Signaling Gateway - 31 July 2009
http://links.ealert.nature.com/ctt?kn=39&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=23&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
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In Signaling Update this week:
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Featured Article
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SMALL-MOLECULE INHIBITORS: ANOTHER ONE BITES THE DUSP
The use of a novel small-molecule inhibitor of Dusp6 reveals the
importance of tightly regulated FGF signaling during cardiac
development.
Original research paper: Nature Chemical Biology advance online
publication, 5 July 2009
http://links.ealert.nature.com/ctt?kn=16&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
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Molecule Pages
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Prion protein
http://links.ealert.nature.com/ctt?kn=24&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
The prion protein (PrPC) binds to several dozen molecules, including
cell surface proteins and glycosaminoglycans, protein kinases and
nucleic acids. PrPC may act as a dynamic cell-surface platform for
the assembly of signaling modules. The transmissible spongiform
encephalopathies (TSEs), or prion diseases, are a group of
neurodegenerative diseases attributed to the conversion of PrPC
into an abnormal, infectious conformer (PrPSc).
Also published this week:
CaBP4
http://links.ealert.nature.com/ctt?kn=4&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
DLK
http://links.ealert.nature.com/ctt?kn=30&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
GLUT4
http://links.ealert.nature.com/ctt?kn=40&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
G protein alpha q
http://links.ealert.nature.com/ctt?kn=7&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
PrKX
http://links.ealert.nature.com/ctt?kn=34&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
Rasgrf1
http://links.ealert.nature.com/ctt?kn=19&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=28&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
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Selected Updates
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T CELL MEMORY: KEEPING ENERGY LEVELS UP
The generation of a long-lived memory CD8+ T-cell population depends
on a switch in energy metabolism from glucose to fatty acid
metabolism, suggesting that metabolism-altering drugs might be useful
for boosting CD8+ T-cell responses.
Original research paper: Nature 460, 103-107 (2009)
http://links.ealert.nature.com/ctt?kn=31&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
EPIGENETICS: MISREADING THE CODE
A chromosomal translocation that fuses the carboxy-terminal PHD
finger of JARID1A to the transactivating domain of nucleoporin 98
(NUP98) can induce acute myeloid leukemia (AML) in mice by
deregulating histone methylation at loci that encode
differentiation-specific transcription factors.
Original research paper: Nature 459, 847-851 (2009)
http://links.ealert.nature.com/ctt?kn=27&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
LEARNING AND MEMORY: HDAC2 IS THE ONE
Histone deacetylase 2 (HDAC2), but not HDAC1, interacts with the
transcriptional corepressor COREST and negatively regulates synapse
formation, spine formation, and learning and memory.
Original research paper: Nature 459, 55-60 (2009)
http://links.ealert.nature.com/ctt?kn=42&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=21&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=36&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
WNT SIGNALING ARRESTS EFFECTOR T CELL DIFFERENTIATION AND GENERATES
CD8+ MEMORY STEM CELLS
Nature Medicine 15, 808-813 (2009)
http://links.ealert.nature.com/ctt?kn=35&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
ACQUIRED MUTATIONS IN TET2 ARE COMMON IN MYELODYSPLASTIC SYNDROMES
Nature Genetics 41, 838-842 (2009)
http://links.ealert.nature.com/ctt?kn=25&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
PATHOGENIC HUNTINGTIN INHIBITS FAST AXONAL TRANSPORT BY ACTIVATING
JNK3 AND PHOSPHORYLATING KINESIN
Nature Neuroscience 12, 864-871 (2009)
http://links.ealert.nature.com/ctt?kn=14&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
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Signaling News
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ITALY INTRODUCES PERFORMANCE-RELATED FUNDING
http://links.ealert.nature.com/ctt?kn=32&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
The Italian government has announced the creation of ANVUR, the
national research evaluation agency, at the same time that it
published a rank of Italy's universities. This ranking, which was
based on an internal research evaluation carried out several years
ago, will be used to allocate up to 7% of the approximately
€7-billion (US$10-billion) national university budget.
More news
http://links.ealert.nature.com/ctt?kn=6&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
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Gateway Updates
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THE OMICS GATEWAY
http://links.ealert.nature.com/ctt?kn=5&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
The Omics Gateway is a comprehensive free online resource that
provides life scientists a convenient portal into publications
relevant to large-scale biology from journals throughout
Nature Publishing Group.
This month, the Omics Gateway provides free access to a paper from
Nature describing the genome of the flatworm Schistosoma japonicum.
http://links.ealert.nature.com/ctt?kn=13&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
Sign up to receive the table of contents e-alert for the
Omics Gateway Update.
http://links.ealert.nature.com/ctt?kn=33&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
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Job of the Week
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Postdoctoral position
Employer: Katholieke Universiteit Leuven
Location: Leuven, Belgium
http://links.ealert.nature.com/ctt?kn=12&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
A postdoctoral position is available in the laboratory of
Prof Mathieu Bollen at KULeuven. The aim of the project is to
generate a constitutively active form of the kinase Melk that can
be used to delineate its function in multipotent neural progenitors,
astrocytes and malignant astrocytoma. The goal of this project is the
development of Melk as a therapeutic anti-cancer target.
More Jobs:
http://links.ealert.nature.com/ctt?kn=2&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=26&m=33764415&r=MTc2ODc4NDI0MAS2&b=2&j=NTQ1NDYxOTMS1&mt=1&rt=0
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