FEBS Letters Special Issue on Protein Folding, Misfolding and Disease

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FEBS Letters Special Issue Volume 583, Issue 16, Pages 2579-2700 (20 August 2009) Protein Folding, Misfolding and Disease Edited by Per Hammarström and Peter Brzezinski Protein aggregation was for decades regarded as a mere nuisance in protein research. This process often occurred after a tedious isolation procedure for functional studies and in concentrated protein solutions used for setting up crystallization screens. Just as frustrating were the early days of protein folding. Scientists were equally frustrated in detecting a turbid sample in the dialysis bag when returning to the lab in the early morning hours as to find that their refolded protein sample lacked specific activity or turned opalescent during rapid dilution of a chemically denatured protein in the stopped flow machine or during thermal denaturation. Few researchers at the time realized that the misfolded states of proteins would hold the key to some of the most severely debilitating diseases known to man. - Click here for a full contents listing - Sign up to receive FEBS Letters Volume/Issue Alerts - Submit your article via FEBS Letters' online submission system: http://ees.elsevier.com/febsletters/ Issue 16 /2009 Managing Editor Felix Wieland Heidelberg University, Heidelberg, Germany Email: felix.wieland@bzh. uni-heidelberg.de Meet the Editors   DATA PROTECTION NOTICE This e-mail has been sent to manojhind2001us1.stemcell@blogger.com from Elsevier Science & Technology Journals, Radarweg 29, 1043 NX Amsterdam, The Netherlands, using Email Reaction's technology and platform. To ensure delivery to your inbox (not bulk or junk folders), please click here to add our address to your safe senders list. You are receiving this e-mail because you are a registered user of ScienceDirect ® and have consented to receive information about related products. If you do not wish to receive general marketing messages from Elsevier Science & Technology Journals, you can visit this page to Unsubscribe, enter you e-mail address, and press the submit button and you will be unsubscribed. To update your ScienceDirect profile please go to the ScienceDirect website, login with your username and password and amend your preferences. Elsevier respects your privacy and does not disclose, sell or rent your personal information to any non-affiliated third parties without your consent, except as may be stated in the Elsevier Privacy Policy. Please visit this page to see Email Reaction's Privacy Policy. For all enquiries, problems or suggestions regarding this service, please contact: fls-marketing@elsevier.com. Copyright © 2009 Elsevier B.V. registered office: Radarweg 29, 1043 NX Amsterdam, The Netherlands, under number 33156677, VAT number 002967455b65. All rights reserved.