August 2009 Volume 10 Number 8
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This month's FEATURED article:
Breaking the chains: structure and function of the deubiquitinases
David Komander, Michael J. Clague and Sylvie Urbe
p550 | doi:10.1038/nrm2731
http://links.ealert.nature.com/ctt?kn=75&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
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From the editors
p501 | doi:10.1038/nrm2743
http://links.ealert.nature.com/ctt?kn=105&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Chromosome biology: OCT4 learns to count
p502 | doi:10.1038/nrm2736
http://links.ealert.nature.com/ctt?kn=92&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Cell signalling: Time for work?
p503 | doi:10.1038/nrm2734
http://links.ealert.nature.com/ctt?kn=14&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
JOURNAL CLUB
Entering a new era with Ero
p503 | doi:10.1038/nrm2741
http://links.ealert.nature.com/ctt?kn=55&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
mRNA transport: EGL picks up its cargo
p504 | doi:10.1038/nrm2733
http://links.ealert.nature.com/ctt?kn=36&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
TECHNOLOGY WATCH
HITS-CLIP hits target | RNA-protein liaisons
p504 | doi:10.1038/nrm2737
http://links.ealert.nature.com/ctt?kn=44&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Cell signalling: Telomerase gets Wnt talking
p504 | doi:10.1038/nrm2739
http://links.ealert.nature.com/ctt?kn=13&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Post-translational modification: The DUB interaction landscape
p505 | doi:10.1038/nrm2740
http://links.ealert.nature.com/ctt?kn=99&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Cancer biology: WAVEing goodbye to invasion
p506 | doi:10.1038/nrm2732
http://links.ealert.nature.com/ctt?kn=54&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Lipid metabolism: An 'IDOL' regulator of blood cholesterol levels
p506 | doi:10.1038/nrm2735
http://links.ealert.nature.com/ctt?kn=15&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
WEB WATCH
Gene expression atlas
p506 | doi:10.1038/nrm2742
http://links.ealert.nature.com/ctt?kn=9&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
IN BRIEF
Stem cells | Cytoskeleton | Chromatin | Cell polarity
p507 | doi:10.1038/nrm2744
http://links.ealert.nature.com/ctt?kn=49&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
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PROGRESS
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Follow the mRNA: a new model for Bicoid gradient formation
Howard D. Lipshitz
p509 | doi:10.1038/nrm2730
The Bicoid (BCD) morphogen gradient was thought to be formed by
diffusion of the protein away from the anterior pole of the
Drosophila melanogaster embryo. A new study shows that a bcd mRNA
gradient prefigures the protein gradient and proposes a model that
combines active mRNA transport with local BCD translation.
Abstract: http://links.ealert.nature.com/ctt?kn=34&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=90&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
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REVIEWS
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Rab GTPases as coordinators of vesicle traffic
Harald Stenmark
p513 | doi:10.1038/nrm2728
Rab GTPases control intracellular vesicle traffic by acting as
regulatable switches that recruit effector molecules when in their
GTP-bound form. The functional coupling between multiple Rab GTPases
ensures the spatiotemporally coordinated regulation of vesicle traffic.
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=106&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Epigenetic dynamics of stem cells and cell lineage commitment:
digging Waddington's canal
Myriam Hemberger, Wendy Dean and Wolf Reik
p526 | doi:10.1038/nrm2727
The life cycle of an organism is characterized by phases of reprogramming
and differentiation during development from the zygote to the adult organism.
Lineage-determining transcription factors and epigenetic mechanisms form
inseparable strands that regulate pluripotency and early cell lineage decisions.
Abstract: http://links.ealert.nature.com/ctt?kn=79&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Random versus directionally persistent cell migration
Ryan J. Petrie, Andrew D. Doyle and Kenneth M. Yamada
p538 | doi:10.1038/nrm2729
Directional cell migration is achieved by forming and stabilizing
protrusions or lamellipodia at the leading edge of the cell. Many factors
and processes can affect leading edge formation, and they often depend
on local regulation of the Rho family of GTPases.
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=50&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Breaking the chains: structure and function of the deubiquitinases
David Komander, Michael J. Clague and Sylvie Urbe
p550 | doi:10.1038/nrm2731
A large superfamily of deubiquitinases (DUBs) has a key role in both
determining protein stability and terminating ubiquitin-dependent
signal transduction. Structural and biochemical studies have started
to reveal the underlying principles by which DUB substrate specificity
is achieved.
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
An additional role for SUMO in ubiquitin-mediated proteolysis
Marie-Claude Geoffroy and Ronald T. Hay
p564 | doi:10.1038/nrm2707
Protein sumoylation affects many biological processes, but it was not
previously thought to target proteins for degradation. Recent findings
unravel a new role for small ubiquitin-like modifier (SUMO) as a signal
for the recruitment of ubiquitin ligases, which leads to protein
ubiquitylation and degradation.
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=95&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
OPINION
Growth, fluctuation and switching at microtubule plus ends
Jonathon Howard and Anthony A. Hyman
p569 | doi:10.1038/nrm2713
The growth of microtubules is accompanied by large fluctuations in
rates and abrupt transitions between phases of growth and shrinkage.
The authors propose that fluctuations in the length of the GTP-tubulin
cap at the microtubule end could be the main source of variation.
Abstract: http://links.ealert.nature.com/ctt?kn=63&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=2&m=33696105&r=MTc2NzYzNjQ2NgS2&b=2&j=NTM3MzU2ODgS1&mt=1&rt=0
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