August 2009 Volume 9 Number 8
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This month's FEATURED article:
Structure and signalling in the IL-17 receptor family
Sarah L. Gaffen
p556 | doi:10.1038/nri2586
http://links.ealert.nature.com/ctt?kn=9&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
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From the editors
p527 | doi:10.1038/nri2613
http://links.ealert.nature.com/ctt?kn=28&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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T cell diversity: T cell subsets rise again
p528 | doi:10.1038/nri2611
http://links.ealert.nature.com/ctt?kn=25&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Dendritic cells: CD14 can do it alone
p529 | doi:10.1038/nri2603
http://links.ealert.nature.com/ctt?kn=2&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
IN BRIEF
Evolution | Dendritic cells | Cytokines
p529 | doi:10.1038/nri2617
http://links.ealert.nature.com/ctt?kn=63&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Regulatory T cells: Immature development
p530 | doi:10.1038/nri2615
http://links.ealert.nature.com/ctt?kn=18&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
B cell responses: Regulating receptor editing
p530 | doi:10.1038/nri2616
http://links.ealert.nature.com/ctt?kn=42&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Innate immunity: DCs take one for the team
p531 | doi:10.1038/nri2605
http://links.ealert.nature.com/ctt?kn=26&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Innate immunity: Endothelial cells as sentinels
p532 | doi:10.1038/nri2608
http://links.ealert.nature.com/ctt?kn=76&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
IN BRIEF
Dendritic cells | T cell differentiation | Tumour immunology
p532 | doi:10.1038/nri2612
http://links.ealert.nature.com/ctt?kn=57&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Haematopoiesis: Instructing fate
p532 | doi:10.1038/nri2618
http://links.ealert.nature.com/ctt?kn=51&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Autoimmunity: Benefits of blocking the immunoproteasome
p533 | doi:10.1038/nri2610
http://links.ealert.nature.com/ctt?kn=69&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
T cell responses: Quantity and quality control by mTOR
p534 | doi:10.1038/nri2609
http://links.ealert.nature.com/ctt?kn=64&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
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REVIEWS
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A cell biological view of Toll-like receptor function: regulation
through compartmentalization
Gregory M. Barton and Jonathan C. Kagan
p535 | doi:10.1038/nri2587
The activation and signalling pathways engaged by Toll-like receptors
(TLRs) are determined by their localization in the cell. Here, the
authors explain how generic cellular machinery involved in the
compartmentalization of receptors and signalling molecules
contributes to TLR function and regulation.
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Mechanisms and functions for the duration of intercellular contacts
made by lymphocytes
Daniel M. Davis
p543 | doi:10.1038/nri2602
The more time you spend with someone, the bigger the impact that
person has on you. And the same is true for lymphocytes. But what are
the molecular and cellular processes that regulate intercellular
contacts made by lymphocytes and how does the duration of these
contacts modulate their effector functions?
Abstract: http://links.ealert.nature.com/ctt?kn=31&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Structure and signalling in the IL-17 receptor family
Sarah L. Gaffen
p556 | doi:10.1038/nri2586
Recent studies defining the structure of and signalling pathways used
by receptors of the interleukin-17 family have led to interesting
comparisons with the pro-inflammatory signalling pathways that are
more commonly associated with innate immune receptors. Sarah Gaffen
therefore suggests that T helper 17 cells might act as a bridge
between innate and adaptive immunity.
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=94&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Oncogenic stress sensed by the immune system: role of natural killer
cell receptors
David H. Raulet and Nadia Guerra
p568 | doi:10.1038/nri2604
Elimination of early neoplastic cells by innate immune cells is an
important protective measure against cancer. Here, the authors
explain that this tumour surveillance is linked to stress pathways
that are activated during tumorigenesis through the induction of
ligands for natural killer cell receptors, particularly NKG2D.
Abstract: http://links.ealert.nature.com/ctt?kn=34&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=99&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Membrane vesicles as conveyors of immune responses
Clotilde Thery, Matias Ostrowski and Elodie Segura
p581 | doi:10.1038/nri2567
Exosomes can act as messengers, carrying biological
information between cells. Here, the authors describe the numerous
effects that exosomes have on immune cells and discuss how they might
be harnessed to promote or limit immune responses for therapeutic
purposes.
Abstract: http://links.ealert.nature.com/ctt?kn=93&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=19&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
----------------------
PERSPECTIVES
----------------------
INNOVATION
The macrophage marches on its phagosome: dynamic assays of phagosome
function
David G. Russell, Brian C. VanderVen, Sarah Glennie, Henry Mwandumba
and Robert S. Heyderman
p594 | doi:10.1038/nri2591
This Innovation article describes recently developed assays that
measure the changing physiology within maturing phagosomes and
discusses how studies using these techniques have shed light on the
biological functions of phagosomes and phagocytes during innate and
adaptive immune responses.
Abstract: http://links.ealert.nature.com/ctt?kn=66&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=80&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
Erratum: The gut microbiota shapes intestinal immune responses during
health and disease
June L. Round and Sarkis K. Mazmanian
p600 | doi:10.1038/nri2614
http://links.ealert.nature.com/ctt?kn=72&m=33705327&r=MTc2NzU2Mjg3MwS2&b=2&j=NTM3OTUwODcS1&mt=1&rt=0
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