13 August 2009 Volume 460 Number 7257, pp 773-924
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including how enzymes containing complex metal clusters metabolize
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are assembled, and how metalloenzymes containing a single metal ion
catalyze the halogenation of small organic molecules.
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----------------------
EDITORIALS
----------------------
Lessons from Antarctica p781
Twenty years on, the success of the Montreal Protocol can help inform
plans to mitigate climate change.
doi:10.1038/460781a
http://links.ealert.nature.com/ctt?kn=42&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
A change of tone p781
There is every reason to be optimistic about the Obama administration's
attitude towards science.
doi:10.1038/460781b
http://links.ealert.nature.com/ctt?kn=129&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
Canine genetics: Stray genes p782
doi:10.1038/460782a
http://links.ealert.nature.com/ctt?kn=16&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Cancer biology: Suicide by nucleotide p782
doi:10.1038/460782b
http://links.ealert.nature.com/ctt?kn=71&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Atmospheric chemistry: Isoprene's fate p782
doi:10.1038/460782c
http://links.ealert.nature.com/ctt?kn=166&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Physics: Salt mined p782
doi:10.1038/460782d
http://links.ealert.nature.com/ctt?kn=149&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Speciation: Multiplying effects pp782-783
doi:10.1038/460782e
http://links.ealert.nature.com/ctt?kn=143&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Neurobiology: Have guts, get nerve p783
doi:10.1038/460783a
http://links.ealert.nature.com/ctt?kn=121&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Evolution: Reinventing the egg p783
doi:10.1038/460783b
http://links.ealert.nature.com/ctt?kn=196&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Soil ecology: As different as day and night p783
doi:10.1038/460783c
http://links.ealert.nature.com/ctt?kn=81&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Molecular biology: A regulator's regulator p783
doi:10.1038/460783d
http://links.ealert.nature.com/ctt?kn=39&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
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JOURNAL CLUB
----------------------
Journal club p783
Omar Tonsi Eldakar
doi:10.1038/460783e
http://links.ealert.nature.com/ctt?kn=286&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
----------------------
NEWS
----------------------
LHC hopes for collisions by Christmas pp784-785
But particle physicists will have to scale back the energies of their
experiments for years.
Eric Hand
doi:10.1038/460784a
http://links.ealert.nature.com/ctt?kn=2&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Science advisers mull priorities p785
Climate change and energy are high on the agenda for Obama's panel.
Alexandra Witze and Lizzie Buchen
doi:10.1038/460785a
http://links.ealert.nature.com/ctt?kn=110&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Ice-core researchers hope to chill out pp786-787
Fresh freezers needed to preserve ancient gas, scientists say.
Rex Dalton
doi:10.1038/460786a
http://links.ealert.nature.com/ctt?kn=264&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Flu database rocked by legal row pp786-787
Dispute over ownership raises concerns among flu scientists.
Declan Butler
doi:10.1038/460786b
http://links.ealert.nature.com/ctt?kn=205&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Climate data spat intensifies pp787-787
Growing demands for access to information swamp scientist.
Olive Heffernan
doi:10.1038/460787a
http://links.ealert.nature.com/ctt?kn=128&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Return of the rat p788
European investment could see knock-out rats catching up with mutant
mice in medical research.
Alison Abbott
doi:10.1038/460788a
http://links.ealert.nature.com/ctt?kn=117&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Satellite data show Indian water stocks shrinking p789
Groundwater depletion raises spectre of shortages.
Quirin Schiermeier
doi:10.1038/460789a
http://links.ealert.nature.com/ctt?kn=164&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Europe prepares for drugs from GM plants p791
doi:10.1038/460791a
http://links.ealert.nature.com/ctt?kn=18&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Presidential panel lays out options for NASA's future p791
doi:10.1038/460791b
http://links.ealert.nature.com/ctt?kn=72&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Batteries feel the benefit of green car money p791
doi:10.1038/460791c
http://links.ealert.nature.com/ctt?kn=84&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Stalled science buildings restart in California p791
doi:10.1038/460791d
http://links.ealert.nature.com/ctt?kn=203&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
German scientists found guilty of negligence p791
doi:10.1038/460791e
http://links.ealert.nature.com/ctt?kn=82&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Novartis targeted by animal-rights extremists p791
doi:10.1038/460791f
http://links.ealert.nature.com/ctt?kn=120&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
----------------------
NEWS FEATURE
----------------------
Atmospheric science: Fixing the sky pp792-795
When nations made plans to save the ozone layer, they didn't factor in
global warming. Quirin Schiermeier reports on how two environmental
problems complicate each other.
