore complex (NPC), the
large macromolecular structure responsible for trafficking between
the nucleus and the cytoplasm. Nup98 is a key player in RNA export
from the nucleus, has a role in the import of some nuclear proteins,
and contributes to proper mitotic regulation during cell division.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=6&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
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Selected Updates
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CANCER BIOLOGY: WAVEING GOODBYE TO INVASION
Reduced expression of the WAVE subunit CYFIP1 (cytoplasmic FMR1
interacting protein 1) causes the loss of epithelial cell adhesion
and promotes tumor progression.
Original research paper: Cell 137, 1047-1061 (2009)
http://links.ealert.nature.com/ctt?kn=31&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
T CELL RESPONSES: QUANTITY AND QUALITY CONTROL BY mTOR
mTOR possesses a T-cell-intrinsic role as a regulator of both CD4+
and CD8+ T-cell differentiation.
Original research paper: Immunity 30, 832–844 (2009)
http://links.ealert.nature.com/ctt?kn=41&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
CANCER PAIN: GETTING ON MY NERVES
Cancer-related pain is induced by secreted granulocyte and
granulocyte-macrophage colony-stimulating factor receptor
(G-CSFR and GM-CSFRalpha)-mediated activation of the Jak-STAT and
MEK-Erk pathways.
Original research paper: Nature Med. 15, 802–807 (2009)
http://links.ealert.nature.com/ctt?kn=7&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=35&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=18&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
A ROLE FOR LIN28 IN PRIMORDIAL GERM-CELL DEVELOPMENT AND GERM-CELL
MALIGNANCY
Nature 460, 909-913 (2009)
http://links.ealert.nature.com/ctt?kn=36&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
A REGULATORY PATHWAY INVOLVING NOTCH1/BETA-CATENIN/ISL1 DETERMINES
CARDIAC PROGENITOR CELL FATE
Nature Cell Biology 11, 951-957 (2009)
http://links.ealert.nature.com/ctt?kn=25&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
ESSENTIAL FUNCTION FOR THE GTPASE TC21 IN HOMEOSTATIC ANTIGEN
RECEPTOR SIGNALING
Nature Immunology 10, 880-888 (2009)
http://links.ealert.nature.com/ctt?kn=34&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
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Signaling News
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IMMORTALITY IMPROVES CELL REPROGRAMMING
http://links.ealert.nature.com/ctt?kn=2&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
Five research teams report in Nature that silencing the p53 pathway
increases the rate at which differentiated cells can be transformed
into induced pluripotent stem (iPS) cells. These iPS cells have
traditionally been created by expressing four factors: Oct3/4, Sox2,
Klf4, and c-Myc. However, disabling the p53 pathway also improved
success rates for other generation techniques, including the use of
plasmid vectors or viral vectors with only two or three factors.
More news
http://links.ealert.nature.com/ctt?kn=21&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
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Gateway Updates
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PSI-NATURE STRUCTURAL GENOMICS KNOWLEDGEBASE - JANUARY UPDATE
http://links.ealert.nature.com/ctt?kn=40&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
The Structural Genomics Knowledgebase is a free portal to research
data and other resources from the Protein Structure Initiative for
structural biologists to keep informed of the latest developments in
their field. This month's update features articles on antibiotic
targets, crystals from tricky proteins and Salicylic Acid Binding
Protein 2.
Sign up to receive monthly updates from the PSI-Nature Structural
Genomics Knowledgebase.
http://links.ealert.nature.com/ctt?kn=33&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
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Job of the Week
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Postdoctoral position
Employer: Massachusetts General Hospital/Harvard Medical School
Location: Boston, MA, USA
http://links.ealert.nature.com/ctt?kn=13&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
A postdoctoral position is available at the Cutaneous Biology
Research Center at MGH/Harvard Medical School. The research project
will focus on Hedgehog signaling and its role in non-melanoma skin
cancer, hair growth and epidermal functions. In vivo and in vitro
assays will be used to determine the physiological and
disease-related functions of Hedgehog pathway components.
More Jobs:
http://links.ealert.nature.com/ctt?kn=4&m=33878250&r=MTc2ODc4NDI0MAS2&b=2&j=NTY2OTkyMzIS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
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