Latest PhD Studentships - 1 September 2009

Welcome to the FindAPhD weekly Newsletter. Listed below are the latest research projects to be advertised on FindAPhD.com.

Bangor University
Investigating the Scientific and Economic Realities of Biochar

University of York
PhD in the Microwave Biorefinery

Bangor University
Breeding a better bee for Wales: the use of genetic techniques to accelerate selection.

University of East Anglia
Model Theory of Exponential Fields

University of Leeds
Design of robust PTFE faced bearings for performance and reliability in large rotating machinery

University of Leeds
Modelling liquid fuels atomisation and vaporisation for industrial gas turbine injectors

University of Aberdeen
The Potential of Transcranial Direct Current Stimulation to Facilitate Motor Learning in Children and Young People with Cerebral Palsy

University of Surrey
STFC/CASE PhD studentship: Development of Silicon Carbide neutron detectors

University of Surrey
PhD Studentship on Trustworthy Voting Systems

Imperial College London
PhD Studentship in Fuel Cells

University of Reading
EngD "Investigating the features that constitute a bat friendly breathable roofing membrane" Collaborative partnership between University of Reading & the Bat Conservation Trust

Cardiff University
PhD Studentship in Archaeological Chemistry

Cardiff University
PhD Studentship in Nanocatalysis

University of Leicester
Biomarkers of Heart Failure

University of Edinburgh
Lakes and Contemporary Climate Change

Many more projects have been added this week! Click here to view them all!

Kind regards,

The FindAPhD.com Team

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Cord Blood America (OTC BB: CBAI): Corporate Profile

Release #:812-69648-em-434148:

Cord Blood America (OTC BB: CBAI): Corporate Profile This is an updated Corporate Profile for Cord Blood America (OTC BB: CBAI).  Do your due diligence.  We believe this Company is in the right sector, with the right management team, at exactly the right time.   Click here to download the .pdf version Click here to download the .pdf version Paul Knopick E & E Communications

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Mol. Biol. Cell Table of Contents for 1 September 2009; Vol. 20, No. 17

		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Mol. Biol. Cell Online Table of Contents Alert

A new issue of Molecular Biology of the Cell is available online:

1 September 2009; Vol. 20, No. 17

The below Table of Contents is available online at: http://www.molbiolcell.org/content/vol20/issue17/?etoc

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Articles

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Distinct Roles for Key Karyogamy Proteins during Yeast Nuclear Fusion

Patricia Melloy, Shu Shen, Erin White, and Mark D. Rose

The Class II Phosphatidylinositol 3 kinase C2β Is Required for the Activation of the K⁺ Channel KCa3.1 and CD4 T-Cells

Shekhar Srivastava, Lie Di, Olga Zhdanova, Zhai Li, Santosha Vardhana, Qi Wan, Ying Yan, Rajat Varma, Jonathan Backer, Heike Wulff, Michael L. Dustin, and Edward Y. Skolnik

Basolateral Internalization of GPI-anchored Proteins Occurs via a Clathrin-independent Flotillin-dependent Pathway in Polarized Hepatic Cells

Tounsia Aït-Slimane, Romain Galmes, Germain Trugnan, and Michèle Maurice

Reduced ATR or Chk1 Expression Leads to Chromosome Instability and Chemosensitization of Mismatch Repair–deficient Colorectal Cancer Cells

Melanie J. Jardim, Qinhong Wang, Ryohei Furumai, Timothy Wakeman, Barbara K. Goodman, and Xiao-Fan Wang

The Insulin-like Growth Factor (IGF)-I E-Peptides Modulate Cell Entry of the Mature IGF-I Protein

Lindsay A. Pfeffer, Becky K. Brisson, Hanqin Lei, and Elisabeth R. Barton

Pericentromeric Sister Chromatid Cohesion Promotes Kinetochore Biorientation

Tessie M. Ng, William G. Waples, Brigitte D. Lavoie, and Sue Biggins

Peroxisome Size Provides Insights into the Function of Autophagy-related Proteins

Taras Y. Nazarko, Jean-Claude Farré, and Suresh Subramani

The Ccr4–Not Deadenylase Subunits CNOT7 and CNOT8 Have Overlapping Roles and Modulate Cell Proliferation

Akhmed Aslam, Saloni Mittal, Frederic Koch, Jean-Christophe Andrau, and G. Sebastiaan Winkler

Budding Yeast SSD1-V Regulates Transcript Levels of Many Longevity Genes and Extends Chronological Life Span in Purified Quiescent Cells

Lihong Li, Yong Lu, Li-Xuan Qin, Ziv Bar-Joseph, Margaret Werner-Washburne, and Linda L. Breeden

Drosophila GoLoco-Protein Pins Is a Target of G_o-mediated G Protein–coupled Receptor Signaling

Damir Kopein and Vladimir L. Katanaev

Central Role of the Oxygen-dependent Degradation Domain of Drosophila HIF/Sima in Oxygen-dependent Nuclear Export

Maximiliano Irisarri, Sofía Lavista-Llanos, Nuria M. Romero, Lázaro Centanin, Andrés Dekanty, and Pablo Wappner

Caenorhabditis elegans FOS-1 and JUN-1 Regulate plc-1 Expression in the Spermatheca to Control Ovulation