Quirin Schiermeier
doi:10.1038/460792a
http://links.ealert.nature.com/ctt?kn=235&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
----------------------
CORRESPONDENCE
----------------------
Ape and human similarities can be deceptive p796
Jonathan Marks
doi:10.1038/460796a
http://links.ealert.nature.com/ctt?kn=291&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Speed of reporting isn't the issue when your work is scooped p796
Ian M. Brooks
doi:10.1038/460796b
http://links.ealert.nature.com/ctt?kn=140&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
European bodies can help to tackle TB worldwide p796
Robin Fears, Alimuddin Zumla and Volker ter Meulen
doi:10.1038/460796c
http://links.ealert.nature.com/ctt?kn=132&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
----------------------
BOOKS AND ARTS
----------------------
Africa's biotechnology battle pp797-798
An influential book accuses Europe of keeping genetically modified
crops out of Africa, but, by polarizing the debate, it undermines
efforts to improve the continent's agriculture.
Ian Scoones and Dominic Glover review Starved for Science:
How Biotechnology Is Being Kept Out of Africa by Robert Paarlberg
doi:10.1038/460797a
http://links.ealert.nature.com/ctt?kn=17&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
The world in a grain of sand pp798-799
Andrew Robinson reviews Sand: A Journey through Science and the
Imagination by Michael Welland
doi:10.1038/460798a
http://links.ealert.nature.com/ctt?kn=261&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
D-Day forecast fictionalized pp799-800
Philip Ball reviews Turbulence by Giles Foden
doi:10.1038/460799a
http://links.ealert.nature.com/ctt?kn=255&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Bling of the Bactrians p800
Josie Glausiusz reviews Afghanistan: Hidden Treasures from the
National Museum, Kabul
doi:10.1038/460800a
http://links.ealert.nature.com/ctt?kn=273&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Mathematical physics: A tight squeeze pp801-802
How can identical particles be crammed together as densely as
possible? A combination of theory and computer simulations shows
how the answer to this intricate problem depends on the shape of
the particles.
Henry Cohn
doi:10.1038/460801a
http://links.ealert.nature.com/ctt?kn=233&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Stem cells: Escaping fates with open states pp802-803
The ability of embryonic stem cells to give rise to any cell type
relies on a remodelling protein that maintains open chromatin. But
the chromatin landscape of these cells may be more complex than
previously thought.
Robert J. Sims III and Danny Reinberg
doi:10.1038/460802a
http://links.ealert.nature.com/ctt?kn=189&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Ecology: Elementary factors pp803-804
The identification of a general connection between biogeochemistry
and the structure of food webs would constitute a considerable advance
in understanding ecosystems. Ecologists are on the case.
Josep Peñuelas and Jordi Sardans
doi:10.1038/460803a
http://links.ealert.nature.com/ctt?kn=260&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Cancer: More than kin and less than kind pp804-807
A gene that is found to be mutated in a type of blood cancer exhibits
properties of both a growth-suppressing tumour suppressor and a
growth-promoting oncogene.
Kevin Shannon and Mignon Loh
doi:10.1038/460804a
http://links.ealert.nature.com/ctt?kn=186&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Chemical biology: Protein picker p805
Andrew Mitchinson
doi:10.1038/460805a
http://links.ealert.nature.com/ctt?kn=35&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
50 & 100 years ago p807
doi:10.1038/460807b
http://links.ealert.nature.com/ctt?kn=49&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Microbial genetics: Love the one you're with pp807-808
Candida albicans is notorious as an opportunistic microbe that causes
thrush and serious systemic disease. For geneticists, however, it offers
continuing revelations into the wondrously varied sex lives of fungi.
Joseph Heitman
doi:10.1038/460807a
http://links.ealert.nature.com/ctt?kn=12&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
----------------------
NEWS AND VIEWS Q&A
----------------------
Technology: Hydrogen-fuelled vehicles pp809-811
Hydrogen is hailed as a non-polluting synthetic fuel that could replace
oil, especially for transport applications. The technology to make this
a reality — particularly hydrogen-storage materials — has been a long
time coming, but the first commercial vehicles might now be only a
few years away.
