September 2009 Volume 9 Number 9
Visit Nature Reviews Immunology online to browse the journal.
Now available at http://links.ealert.nature.com/ctt?kn=76&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Please note that you need to be a subscriber to enjoy full text
access to Nature Reviews Immunology online. To purchase a
subscription, please visit:
http://links.ealert.nature.com/ctt?kn=29&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Alternatively, to recommend a subscription to your library, please
visit http://links.ealert.nature.com/ctt?kn=52&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
*********************************************************************
Nature Reviews Immunology Impact Factor: 30.01*
(*2008 Journal Citation Report (Thomson Reuters, 2009))
*********************************************************************
=========================== ADVERTISEMENT ===========================
Welcome to more choice. Buy 4, get 2 FREE.
Choose from 200 newly released reagents, more sizes, and
fast, free, expert support in under 4 hours. Now choose any
4 fluorochrome or biotin-labeled antibodies from our entire
portfolio and choose 2 more FREE with no quantity limit.
Welcome to a more colorful world(SM). Visit bdbiosciences.com/choice
for more information.
http://links.ealert.nature.com/ctt?kn=24&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
=====================================================================
=========================== ADVERTISEMENT ===========================
IT'S NOW FREE TO POST YOUR VACANCY ON
naturejobs.com
http://links.ealert.nature.com/ctt?kn=40&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
It's the breakthrough you've been waiting for. Naturejobs.com - the
scientific jobs board from Nature now lets you advertise your vacancy
completely FREE OF CHARGE
Go to http://links.ealert.nature.com/ctt?kn=61&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0 or telephone:
Europe: +44 (0) 20 78434961
US: + 1 800 9897718
=====================================================================
=========================== ADVERTISEMENT ===========================
YOUR SCIENCE CAREER: WHAT NEXT?
Explore your options at The Source Event: London 25/09/2009 and
Berlin 04/12/09. Throughout the day conference sessions and workshops
will tackle a range of science career issues. Running alongside this
is a FREE career fair where you can meet employers who are actively
looking to recruit scientists.
Register now at: http://links.ealert.nature.com/ctt?kn=41&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
=====================================================================
This month's FEATURED article:
Stromal cell contributions to the homeostasis and functionality of
the immune system
Scott N. Mueller and Ronald N. Germain
p618 | doi:10.1038/nri2588
http://links.ealert.nature.com/ctt?kn=39&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
=====================================================================
From the editors
p601 | doi:10.1038/nri2632
http://links.ealert.nature.com/ctt?kn=66&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
Phagocytosis: Don't eat the HSCs
p603 | doi:10.1038/nri2627
http://links.ealert.nature.com/ctt?kn=67&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Thymocyte development: The identification of THEMIS
p604 | doi:10.1038/nri2624
http://links.ealert.nature.com/ctt?kn=70&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Viral immunity: Are men and women different?
p604 | doi:10.1038/nri2631
http://links.ealert.nature.com/ctt?kn=73&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
T cell development: Lead role for BCL-6 in TFH cell development
p605 | doi:10.1038/nri2626
http://links.ealert.nature.com/ctt?kn=77&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Natural killer cells: Stop, look, listen
p606 | doi:10.1038/nri2628
http://links.ealert.nature.com/ctt?kn=55&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
IN BRIEF
Regulatory T cells | Immune responses | Phagocytosis
p606 | doi:10.1038/nri2633
http://links.ealert.nature.com/ctt?kn=9&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Inflammation: Finding the T in fat
p607 | doi:10.1038/nri2630
http://links.ealert.nature.com/ctt?kn=47&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
----------------------
REVIEWS
----------------------
Article series: Tissue-specific immune responses
http://links.ealert.nature.com/ctt?kn=62&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Interdependence of hypoxic and innate immune responses
Victor Nizet and Randall S. Johnson
p609 | doi:10.1038/nri2607
At low levels of oxygen at sites of tissue infection, innate immune
cells can adapt to survive and even enhance their antimicrobial
functions. Recent studies show how this is controlled by
hypoxia-inducible factor (HIF) downstream of nuclear factor-[kappa]B
activation.
