27 August 2009 Volume 460 Number 7259, pp 1057 - 1170
Visit Nature online to browse the journal.
Now available at http://links.ealert.nature.com/ctt?kn=226&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Please note that you need to be a subscriber to enjoy full text access
to Nature online. To purchase a subscription, please visit:
http://links.ealert.nature.com/ctt?kn=92&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.com/ctt?kn=49&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Purchase PureYield(tm) Plasmid 10-minute Minipreps and get the
Wizard(r) SV Gel and PCR Clean-Up system for a great price!*
The Great Plasmid Prep Rally: Crossing the globe with special
events and great deals. Try the speed, purity and yield of
Promega Purification today!
http://links.ealert.nature.com/ctt?kn=251&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
* for a limited time, may vary by geography.
=====================================================================
=========================== ADVERTISEMENT ===========================
Get an Immune Response Biomarker Services Grant
We will select the top research plan from those submitted and will perform
Immune Response Biomarker Profiling on 20 samples from that laboratory.
http://links.ealert.nature.com/ctt?kn=273&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Click here to enter the biomarker discovery grant application
http://links.ealert.nature.com/ctt?kn=287&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
CID=BN-087851-Nature082609Survey
=====================================================================
=========================== ADVERTISEMENT ===========================
FREE ARTICLE
Endocrine disease: Treating type 2 diabetes
Four new studies bolster the case for the role of innate and adaptive
immune cells in the transition from obesity to type 2 diabetes. Find
out more by reading the first in-depth analysis of the scientific and
commercial potential of the work in SciBX: Science-Business eXchange.
ACCESS TO MORE THAN 30 FREE ARTICLES from the SciBX Cover Story
Archive HERE
http://links.ealert.nature.com/ctt?kn=6&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
=====================================================================
----------------------
EDITORIALS
----------------------
The ethics of egg manipulation p1057
Cell research reopens the debate on embryo destruction, egg donation
and what is natural.
doi:10.1038/4601057a
http://links.ealert.nature.com/ctt?kn=95&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
All the news you need p1057
doi:10.1038/4601057b
http://links.ealert.nature.com/ctt?kn=104&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
Human behaviour: Walking in circles p1060
doi:10.1038/4601060a
http://links.ealert.nature.com/ctt?kn=101&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Physiology: Smooth transitions p1060
doi:10.1038/4601060b
http://links.ealert.nature.com/ctt?kn=69&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Cancer biology: A nasty cut p1060
doi:10.1038/4601060c
http://links.ealert.nature.com/ctt?kn=74&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Ecology: Winter warmer p1060
doi:10.1038/4601060d
http://links.ealert.nature.com/ctt?kn=80&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Model organisms: A new kind of knock out p1060
doi:10.1038/4601060e
http://links.ealert.nature.com/ctt?kn=85&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Nanotechnology: Origami bridge pp1060-1061
doi:10.1038/4601060f
http://links.ealert.nature.com/ctt?kn=129&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Biology: Following in the wake p1061
doi:10.1038/4601061a
http://links.ealert.nature.com/ctt?kn=99&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Physics: Trip the light magnetic p1061
doi:10.1038/4601061b
http://links.ealert.nature.com/ctt?kn=112&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Plant biology: The other garden path p1061
doi:10.1038/4601061c
http://links.ealert.nature.com/ctt?kn=106&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Geoscience: Ground down p1061
doi:10.1038/4601061d
http://links.ealert.nature.com/ctt?kn=124&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
----------------------
JOURNAL CLUB
----------------------
Journal club p1061
Paul Riley
doi:10.1038/4601061e
http://links.ealert.nature.com/ctt?kn=118&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
----------------------
NEWS
----------------------
News briefing pp1062-1063
doi:10.1038/4601062a
http://links.ealert.nature.com/ctt?kn=146&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Chemical-safety costs uncertain p1065
Researchers and regulators disagree on how REACH legislation will
affect costs and loss of animal lives.
Natasha Gilbert
doi:10.1038/4601065a
http://links.ealert.nature.com/ctt?kn=133&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
China boosts pandemic surveillance p1066
But lack of screening could hamper efforts.
