Signaling Gateway - 19 June 2009
http://links.ealert.nature.com/ctt?kn=35&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=28&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
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In Signaling Update this week:
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Featured Article
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INFECTIOUS DISEASE: MYCOBACTERIA SET UP CAMP IN MACROPHAGES
Phagocytosed Mycobacterium tuberculosis produces a burst of cAMP in
macrophages that subverts the host immune response.
Original research paper: Nature advance online publication,
10 June 2009
http://links.ealert.nature.com/ctt?kn=13&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
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Molecule Pages
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G protein alpha z
http://links.ealert.nature.com/ctt?kn=21&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
G protein alpha z (G[alpha]z) is a Gi-class alpha heterotrimeric
G protein subunit with intrinsic GTPase activity. G[alpha]z is
pertussis toxin-insensitive and regulates adenylyl cyclases.
G[alpha]z alone or through release of G[beta][gamma] can suppress
intracellular levels of cyclic AMP in response to select agonists.
Mice with disrupted G[alpha]z are viable; however, can display
impaired platelet aggregation at physiological concentrations of
epinephrine and altered responses to several neuroactive drugs.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=5&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
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Selected Updates
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T CELL DIFFERENTIATION: THE TH1 TWO STEP
TH1 cell differentiation is mediated by activation of a
T-cell receptor (TCR)-IFNgamma-T-bet signaling loop, followed by
activation of an IL-12-T-bet signaling loop.
Original research paper: Immunity 30, 673-683 (2009)
http://links.ealert.nature.com/ctt?kn=29&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
PROSTATE CANCER: RESISTANCE IS (HOPEFULLY) FUTILE
Three papers describe promising new ways in which the androgen
receptor (AR) might be targeted to overcome resistance to
anti-androgen therapy for prostate cancer.
Original research paper: Proc. Natl Acad. Sci. USA 106,
7233-7238 (2009)
http://links.ealert.nature.com/ctt?kn=36&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
NEURODEGENERATIVE DISEASE: NURR1 PUTS A DAMPENER ON INFLAMMATION
The nuclear receptor NURR1 can suppress potentially neurotoxic
inflammatory gene expression in microglia and astrocytes to protect
dopaminergic neurons from inflammation-induced death.
Original research paper: Cell 137, 47-59 (2009)
http://links.ealert.nature.com/ctt?kn=6&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=30&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=16&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
GENES THAT MEDIATE BREAST CANCER METASTASIS TO THE BRAIN
Nature 459, 1005-1009 (2009)
http://links.ealert.nature.com/ctt?kn=31&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
THE FANC PATHWAY AND BLM COLLABORATE DURING MITOSIS TO PREVENT
MICRO-NUCLEATION AND CHROMOSOME ABNORMALITIES
Nature Cell Biology 11, 761-768 (2009)
http://links.ealert.nature.com/ctt?kn=22&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
PERSISTENT SIGNALING INDUCED BY FTY720-PHOSPHATE IS MEDIATED BY
INTERNALIZED S1P1 RECEPTORS
Nature Chemical Biology 5, 428-434 (2009)
http://links.ealert.nature.com/ctt?kn=32&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
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Signaling News
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WOMEN AT THE TOP
http://links.ealert.nature.com/ctt?kn=27&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
Women faculty members in science, math and engineering are climbing
the academic ladder at top US research universities, according to a
report released on 2 June by the US National Research Council.
The study finds that women do well once they are in the pipeline for
academic opportunities, but that they are still under-represented in
the top ranks.
More news
http://links.ealert.nature.com/ctt?kn=26&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - JUNE UPDATE
http://links.ealert.nature.com/ctt?kn=12&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and
bioinformaticians to explore, visualize and mine signaling events.
This month's update features Glucocorticoid receptor signaling and
ErbB4 signaling events.
Sign up here to receive the monthly update alert for the NCI-Nature
Pathway Interaction Database.
http://links.ealert.nature.com/ctt?kn=20&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
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Job of the Week
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Postdoctoral position
Employer: Fox Chase Cancer Center
Location: Philadelphia, Pennsylvania, USA
http://links.ealert.nature.com/ctt?kn=11&m=33432504&r=MTc2ODc4NDI0MAS2&b=2&j=NTE3MjQwMjES1&mt=1&rt=0
Fox Chase Cancer Center has postdoctoral positions available on
several NIH-funded projects including cancer genetics and signaling,
cancer prevention and control, host defense and molecular medicine.
Fox Chase fosters an environment conducive to strong collaboration
across all disciplines, both scientific and medical.
More Jobs:
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To advertise a job in this spot, please contact Naturejobs.
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