September 2009 Volume 6 Number 9
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Reviews and Perspective articles from leading specialists in cardiovascular
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The Molecular Imaging Series covers every aspect of the visualization
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EDITORIAL
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An ounce of prevention
Valentin Fuster
p553 | doi:10.1038/nrcardio.2009.153
http://links.ealert.nature.com/ctt?kn=4&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Interventional cardiology: PCI after fibrinolysis: is timing everything?
p555 | doi:10.1038/nrcardio.2009.122
http://links.ealert.nature.com/ctt?kn=6&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Thrombosis: Surgical stockings do not prevent thrombosis after stroke
p556 | doi:10.1038/nrcardio.2009.132
http://links.ealert.nature.com/ctt?kn=15&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Prevention: Lowering cholesterol in statin-intolerant patients
p556 | doi:10.1038/nrcardio.2009.133
http://links.ealert.nature.com/ctt?kn=19&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Statin therapy for primary prevention
p557 | doi:10.1038/nrcardio.2009.134
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Arrhythmias: Sleep apneas lead to nocturnal arrhythmias in older men
p558 | doi:10.1038/nrcardio.2009.124
http://links.ealert.nature.com/ctt?kn=14&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Risks associated with PR prolongation
p558 | doi:10.1038/nrcardio.2009.126
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Acute coronary syndromes: Outcomes of cardiac catheterization: STEMI versus
NSTEMI
p559 | doi:10.1038/nrcardio.2009.123
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Congenital conditions: Valve versus stent for RVOT obstruction
p559 | doi:10.1038/nrcardio.2009.125
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Ejection fraction and risk prediction
p559 | doi:10.1038/nrcardio.2009.128
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Intervention: Does PCI reduce long-term cardiovascular risks?
p560 | doi:10.1038/nrcardio.2009.127
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Risk factors: A new model for predicting 30-year CVD risk
p560 | doi:10.1038/nrcardio.2009.129
http://links.ealert.nature.com/ctt?kn=48&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
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NEWS AND VIEWS
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Risk factors: The obesity paradox-an artifact of small sample size?
George A. Bray
p561 | doi:10.1038/nrcardio.2009.140
Intentional weight loss is associated with many benefits, including reduced
mortality and cardiometabolic and inflammatory risk, as well as improved
quality of life. Unintentional weight loss, however, is often a harbinger
of future ill-health. Separating these types of weight loss in clinical
trials is sometimes difficult and in small trials can produce the 'obesity
paradox'.
http://links.ealert.nature.com/ctt?kn=46&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Atrial fibrillation: Preventing serious complications during AF ablation
Aman Chugh and Hakan Oral
p562 | doi:10.1038/nrcardio.2009.136
Cappato et al. have reviewed the major causes of death in patients undergoing
catheter ablation of atrial fibrillation. Many of these complications could
be prevented by careful catheter manipulation, implementing safe energy
settings, adequate anticoagulation, and esophageal monitoring. Urgent
pericardial drainage is critical in avoiding death related to cardiac
tamponade.
http://links.ealert.nature.com/ctt?kn=51&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Imaging: Reducing cardiac CT radiation through community outreach
Victor Y. Cheng and Daniel S. Berman
p564 | doi:10.1038/nrcardio.2009.139
Radiation exposure from cardiac CT is currently under a high level of
scrutiny, and many patients may be receiving excessive radiation from this
test. A study by Raff and colleagues-aimed at reducing this radiation through
a statewide initiative-helps define the potential for improving the safety
of cardiac CT at community medical centers.
http://links.ealert.nature.com/ctt?kn=49&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Risk factors: Lipoprotein(a) and coronary disease-moving closer to causality
John Danesh and Sebhat Erqou
p565 | doi:10.1038/nrcardio.2009.138
Lipoprotein(a) has been studied as a risk factor for coronary heart disease,
but whether a causal relationship exists has been unclear. A study by
Kamstrup and colleagues examining genetically mediated increases in
lipoprotein(a) concentration now provides evidence that it could indeed
represent a causal coronary risk factor.
http://links.ealert.nature.com/ctt?kn=60&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Stem cells: REGENT trial-the end of cell therapy for MI?
Rasmus S. Ripa and Jens Kastrup
p567 | doi:10.1038/nrcardio.2009.137
Unselected bone-marrow-derived mononuclear cells seem to improve left
ventricular function and perhaps short-term clinical outcomes for patients
with acute myocardial infarction. The REGENT trial aimed to elucidate whether
infusion of selected hematopoetic progenitor cells increases this effect
in patients with large infarcts and attenuated left ventricular ejection
fraction.
http://links.ealert.nature.com/ctt?kn=55&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
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REVIEWS
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Molecular imaging in cardiovascular disease: targets and opportunities
Stanley Y. Shaw
Published online: 21 July 2009
p569 | doi:10.1038/nrcardio.2009.119
Currently available imaging techniques provide anatomical definition and
functional information and have limited ability to report on disease
processes at the molecular level. Molecular imaging techniques can, however,
supply information about specific proteins, biomolecules, biological pathways
or cellular processes. Here, Stanley Shaw discusses molecular imaging targets
used in cardiovascular research and emerging approaches to the discovery
or application of new molecular imaging probes.
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=58&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Cardiovascular risk factors in patients with chronic kidney disease
Sarina van der Zee, Usman Baber, Sammy Elmariah, Jonathan Winston and
Valentin Fuster
Published online: 21 July 2009
p580 | doi:10.1038/nrcardio.2009.121
Traditional and nontraditional factors increase cardiovascular risk in
patients with kidney disease. In this Review, Dr. van der Zee and colleagues
highlight important cardiovascular risk factors in patients with varying
degrees of kidney function and discuss therapeutic strategies for reducing
cardiovascular risk in these patients.
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Vascular dysfunction in idiopathic dilated cardiomyopathy
Santiago Roura and Antoni Bayes-Genis
Published online: 28 July 2009
p590 | doi:10.1038/nrcardio.2009.130
The underlying cause of idiopathic dilated cardiomyopathy remains unknown,
although studies have suggested a genetic component or involvement of
inflammatory and autoimmune responses. Several studies have also shown
that vascular dysfunction is present in idiopathic dilated cardiomyopathy.
Roura and Bayes-Genis review these studies and suggest a reinterpretation
of the pathophysiology in terms of the vascular changes.
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Fruits, vegetables and coronary heart disease
Luc Dauchet, Philippe Amouyel and Jean Dallongeville
Published online: 04 August 2009
p599 | doi:10.1038/nrcardio.2009.131
Consumption of fruit and vegetables has been associated with reduced risk
of coronary heart disease. This Review discusses epidemiological studies
of the association between fruit and vegetable consumption and coronary
heart disease, and assesses the significance of the findings.
Abstract: http://links.ealert.nature.com/ctt?kn=85&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=77&m=33897669&r=MTc2NDI1MzEzNAS2&b=2&j=NTY5NTE2MDQS1&mt=1&rt=0
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