Susan M. Hiatt, Holli M. Duren, Y. John Shyu, Ronald E. Ellis, Naoki Hisamoto, Kunihiro Matsumoto, Ken-ichi Kariya, Tom K. Kerppola, and Chang-Deng Hu

Annexin A2 Regulates Phagocytosis of Photoreceptor Outer Segments in the Mouse Retina

Ah-Lai Law, Qi Ling, Katherine A. Hajjar, Clare E. Futter, John Greenwood, Peter Adamson, Silène T. Wavre-Shapton, Stephen E. Moss, and Matthew J. Hayes

The Rho-Guanine Nucleotide Exchange Factor Domain of Obscurin Activates RhoA Signaling in Skeletal Muscle

Diana L. Ford-Speelman, Joseph A. Roche, Amber L. Bowman, and Robert J. Bloch

Identification of a Distal GLUT4 Trafficking Event Controlled by Actin Polymerization

Jamie A. Lopez, James G. Burchfield, Duncan H. Blair, Katarina Mele, Yvonne Ng, Pascal Vallotton, David E. James, and William E. Hughes

ZO-1 Stabilizes the Tight Junction Solute Barrier through Coupling to the Perijunctional Cytoskeleton

Christina M. Van Itallie, Alan S. Fanning, Arlene Bridges, and James M. Anderson

Regulation of Fission Yeast Myosin-II Function and Contractile Ring Dynamics by Regulatory Light-Chain and Heavy-Chain Phosphorylation

Thomas E. Sladewski, Michael J. Previs, and Matthew Lord

Divergent S Phase Checkpoint Activation Arising from Prereplicative Complex Deficiency Controls Cell Survival

Eric Lau, Gary G. Chiang, Robert T. Abraham, and Wei Jiang

A Distinct Mechanism to Achieve Efficient Signal Recognition Particle (SRP)–SRP Receptor Interaction by the Chloroplast SRP Pathway

Peera Jaru-Ampornpan, Thang X. Nguyen, and Shu-ou Shan

Glucosidase II β Subunit Modulates N-Glycan Trimming in Fission Yeasts and Mammals

Ivan D. Stigliano, Julio J. Caramelo, Carlos A. Labriola, Armando J. Parodi, and Cecilia D'Alessio

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Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 6 Issue 9

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY

September 2009 Volume 6 Number 9

Visit Nature Reviews Gastroenterology & Hepatology online to browse the
journal.

Now available at
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----------------------
EDITORIAL
----------------------
Addicted to acid suppression
Stephen B. Hanauer
p497 | doi:10.1038/nrgastro.2009.146
http://links.ealert.nature.com/ctt?kn=44&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Pancreas: Pancreatic cancer-effects of BMI on risk, age of onset, and
survival
p499 | doi:10.1038/nrgastro.2009.136
http://links.ealert.nature.com/ctt?kn=54&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Pancreas: Prognostic indicator in acute pancreatitis
p500 | doi:10.1038/nrgastro.2009.130
http://links.ealert.nature.com/ctt?kn=52&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Nutrition: Dietary nutrient composition affects progression of liver
disease
p500 | doi:10.1038/nrgastro.2009.135
http://links.ealert.nature.com/ctt?kn=50&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Celiac disease: Undiagnosed cases-rising prevalence, increased mortality
p501 | doi:10.1038/nrgastro.2009.131
http://links.ealert.nature.com/ctt?kn=48&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Nutrition: Carbohydrate malabsorption in chronic intestinal disorders
p501 | doi:10.1038/nrgastro.2009.132
http://links.ealert.nature.com/ctt?kn=22&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Physical activity improves NAFLD
p501 | doi:10.1038/nrgastro.2009.134
http://links.ealert.nature.com/ctt?kn=15&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Genetics: Genetic variants associated with primary biliary cirrhosis
p502 | doi:10.1038/nrgastro.2009.133
http://links.ealert.nature.com/ctt?kn=17&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Colorectal cancer: CT colonography for colorectal cancer screening
p502 | doi:10.1038/nrgastro.2009.137
http://links.ealert.nature.com/ctt?kn=5&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Hepatitis C: Should antiviral therapy be offered to elderly patients?
Annarosa Floreani
p503 | doi:10.1038/nrgastro.2009.138
Relatively little information exists on the prognosis for elderly patients
with chronic hepatitis C (CHC). Moreover, the majority of randomized,
clinical trials of hepatitis C treatment exclude elderly patients.
Findings from a 2009 clinical study address risk of hepatocellular
carcinoma, life expectancy and the influence of antiviral therapy in
elderly patients with CHC.
http://links.ealert.nature.com/ctt?kn=6&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Nonalcoholic fatty liver disease: Disease and comorbidity-effects on
quality of life
Giulio Marchesini and Giampaolo Bianchi
p504 | doi:10.1038/nrgastro.2009.142
Nonalcoholic fatty liver disease has long been neglected by health-care
professionals unless affected patients develop cirrhosis; however, new
research shows this disease impairs health-related quality of life. The
association of nonalcoholic fatty liver disease with chronic metabolic
diseases and cardiovascular complications restricts our ability to
define a specific role for liver damage in the poor perceived health
status of these patients.
http://links.ealert.nature.com/ctt?kn=42&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Large intestine: Remission of lymphocytic colitis with budesonide
Curt Tysk
p506 | doi:10.1038/nrgastro.2009.139
Few randomized, controlled trials have investigated the efficacy of
pharmacological treatment for lymphocytic colitis. Data from a new
randomized, placebo-controlled trial have demonstrated the efficacy
of budesonide in inducing remission of this disease; this study is an
important contribution to this field.
http://links.ealert.nature.com/ctt?kn=40&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Colorectal cancer: Irinotecan therapy-following a trail of breadcrumbs?
Richard M. Goldberg and Bert H. O'Neil
p507 | doi:10.1038/nrgastro.2009.140
The optimal therapy for patients with metastatic and treatment-refractory
colorectal cancer is controversial. Questions with regard to both the
sequence and combinations of different drugs need to be answered by
well-designed and adequately powered studies before the most appropriate
option for second-line treatment for these patients can be defined.
http://links.ealert.nature.com/ctt?kn=36&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Hepatitis C: The role of new interferons in the era of STAT-C
Rami Moucari and Patrick Marcellin
p509 | doi:10.1038/nrgastro.2009.141
More than 50% of patients infected with HCV genotype 1 fail respond to
standard treatment with peginterferon plus ribavirin. Potent treatment
strategies are urgently needed to improve outcomes for such patients.
Novel interferons and specifically targeted antiviral therapy for HCV
(STAT-C) represent promising strategies.
http://links.ealert.nature.com/ctt?kn=34&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Crohn's disease: How modern is the management of fistulizing disease?
Alessandro Fichera
p511 | doi:10.1038/nrgastro.2009.109
Considerable advances in tools for the diagnosis and management of Crohn's
disease have been made. Despite technological progress, a new study
reports that more than one-third of patients with Crohn's disease are
still diagnosed with fistulizing disease intraoperatively and that the
surgical management of these patients is not well characterized.
http://links.ealert.nature.com/ctt?kn=26&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