Jane Qiu
doi:10.1038/4601066a
http://links.ealert.nature.com/ctt?kn=136&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
US plans for science outreach to Muslim world p1067
White House to send scientists as envoys.
Alexandra Witze
doi:10.1038/4601067a
http://links.ealert.nature.com/ctt?kn=140&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Fossil protection law comes under fire p1067
Palaeontologists aim to clamp down on illegal trade.
Rex Dalton
doi:10.1038/4601067b
http://links.ealert.nature.com/ctt?kn=143&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Japan relaxes human stem-cell rules p1068
But scientists fear it is too late to regain lost ground.
David Cyranoski
doi:10.1038/4601068a
http://links.ealert.nature.com/ctt?kn=30&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
FDA narrows drug label usage p1069
Cancer treatments limited to specific gene variants.
Elie Dolgin
doi:10.1038/4601069a
http://links.ealert.nature.com/ctt?kn=28&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Canada assumes weighty mantle p1070
Instrument to help redefine the kilogram makes a transatlantic move.
Nicola Jones
doi:10.1038/4601070a
http://links.ealert.nature.com/ctt?kn=34&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
----------------------
NEWS FEATURES
----------------------
Medicine: Last chance clinic pp1071-1075
Some diseases defy diagnosis. Brendan Maher meets two people who hope
that the US National Institutes of Health can help.
Brendan Maher
doi:10.1038/4601071a
http://links.ealert.nature.com/ctt?kn=32&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Robotics: The bot that plays ball pp1076-1078
He looks like a child and plays like a child. But can the iCub robot
reveal how a child learns and thinks? Nicola Nosengo reports.
Nicola Nosengo
doi:10.1038/4601076a
http://links.ealert.nature.com/ctt?kn=36&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
----------------------
CORRESPONDENCE
----------------------
OPINION
Italy leads the way in supporting African biotechnology p1079
Francisco E. Baralle
doi:10.1038/4601079a
http://links.ealert.nature.com/ctt?kn=46&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Investors likely to venture back as crisis subsides p1079
J. Leslie Glick
doi:10.1038/4601079b
http://links.ealert.nature.com/ctt?kn=42&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Czech bibliometric system fosters mediocre research p1079
Jan Konvalinka et al.
doi:10.1038/4601079c
http://links.ealert.nature.com/ctt?kn=44&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Non-scientists could still contribute to reform of the ERC p1079
Wilhelm Krull, Jakob Edler and Michael Stampfer
doi:10.1038/4601079d
http://links.ealert.nature.com/ctt?kn=38&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
----------------------
OPINION
----------------------
Chemical regulators have overreached pp1080-1081
The costs -- both in animal lives and euros -- of the European REACH
legislation on chemical testing are escalating. Thomas Hartung and
Costanza Rovida argue for a suspension of certain toxicity tests.
Thomas Hartung and Costanza Rovida
doi:10.1038/4601080a
http://links.ealert.nature.com/ctt?kn=40&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
----------------------
BOOKS AND ARTS
----------------------
Bridging the gender gap in Indian science p1082
A set of biographies reveals the trials and triumphs of India's women
researchers, says Asha Gopinathan.
Asha Gopinathan reviews Lilavati's Daughters: The Women Scientists
of India by Rohini Godbole and Ram Ramaswamy
doi:10.1038/4601082a
http://links.ealert.nature.com/ctt?kn=61&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
The many faces of mathematics p1083
Eric L. Altschuler reviews Mathematicians: An Outer View of the Inner
World by Mariana Cook
doi:10.1038/4601083a
http://links.ealert.nature.com/ctt?kn=59&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Numerical reading p1083
Joanne Baker
doi:10.1038/4601083b
http://links.ealert.nature.com/ctt?kn=57&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Q&A: Science pop songsters p1084
The US band They Might Be Giants has played rock to adults for more
than two decades -- and to children since 2002. Next week it releases
the album Here Comes Science, with educational tunes about the
elements and evolution. John Linnell, who fronts the band with
John Flansburgh, explains why a science-friendly thread runs through
their music.
