Signaling Gateway - 12 June 2009
http://links.ealert.nature.com/ctt?kn=55&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=47&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
KINASES: AN ACTIVATING INHIBITOR?
ATP-competitive inhibitors induce phosphorylation priming of the
protein kinases Akt and PKC, suggesting that nucleotide binding,
rather than intrinsic catalytic activity, stimulates kinase
activation.
Original research paper: Nature Chemical Biology advance online
publication, 24 May 2009
http://links.ealert.nature.com/ctt?kn=18&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
------------------------
Molecule Pages
------------------------
Prep1
http://links.ealert.nature.com/ctt?kn=57&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
Prep1 (also called pKNOX1) is a homeodomain protein that has great
functional importance in embryonic development. It binds to the
homeoprotein Pbx1 and its other homologs Pbx2-4 to form a DNA-binding
complex. This complex can interact with at least one other protein
to form a trimer that increases the DNA sequence selectivity.
Hypomorphic Prep1 embryos indicate that Prep1 has an important
function in hematopoietic stem cells.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=37&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
-------------------
Selected Updates
-------------------
METASTASIS: ATTACK OF THE MUTANT P53
Mutant p53 and wild-type p63 have opposing roles in transforming
growth factor beta (TGFbeta)-induced metastasis.
Original research paper: Cell 137, 87-98 (2009)
http://links.ealert.nature.com/ctt?kn=53&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
PROTEOMICS: BIOMARKERS ON A NANOSCALE
The nanofluidic proteomic assay (NIA) separates proteins according to
their individual isoelectric points — which change according to
phosphorylation — and hence could be used to assess differences in
signaling behavior and protein expression in tumors.
Original research paper: Nature Med. 15, 566-571 (2009)
http://links.ealert.nature.com/ctt?kn=6&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
SYSTEMS BIOLOGY: A FUNCTIONAL BLUEPRINT OF E. COLI
The integration of proteomics data with genomic-context analysis has
permitted the development of a protein-function prediction tool to
annotate functional orphans in Escherichia coli.
Original research paper: PloS Biol. 7, e100096 (2009)
http://links.ealert.nature.com/ctt?kn=40&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=52&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
------------------------
Research Library
------------------------
http://links.ealert.nature.com/ctt?kn=15&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
POLAR GRADIENTS OF THE DYRK-FAMILY KINASE POM1 COUPLE CELL LENGTH
WITH THE CELL CYCLE
Nature 459, 852-856 (2009)
http://links.ealert.nature.com/ctt?kn=25&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
THE PATCHED DEPENDENCE RECEPTOR TRIGGERS APOPTOSIS THROUGH A
DRAL-CASPASE-9 COMPLEX
Nature Cell Biology 11, 739-746 (2009)
http://links.ealert.nature.com/ctt?kn=24&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
IN VIVO EFFECTS OF A GPR30 ANTAGONIST
Nature Chemical Biology 5, 421-427 (2009)
http://links.ealert.nature.com/ctt?kn=54&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
------------------------
Signaling News
------------------------
NATURE STRUCTURAL AND MOLECULAR BIOLOGY: FOCUS ON PROTEIN FOLDING
http://links.ealert.nature.com/ctt?kn=8&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
A special Focus on Protein Folding in the June issue of Nature
Structural and Molecular Biology explores the folding of polypeptide
sequences to yield proteins with different structures, properties and
functions. This Focus presents reviews on the basic concepts of
protein folding and why molecular chaperones are needed in the cell,
as well as the different methodologies that have been used to study
protein folding.
More news
http://links.ealert.nature.com/ctt?kn=26&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
-------------------------
Gateway Updates
-------------------------
PSI-NATURE STRUCTURAL GENOMICS KNOWLEDGEBASE - JUNE UPDATE
http://links.ealert.nature.com/ctt?kn=16&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
The Structural Genomics Knowledgebase is a free portal to research
data and other resources from the Protein Structure Initiative for
structural biologists to keep informed of the latest developments
in their field. This month's update features articles on tackling
influenza, 10 tips for crystallizing membrane proteins, and Hda and
DNA replication.
Sign up to receive monthly updates from the PSI-Nature Structural
Genomics Knowledgebase.
http://links.ealert.nature.com/ctt?kn=41&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
-----------------------------
Job of the Week
-----------------------------
Postdoctoral position
Employer: Karolinska Institute
Location: Stockholm, Sweden
http://links.ealert.nature.com/ctt?kn=27&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
A postdoctoral position is available at the Karolinksa Institute to
study the functional roles and signaling mechanisms of neuronal
growth factors during neural development and the response to injury.
The successful candidate will have experience in the areas of growth
factor signaling or developmental neuroscience.
More Jobs:
http://links.ealert.nature.com/ctt?kn=14&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=49&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://links.ealert.nature.com/ctt?kn=7&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://links.ealert.nature.com/ctt?kn=38&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
For further technical assistance or any other enquiries, please click here:
http://links.ealert.nature.com/ctt?kn=33&m=33403872&r=MTc2ODc4NDI0MAS2&b=2&j=NTEzMjEyMDgS1&mt=1&rt=0
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2009 Nature Publishing Group
---------------------------------------------------------------------