----------------------
REVIEWS
----------------------
Mechanisms of growth impairment in pediatric Crohn's disease
Thomas D. Walters and Anne M. Griffiths
p513 | doi:10.1038/nrgastro.2009.124
Restoration of normal growth is a marker of success of therapy in
pediatric Crohn's disease. This Review highlights current understanding
of the complex pathophysiologic mechanisms that contribute to growth
impairment, which clearly stems from more than simply injudicious chronic
corticosteroid use and inadequate nutrition.
Abstract: http://links.ealert.nature.com/ctt?kn=85&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Insights into the future of gastric acid suppression
Kenneth R. DeVault and Nicholas J. Talley
p524 | doi:10.1038/nrgastro.2009.125
The development of effective acid-suppression therapy has revolutionized
the treatment of acid-related diseases. This Review provides an update
on the status of acid-suppression therapy and includes discussion of
the efficacy and safety of available agents, novel agents in development,
risks of acid suppression, and directions for future research.
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=62&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Diagnosis and management of acute cholangitis
John G. Lee
Published online: 04 August 2009
p533 | doi:10.1038/nrgastro.2009.126
Acute cholangitis is a bacterial infection of the biliary tract that
occurs in an obstructed system and is characterized by fever, abdominal
pain and jaundice. No universally accepted consensus for the diagnosis
of acute cholangitis exists. This Review describes current recommendations
for the diagnosis and management of this disease and discusses the merits
and drawbacks of the most comprehensive guidelines available.
Abstract: http://links.ealert.nature.com/ctt?kn=84&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

Management of acute liver failure
R. Todd Stravitz and David J. Kramer
Published online: 04 August 2009
p542 | doi:10.1038/nrgastro.2009.127
Acute liver failure is the abrupt loss of hepatocellular function in a
patient with a previously normal liver. In this Review, Stravitz and
Kramer discuss the intensive care management of patients with acute liver
failure, the treatment of complications to prevent multi-organ-system
failure, and the role of orthotopic liver transplantation in this setting.
Abstract: http://links.ealert.nature.com/ctt?kn=82&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=86&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

----------------------
PERSPECTIVES
----------------------
OPINION
Does PPI therapy predispose to Clostridium difficile infection?
Chaitanya Pant, Phillip Madonia and Anil Minocha
p555 | doi:10.1038/nrgastro.2009.128
The incidence of Clostridium difficile infection has dramatically risen,
in concert with the increasing use of PPIs for gastric acid suppression.
This Perspective focuses on the role that PPI use may have in C. difficile
infection, and weighs up the pros and cons of PPI therapy.
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=77&m=33941485&r=MTc2OTYyOTQ2MwS2&b=2&j=NTczMjM1NDIS1&mt=1&rt=0

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Nature Methods Contents: September 2009 Volume 6 pp 623 - 686

NATURE METHODS

September 2009 Volume 6 Number 9, pp 623 - 686

Visit Nature Methods online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=134&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

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=====================================================================

----------------------
EDITORIAL
----------------------
Metagenomics versus Moore's law p623
Metagenomics sprang from advances in sequencing technology,
and continued improvements are providing data in quantities
unimaginable a few years ago. But without concerted efforts,
the amount of data will quickly outpace the ability of scientists
to analyze it.
doi:10.1038/nmeth0909-623
http://links.ealert.nature.com/ctt?kn=51&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