Brendan Maher
doi:10.1038/4601084a
http://links.ealert.nature.com/ctt?kn=55&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Stem cells: The promises and perils of p53 pp1085-1086
Five studies show that disabling p53, an essential tumour-suppressor
protein, improves the efficiency of stem-cell production. Are these
results a 'heads up' that cancer cells and stem cells are disturbingly
similar?
Valery Krizhanovsky and Scott W. Lowe
doi:10.1038/4601085a
http://links.ealert.nature.com/ctt?kn=53&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Extrasolar planets: Secrets that only tides will tell pp1086-1087
Evidence that the most recently discovered extrasolar planet is virtually
at the end of its life is a surprise. The odds of that are very low --
similar to drawing two consecutive red aces from a well-shuffled deck
of cards.
Douglas P. Hamilton
doi:10.1038/4601086a
http://links.ealert.nature.com/ctt?kn=10&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Developmental biology: Jumping-gene roulette pp1087-1088
Jumping genes, which make DNA copies of themselves through an RNA
middleman, provide a stochastic process for generating brain diversity
among humans. The effect of their random insertion, however, is a bit
of a gamble.
Sandra L. Martin
doi:10.1038/4601087a
http://links.ealert.nature.com/ctt?kn=2&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Optics: Ultrafast X-ray photography pp1088-1090
A super-fast, lensless microscope has been developed that works by
decoding the diffraction patterns of bright, laser-like flashes of
X-rays. This advance should enable ultrafast events at the nanoscale
to be recorded.
Margaret M. Murnane and Jianwei Miao
doi:10.1038/4601088a
http://links.ealert.nature.com/ctt?kn=5&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
50 & 100 years ago p1090
doi:10.1038/4601090a
http://links.ealert.nature.com/ctt?kn=8&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Solid-state physics: An insulator's metallic side pp1090-1091
Certain insulators have conducting surfaces that arise from subtle
chemical properties of the bulk material. The latest experiments
suggest that such surfaces may compete with graphene in electronic
applications.
Joel Moore
doi:10.1038/4601090b
http://links.ealert.nature.com/ctt?kn=25&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Gamma-ray bursts: Maybe not so old after all pp1091-1092
The discovery of a short-lived [gamma]-ray burst at a surprisingly
early epoch in the history of the Universe shows how much is still
unknown about the evolution of the parent systems of such bursts.
Enrico Ramirez-Ruiz and William Lee
doi:10.1038/4601091a
http://links.ealert.nature.com/ctt?kn=24&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
----------------------
ARTICLE
----------------------
Developmental and species-divergent globin switching are driven by
BCL11A pp1093-1097
The contribution of changes in cis-regulatory elements or trans-acting
factors to differences in gene expression between species is not well
understood. Here it is found that, in transgenic mice containing the
human [beta]-globin locus, the expression of BCL11A differs between
mouse and human and is a critical mediator of species-divergent globin
switching.
Vijay G. Sankaran et al.
doi:10.1038/nature08243
Abstract: http://links.ealert.nature.com/ctt?kn=177&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=16&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Nature Lab Offers is coming September 24!
Save money on products used in your lab: cell cultures,
antibodies, lab consumables, imaging equipment, DNA and
RNA isolation products, gene targeting equipment, centrifuges,
and so much more.
Register today and be the first to receive your Nature Lab
Offers coupons.
http://links.ealert.nature.com/ctt?kn=139&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
=====================================================================
----------------------
LETTERS
----------------------
An orbital period of 0.94 days for the hot-Jupiter planet
WASP-18b pp1098-1100
'Hot Jupiters' abound in lists of known extrasolar planets. Those
closest to their parent stars have strong tidal interactions, leading
to the suggestion that systems such as OGLE-TR-56 could be used as
tests of tidal dissipation theory. Here, the discovery of planet
WASP-18b is reported, with an orbital period of 0.94 days and a tidal
interaction an order of magnitude stronger than that of OGLE-TR-56b.
Either WASP-18 is in a rare, short-lived state, or the tidal dissipation
in this system must be weaker than in the Solar System.
