Signaling Gateway - 05 June 2009
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=30&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
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In Signaling Update this week:
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Featured Article
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CANCER: A TUMOR SUPPRESSOR IS DSCRIBED ON CHROMOSOME 21
The protein products of two genes on chromosome 21, Dscr1 and Dyrk1a,
suppress angiogenesis and inhibit tumor growth by antagonizing VEGF
signaling.
Original research paper: Nature advance online publication,
20 May 2009
http://links.ealert.nature.com/ctt?kn=15&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
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Molecule Pages
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Integrin alpha 2
http://links.ealert.nature.com/ctt?kn=25&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
Integrin [alpha]2 is one of the twelve [alpha] integrins that can
form a functional receptor with the integrin [beta]1 subunit.
The [alpha]2[beta]1 heterodimer is a high-affinity receptor for many
collagen subtypes. In addition to collagens, integrin [alpha]2[beta]1
can bind to several other proteins, including laminins, endorepellin
and decorin. Integrin [alpha]2[beta]1 is essential for platelet
function, mammary-gland branching morphogenesis and angiogenesis.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=4&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
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Selected Updates
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INFLAMMATION: TARGETING TNF
Oral delivery can specifically target siRNA-loaded particles to
macrophages, where they silence expression of mitogen-activated
protein kinase kinase kinase kinase 4 (MAP4K4), a serine/threonine
kinase that influences the expression of the pro-inflammatory
cytokine tumor necrosis factor (TNF).
Original research paper: Nature 458, 1180-1184 (2009)
http://links.ealert.nature.com/ctt?kn=34&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
THERAPEUTICS: SELECTIVELY TARGETING TURNOVER
Inhibition of NAE (NEDD8-activating enzyme) interferes with the
ubiquitin–proteasome system (UPS) and induces regression of lung
tumour xenografts.
Original research paper: Nature 458, 732-736 (2009)
http://links.ealert.nature.com/ctt?kn=42&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
TUMOUR SUPPRESSORS: MULTI-TASKING
Three papers show that retinoblastoma (Rb) possesses functions
outside of its traditional role as an inhibitor of cell cycle
progression.
Original research paper: Cancer Cell 15, 184-194 (2009)
http://links.ealert.nature.com/ctt?kn=5&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=37&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=20&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
MUTATIONS OF MULTIPLE GENES CAUSE DEREGULATION OF NF-[kappa]B IN
DIFFUSE LARGE B-CELL LYMPHOMA
Nature 459, 717-721 (2009)
http://links.ealert.nature.com/ctt?kn=38&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
THE KINESIN-14 KLP2 ORGANIZES MICROTUBULES INTO PARALLEL BUNDLES BY
AN ATP-DEPENDENT SORTING MECHANISM
Nature Cell Biology 11, 724-730 (2009)
http://links.ealert.nature.com/ctt?kn=26&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
LOCALIZED DIACYLGLYCEROL DRIVES THE POLARIZATION OF THE
MICROTUBULE-ORGANIZING CENTER IN T CELLS
Nature Immunology 10, 627-635 (2009)
http://links.ealert.nature.com/ctt?kn=35&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
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Signaling News
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MICROSCOPIC MARVELS: MAGNIFYING POWER
http://links.ealert.nature.com/ctt?kn=19&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
New microscopes are revealing sights that have never been seen
before. Nature profiles five machines - including an
ultrahigh-voltage electron microscope, a stimulated emission
depletion (STED) microscope, and a microscope on a chip - that are
changing how biologists view the world.
More news
http://links.ealert.nature.com/ctt?kn=32&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
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Gateway Updates
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THE CELL MIGRATION GATEWAY - JUNE UPDATE
http://links.ealert.nature.com/ctt?kn=29&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's featured articles include
Inflammation-induced metastasis: Moving at a Snail's pace
and Interactions at the front: Arg(uing) with cortactin.
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
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Spotlighted Conference
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TRP Channels: From Sensory Signaling to Human Disease
Date: September 26–27, 2009
Location: Nobel Forum, Karolinska Institutet, Stockholm
http://links.ealert.nature.com/ctt?kn=40&m=33358820&r=MTc2ODc4NDI0MAS2&b=2&j=NTA4ODM1MjgS1&mt=1&rt=0
This two-day conference at the Karolinska Institutet in Stockholm
will provide a forum for scientists who use diverse approaches to
study TRP channels in different model organisms and systems to
present and discuss the latest and most exciting developments in the
field. Speakers include Craig Montell, Bernd Nilius, Barbara Ehrlich,
David Clapham and many others.
More events:
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Job of the Week
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Webmaster, Signaling Gateway
Employer: San Diego Supercomputer Center, UC San Diego
Location: San Diego, California, USA
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The UCSD-Nature Signaling Gateway seeks an application and
web developer. The successful applicant will work with San Diego
Supercomputer Center (SDSC) programmers and Nature Publishing Group
editors to design, develop and maintain the applications that
constitute the Signaling Gateway Molecule Pages. The ideal candidate
will have a strong background in web, Java application and
Unix programming.
More Jobs:
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To advertise a job in this spot, please contact Naturejobs.
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