----------------------
CORRESPONDENCE
----------------------
CASD-NMR: critical assessment of automated structure determination
by NMR pp625 - 626
Antonio Rosato et al.
doi:10.1038/nmeth0909-625
http://links.ealert.nature.com/ctt?kn=52&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Targeting ancient DNA p629
A method that allows precise capture of Neanderthal genome sequences
will permit detailed comparison of modern and ancient humans.
Nicole Rusk
doi:10.1038/nmeth0909-629
http://links.ealert.nature.com/ctt?kn=53&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

Tethered together pp630 - 631
Researchers describe a genetic approach to identify the native
components responsible for forming molecular transport junctions
between the mitochondria and the endoplasmic reticulum.
Allison Doerr
doi:10.1038/nmeth0909-630a
http://links.ealert.nature.com/ctt?kn=54&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

Location, location, location pp630 - 631
A strategy for selectively disabling activated neurons helps
researchers to characterize brain circuitry controlling
addiction-related behaviors.
Michael Eisenstein
doi:10.1038/nmeth0909-630b
http://links.ealert.nature.com/ctt?kn=49&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

News in brief p631
doi:10.1038/nmeth0909-631
http://links.ealert.nature.com/ctt?kn=50&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

Reading between the lines p632
A phenotype prediction tool helps 'fill in the blanks' for expression
microarrays, extending their predictive power and uncovering
once-hidden biases.
Michael Eisenstein
doi:10.1038/nmeth0909-632
http://links.ealert.nature.com/ctt?kn=75&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

Stopping intracellular leakage with chemistry p634
Researchers develop a strategy to improve the intracellular retention
of fluorescent probes and thus their imaging sensitivity.
Allison Doerr
doi:10.1038/nmeth0909-634
http://links.ealert.nature.com/ctt?kn=73&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Google 'EarthWorm' pp635 - 636
A three-dimensional digital atlas allows cell-by-cell navigation of
Caenorhabditis elegans.
William A Mohler
doi:10.1038/nmeth0909-635
http://links.ealert.nature.com/ctt?kn=74&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

The 'rare biosphere': a reality check pp636 - 637
Methods for error correction and classification of metagenomic
datasets suggest that the rare biosphere is not as large as
previously assumed.
Jens Reeder and Rob Knight
doi:10.1038/nmeth0909-636
http://links.ealert.nature.com/ctt?kn=71&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

----------------------
BRIEF COMMUNICATIONS
----------------------
Accurate determination of microbial diversity from 454 pyrosequencing
data pp639 - 641
PyroNoise, an algorithm that preclusters the flowgrams generated on a
454 GS FLX with DNA extracted from microbial samples can distinguish
between noise and genuine sequence diversity in a metagenomic
dataset.
Christopher Quince et al.
doi:10.1038/nmeth.1361
Abstract: http://links.ealert.nature.com/ctt?kn=72&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

Modular scanning FCS quantifies receptor-ligand interactions in
living multicellular organisms pp643 - 645
A combination of static-volume, two-focus and dual-color scanning
fluorescence correlation spectroscopy is used for the in vivo
analysis of receptor-ligand interactions in living zebrafish embryos.
The measured binding affinities suggest that Fgf8 binds to both
Fgfr1 and Fgfr4 during gastrulation.
Jonas Ries et al.
doi:10.1038/nmeth.1355
Abstract: http://links.ealert.nature.com/ctt?kn=70&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

Digital transcriptome profiling using selective hexamer priming for
cDNA synthesis pp647 - 649
To deplete abundant rRNA from total RNA during cDNA library
generation, hexamer primers that perfectly match rRNA are removed.
These 'not so randomly primed' cDNA libraries can be generated from
small amount of total RNA, preserve strand orientation and are
equally enriched in polyadenylated and non-polyadenylated
transcripts.
Christopher D Armour et al.
doi:10.1038/nmeth.1360
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=65&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

Crystallographic ab initio protein structure solution below atomic
resolution pp651 - 653
A general approach to address the 'phase problem' in protein
crystallography is described, allowing protein structures to be
directly solved from 2 A resolution diffraction data without using
heavy atom doping or relying on a preexisting structure model
for molecular replacement.
Dayte D Rodriguez et al.
doi:10.1038/nmeth.1365
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=13&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

Isolation of deletion alleles by G4 DNA-induced
mutagenesis pp655 - 657
Deletions of polyguanine tracts in Caenorhabditis elegans deficient
in the DOG-1 DNA helicase can be exploited to generate deletion
alleles of several genes for which no such alleles exist in this
organism.
Daphne B Pontier, Evelien Kruisselbrink, Victor Guryev and Marcel
Tijsterman
doi:10.1038/nmeth.1362
Abstract: http://links.ealert.nature.com/ctt?kn=14&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=16&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

ErythRED, a hESC line enabling identification of erythroid
cells pp659 - 662
A human embryonic stem cell line, ErythrRED, harbors a red
fluorescent protein under the control of regulatory sequences
from the beta-globin locus, as a reporter for erythroid
differentiation.
Tanya Hatzistavrou et al.
doi:10.1038/nmeth.1364
Abstract: http://links.ealert.nature.com/ctt?kn=17&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=18&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