Louis Schlapbach
doi:10.1038/460809a
http://links.ealert.nature.com/ctt?kn=73&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
----------------------
INSIGHT
----------------------
EDITORIAL
Metalloproteins p813
Joshua Finkelstein
doi:10.1038/460813a
http://links.ealert.nature.com/ctt?kn=204&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
REVIEW ARTICLE
Structure–function relationships of anaerobic gas-processing metalloenzymes
pp814-822
Juan C. Fontecilla-Camps et al.
doi:10.1038/nature08299
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=222&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Metalloproteins and metal sensing pp823-830
Kevin J. Waldron, Julian C. Rutherford, Dianne Ford and Nigel J. Robinson
doi:10.1038/nature08300
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=183&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Function and biogenesis of iron–sulphur proteins pp831-838
Roland Lill
doi:10.1038/nature08301
Abstract: http://links.ealert.nature.com/ctt?kn=50&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=93&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Molybdenum cofactors, enzymes and pathways pp839-847
Günter Schwarz, Ralf R. Mendel and Markus W. Ribbe
doi:10.1038/nature08302
Abstract: http://links.ealert.nature.com/ctt?kn=154&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=130&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Mechanistic considerations of halogenating enzymes pp848-854
Alison Butler and Moriah Sandy
doi:10.1038/nature08303
Abstract: http://links.ealert.nature.com/ctt?kn=270&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=106&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Design of functional metalloproteins pp855-862
Yi Lu, Natasha Yeung, Nathan Sieracki and Nicholas M. Marshall
doi:10.1038/nature08304
Abstract: http://links.ealert.nature.com/ctt?kn=180&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=250&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
----------------------
ARTICLE
----------------------
Chd1 regulates open chromatin and pluripotency of embryonic stem cells
pp863-868
A hallmark of stem cells is an open chromatin largely devoid of
heterochromatin, but which molecules are required to maintain it is
unknown, as well as whether an open chromatin is necessary for the
differentiation potential of stem cells. Here, the chromatin
remodelling factor Chd1 is shown to be required to maintain the open
chromatin state of pluripotent mouse embryonic stem cells and to be
essential for the pluripotency of these cells.
Alexandre Gaspar-Maia et al.
doi:10.1038/nature08212
Abstract: http://links.ealert.nature.com/ctt?kn=184&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=247&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
----------------------
LETTERS
----------------------
The diversity of type Ia supernovae from broken symmetries pp869-872
The near uniformity of the light curves of type Ia supernovae makes them
good 'standard candles' for measuring cosmic expansion, but a correction
must be applied to account for the fact that the brighter ones have
broader light curves. Here, multi-dimensional modelling of the explosion
physics and radioactive transfer reveals that failing to correct for an
effect on the slope and normalization of the width-luminosity relation
could lead to systematic overestimates of up to 2% of the distance to
remote supernovae.
D. Kasen, F. K. Röpke and S. E. Woosley
doi:10.1038/nature08256
Abstract: http://links.ealert.nature.com/ctt?kn=190&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Storms in the tropics of Titan pp873-875
The presence of small-scale channels and dry riverbeds at latitudes
thought incapable of supporting convection on Saturn's moon Titan has
therefore been suggested to be due to mechanisms unrelated to
precipitation. Here, however, the presence of bright, transient,
tropospheric clouds in tropical latitudes is reported. It is thought
that convective pulses at one latitude can trigger short-term convection
at other latitudes, resulting in methane rain.
E. L. Schaller, H. G. Roe, T. Schneider and M. E. Brown
doi:10.1038/nature08193
Abstract: http://links.ealert.nature.com/ctt?kn=172&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=258&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Dense packings of the Platonic and Archimedean solids pp876-879
Kepler's conjecture gives the densest possible packing for spherical
particles but, until now, there has not been an analogous system for
determining dense polyhedral packings. Using a variety of multiparticle
initial configurations it has now been possible to determine the
densest known packings for the Platonic solids and to conjecture
that those of Platonic and Archimedean solids with central symmetry
are given by their corresponding densest lattice packings.
