Signaling Gateway - 24 July 2009
http://links.ealert.nature.com/ctt?kn=72&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=5&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
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In Signaling Update this week:
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Featured Article
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FGF SIGNALING: IT'S A WRAP
Fibroblast growth factor signaling regulates the switch from
migration to differentiation in Drosophila glial cells.
Original research paper: Nature advance online publication,
13 July 2009
http://links.ealert.nature.com/ctt?kn=53&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
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Molecule Pages
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Ect2
http://links.ealert.nature.com/ctt?kn=68&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
Epithelial cell transforming 2 oncogene (Ect2) is a guanine
nucleotide exchange factor (GEF) for the Rho family of small GTPases.
It is localized in the nucleus in interphase, but Ect2 derivatives
with transforming activity are also detected in the cytoplasm, where
they can activate Rho GTPases. Ect2 is an important regulator of
cytokinesis, but is also involved in mitosis, G1/S progression, cell
migration, epithelial cell polarity and cell–cell attachment.
Also published this week:
Abca3
http://links.ealert.nature.com/ctt?kn=18&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
Arf-like protein 13B
http://links.ealert.nature.com/ctt?kn=35&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
Gat1
http://links.ealert.nature.com/ctt?kn=61&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
GCAP2
http://links.ealert.nature.com/ctt?kn=11&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
TC10
http://links.ealert.nature.com/ctt?kn=20&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=33&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
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Signaling Resources
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NEW SIGNALING GATEWAY PLUGIN FOR BIOGPS
http://links.ealert.nature.com/ctt?kn=47&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
BioGPS is a gene portal that offers users the ability to customize
gene annotation reports by drawing content from multiple online
databases. The new Signaling Gateway plugin enables users to
visualize data from the Molecule Pages side-by-side with any of the
other 100+ plugins in the BioGPS plugin library.
http://links.ealert.nature.com/ctt?kn=65&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
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Selected Updates
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BREAST CANCER: METASTASIS ON THE BRAIN
Gene expression analysis of breast cancer cells that exhibit
specificity for brain metastasis reveals that aberrant expression
of the alpha-2,6-sialyltransferase ST6GALNAC5 facilitates
transmigration of cancer cells through the blood-brain barrier.
Original research paper: Nature 459, 1005-1009 (2009)
http://links.ealert.nature.com/ctt?kn=27&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
DEVELOPMENT: TERMINAL DIFFERENTIATION
Multiple cues are integrated into the neuronal lineage to initiate
the expression of terminal differentiation genes that specify the
identity of a neuron.
Original research paper: Dev. Cell 16, 563-575 (2009)
http://links.ealert.nature.com/ctt?kn=23&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
INFLAMMATORY DISEASES: TARGETING PROSTANOID RECEPTORS
The prostanoid EP2 and EP4 receptors can regulate immune responses,
suggesting that these G-protein-coupled receptors might be a new
target for the treatment of immuno-inflammatory disorders.
Original research paper: Nature Med. 15, 633-640 (2009)
http://links.ealert.nature.com/ctt?kn=3&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=16&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=43&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
MODULATION OF MICRORNA PROCESSING BY P53
Nature 460, 529-533 (2009)
http://links.ealert.nature.com/ctt?kn=34&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
IMMUNOLOGICAL SYNAPSE FORMATION INHIBITS, VIA NF-[KAPPA]B AND FOXO1,
THE APOPTOSIS OF DENDRITIC CELLS
Nature Immunology 10, 753-760 (2009)
http://links.ealert.nature.com/ctt?kn=31&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
THE STRUCTURE OF SHH IN COMPLEX WITH HHIP REVEALS A RECOGNITION ROLE
FOR THE SHH PSEUDO ACTIVE SITE IN SIGNALING
Nature Structural & Molecular Biology 16, 691-697 (2009)
http://links.ealert.nature.com/ctt?kn=42&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
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Signaling News
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NATURE REVIEWS CANCER ARTICLE SERIES: THERAPEUTIC RESISTANCE
http://links.ealert.nature.com/ctt?kn=51&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
Resistance to therapy - chemotherapy or radiotherapy - is an
increasing problem in the care of patients with cancer. Numerous
culprits have been identified, including environmental adaptations
to therapy, aberrant regulation of drug transporters and signaling
feedback loops that bypass targeted therapies. Beginning in the
July 2009 issue, Nature Reviews Cancer will be publishing a series
of articles that take a look at different aspects of therapeutic
resistance.
More news
http://links.ealert.nature.com/ctt?kn=54&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - JULY UPDATE
http://links.ealert.nature.com/ctt?kn=17&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update includes "Golgi: Sugar pHorming" and
"Carbohydrate length: How to say when".
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://links.ealert.nature.com/ctt?kn=37&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
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Job of the Week
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Post Doctoral Research Associate
Employer: University of Cambridge
Location: Cambridge, UK
http://links.ealert.nature.com/ctt?kn=36&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
A Wellcome Trust-funded position is available in the laboratory of
Prof Dermot Cooper at the University of Cambridge to study cyclic AMP
compartmentation and calcium-sensitive adenylyl cyclases. An
extensive background in molecular biological methods is essential and
modern imaging techniques are also desirable. For enquiries, please
contact DMF Cooper (dmfc2@cam.ac.uk). Further information can be
found at http://links.ealert.nature.com/ctt?kn=30&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0.
More Jobs:
http://links.ealert.nature.com/ctt?kn=15&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=66&m=33706785&r=MTc2ODc4NDI0MAS2&b=2&j=NTM4MDQ1NDYS1&mt=1&rt=0
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