A customized and versatile high-density genotyping array for the
mouse pp663 - 666
This array with 623,124 SNP probes and 916,269 probes to query
structural variants opens the door to a detailed characterization
of genetic diversity in laboratory mouse strains. This will allow
genome-wide association studies in mice.
Hyuna Yang et al.
doi:10.1038/nmeth.1359
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
A 3D digital atlas of C. elegans and its application to single-cell
analyses pp667 - 672
A digital atlas of C. elegans at the post-embryonic L1 stage is
presented, along with automated methods for nucleus segmentation
and annotation. These resources will enable quantitative analyses
of nuclear spatial arrangements as well as high-throughput
single-cell analyses in this organism.
Fuhui Long et al.
doi:10.1038/nmeth.1366
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=9&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

Phymm and PhymmBL: metagenomic phylogenetic classification
with interpolated Markov models pp673 - 676
This algorithm for the assignment of phylogenetic groups to
fragments generated by metagenomic sequencing projects improves
on the currently required 1 kb fragment length for classification.
Trained on 539 complete genomes, Phymm can classify reads as
short as 100 bp. Combining Phymm with the sequence alignment
algorithm BLAST further improves accuracy.
Arthur Brady and Steven L Salzberg
doi:10.1038/nmeth.1358
Abstract: http://links.ealert.nature.com/ctt?kn=39&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

BreakDancer: an algorithm for high-resolution mapping of genomic
structural variation pp677 - 681
This software package provides genome-wide detection of structural
variants (insertions, deletions, inversions and inter- and
intrachromosomal translocations) from 50-base-pair paired-end
reads. The sizes of the detected variants vary from 10 base pairs
to 1 megabase pair.
Ken Chen et al.
doi:10.1038/nmeth.1363
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

----------------------
TECHNOLOGY FEATURE
----------------------
Microfluidics: the great divide pp683 - 686
Although many intricate microfluidic devices have been created in
academic laboratories around the world, far fewer have been
commercialized for wider use. But several efforts are underway
to bridge this divide.
Nathan Blow
doi:10.1038/nmeth0909-683
http://links.ealert.nature.com/ctt?kn=45&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

----------------------
APPLICATION NOTES
----------------------
Analysis of 5' transcript heterogeneity by high-throughput
sequencing of cDNA
Pietro D Spanu and Ken Doyle
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=42&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

Functional isolation of staurosporine binding protein kinases using
CCMS technology
Erik Dulsner, Jenny J Fischer, Christian Jurinke and Hubert Koster
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

HybSelect: high-throughput access to genomic regions of interest
for targeted next-generation sequencing
Daniel Summerer
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=164&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

Highly specific detection of phosphorylated proteins by Duolink
Mats Gullberg and Ann-Catrin Andersson
Abstract: http://links.ealert.nature.com/ctt?kn=147&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=145&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Nature Genetics
Focus on Copy Number Variation

Individual genomes vary, not only in sequence, but in both their structural organization and in the number of sequence copies they contain. We now have the technology to understand the mechanisms by which genomes diverge, and to investigate the consequences of copy number variation for gene expression and clinical phenotypes.

With sponsorship from Agilent Technologies, Nature Genetics presents a Focus on copy number variation highlighting the complementary roles of paired-end sequencing and oligonucleotide array technology in research discovery.

Free access to the articles is available by visiting: http://links.ealert.nature.com/ctt?kn=29&m=33940600&r=MTc2NjExMzUwMAS2&b=2&j=NTczMDM2MzUS1&mt=1&rt=0

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Signaling Update contents for 28 August 2009

*********************************************************************
Signaling Gateway - 28 August 2009
http://links.ealert.nature.com/ctt?kn=38&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0
*********************************************************************

Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=11&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

*********************************************************************
In Signaling Update this week:

------------------------
Featured Article
------------------------
SENESCENCE: DNA DAMAGE RESPONSE TRIGGERS CYTOKINE PRODUCTION

Severe genotoxic stress induces senescence and stimulates the DNA
damage response pathway to induce secretion of inflammatory
cytokines.

Original research paper: Nature Cell Biology 11, 973-979 (2009)

http://links.ealert.nature.com/ctt?kn=23&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

------------------------
Molecule Pages
------------------------
CLEC5A
http://links.ealert.nature.com/ctt?kn=7&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

CLEC5A (C-type lectin 5A) is a type 2 transmembrane protein with an
extracellular C-type lectin-like domain. It associates in the plasma
membrane with the adaptor protein Dap12. Signaling through this
complex stimulates osteoclastogenesis and bone remodeling. CLEC5A is
a receptor for Dengue virus on the surface of macrophages and this
interaction triggers the release of proinflammatory cytokines.

Also published this week:

CLEC-1
http://links.ealert.nature.com/ctt?kn=10&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

Search the molecule pages
http://links.ealert.nature.com/ctt?kn=8&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

-------------------
Selected Updates
-------------------
Cell signalling: Telomerase gets Wnt talking
The telomerase reverse transcriptase (TERT) subunit of telomerase
interacts with the ATP-dependent chromatin remodeling factor BRG1 at
specific sites in Wnt-dependent target genes to regulate
Wnt–beta-catenin-mediated transcription.
Original research paper: Nature 460, 66-72 (2009)
http://links.ealert.nature.com/ctt?kn=2&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

METASTASIS: T-ALL ORDER
The chemokine receptor CCR7 is necessary for infiltration of T-cell
acute lymphoblastic leukemia (T-ALL) cells into the central nervous
system (CNS), suggesting that pharmacological inhibition of CCR7
might help reduce CNS relapse.
Original research paper: Nature 459, 1000-1004 (2009)
http://links.ealert.nature.com/ctt?kn=1&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