Coel Hellier et al.
doi:10.1038/nature08245
Abstract: http://links.ealert.nature.com/ctt?kn=176&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=275&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
A tunable topological insulator in the spin helical Dirac transport
regime pp1101-1105
Helical Dirac fermions are charge carriers that behave as massless
relativistic particles with an intrinsic angular momentum (spin)
locked to their translational momentum, a property desirable for
spintronic and computing technologies. It has recently been proposed
that such fermions may exist at the edges of certain types of
topologically ordered insulators. Here, the realization and
characterization of such a system is reported; the results reveal
nearly 100 per cent spin polarization, even up to room temperature.
D. Hsieh et al.
doi:10.1038/nature08234
Abstract: http://links.ealert.nature.com/ctt?kn=175&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=280&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Topological surface states protected from backscattering by chiral
spin texture pp1106-1109
Topological insulators are materials in which a relativistic effect
known as spin-orbit coupling gives rise to surface states that resemble
chiral edge modes in quantum Hall systems, but with unconventional spin
textures. It has been suggested that a feature of such spin-textured
boundary states is their insensitivity to spin-independent scattering,
which is thought to protect them from backscattering. Here, scanning
tunnelling spectroscopy and angle-resolved photoemission spectroscopy
are used to confirm this prediction.
Pedram Roushan et al.
doi:10.1038/nature08308
Abstract: http://links.ealert.nature.com/ctt?kn=174&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=285&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Demonstration of a spaser-based nanolaser pp1110-1112
Nanoplasmonics promises to revolutionize applications ranging from
sensing and biomedicine to imaging and information technology, but its
full development is hindered by the lack of devices that can generate
coherent plasmonic fields. In theory, this is possible with a so-called
'spaser' -- analogous to a laser -- which would generate stimulated
emission of surface plasmons. This is now realized experimentally, and
should enable many new technological developments.
M. A. Noginov et al.
doi:10.1038/nature08318
Abstract: http://links.ealert.nature.com/ctt?kn=253&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=256&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
2,000-year-long temperature and hydrology reconstructions from the
Indo-Pacific warm pool pp1113-1116
Temperature reconstructions for the surface of the Northern Hemisphere
are based largely on terrestrial records from extra-tropical or
high-elevation sites, despite the fact that global average surface
temperature changes closely follow those of the global tropics, which
are 75 per cent ocean. Here, a decadally resolved continuous sea
surface temperature is reconstructed for the Indo-Pacific warm pool
that spans the past 2,000 years, allowing for comparison with
observations.
Delia W. Oppo, Yair Rosenthal and Braddock K. Linsley
doi:10.1038/nature08233
Abstract: http://links.ealert.nature.com/ctt?kn=255&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=264&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Surface hydrophobin prevents immune recognition of airborne fungal
spores pp1117-1121
Fungal spores are ubiquitous in the air we breathe and contain many
antigens and allergens, and yet they neither continuously activate
the host innate immune cells nor induce detrimental inflammatory
responses after their inhalation. Here, the surface layer on dormant
spores is shown to mask their recognition by the immune system and
hence prevent an immune response.
Vishukumar Aimanianda et al.
doi:10.1038/nature08264
Abstract: http://links.ealert.nature.com/ctt?kn=257&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=271&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
EBI2 mediates B cell segregation between the outer and centre follicle
pp1122-1126
B cells migrate to the outer or centre lymphoid follicle at different
stages of antibody responses. Here it is shown that activated B cells
must downregulate the orphan G protein-coupled receptor EBI2 to migrate
to the centre follicles, where they mount T dependent antibody responses
and establish germinal centres.
Joao P. Pereira, Lisa M. Kelly, Ying Xu and Jason G. Cyster
doi:10.1038/nature08226
Abstract: http://links.ealert.nature.com/ctt?kn=259&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=237&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
L1 retrotransposition in human neural progenitor cells pp1127-1131
Long interspersed element 1 (LINE-1 or L1) retrotransposons have been
shown to move throughout the genomes of adult rat neural progenitor
cells (NPCs) in vitro and in the mouse brain. Here, NPCs isolated from
human fetal brain and derived from human embryonic stem cells are shown
to support the retrotransposition of engineered human L1s in vitro,
which could contribute to individual somatic mosaicism.
