Signaling Gateway - 10 July 2009
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=30&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
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In Signaling Update this week:
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Featured Article
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UBIQUITIN LIGASES: LONG LIVE THE WORM
A specific E2/E3 ubiquitin ligase complex is essential for
dietary-restriction-induced longevity in worms.
Original research paper: Nature advance online publication,
24 June 2009
http://links.ealert.nature.com/ctt?kn=15&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
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Selected Updates
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ANTIVIRAL IMMUNITY: TRIMMING THE RESPONSE
The influenza A virus non-structural protein 1 (NS1) inhibits the
production of type I interferons and antiviral immunity by preventing
TRIM25-mediated ubiquitylation of the intracellular viral sensor
retinoic acid-inducible gene I (RIG-I).
Original research paper: Cell Host Microbe 5, 439-449 (2009)
http://links.ealert.nature.com/ctt?kn=31&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
NEURONAL METABOLISM: A QUESTION OF BALANCE
By actively downregulating glycolysis, neurons shift their metabolic
balance towards pathways responsible for maintaining their
antioxidant status, and thus their survival.
Original research paper: Nature Cell Biol. 11, 747-752 (2009)
http://links.ealert.nature.com/ctt?kn=38&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
ANTI-OBESITY DRUGS: IMPROVING SLEEP MAY PROMOTE WEIGHT LOSS
T-type Ca2+ channels regulate both sleep and weight maintenance,
suggesting that sleep regulation might represent a potential
therapeutic strategy for obesity.
Original research paper: J. Clin. Invest. 119, 1659-1667 (2009)
http://links.ealert.nature.com/ctt?kn=5&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=32&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=19&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
THE ARP2/3 COMPLEX AND WASP ARE REQUIRED FOR APICAL TRAFFICKING OF
DELTA INTO MICROVILLI DURING CELL FATE SPECIFICATION OF SENSORY ORGAN
PRECURSORS
Nature Cell Biology 11, 815-824 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
THE E3 UBIQUITIN LIGASE NRDP1 'PREFERENTIALLY' PROMOTES TLR-MEDIATED
PRODUCTION OF TYPE I INTERFERON
Nature Immunology 10, 744-752 (2009)
http://links.ealert.nature.com/ctt?kn=25&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
LIN28 PROMOTES TRANSFORMATION AND IS ASSOCIATED WITH ADVANCED HUMAN
MALIGNANCIES
Nature Genetics 41, 843-848 (2009)
http://links.ealert.nature.com/ctt?kn=34&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
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Signaling News
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NATURE REVIEWS MICROBIOLOGY POSTER: INHIBITION OF THE REPLICATIVE
CYCLE OF HEPATITIS C VIRUS
http://links.ealert.nature.com/ctt?kn=8&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
An estimated 170 million people globally are infected with the
hepatitis C virus (HCV), which can result in the development of liver
cirrhosis and hepatocellular carcinoma. As a result, there is
considerable interest in identifying specific inhibitors of HCV
replication. This FREE poster summarizes the replicative cycle of HCV
and the principal targets for specific antiviral agents that are
currently being developed.
More news
http://links.ealert.nature.com/ctt?kn=29&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
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Gateway Updates
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THE CELL MIGRATION GATEWAY – JULY UPDATE
http://links.ealert.nature.com/ctt?kn=27&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's update features "Breast cancer metastasis:
A micro-cascade" and "Centrosome orientation: Cell-cell contacts
at PAR".
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
http://links.ealert.nature.com/ctt?kn=14&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
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Job of the Week
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Postdoctoral Research Fellow
Employer: Genentech
Location: South San Francisco, CA, USA
http://links.ealert.nature.com/ctt?kn=12&m=33558416&r=MTc2ODc4NDI0MAS2&b=2&j=NTI4NjgwMTMS1&mt=1&rt=0
A post-doctoral position is available in Andy Chan's lab for an
independent scientist to study lymphocyte signaling and function in
normal immunity and autoimmunity. The laboratory has interests in
a broad number of scientific areas including T and B cell antigen
receptor signaling, lymphocyte development, predisposing factors in
autoimmunity and regulation of immune function through the
cytoskeleton.
More Jobs:
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To advertise a job in this spot, please contact Naturejobs.
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