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=85&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Article series: Tissue-specific immune responses
http://links.ealert.nature.com/ctt?kn=62&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Stromal cell contributions to the homeostasis and functionality of
the immune system
Scott N. Mueller and Ronald N. Germain
p618 | doi:10.1038/nri2588
This Review looks at how immune events in the secondary lymphoid
organs can be influenced by the non-haematopoietic stromal cells that
support the microarchitecture of the lymph nodes and spleen.
Specialized subsets of stromal cells can provide regional control to
nurture or direct the most appropriate responses to pathogens.
Abstract: http://links.ealert.nature.com/ctt?kn=39&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=86&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Rho family GTPases and their regulators in lymphocytes
Victor L. J. Tybulewicz and Robert B. Henderson
p630 | doi:10.1038/nri2606
This Review describes the recent insights gained from studies of
knockout mice indicating that Rho family GTPases and their regulators
transduce signals from receptors for antigen, chemokines and adhesion
molecules, making them key components of lymphocyte development,
activation and migration.
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Cytokine determinants of viral tropism
Grant McFadden, Mohamed R. Mohamed, Masmudur M. Rahman and Eric
Bartee
p645 | doi:10.1038/nri2623
Grant McFadden and colleagues discuss how the interferons and tumour
necrosis factor can establish an intracellular antiviral state that
determines the specificity of a particular virus for a specific cell
type, tissue or species. Our knowledge of these antiviral cytokines
can be exploited to enhance immunity against zoonotic infections and
to improve the therapeutic specificity of tumour-targeted viruses.
Abstract: http://links.ealert.nature.com/ctt?kn=36&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=20&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
----------------------
PERSPECTIVES
----------------------
OPINION
Signalling crosstalk in B cells: managing worth and need
Michael P. Cancro
p657 | doi:10.1038/nri2621
Here, Michael Cancro proposes a model to explain how B cell fate is
determined by balancing signals that select B cells of suitable
reactivity with signals that support survival. This balance is said
to be mediated by crosstalk between the mediators downstream of the
B cell receptor (BCR) and receptor for B cell-activating factor
(BAFFR).
Abstract: http://links.ealert.nature.com/ctt?kn=35&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
VIEWPOINT
The precursors of memory: models and controversies
Rafi Ahmed, Michael J. Bevan, Steven L. Reiner and Douglas T. Fearon
p662 | doi:10.1038/nri2619
Understanding how memory T cells develop has important implications
for vaccine design. Here, Nature Reviews Immunology asks four leading
researchers in this field their thoughts on the ontogeny and lineage
relationships of memory T cells.
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Mucosal Immunology's call for Cover Images!
The editors of Mucosal Immunology are seeking illustrative images
which are unique or highly illustrative of specific occurrences in
mucosal immunology for use on the 2010 cover. Should your image be
selected, you will be credited in print and online and we'll send you
a print of the cover as a thank you.
http://links.ealert.nature.com/ctt?kn=22&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
All readers and contributors to Mucosal Immunology are eligible. They
should be accompanied by a brief one-paragraph description not to
exceed 200 words of relevant clinical or basic scientific
information.
The closing date for ALL cover image submissions is the 31st August,
2009. Please email your images to mi@nature.com.
=====================================================================
You have been sent this Table of Contents Alert because you have
opted in to receive it. You can change or discontinue your e-mail
alerts at any time, by modifying your preferences on your nature.com
account at: http://links.ealert.nature.com/ctt?kn=48&m=33917995&r=MTc2NzU2Mjg3MwS2&b=2&j=NTcxMDQ2MzYS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration
department: registration@nature.com
For print subscription enquiries, please contact our subscription
department: subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2009 Nature Publishing Group
=====================================================================
