August 2009 Volume 5 Number 8
Visit Nature Reviews Nephrology online to browse the journal.
Now available at
http://links.ealert.nature.com/ctt?kn=30&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Please note that you need to be a subscriber to enjoy full text access
to Nature Reviews Nephrology online. To purchase a subscription,
please visit:
http://links.ealert.nature.com/ctt?kn=50&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.com/ctt?kn=73&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
*********************************************************************
Nature Reviews Nephrology Impact Factor: 5.594*
(*Journal Citation Reports, Thomson, 2005)
*********************************************************************
=========================== ADVERTISEMENT ===========================
ISN Nexus Symposium: The Kidney and the Vascular System: Emerging
Culprits in Pathogenesis and Advances in Therapy.
http://links.ealert.nature.com/ctt?kn=83&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
April 15-18, 2010; Kyoto (Japan)
=====================================================================
=========================== ADVERTISEMENT ===========================
Metabolic Syndrome web focus - 16 new articles!
http://links.ealert.nature.com/ctt?kn=20&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
The Metabolic Syndrome web focus showcases a collection of original
research articles from our Academic and Nature Reviews titles that
provide further insight into this global disease.
Featured titles include: American Journal of Hypertension, Nature Reviews
Endocrinology, Obesity and many more.
8 distinguished titles, 16 insightful articles, one growing epidemic.
View the Metabolic Syndrome web focus online FREE of charge at
http://links.ealert.nature.com/ctt?kn=20&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
=====================================================================
----------------------
EDITORIAL
----------------------
Addressing the global drink problem
Chloe Harman
p427 | doi:10.1038/nrneph.2009.126
http://links.ealert.nature.com/ctt?kn=10&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
Transplantation: HTK solution: should it replace UW solution for kidney
preservation?
p429 | doi:10.1038/nrneph.2009.81
http://links.ealert.nature.com/ctt?kn=15&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
IN BRIEF
Bone | Diabetes | Dialysis | Chronic kidney disease
p430 | doi:10.1038/nrneph.2009.103
http://links.ealert.nature.com/ctt?kn=48&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Dialysis: Intensifying dialysis to optimize pregnancy outcome
p430 | doi:10.1038/nrneph.2009.106
http://links.ealert.nature.com/ctt?kn=39&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Dialysis: Subcutaneous erythropoietin administration increases the risk
of access failure
p431 | doi:10.1038/nrneph.2009.107
http://links.ealert.nature.com/ctt?kn=74&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Retraction: Japan's experience with living-donor kidney transplantation
across ABO barriers
p431 | doi:10.1038/nrneph.2009.112
http://links.ealert.nature.com/ctt?kn=86&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Connective tissue diseases: Kidney damage is a key predictor of mortality
in SLE
p431 | doi:10.1038/nrrheum.2009.67
http://links.ealert.nature.com/ctt?kn=51&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Hypertension: A test to predict early pre-eclampsia
p432 | doi:10.1038/nrneph.2009.104
http://links.ealert.nature.com/ctt?kn=22&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
IN BRIEF
Proteinuria | Anemia | Transplantation | Tubular disease
p432 | doi:10.1038/nrneph.2009.105
http://links.ealert.nature.com/ctt?kn=92&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Transplantation: Pump it up: conserving a precious resource?
Choli Hartono and Manikkam Suthanthiran
p433 | doi:10.1038/nrneph.2009.110
Determining the optimal method for preserving deceased-donor kidneys
is crucial for improving long-term transplant success. A randomized,
controlled trial has compared two methods-hypothermic machine perfusion
and cold storage preservation.
http://links.ealert.nature.com/ctt?kn=63&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Dialysis: Some patients may benefit from using high-flux membranes
Victor F. Seabra, Jacob J. Clarenbach and Bertrand L. Jaber
p434 | doi:10.1038/nrneph.2009.95
Mortality rates of patients with low levels of serum albumin, a marker
of malnutrition and inflammation, are lower when hemodialysis is
performed with high-flux membranes than with low-flux membranes.
http://links.ealert.nature.com/ctt?kn=94&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Proteinuria: Is the ONTARGET renal substudy actually off target?
