August 2009 Volume 5 Number 8
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RESEARCH HIGHLIGHTS
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Alzheimer disease: Tau wanders around the brain
p405 | doi:10.1038/nrneurol.2009.110
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Stroke: Retinal small-vessel changes and lacunar stroke
p406 | doi:10.1038/nrneurol.2009.101
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IN BRIEF
Parkinson disease | Movement disorders | Neurodegenerative disease | Epilepsy
p406 | doi:10.1038/nrneurol.2009.89
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Neuromuscular disease: Potential therapy for hereditary myopathy
p407 | doi:10.1038/nrneurol.2009.102
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Motor neuron disease: KIFAP3 polymorphisms and survival in ALS
p407 | doi:10.1038/nrneurol.2009.103
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Dementia: Test your memory0-a waiting room test for dementia
p408 | doi:10.1038/nrneurol.2009.109
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Neuro-oncology: The vascular basement membrane in brain metastasis
p408 | doi:10.1038/nrneurol.2009.112
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Emergency status justified for TIA
p409 | doi:10.1038/nrneurol.2009.104
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Multiple sclerosis: Breastfeeding could reduce MS relapse
p410 | doi:10.1038/nrneurol.2009.111
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Parkinson disease: Deep brain stimulation does not affect cognitive functions
in Parkinson disease
p410 | doi:10.1038/nrneurol.2009.113
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NEWS AND VIEWS
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Alzheimer disease: Alzheimer disease neuropathology in the oldest old
Jillian J. Kril
p411 | doi:10.1038/nrneurol.2009.105
As the human lifespan increases, the number of people living beyond their
nineties is rising rapidly. This changing population demographic will have
an effect on many aspects of health and society, including the number of
people living with dementia. To accurately diagnose dementia, we must
understand the relationship between the observed neuropathology and age.
http://links.ealert.nature.com/ctt?kn=11&m=33812065&r=MTc2NDUyMzIwMwS2&b=2&j=NTUxNzQyNTMS1&mt=1&rt=0
Cerebral aneurysms: To clip or to coil? That is no longer the question
E. Sander Connolly Jr and Philip M. Meyers
p412 | doi:10.1038/nrneurol.2009.106
The relative merits of clipping and endovascular coiling to treat ruptured
intracranial aneurysms are the subject of an ongoing debate. The latest
results from the International Subarachnoid Aneurysm Trial offer reassurance
regarding the long-term outcomes of coiling and provide support for an
individualized approach.
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Epilepsy: Should valproate be avoided during childbearing years?
Luigi Maccotta and Joseph E. Sullivan
p414 | doi:10.1038/nrneurol.2009.92
In utero exposure to antiepileptic drugs carries teratogenic risks, but
little is known about the potential effects of such agents on neurocognitive
development. The results from a large prospective study that set out to
address this issue add to the mounting evidence against the use of valproate
in women with epilepsy during childbearing years.
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Movement disorders: Psychogenic movement disorders: what do neurologists do?
Jon Stone and Alan Carson
p415 | doi:10.1038/nrneurol.2009.108
Patients with psychogenic movement disorders are usually diagnosed by
neurologists and referred to psychiatrists for treatment. A survey of
members of the Movement Disorder Society highlights difficulties in
cross-specialty management of such patients. The findings have implications
for the development of new criteria for conversion disorder in the Diagnostic
and Statistical Manual of Mental Disorders.
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Dementia: Assessing the risk of dementia in the aging population
Blossom C. M. Stephan and Carol Brayne
p417 | doi:10.1038/nrneurol.2009.107
A method for determining which patients are at a high risk of developing
dementia could improve preventative care, early diagnosis, and the
identification of individuals for clinical trials. The late-life dementia
risk index has been developed to fulfill this need in older adults, but
does the model provide sufficient accuracy and reliability in assessing
such risk?
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REVIEWS
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Advances in the genetics of glioblastoma: are we reaching critical mass?