EVOLUTION: PROTEIN KINASES MIX IT UP
High-throughput mass spectrometry of the phosphoproteomes of three
yeast species that are separated by 400-600 million years of
evolution - Saccharomyces cerevisiae, Candida albicans and
Schizosaccharomyces pombe - has revealed the rate at which
kinase-substrate interactions change.
Original research paper: PLoS Biol. 7, e1000134 (2009)
http://links.ealert.nature.com/ctt?kn=4&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

More Updates:
http://links.ealert.nature.com/ctt?kn=16&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

------------------------
Research Library
------------------------
http://links.ealert.nature.com/ctt?kn=15&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

LINKING THE p53 TUMOUR SUPPRESSOR PATHWAY TO SOMATIC CELL
REPROGRAMMING
Nature 460, 1140-1144 (2009)
http://links.ealert.nature.com/ctt?kn=18&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

A MOUSE MODEL OF ATR-SECKEL SHOWS EMBRYONIC REPLICATIVE STRESS AND
ACCELERATED AGING
Nature Genetics 41, 891-898 (2009)
http://links.ealert.nature.com/ctt?kn=28&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

AVID INTERACTIONS UNDERLIE THE LYS63-LINKED POLYUBIQUITIN BINDING
SPECIFICITIES OBSERVED FOR UBA DOMAINS
Nature Structural & Molecular Biology 16, 883-889 (2009)
http://links.ealert.nature.com/ctt?kn=32&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

------------------------
Signaling News
------------------------
DNA SWAP COULD AVOID INHERITED DISEASES
http://links.ealert.nature.com/ctt?kn=33&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

Mutations in mitochondrial DNA are linked to a variety of diseases,
including diabetes, mitochondrial myopathies and Leigh syndrome.
In experiments in rhesus macaques, US researchers transferred DNA
from the nucleus of one egg into the empty nucleus of another egg
without carrying over any mitochondrial DNA in the process. This
technique may help mothers avoid passing on mitochondrial DNA
mutations to their offspring.

More news
http://links.ealert.nature.com/ctt?kn=13&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

-------------------------
Gateway Updates
-------------------------
THE FUNCTIONAL GLYCOMICS GATEWAY - AUGUST UPDATE
http://links.ealert.nature.com/ctt?kn=24&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.

This month's update includes "Profiling proteoglycans: RIP them out"
and "Tumor suppression: Glycosyltransferases loom LARGE".

Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://links.ealert.nature.com/ctt?kn=37&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

-----------------------------
Job of the Week
-----------------------------
Postdoctoral Fellow
Employer: Novo Nordisk Center for Protein Research
Location: University of Copenhagen, Denmark
http://links.ealert.nature.com/ctt?kn=30&m=33939947&r=MTc2ODc4NDI0MAS2&b=2&j=NTcyOTY2MzES1&mt=1&rt=0

A postdoctoral position is available at the Novo Nordisk Center for
Protein Research to study the mechanisms regulating the development
of hepatic steatosis. The project involves the use of state of the
art mass spectrometry to analyze protein posttranslational
modifications involved in the development of fatty liver associated
to the metabolic syndrome. Proteomic methodology will be applied to
globally assess posttranslational modifications and a systems biology
approach used to analyze these and other complex data sets.

More Jobs:
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To advertise a job in this spot, please contact Naturejobs.
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Nature Reviews Rheumatology - Table of Contents alert Volume 5 Issue 9

NATURE REVIEWS RHEUMATOLOGY

September 2009 Volume 5 Number 9

Visit Nature Reviews Rheumatology online to browse the journal.

Now available at
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Nature Reviews Rheumatology Impact Factor: 5.677*
(*Journal Citation Reports, Thomson, 2005)
*********************************************************************

=========================== ADVERTISEMENT ===========================

Interested in Wnt signaling? Please take a look at these articles that
have recently appeared within the pages of Nature Reviews Rheumatology:

Osteoimmunology: Wnt antagonists: for better or worse?
Rik J. Lories, Frank P. Luyten

Wnt and PPAR [gamma] signaling in osteoblastogenesis and adipogenesis
Ichiro Takada, Alexander P. Kouzmenko and Shigeaki Kato

Wnt-[beta]-catenin signaling in the pathogenesis of osteoarthritis
Maripat Corr

The role of Wnt proteins in arthritis
Jochen Zwerina, Jean-Pierre David, Georg Schett

[beta]-Catenin in the race to fracture repair: in it to Wnt
David Silkstone, Helen Hong, Benjamin A Alman

http://links.ealert.nature.com/ctt?kn=17&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

=====================================================================

=========================== ADVERTISEMENT ===========================

Rheumatology Study Day/Symposium,
23 September,
Royal College of Physicians of Edinburgh

Programme and registration details at:
http://links.ealert.nature.com/ctt?kn=94&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0
or from: c.gray@rcpe.ac.uk

=====================================================================

"Officially endorsed by the Asia Pacific League of Associations for
Rheumatology"