Nicole G. Coufal et al.
doi:10.1038/nature08248
Abstract: http://links.ealert.nature.com/ctt?kn=261&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=233&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Suppression of induced pluripotent stem cell generation by the
p53–p21 pathway pp1132-1135
Induced pluripotent stem (iPS) cells are generated from mouse and
human somatic cells by the introduction of four genes, but with low
efficiency. Here it is reported that 10% of transduced mouse embryonic
fibroblasts lacking p53 became iPS cells, even without the Myc
retrovirus, and iPS cells were also generated from terminally
differentiated T lymphocytes in the p53-null background.
Hyenjong Hong et al.
doi:10.1038/nature08235
Abstract: http://links.ealert.nature.com/ctt?kn=263&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=113&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
The Ink4/Arf locus is a barrier for iPS cell reprogramming
pp1136-1139
The Ink4/Arf tumour suppressor locus encodes the three potent tumour
suppressors p16Ink4a, p15Ink4b and p19Arf. Here the locus is shown
to be rate-limiting for reprogramming, and its transient inhibition
significantly improves the generation of induced pluripotent stem
cells. Furthermore, ageing is shown to upregulate the Ink4/Arf locus,
with less efficient reprogramming seen in cells from old organisms.
Han Li et al.
doi:10.1038/nature08290
Abstract: http://links.ealert.nature.com/ctt?kn=265&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=110&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
pp1140-1144
Expression of pluripotency factors and oncogenes can reprogram somatic
cells to induced pluripotent stem cells, albeit with low frequency and
a tendency to induce malignant transformation. Here, reprogramming
factors are shown to activate the p53 pathway, providing insights into
reprogramming mechanisms.
Teruhisa Kawamura et al.
doi:10.1038/nature08311
Abstract: http://links.ealert.nature.com/ctt?kn=267&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=122&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Immortalization eliminates a roadblock during cellular reprogramming
into iPS cells pp1145-1148
Pluripotency can be induced in somatic cells by overexpression of a
set of transcription factors, but the process has extremely low
efficiency and slow kinetics. Here, cells with low endogenous p19Arf
levels and immortal fibroblasts deficient for components of the
Arf-Trp53 pathway yield induced pluripotent stem cell colonies with
up to threefold faster kinetics and at a significantly higher
efficiency than wild-type cells, reaching frequencies of up to 100%.
Jochen Utikal et al.
doi:10.1038/nature08285
Abstract: http://links.ealert.nature.com/ctt?kn=269&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
A p53-mediated DNA damage response limits reprogramming to ensure iPS
cell genomic integrity pp1149-1153
It is shown that p53 is critically involved in preventing the
reprogramming of cells carrying various types of DNA damage, including
short telomeres, DNA repair deficiencies, or exogenously inflicted DNA
damage. Eliminating p53 expression allows efficient reprogramming in
the face of DNA damage and the generation of induced pluripotent stem
cells carrying persistent DNA damage and chromosomal aberrations.
Rosa M. Marion et al.
doi:10.1038/nature08287
Abstract: http://links.ealert.nature.com/ctt?kn=270&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-[beta]
transcriptional complex pp1154-1158
Here it is shown that PRDM16, a zinc finger protein that controls
the switch from myoblastic precursors to brown fat cells, works
together with C/EBP-[beta] and that expression of this transcriptional
unit is sufficient to induce a fully functional brown fat program in
naive fibroblasts. Transplantation of such fibroblasts into mice
creates a brown fat pad that acts as a sink for glucose.
Shingo Kajimura et al.
doi:10.1038/nature08262
Abstract: http://links.ealert.nature.com/ctt?kn=278&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=186&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Riboflavin kinase couples TNF receptor 1 to NADPH oxidase
pp1159-1163
Riboflavin kinase is shown to couple TNF receptor 1 to reactive
oxygen production by the FAD-dependent NADPH oxidase.