S. Torquato and Y. Jiao
doi:10.1038/nature08239
Abstract: http://links.ealert.nature.com/ctt?kn=148&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=151&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Atlantic hurricanes and climate over the past 1,500 years pp880-883
Tropical cyclone activity in the Atlantic, as measured by annual storm
counts, reached unusually high levels over the past decade. This
recent activity is now placed in a longer-term context by comparing
two independent estimates of hurricane activity over the past 1,500
years; there is evidence of a peak in Atlantic tropical cyclone
activity during medieval times (around AD 1000) that rivals or
exceeds recent levels of activity.
Michael E. Mann, Jonathan D. Woodruff, Jeffrey P. Donnelly and Zhihua Zhang
doi:10.1038/nature08219
Abstract: http://links.ealert.nature.com/ctt?kn=201&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=229&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Glacial effects limiting mountain height pp884-887
There are indications that the general height of mountain ranges is
directly influenced by the extent of glaciation through an efficient
denudation mechanism known as the glacial buzzsaw. Here, a global
analysis of topography shows that variations in maximum mountain
height correlate closely with climate-controlled gradients in snowline
altitude rather than with tectonic activity. Further, the use of a
numerical model self-consistently produces the hypsometric signature
of the glacial buzzsaw.
D. L. Egholm, S. B. Nielsen, V. K. Pedersen and J.-E. Lesemann
doi:10.1038/nature08263
Abstract: http://links.ealert.nature.com/ctt?kn=202&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Pelvic claspers confirm chondrichthyan-like internal fertilization in
arthrodires pp888-889
The placoderms are a large group of primitive armoured fishes, which,
although now extinct, could shed light on the evolution of jawed
vertebrates. Recent fossil finds have been discovered with embryos,
illustrating that fertilization was internal, but direct evidence for
this was missing. Here, the discovery of a completely ossified pelvic
clasper in a male Incisoscutum ritchiei confirms internal fertilization
in arthrodires, a large and important placoderm group.
Per Ahlberg, Kate Trinajstic, Zerina Johanson and John Long
doi:10.1038/nature08176
Abstract: http://links.ealert.nature.com/ctt?kn=225&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Homothallic and heterothallic mating in the opportunistic pathogen
Candida albicans pp890-893
Until recently, the human pathogenic yeast Candida albicans was thought
to be strictly asexual, existing only as an obligate diploid. However,
here it is shown that under specific conditions - in the absence
of the secreted protease Bar1 - efficient same-sex mating can
take place.
Kevin Alby, Dana Schaefer and Richard J. Bennett
doi:10.1038/nature08252
Abstract: http://links.ealert.nature.com/ctt?kn=170&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=246&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Programming cells by multiplex genome engineering and accelerated
evolution pp894-898
Genomic diversity is difficult to generate in the laboratory in an
efficient way. Here, multiplex automated genome engineering (MAGE)
is described for large-scale programming and evolution of cells. It is
an automated and efficient approach that expedites the design and
evolution of organisms with new and improved properties.
Harris H. Wang et al.
doi:10.1038/nature08187
Abstract: http://links.ealert.nature.com/ctt?kn=133&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=97&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Intrinsic light response of retinal horizontal cells of teleosts
pp899-903
It has recently become apparent that rods and cones are not the only
photoreceptors in mammals. A third class, known as intrinsically
photosensitive retinal ganglion cells, use the photopigment melanopsin
and mediate non-image-forming visual functions such as circadian
photoentrainment. In teleost fish, a subset of horizontal cells is
now shown to be photosensitive; the photopigment responsible for this
seems to be melanopsin.
Ning Cheng, Takashi Tsunenari and King-Wai Yau
doi:10.1038/nature08175
Abstract: http://links.ealert.nature.com/ctt?kn=135&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=144&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
pp904-908
Acquired uniparental disomy (aUPD), a common feature of cancer genomes,
is associated with gain-of-function mutations of proto-oncogenes as
well as with loss-of-function mutations of tumour suppressor genes.
Here, gain-of-function mutations of the C-CBL tumour suppressor are
shown to be tightly associated with aUPD of the 11q arm in certain
myeloid neoplasms.