Piero Ruggenenti and Giuseppe Remuzzi
p436 | doi:10.1038/nrneph.2009.109
ONTARGET showed that dual renin-angiotensin system blockade prevents
microalbuminuria but facilitates transient renal function impairment
in nonproteinuric patients with atherosclerotic vascular disease or
diabetes. These findings should not be used as an excuse not to optimize
renin-angiotensin system inhibition and target urinary protein in patients
with proteinuric nephropathies.
http://links.ealert.nature.com/ctt?kn=76&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Dialysis: Normovolemia is a therapeutic target for hypertension
Matthias P. Horl and Walter H. Horl
p438 | doi:10.1038/nrneph.2009.93
In patients with hypertension in hemodialysis, dry-weight reduction by
additional ultrafiltration leads to decreases in systolic and diastolic
blood pressure. Ultrafiltration combined with daily dietary salt
restriction should, therefore, be recommended to these patients, even
in the absence of clinical signs of volume overload.
http://links.ealert.nature.com/ctt?kn=45&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
----------------------
REVIEWS
----------------------
The role of transient receptor potential channels in kidney disease
Titia E. Woudenberg-Vrenken, Rene J. M. Bindels and Joost G. J. Hoenderop
Published online: 23 June 2009
p441 | doi:10.1038/nrneph.2009.100
The transient receptor potential (TRP) is a protein superfamily whose
members include 28 proteins known to be expressed in humans. Several
TRPs are also expressed along the human nephron, and Titia
Woudenberg-Vrenken and her colleagues discuss the evidence on the
function of these renal TRPs and the possible relationship between channel
or channel-regulation dysfunction and disease.
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Chemotherapy-associated renal dysfunction
Vaibhav Sahni, Devasmita Choudhury and Ziauddin Ahmed
Published online: 30 June 2009
p450 | doi:10.1038/nrneph.2009.97
The presence of renal dysfunction in a patient receiving chemotherapy
can be devastating. Many patients with cancer have underlying compromised
renal function, and some chemotherapeutic agents actually induce renal
abnormalities. In this Review, Sahni and colleagues highlight the renal
problems associated with current chemotherapeutic agents and describe
preventive strategies that can reduce the risk of renal complications
in patients receiving these agents.
Abstract: http://links.ealert.nature.com/ctt?kn=71&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
New insights into the role of podocytes in proteinuria
Jaakko Patrakka and Karl Tryggvason
Published online: 07 July 2009
p463 | doi:10.1038/nrneph.2009.108
The fact that numerous systemic and renal disorders result in progressive
proteinuria illustrates the importance of the glomerular filtration
barrier. In this concise Review, authors from Stockholm provide an update
on the structure and function of the glomerular filtration barrier and
the pathogenesis of proteinuria, with a particular emphasis on the
involvement of podocytes. The discussion encompasses newly identified
pathogenic players, including TRPC6, phospholipase C [epsi], MYH9 and
the urokinase receptor.
Abstract: http://links.ealert.nature.com/ctt?kn=93&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Controversies in the treatment of idiopathic membranous nephropathy
Meryl Waldman and Howard A. Austin III
Published online: 07 July 2009
p469 | doi:10.1038/nrneph.2009.101
The nephrologist must consider several difficult questions when faced
with a patient who has a new diagnosis of idiopathic membranous
nephropathy (IMN). Here, authors from the National Institutes of Health
corral the latest trial data to provide an update on the 'who', 'when'
and 'how' of IMN treatment. They focus particularly on agents that have
been studied as alternatives to cytotoxic drugs and ciclosporin, including
mycophenolate mofetil, rituximab and adrenocorticotropic hormone.
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
----------------------
CASE STUDY
----------------------
HNF1B-related diabetes triggered by renal transplantation
Julien Zuber, Christine Bellanne-Chantelot, Claire Carette, Guillaume
Canaud, Sandrine Gobrecht, Khaled Gaha, Vincent Mallet, Frank Martinez,
Eric Thervet, Jose Timsit, Christophe Legendre and Daniele Dubois-Laforgue
p480 | doi:10.1038/nrneph.2009.98
Zuber and colleagues from Paris describe a case of diabetes that developed
after renal transplantation in a young, white, nonobese man. Genetic
screening detected a newly described deletion in the gene encoding
hepatocyte nuclear factor 1 homeobox B, HNF1B, indicating that mutations
in HNF1B might account for some 'unexpected' cases of new-onset diabetes
after transplantation. Minimization of tacrolimus exposure and withdrawal
of steroids markedly reduced the patient's insulin requirement.
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
YOUR SCIENCE CAREER: WHAT NEXT?
Explore your options at The Source Event: London 25/09/2009 and Berlin
04/12/09. Throughout the day conference sessions and workshops will
tackle a range of science career issues. Running alongside this is a
FREE career fair where you can meet employers who are actively looking
to recruit scientists.
Register now at:
http://links.ealert.nature.com/ctt?kn=41&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
=====================================================================
You have been sent this Table of Contents Alert because you have opted
in to receive it. You can change or discontinue your e-mail alerts at
any time, by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=36&m=33753820&r=MTc2NDE4ODIzOQS2&b=2&j=NTQzNzU5MTAS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2009 Nature Publishing Group
=====================================================================