----------------------
RESEARCH HIGHLIGHTS
----------------------
Rheumatoid arthritis: Hit the road, JAKs!
p465 | doi:10.1038/nrrheum.2009.151
http://links.ealert.nature.com/ctt?kn=24&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Smoking delays CIA onset in mice
p466 | doi:10.1038/nrrheum.2009.125
http://links.ealert.nature.com/ctt?kn=22&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Acute inflammatory arthritis: IL-1 Trap prevents and treats gouty arthritis
in a new mouse model
p466 | doi:10.1038/nrrheum.2009.156
http://links.ealert.nature.com/ctt?kn=20&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Connective tissue diseases: Elucidating the origins of lung fibrosis
p467 | doi:10.1038/nrrheum.2009.153
http://links.ealert.nature.com/ctt?kn=18&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

IN BRIEF
Imaging | Inflammation | Osteoarthritis | Vasculitis syndromes
p467 | doi:10.1038/nrrheum.2009.160
http://links.ealert.nature.com/ctt?kn=83&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Rheumatoid arthritis: An alternative to methotrexate?
p468 | doi:10.1038/nrrheum.2009.152
http://links.ealert.nature.com/ctt?kn=102&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

IN BRIEF
Rheumatoid arthritis | Osteoarthritis | Lyme arthritis | Connective tissue
diseases
p468 | doi:10.1038/nrrheum.2009.161
http://links.ealert.nature.com/ctt?kn=84&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Rheumatoid arthritis: Tenascin C: a candidate for chronic inflammation?
p469 | doi:10.1038/nrrheum.2009.132
http://links.ealert.nature.com/ctt?kn=26&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Rheumatoid arthritis: The immunoproteasome as an anti-inflammatory target?
p469 | doi:10.1038/nrrheum.2009.155
http://links.ealert.nature.com/ctt?kn=32&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Bone: Monitoring BMD after bisphosphonate treatment: is it worth it?
p470 | doi:10.1038/nrrheum.2009.129
http://links.ealert.nature.com/ctt?kn=36&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Metabolic bone diseases: Improving strength and balance helps prevent falls
p470 | doi:10.1038/nrrheum.2009.154
http://links.ealert.nature.com/ctt?kn=38&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Regenerative medicine: Skin and bones (and cartilage): the dermal fibroblast
connection
Rocky S. Tuan
p471 | doi:10.1038/nrrheum.2009.170
New research reports that primary human dermal fibroblasts seeded into
a three-dimensional biodegradable matrix can differentiate in vitro into
osteoblasts and chondrocytes, and form three-dimensional bone-like and
cartilage-like constructs, respectively. Is skeletal tissue engineering
from skin biopsy tissue on the horizon?
http://links.ealert.nature.com/ctt?kn=40&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Pain: Limitations of guidelines for low back pain therapy
Andrea D. Furlan and Vicki Pennick
p473 | doi:10.1038/nrrheum.2009.172
The latest guidelines from the American Pain Society (APS) provide a
comprehensive analysis of the evidence on the use of interdisciplinary
rehabilitation and surgical and interventional procedures for the treatment
and diagnosis of chronic low back pain. But will they have any impact on
clinical practice?
http://links.ealert.nature.com/ctt?kn=4&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Comorbidities: Should cancer screening be routine in rheumatoid arthritis?
Eric L. Matteson
p474 | doi:10.1038/nrrheum.2009.173
The degree to which the elevated risk of malignant lymphomas in patients
with rheumatoid arthritis (RA) is related to disease activity or to
therapy is uncertain. Evidence is mounting in support of a strategy of
more-intensive cancer screening in these patients.
http://links.ealert.nature.com/ctt?kn=41&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Therapy: The as-yet unfulfilled promise of p38 MAPK inhibitors
Susan E. Sweeney
p475 | doi:10.1038/nrrheum.2009.171
Clinical tests of the novel small-molecule inhibitor of p38[alpha] MAPK,
VX-702, have resulted in an all-too-familiar outcome: modest clinical
efficacy and transient inhibition of inflammatory markers. Why have
p38[alpha] inhibitors failed, and what can we learn about the regulation
of signal transduction pathways in inflammatory arthritis?
http://links.ealert.nature.com/ctt?kn=11&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Genetics: Every shared epitope allele for itself?
Diane van der Woude and Tom W. J. Huizinga
p477 | doi:10.1038/nrrheum.2009.174
What is the relationship between genetic and environmental risk factors
in predisposing for rheumatoid arthritis (RA)? A new study provides more
details on the interaction between the HLA DRB1 shared epitope (SE) alleles
and smoking in conferring the risk of autoantibody-positive RA.
http://links.ealert.nature.com/ctt?kn=8&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Therapy: Another bad break for proton-pump inhibitors?
Laura E. Targownik
p478 | doi:10.1038/nrrheum.2009.176
Medications that inhibit gastric acid secretion are standard co-therapy
with NSAIDs, but evidence is emerging of a link between prolonged use of
these agents and an increased risk of hip fracture.
http://links.ealert.nature.com/ctt?kn=15&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Genetics: Mutations in the IL1RN locus lead to autoinflammation
Cem Gabay and Gaby Palmer
p480 | doi:10.1038/nrrheum.2009.177
The results of two new studies suggest mutations in the gene encoding
the interleukin (IL)-1 receptor antagonist (IL-1Ra) are responsible for
a spectrum of childhood inflammatory disorders characterized by an imbalance
in IL-1 expression. What implications do these intriguing results have for
the diagnosis and management of IL1-driven inflammatory disorders?
http://links.ealert.nature.com/ctt?kn=59&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