Masashi Sanada et al.
doi:10.1038/nature08240
Abstract: http://links.ealert.nature.com/ctt?kn=63&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=231&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
A role for Lin28 in primordial germ-cell development and germ-cell
malignancy pp909-913
In order to investigate the earliest molecular mechanisms of germ cell
specification, mouse embryonic stem cells were differentiated into
putative primordial germ cells (PGCs) in vitro. The use of inhibitory
RNAs to then screen candidate genes for effects on the development of
these cells demonstrates a genetic pathway for PGC specification
involving Lin28, a negative regulator of let-7 microRNA processing.
Jason A. West et al.
doi:10.1038/nature08210
Abstract: http://links.ealert.nature.com/ctt?kn=266&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Multiple roles for MRE11 at uncapped telomeres pp914-918
The ends of linear eukaryotic chromosomes are capped by sequences known
as telomeres. Although telomeres are essentially one half of a DNA
double-strand break, which is a pathogenic lesion that must be repaired,
telomeres do not normally activate DNA damage repair pathways. Here,
the three-member MRN complex is shown to serve two roles at the
telomere: it protects newly synthesized telomeric ends from repair
factors and it promotes a type of fusion repair when the telomere
is not functioning properly.
Yibin Deng, Xiaolan Guo, David O. Ferguson and Sandy Chang
doi:10.1038/nature08196
Abstract: http://links.ealert.nature.com/ctt?kn=272&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
Careers and Recruitment
Canadian changes in the air p920
British Columbia aims to become a leader in clean-energy technology.
Virginia Gewin tracks progress.
doi:10.1038/nj7257-920a
http://links.ealert.nature.com/ctt?kn=254&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
----------------------
FUTURES
----------------------
Bombs away! p924
Happy landings.
Paul Di Filippo
doi:10.1038/460924a
http://links.ealert.nature.com/ctt?kn=199&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
12 August 2009
Satellite-based estimates of groundwater depletion in India
Matthew Rodell, Isabella Velicogna and James S. Famiglietti
doi:10.1038/nature08238
Abstract: http://links.ealert.nature.com/ctt?kn=220&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=220&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Direct activation of protein kinases by unanchored polyubiquitin chains
Zong-Ping Xia et al.
doi:10.1038/nature08247
Abstract: http://links.ealert.nature.com/ctt?kn=198&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=198&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
The importance of niches for the maintenance of species diversity
Jonathan M. Levine and Janneke HilleRisLambers
doi:10.1038/nature08251
Abstract: http://links.ealert.nature.com/ctt?kn=167&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=167&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
The structural basis of tail-anchored membrane protein recognition by Get3
Agnieszka Mateja et al.
doi:10.1038/nature08319
Abstract: http://links.ealert.nature.com/ctt?kn=259&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=259&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Stem cells: The promises and perils of p53
Five studies show that disabling p53, an essential tumour-suppressor
protein, improves the efficiency of stem-cell production. Are these
results a 'heads up' that cancer cells and stem cells are disturbingly
similar?
Valery Krizhanovsky and Scott W. Lowe
doi:10.1038/nature08367
http://links.ealert.nature.com/ctt?kn=185&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
09 August 2009
Suppression of induced pluripotent stem cell generation by the p53–p21
pathway
Hyenjong Hong et al.
doi:10.1038/nature08235
Abstract: http://links.ealert.nature.com/ctt?kn=253&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=253&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Immortalization eliminates a roadblock during cellular reprogramming
into iPS cells
Jochen Utikal et al.
doi:10.1038/nature08285
Abstract: http://links.ealert.nature.com/ctt?kn=211&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=211&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
A p53-mediated DNA damage response limits reprogramming to ensure iPS
cell genomic integrity
Rosa M. Marión et al.
doi:10.1038/nature08287
Abstract: http://links.ealert.nature.com/ctt?kn=271&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=271&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
The Ink4/Arf locus is a barrier for iPS cell reprogramming
Han Li et al.
doi:10.1038/nature08290
Abstract: http://links.ealert.nature.com/ctt?kn=96&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=96&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Topological surface states protected from backscattering by chiral spin
texture
Pedram Roushan et al.
doi:10.1038/nature08308
Abstract: http://links.ealert.nature.com/ctt?kn=66&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
Teruhisa Kawamura et al.
doi:10.1038/nature08311
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=33853205&r=MjA1NTkxMDA2MAS2&b=2&j=NTY2MDQ4MjcS1&mt=1&rt=0
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