Benjamin Yazdanpanah et al.
doi:10.1038/nature08206
Abstract: http://links.ealert.nature.com/ctt?kn=274&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=187&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
----------------------
CORRIGENDA
----------------------
Liquid water on Enceladus from observations of ammonia and 40Ar in
the plume p1164
J. H. Waite Jr et al.
doi:10.1038/nature08352
http://links.ealert.nature.com/ctt?kn=193&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
CBP/p300-mediated acetylation of histone H3 on lysine 56 p1164
Chandrima Das, M. Scott Lucia, Kirk C. Hansen and Jessica K. Tyler
doi:10.1038/nature08360
http://links.ealert.nature.com/ctt?kn=195&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
Prospects
A sequence for success p1167
The next generation of DNA sequencers could create more genomics
jobs, says Paul Smaglik.
doi:10.1038/nj7259-1167a
http://links.ealert.nature.com/ctt?kn=135&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Postdoc journal
A strong idea p1167
Hard work can sometimes bring success.
Sam Walcott
doi:10.1038/nj7259-1167b
http://links.ealert.nature.com/ctt?kn=149&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
In Brief
UK grants in refund threat p1167
Research councils will decide how to repay government.
doi:10.1038/nj7259-1167c
http://links.ealert.nature.com/ctt?kn=147&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
In Brief
College salaries put on ice p1167
Pay caps and cuts expected at most academic institutions.
doi:10.1038/nj7259-1167d
http://links.ealert.nature.com/ctt?kn=159&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
In Brief
A guide for policy work p1167
Updated, expanded edition freely available online.
doi:10.1038/nj7259-1167e
http://links.ealert.nature.com/ctt?kn=156&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
----------------------
FUTURES
----------------------
The Gower Street cuckoos p1170
It's a growing problem.
Joe Dunckley
doi:10.1038/4601170a
http://links.ealert.nature.com/ctt?kn=221&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
26 August 2009
Population context determines cell-to-cell variability in endocytosis
and virus infection
Berend Snijder et al.
doi:10.1038/nature08282
Abstract: http://links.ealert.nature.com/ctt?kn=213&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=213&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Photosystem I gene cassettes are present in marine virus genomes
Itai Sharon et al.
doi:10.1038/nature08284
Abstract: http://links.ealert.nature.com/ctt?kn=210&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=210&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Modification of CO2 avoidance behaviour in Drosophila by inhibitory
odorants
Stephanie Lynn Turner and Anandasankar Ray
doi:10.1038/nature08295
Abstract: http://links.ealert.nature.com/ctt?kn=215&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=215&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
The avian Z-linked gene DMRT1 is required for male sex determination
in the chicken
Craig A. Smith et al.
doi:10.1038/nature08298
Abstract: http://links.ealert.nature.com/ctt?kn=172&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=172&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Mitochondrial gene replacement in primate offspring and embryonic
stem cells
Masahito Tachibana et al.
doi:10.1038/nature08368
Abstract: http://links.ealert.nature.com/ctt?kn=165&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=165&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
23 August 2009
Co-translational mRNA decay in Saccharomyces cerevisiae
Wenqian Hu et al.
doi:10.1038/nature08265
Abstract: http://links.ealert.nature.com/ctt?kn=164&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=164&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Structure of a tetrameric MscL in an expanded intermediate state
Zhenfeng Liu, Chris S. Gandhi and Douglas C. Rees
doi:10.1038/nature08277
Abstract: http://links.ealert.nature.com/ctt?kn=183&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=183&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
Yoshiko Maida et al.
doi:10.1038/nature08283
Abstract: http://links.ealert.nature.com/ctt?kn=180&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=180&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Scientific American: More than 100 Nobel Prize winners — from Albert
Einstein to Niels Bohr — have chosen to share their discoveries in the
pages of Scientific American.
Isn't it time you gave our latest issue a RISK-FREE examination?
=====================================================================
You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=48&m=33931412&r=MjA1NTkxMDA2MAS2&b=2&j=NTcxNTk5OTcS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2009 Nature Publishing Group
=====================================================================