----------------------
REVIEWS
----------------------
Paget disease: when to treat and when not to treat
Frederick R. Singer
Published online: 04 August 2009
p483 | doi:10.1038/nrrheum.2009.149
Patients with Paget disease are often asymptomatic, but some experience
considerable morbidity in the form of bone pain and skeletal deformity,
as well as a variety of regional complications. Bisphosphonates are an
effective treatment for Paget disease, but questions still need answering
as to when and when not to treat symptomatic and asymptomatic patients
with this potentially painful and deforming disease.
Abstract: http://links.ealert.nature.com/ctt?kn=87&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Prognostic factors in rheumatoid arthritis in the era of biologic agents
Alla Skapenko, Iryna Prots and Hendrik Schulze-Koops
Published online: 28 July 2009
p491 | doi:10.1038/nrrheum.2009.157
In patients with rheumatoid arthritis, the benefits of tight control of
inflammation to prevent or delay joint erosion are clear. Markers predictive
of erosive disease enable physicians to identify those patients who would
benefit most from aggressive therapy, thus avoiding unnecessary risks and
costs associated with this intensive treatment approach. This Review
discusses various prognostic factors as well as issues that confound their
identification and application.
Abstract: http://links.ealert.nature.com/ctt?kn=88&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Fracture prevention in men
Piet Geusens, Philip Sambrook and Willem Lems
Published online: 28 July 2009
p497 | doi:10.1038/nrrheum.2009.148
The risk of experiencing a fracture is lower in men than in women beyond
the age of 50 years, but the burden of fractures is, nevertheless,
substantial in men. This difference in fracture incidence is likely to
be accounted for by differences in bone-related and fall-related factors,
which are outlined, along with other data relating to the epidemiology,
pathophysiology and treatment options for osteoporosis in men, in this Review.
Abstract: http://links.ealert.nature.com/ctt?kn=85&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

Idiopathic sensorineural hearing disorders in adults-a pragmatic approach
David L. George and Sagun Pradhan
Published online: 04 August 2009
p505 | doi:10.1038/nrrheum.2009.150
Sensorineural hearing disorders are more common in patients with rheumatic
disease than in the general population, so it is important that
rheumatologists know how to diagnose and treat these comorbidities. In
this Review, the categories of sensorineural hearing loss are introduced,
and diagnostic and therapeutic approaches for these disorders are outlined.
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=45&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

----------------------
CASE STUDY
----------------------
Resolution of pansclerotic morphea after treatment with antithymocyte globulin
Philip Song, Christopher Gocke, Fredrick M. Wigley and Francesco Boin
p513 | doi:10.1038/nrrheum.2009.159
Song and colleagues describe the diagnosis and treatment of a 50-year old
man with pansclerotic morphea with immune-mediated bone-marrow failure
and cytopenias. Although standard therapies for fibrotic skin disorders
were ineffective, the patient responded to T-cell-targeted treatment with
antithymocyte globulin.
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=51&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

----------------------
PERSPECTIVES
----------------------
OPINION
The evidence for non-pharmacological therapy of hand and hip OA
Kare B. Hagen, Geir Smedslund, Rikke H. Moe, Margreth Grotle, Ingvild Kjeken
and Tore K. Kvien
p517 | doi:10.1038/nrrheum.2009.158
Clinical guidelines and recommendations, as well as clinicians and patients,
consider non-pharmacological modalities to be the mainstay of treatment
for osteoarthritis (OA). Despite this consensus in opinion, however, the
evidence base for the non-pharmacological management of hand and hip OA
continues to lag far behind that for knee OA, which suggests that more
research is required to optimize the management of hand and hip OA.
Abstract: http://links.ealert.nature.com/ctt?kn=79&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=50&m=33939805&r=MTc2NDQ4MTc5OAS2&b=2&j=NTcyOTQzNTUS1&mt=1&rt=0

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US plans for science outreach to Muslim world
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Canada assumes weighty mantle
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Robotics: The bot that plays ball
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Investors likely to venture back as crisis subsides
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Czech bibliometric system fosters mediocre research
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Non-scientists could still contribute to reform of the ERC
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Bridging the gender gap in Indian science
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The many faces of mathematics
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Q&A: Science pop songsters
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Extrasolar planets: Secrets that only tides will tell
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Optics: Ultrafast X-ray photography
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Solid-state physics: An insulator's metallic side
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Gamma-ray bursts: Maybe not so old after all
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An orbital period of 0.94 days for the hot-Jupiter planet WASP-18b
Coel Hellier et al.
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A tunable topological insulator in the spin helical Dirac transport
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Topological surface states protected from backscattering by chiral
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M. A. Noginov et al.
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Computational complexity of interacting electrons and fundamental
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Norbert Schuch & Frank Verstraete
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Catalyst preparation for CMOS-compatible silicon nanowire synthesis
Vincent T. Renard et al.
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Ultralong quantum optical data storage using an optical locking technique
Byoung S. Ham
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Radiative heat transfer at the nanoscale
Emmanuel Rousseau et al.
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Single-shot terahertz-field-driven X-ray streak camera
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Structural colour printing using a magnetically tunable and
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Hyoki Kim et al.
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