Benjamin Purow and David Schiff
Published online: 14 July 2009
p419 | doi:10.1038/nrneurol.2009.96
Glioblastoma is the most common primary malignant brain tumor in adults,
causing over 10,000 deaths each year in the US alone. Given the resistance
of this tumor to standard surgery, radiation and chemotherapy, attention
has focused on identifying the underlying genetic lesions in the hope of
developing new treatment strategies. Purow and Schiff review the current
state of knowledge of the genetics of glioblastoma and discuss the
implications for future therapies.
Abstract: http://links.ealert.nature.com/ctt?kn=90&m=33812065&r=MTc2NDUyMzIwMwS2&b=2&j=NTUxNzQyNTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=33812065&r=MTc2NDUyMzIwMwS2&b=2&j=NTUxNzQyNTMS1&mt=1&rt=0
The rehabilitation of hemianopic dyslexia
Susanne Schuett
Published online: 07 July 2009
p427 | doi:10.1038/nrneurol.2009.97
Patients with hemianopic dyslexia experience serious reading difficulties,
with word identification and the abilities to plan and guide reading eye
movements being severely disturbed. In this Review, Schuett explores the
clinical features and the underlying functional and anatomical bases of
hemianopic dyslexia, before critically examining the available therapies
for rehabilitation of this condition.
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=33812065&r=MTc2NDUyMzIwMwS2&b=2&j=NTUxNzQyNTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=36&m=33812065&r=MTc2NDUyMzIwMwS2&b=2&j=NTUxNzQyNTMS1&mt=1&rt=0
A guide to disorders causing transient loss of consciousness: focus on syncope
J. Gert van Dijk, Roland D. Thijs, David G. Benditt and Wouter Wieling
Published online: 14 July 2009
p438 | doi:10.1038/nrneurol.2009.99
Transient loss of consciousness is a spell of unconsciousness characterized
by abrupt onset, short duration, and spontaneous and complete recovery.
In this article, van Dijk et al. provide an overview of the various forms
of TLOC, focusing particularly on reflex syncope. They highlight key clues
to the diagnosis of these conditions and emphasize the importance of a
multidisciplinary approach to the management of patients with TLOC.
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=33812065&r=MTc2NDUyMzIwMwS2&b=2&j=NTUxNzQyNTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=33812065&r=MTc2NDUyMzIwMwS2&b=2&j=NTUxNzQyNTMS1&mt=1&rt=0
Migraine during pregnancy: is it more than a headache?
Stephen A. Contag, Heather L. Mertz and Cheryl D. Bushnell
Published online: 14 July 2009
p449 | doi:10.1038/nrneurol.2009.100
Pregnancy can have an unpredictable effect on the frequency and nature
of migraines. In this article, Contag et al. examine the association of
migraine with pregnancy and pregnancy-related complications, notably
pre-eclampsia. The authors also review the diagnosis and management of
migraine headaches that precede or develop during pregnancy, and explore
the risks associated with the available treatment options.
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=33812065&r=MTc2NDUyMzIwMwS2&b=2&j=NTUxNzQyNTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=9&m=33812065&r=MTc2NDUyMzIwMwS2&b=2&j=NTUxNzQyNTMS1&mt=1&rt=0
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CASE STUDY
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A case of Rasmussen encephalitis treated with rituximab
Barbara Thilo, Robert Stingele, Karina Knudsen, Rainer Boor, Christian
G. Bien, Gunther Deuschl and Nicolas Lang
p458 | doi:10.1038/nrneurol.2009.98
Rasmussen encephalitis is a chronic inflammatory disease that results in
progressive degeneration of one cerebral hemisphere. Immunotherapies for
this condition have traditionally targeted T-cell-mediated immunity, but
Thilo et al. now report a case in which effective seizure control was
achieved through use of the anti-B-cell antibody rituximab.
Abstract: http://links.ealert.nature.com/ctt?kn=1&m=33812065&r=MTc2NDUyMzIwMwS2&b=2&j=NTUxNzQyNTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=49&m=33812065&r=MTc2NDUyMzIwMwS2&b=2&j=NTUxNzQyNTMS1&mt=1&rt=0
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