FEBS Letters Virtual Special Issue We encourage you to take a look at the FEBS Letters Virtual Special Issue on "Biology of Danger and Defence", a collection of some of the best articles published in FEBS Letters in the field of immunology and beyond. When an organism comes into contact with a noxious entity, it is normally capable of recognizing it as a potential source of danger. The danger stimulus is then translated into a network of signals, which ultimately switch on an ad hoc defence programme. Understanding the mechanisms underlying these pathways is a matter of utmost importance in biology and medicine. Many of the studies within this Special Issue focus on signalling pathways, shedding light onto the molecular mechanisms of danger and defence. We hope you will find this issue illuminating. Table of Contents I. Inflammatory response Involvement of phosphatidylinositol-3-kinase and ERK pathways in the production of TGF-b1 by macrophages treated with liposomes composed of phosphatidylserine, Masaki Otsuka, Yoichi Negishi, Yukihiko Aramaki, Volume 581, Issue 2, Pages 325-330 Interferon gamma-dependent transactivation of epidermal growth factor receptor, Elena Burova, Konstantin Vassilenko, Victoria Dorosh, Ilya Gonchar, Nikolai Nikolsky, Volume 581, Issue 7, Pages 1475-1480 Macrophage migration inhibitory factor (MIF) promotes fibroblast migration in scratch-wounded monolayers in vitro, Manfred Dewor, Guy Steffens, Regina Krohn, Christian Weber, Jens Baron, Jürgen Bernhagen, Volume 581, Issue 24, Pages 4734-4742 Up-regulation of heme oxygenase-1 expression through the Rac1/NADPH oxidase/ROS/p38 signaling cascade mediates the anti-inflammatory effect of 15-deoxy-D12,14-prostaglandin J2 in murine macrophages, Hye-Young Hong, Woo-Kwang Jeon, Byung-Chul Kim, Volume 582, Issue 6, Pages 861-868 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation, Susan M. Baker, Namho Kim, Anna M. Gumpert, Dominique Segretain, Matthias M. Falk, Volume 582, Issue 29, Pages 4039-4046 Contribution of IL-12R mediated feedback loop to Th1 cell differentiation, Attila Becskei, Michael J. Grusby, Volume 581, Issue 27, Pages 5199-5206 Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism, Lucas Bleicher, Patricia Ribeiro de Moura, Leandra Watanabe, Didier Colau, Laure Dumoutier, Jean-Christophe Renauld, Igor Polikarpov, Volume 582, Issue 20, Pages 2985-2992 Structure-dependent functional properties of human defensin 5, Erik de Leeuw, Scott R. Burks, Xiangqun Li, Joseph P.Y. Kao, Wuyuan Lu, Volume 581, Issue 3, Pages 515-520 II. Toll-like receptor signalling MAPPIT analysis of TLR adaptor complexes, Peter Ulrichts, Frank Peelman, Rudi Beyaert, Jan Tavernier, Volume 581, Issue 4, Pages 629-636 Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88, Tadashi Nishiya, Emi Kajita, Takahiro Horinouchi, Arata Nishimoto, Soichi Miwa, Volume 581, Issue 17, Pages 3223-322 Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6, Lu Chen, Wei Dong, Tingting Zou, Lu Ouyang, Guoqing He, Yingle Liu, Yipeng Qi, Volume 582, Issue 19, Pages 2843-2849 Toll-like receptors stimulate regulated intramembrane proteolysis of the CSF-1 receptor through Erk activation, Gary Glenn, Peter van der Geer, Volume 582, Issue 6, Pages 911-915 III. The cell's response to microbial insults Characterisation of cyclin D1 down-regulation in coronavirus infected cells, Sally M. Harrison, Brian K. Dove, Lisa Rothwell, Pete Kaiser, Ian Tarpey, Gavin Brooks, Julian A. Hiscox, Volume 581, Issue 7, Pages 1275-1286 Elimination of a bacterial pore-forming toxin by sequential endocytosis and exocytosis, Matthias Husmann, Erik Beckmann, Klaus Boller, Nicole Kloft, Stefan Tenzer, Wiesia Bobkiewicz, Claudia Neukirch, Hagan Bayley, Sucharit Bhakdi, Volume 583, Issue 2, Pages 337-344 Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages, Elisabeth Elass, Bernadette Coddeville, Laurent Kremer, Marlène Mortuaire, Joël Mazurier, Yann Guérardel, Volume 582, Issue 3, Pages 445-450 IV. Defence mechanisms in plants Diverse stress signals activate the C1 subgroup MAP kinases of Arabidopsis, 11 April 2007 Dolores Ortiz-Masia, Miguel A. Perez-Amador, Juan Carbonell, Maria J. Marcote, Volume 581, Issue 9, Pages 1834-1840 Genetic interaction and phenotypic analysis of the Arabidopsis MAP kinase pathway mutations mekk1 and mpk4 suggests signaling pathway complexity, Shih-Heng Su, Maria Cristina Suarez-Rodriguez, Patrick Krysan, Volume 581, Issue 17, Pages 3171-3177 Calmodulin-binding transcription activator (CAMTA) 3 mediates biotic defense responses in Arabidopsis, Yael Galon, Roy Nave, Joy M. Boyce, Dikla Nachmias, Marc R. Knight, Hillel Fromm, Volume 582, Issue 6, Pages 943-948 Salicylic acid production in response to biotic and abiotic stress depends on isochorismate in Nicotiana benthamiana, Jérémy Catinot, Antony Buchala, Eliane Abou-Mansour, Jean-Pierre Métraux, Volume 582, Issue 4, Pages 473-478 | Issue 2 /2009
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