September 2009 Volume 10 Number 9
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Nature Reviews Molecular Cell Biology
Focus on Endocytosis
September 2009
Endocytic membrane trafficking involves the cellular internalization
and sorting of extracellular molecules, plasma membrane proteins and
lipids. Endocytosis is required for a vast number of functions, including
nutrient uptake, cell adhesion and migration, receptor signalling,
pathogen entry and cell polarity.
This special Focus reflects the diversity and complexity of endocytic
trafficking processes and their associated machineries. Access the
Focus articles, as well other relevant content from Nature Publishing
Group titles, online at:
http://links.ealert.nature.com/ctt?kn=12&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
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This month's FEATURED article:
Tickets to ride: selecting cargo for clathrin-regulated internalization
Linton M. Traub
p583 | doi:10.1038/nrm2751
http://links.ealert.nature.com/ctt?kn=47&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
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From the editors
p575 | doi:10.1038/nrm2758
http://links.ealert.nature.com/ctt?kn=49&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Proteomics: Getting the numbers right
p577 | doi:10.1038/nrm2759
http://links.ealert.nature.com/ctt?kn=54&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Stem cells: The great iPS barrier
p578 | doi:10.1038/nrm2753
http://links.ealert.nature.com/ctt?kn=52&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Small RNAs: Bound to silence
p578 | doi:10.1038/nrm2754
http://links.ealert.nature.com/ctt?kn=39&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
IN BRIEF
Endocytosis | Endocytosis | Endocytosis
p579 | doi:10.1038/nrm2756
http://links.ealert.nature.com/ctt?kn=30&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Small RNAs: p53 makes microRNAs mature
p580 | doi:10.1038/nrm2749
http://links.ealert.nature.com/ctt?kn=57&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Cytoskeleton: Getting to the TIP
p580 | doi:10.1038/nrm2752
http://links.ealert.nature.com/ctt?kn=65&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
IN BRIEF
RNA decay | Autophagy | RNA interference
p580 | doi:10.1038/nrm2760
http://links.ealert.nature.com/ctt?kn=31&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Endocytosis: Joint efforts of ESCRTs
p581 | doi:10.1038/nrm2757
http://links.ealert.nature.com/ctt?kn=67&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
JOURNAL CLUB
Seeing is believing
p582 | doi:10.1038/nrm2747
http://links.ealert.nature.com/ctt?kn=78&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Chromatin: A positive twist
p582 | doi:10.1038/nrm2750
http://links.ealert.nature.com/ctt?kn=80&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
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Focus on: Endocytosis
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REVIEWS
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Tickets to ride: selecting cargo for clathrin-regulated internalization
Linton M. Traub
p583 | doi:10.1038/nrm2751
Clathrin-mediated endocytosis dynamically regulates the composition of
the plasma membrane in eukaryotic cells by internalizing transmembrane
proteins, bound ligands and lipids. To regulate the uptake of a vast
array of cargo molecules, specific sorting signals in cargoes are
decoded by different cytosolic adaptor proteins.
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=47&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Pathways and mechanisms of endocytic recycling
Barth D. Grant and Julie G. Donaldson
p597 | doi:10.1038/nrm2755
Studies of cargo proteins that are internalized independently of
clathrin have revealed new pathways and mechanisms of endocytic recycling.
Precise temporal and spatial regulation of recycling pathways is crucial
for various cellular processes, including cytokinesis, cell adhesion,
morphogenesis, cell fusion, learning and memory.
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Endocytosis and signalling: intertwining molecular networks
Alexander Sorkin and Mark von Zastrow
p609 | doi:10.1038/nrm2748
It is now recognized that cell signalling and endocytic membrane
trafficking are intimately and bidirectionally linked in animal cells.
The mechanistic and functional principles that underlie the relationship
between these cellular processes are becoming increasingly evident
across many systems.
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets
function
Paul Saftig and Judith Klumperman
p623 | doi:10.1038/nrm2745
Lysosomes are the primary catabolic compartments of eukaryotic cells.
They degrade extracellular material that has been internalized by
endocytosis and intracellular components that have been sequestered
by autophagy. Emerging evidence suggests that there are multiple
lysosomal delivery pathways that together allow the regulated and
sequential deposition of lysosomal components.
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=3&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
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PROGRESS
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Regulatory roles of natural antisense transcripts
Mohammad Ali Faghihi and Claes Wahlestedt
p637 | doi:10.1038/nrm2738
Natural antisense transcripts are frequently functional and are involved
in regulating gene expression. The authors summarize the proposed actions
of antisense transcript into four models, each corresponding to a putative
regulatory mechanism for a subset of antisense transcripts.
Abstract: http://links.ealert.nature.com/ctt?kn=63&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
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PERSPECTIVES
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OPINION
Biology under construction: in vitro reconstitution of cellular function
Allen P. Liu and Daniel A. Fletcher
p644 | doi:10.1038/nrm2746
The reconstitution of biological processes from purified components is
a powerful approach to understanding the principles that govern cellular
organization. The recent development of new experimental techniques is
enabling the reconstitution of increasingly complex cellular systems.
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=33897728&r=MTc2NzYzNjQ2NgS2&b=2&j=NTY5NTQyMjES1&mt=1&rt=0
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