August 13 2009
See also the Niche's coverage of the ISSCR annual meeting in Barcelona:
http://links.ealert.nature.com/ctt?kn=13&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
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OUR TOP STORIES
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The delivery dilemma
If stem cell therapies are going to succeed in the clinic, researchers must determine the safest and most efficient ways to transplant cells into the body.
http://links.ealert.nature.com/ctt?kn=26&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
Irving Weissman: creating a standard for stem cell therapies and culturing the unorthodox
The new president of the ISSCR says that to move forward, the field must think outside the box
http://links.ealert.nature.com/ctt?kn=7&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
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ARTICLES KEYING OFF RECENT PUBLICATIONS
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Immortality improves cell reprogramming
Hong, H. et al. Nature advance online publication doi:10.1038/nature08235 (2009)
Utikal, J. et al. Nature advance online publication doi:10.1038/nature08285 (2009)
Marión, R. M. et al. Nature advance online publication doi:10.1038/nature08287 (2009)
Li, H. et al. Nature advance online publication doi:10.1038/nature08290 (2009)
Kawamura, T. et al. Nature advance online publication doi:10.1038/nature08311 (2009)
http://links.ealert.nature.com/ctt?kn=27&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
See also: Another job for p53
http://links.ealert.nature.com/ctt?kn=31&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
Building bones from stem cells
A thorough analysis finds tissue-specific stem cells make chemically and functionally different bone than embryonic ones
Gentleman, E. et al. Nature Materials advance online publication, doi:10.1038/nmat2505 (26 July 2009)
http://links.ealert.nature.com/ctt?kn=30&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
Human embryonic stem cell research stuck on two early lines
Field shows legacy of funding policies, early-mover advantage
Scott, C.T., McCormick, J.B. & Owen-Smith, J. And then there were two: demand and use of hESC lines. Nature Biotechnol. 27, 696-697 (2009)
http://links.ealert.nature.com/ctt?kn=25&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
Cancer stem cells resemble healthy stem cells, resist chemotherapy
Recent papers show how tumour-initiating cells work, and why they're hard to treat
Creighton, C.J. et al. Proc. Natl. Acad. Sci.; advance online publication, doi:10.1073/pnas.0905718106 (3 August 2009)
Shimono, Y. et al. Cell 138, 592-603 (2009)
http://links.ealert.nature.com/ctt?kn=8&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
The innate debate over HSCs
New evidence confirms the instructive role of cytokines in blood stem cell differentiation
Rieger, M. et al. Science 325, 217-218 (2009)
Sarrazin, S. et al. Cell 138, 300-313 (2009)
http://links.ealert.nature.com/ctt?kn=19&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
Finding the cell that fuels the tumour
A study of precancerous breast tissue pins blame on progenitor cells
Lim, E. et al. Nature Med. advance online publication, doi:10.1038/nm.2000 (2 August 2009).
http://links.ealert.nature.com/ctt?kn=42&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
iPS cells make mice that make mice
Years after their derivation, induced pluripotent stem cells pass the most rigorous test of pluripotency
Zhao, X-Y. et al. Nature advance online publication, doi:10.1038/nature08267 (23 July 2009)
Kang, L. et al. Cell Stem Cell advance online publication, doi:10.1016/j.stem.2009.07.001 (23 July 2009)
Boland, M. J. et al. Nature advance online publication, doi:10.1038/nature08310 (2 August 2009)
http://links.ealert.nature.com/ctt?kn=9&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
Cell origin and variation in induced pluripotent stem cell lines
iPS cells from tail-tip fibroblasts tend toward teratomas
Miura, K. et al. Nature Biotechnol. Advance online publication, doi:10.1038/nbt.1554 (9 July 2009)
http://links.ealert.nature.com/ctt?kn=28&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
The architecture of pluripotency
Does a chromatin-remodelling factor affect the pluripotency of ES cells?
Gaspar-Maia, A. et al. Nature doi:10.1038/nature08212 (published online 8 July 2009)
http://links.ealert.nature.com/ctt?kn=17&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
A good nose for stem cells (Subscription to Nat Methods required)
Cells can be delivered to the rodent brain noninvasively, via the nasal cavity
Danielyan, L. et al. Eur. J. Cell Biol. 88, 315-324 (2009)
http://links.ealert.nature.com/ctt?kn=12&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
The highs and lows of pluripotency (Subscription to Nat Reviews Genetics required)
ES cell populations have a distinct profile of NANOG expression that has consequences for stem cell differentiation
Kalmar, T. et al. PLoS Biol. 7, e1000149 (2009)
http://links.ealert.nature.com/ctt?kn=35&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
Editor retracts sperm-creation paper
Plagiarism accusation hits stem-cell research.
http://links.ealert.nature.com/ctt?kn=14&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
Setback for Huntington's disease therapy
Brain-tissue transplants don't last very long in patients.
Cicchetti, F. et al. Proc. Natl Acad. Sci. USA advance online publication doi:10.1073/pnas.0904239106 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
Heart, heal thyself
A mouse study finds that, surprisingly, heart muscle can be made to proliferate.
Bersell, K., Arab, S., Haring, B. & Kuhn, B. Cell 138, 257-270 (2009)
http://links.ealert.nature.com/ctt?kn=6&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
Mother of all heart cells
Clues about how human hearts form hint at routes to cell-based therapies.
Bu, L. et al. Nature 460, 113-117 (2009)
http://links.ealert.nature.com/ctt?kn=10&m=33870506&r=MTc2NjM3NTc5MQS2&b=2&j=NTY2NTY3NTIS1&mt=1&rt=0
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