July 23 2009
See also the Niche's coverage of the ISSCR annual meeting in Barcelona:
http://links.ealert.nature.com/ctt?kn=23&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
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OUR TOP STORIES
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Commentary
Stem cell: what's in a name?
Clearer terminology could alleviate confusion
http://links.ealert.nature.com/ctt?kn=29&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
News Feature
The cell that might save sight
Why stem-cell therapy could start with the eyes
http://links.ealert.nature.com/ctt?kn=27&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
Q&A
Wolf Reik: elucidating epigenetics in early mammalian embryos
The Babraham Institute researcher discusses ELF5, needed technological advancements and the next steps for his research
Hemberger, M., Dean, W. & Reik, W. Nature Rev. Mol. Cell Biol. advance online publication, doi:10.1038/nrm2727 (15 July 2009).
http://links.ealert.nature.com/ctt?kn=17&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
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ARTICLES KEYING OFF RECENT PUBLICATIONS
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Inside The Paper: A peek into peer review
Human heart progenitors identified
Single progenitor generates diverse lineages
Bu, L. et al. Nature 460, 113-117 (2009).
http://links.ealert.nature.com/ctt?kn=31&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
See related Nature news story, How to fix a broken heart
http://links.ealert.nature.com/ctt?kn=14&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
A satellite cell surprise
Muscle stem cells have unexpected age-dependent genetic requirements
Lepper, C., Conway, S. J. & Fan, C.-M. Nature advance online publication, doi:10.1038/nature08209 (25 June 2009).
http://links.ealert.nature.com/ctt?kn=18&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
Add microRNA to make smooth muscle
How a pair of microRNAs control differentiation and proliferation in a heart-cell lineage
Cordes, K. R. et al. Nature advance online publication, doi:10.1038/nature08195 (5 July 2009).
http://links.ealert.nature.com/ctt?kn=1&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
Another technique for studying expression in single cells
A reusable cDNA library offers a new approach
Taniguchi, K. et al. Nature Methods advance online publication, doi:10.1038/nmeth.1338 (14 June 2009).
http://links.ealert.nature.com/ctt?kn=13&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
Wnt function expands to mature T lymphocytes
Wnt signaling in mature T cells blocks differentiation and generates stem-like memory T cells
Gattinoni, L. et al. Nature Med. advance online publication, doi:10.1038/nm.1982 (14 June 2009).
http://links.ealert.nature.com/ctt?kn=16&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
Regenerating limb tissue may not dedifferentiate
Defying accepted notions, cells in newly growing salamander legs seem to remember their origin
Kragl, M. et al. Nature 460, 60-65 (2009).
http://links.ealert.nature.com/ctt?kn=30&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
A new role for Oct4
Pluripotency regulator controls X-chromosome inactivation
Donohoe, M. E., Silva S. S., Pinter, S. F., Xu, N. & Lee, J. T. Nature advance online publication, doi:10.1038/nature08098 (17 June 2009).
http://links.ealert.nature.com/ctt?kn=9&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
A tale of two LIFS
Parallel pathways control pluripotency in mouse embryonic stem cells
Niwa, H., Ogawa, K., Shimosato, D. & Adahci, K. Nature 460, 118-122 (2009).
http://links.ealert.nature.com/ctt?kn=7&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
On your (histone) marks...get set...go!
Epigenetic marks for gene activation precede fertilization
Hammoud, S. S. et al. Nature advance online publication, doi:10.1038/nature08162 (14 June 2009).
http://links.ealert.nature.com/ctt?kn=5&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
How retinoic acid makes motor neurons
Surprising protein-DNA interaction may be a general mechanism
Lee, S. et al. Neuron 62, 641-654 (2009).
http://links.ealert.nature.com/ctt?kn=15&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
Fat in bone marrow stalls engraftment
Genetic, pharmacological interventions indicate that adipocytes stall haematopoiesis, engraftment
Naveiras, O. et al. Nature advance online publication, doi:10.1038/nature08099 (10 June 2009).
http://links.ealert.nature.com/ctt?kn=11&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
Secreted anti-Notch ligand encourages neuron formation
EGFL7 reported as first natural, soluble Notch receptor antagonist
Schmidt, M. H. H. et al. Nature Cell Biol. advance online publication, doi:10.1038/ncb1896 (7 June 2009).
http://links.ealert.nature.com/ctt?kn=10&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
Haematopoiesis, no hedgehog needed
A surprising finding has implications for treating blood cancers and for assessing the results of genetic knockdowns
Gao, J. et al. Cell Stem Cell 4, 548-558 (2009).
Hofmann, I. et al. Cell Stem Cell 4, 559-567 (2009).
http://links.ealert.nature.com/ctt?kn=24&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
Gene therapy combined with reprogramming makes disease-free cells
Cells containing mutations for Fanconi anaemia can be repaired and reprogrammed
Reya, A. et al. Nature advance online publication, doi:10.1038/nature08129 (31 May 2009).
http://links.ealert.nature.com/ctt?kn=3&m=33700205&r=MTc2NjM3NTc5MQS2&b=2&j=NTM3NDk5ODIS1&mt=1&rt=0
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