July 2009 Volume 7 Number 7
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Nature Reviews Microbiology
Poster on inhibition of the replicative cycle of hepatitis C virus
It is estimated that 170 million people are infected with the
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This month's FEATURED article:
Common strategies for antigenic variation by bacterial, fungal and
protozoan pathogens
Kirk W. Deitsch, Sheila A. Lukehart and James R. Stringer
p493 | doi:10.1038/nrmicro2145
http://links.ealert.nature.com/ctt?kn=58&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
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In this issue
p477 | doi:10.1038/nrmicro2179
http://links.ealert.nature.com/ctt?kn=15&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Editorial: Safety from farm to fork
p478 | doi:10.1038/nrmicro2181
Abstract: http://links.ealert.nature.com/ctt?kn=73&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=50&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Bacterial pathogenesis: Taking iron from the fire
p479 | doi:10.1038/nrmicro2172
http://links.ealert.nature.com/ctt?kn=28&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Parasitology: PADding up for differentiation
p480 | doi:10.1038/nrmicro2168
http://links.ealert.nature.com/ctt?kn=39&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Antiviral immunity: TRIMming the response
p480 | doi:10.1038/nrmicro2170
http://links.ealert.nature.com/ctt?kn=44&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Phage biology: Uncorking the phage capsid
p480 | doi:10.1038/nrmicro2180
http://links.ealert.nature.com/ctt?kn=19&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
IN BRIEF
Environmental microbiology | Microbial ecology | Fungal genomics
p481 | doi:10.1038/nrmicro2177
http://links.ealert.nature.com/ctt?kn=32&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Bacterial pathogenesis: Disruptive influence
p482 | doi:10.1038/nrmicro2173
http://links.ealert.nature.com/ctt?kn=85&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Bacterial physiology: Release the vesicles
p482 | doi:10.1038/nrmicro2178
http://links.ealert.nature.com/ctt?kn=4&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
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NEWS AND ANALYSIS
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GENOME WATCH
Milk and two oligosaccharides
Alan Walker
p483 | doi:10.1038/nrmicro2169
http://links.ealert.nature.com/ctt?kn=61&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
DISEASE WATCH
In the News
p484 | doi:10.1038/nrmicro2175
http://links.ealert.nature.com/ctt?kn=13&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
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PROGRESS
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Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis
K. Heran Darwin
p485 | doi:10.1038/nrmicro2148
Tagging eukaryotic proteins with ubiquitin can target them for proteasomal
degradation. However, despite the presence of proteasomes in several
bacterial and all archaeal species, prokaryotic homologues of ubiquitin
were presumed to be absent. In this Progress article, Heran Darwin
describes the characterization of a prokaryotic ubiquitin-like protein
(Pup) that is covalently attached to proteins, resulting in their
proteasome-mediated degradation.
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=92&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
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REVIEWS
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Common strategies for antigenic variation by bacterial, fungal and
protozoan pathogens
Kirk W. Deitsch, Sheila A. Lukehart and James R. Stringer
p493 | doi:10.1038/nrmicro2145
To evade immune responses in mammalian hosts, many pathogens use complex
genetic systems to vary the surface antigens that are recognized by host
defences. In this Review, Kirk Deitsch and colleagues highlight how bacterial,
protozoan and fungal pathogens from distinct evolutionary lineages have
evolved surprisingly similar mechanisms for antigenic variation.
Abstract: http://links.ealert.nature.com/ctt?kn=58&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Epigenetic regulation in African trypanosomes: a new kid on the block
Luisa M. Figueiredo, George A. M. Cross and Christian J. Janzen
p504 | doi:10.1038/nrmicro2149
The identification of post-translational histone modifications and
chromatin-modifying enzymes in eukaryotic parasites has widened the field
of research into epigenetic regulation. Figueiredo, Cross and Janzen
compare the role of epigenetics in Trypanosoma brucei and humans and
discuss how studies in such parasites might yield useful information about
the evolution of epigenetic processes.
Abstract: http://links.ealert.nature.com/ctt?kn=84&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=36&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
The versatility and adaptation of bacteria from the genus Stenotrophomonas
Robert P. Ryan, Sebastien Monchy, Massimiliano Cardinale, Safiyh Taghavi,
Lisa Crossman, Matthew B. Avison, Gabriele Berg, Daniel van der Lelie and
J. Maxwell Dow
p514 | doi:10.1038/nrmicro2163
Bacteria from the genus Stenotrophomonas are found in a wide range of
different environments. Here, Ryan et al. compare the recently sequenced
genomes of two different Stenotrophomonas species to highlight the possible
genetic basis of adaptation to these different niches.
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=96&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Clostridium difficile infection: new developments in epidemiology and
pathogenesis
Maja Rupnik, Mark H. Wilcox and Dale N. Gerding
p526 | doi:10.1038/nrmicro2164
Since 2001, the prevalence and severity of Clostridium difficile infection
have increased substantially, and C. difficile is now considered to be one
of the most important causes of health care-associated infections. Here,
Rupnik, Wilcox and Gerding discuss the recent epidemiological changes in
C. difficile infection and our current knowledge of C. difficile virulence
factors.
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=88&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
Myths and misconceptions: the origin and evolution of Mycobacterium
tuberculosis
Noel H. Smith, R. Glyn Hewinson, Kristin Kremer, Roland Brosch and
Stephen V. Gordon
p537 | doi:10.1038/nrmicro2165
The evolution and molecular characteristics of the Mycobacterium tuberculosis
complex are hotly debated. Here, Noel Smith and colleagues address several
misconceptions about the origins of tuberculosis that have arisen over
the years.
Abstract: http://links.ealert.nature.com/ctt?kn=90&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=33421331&r=MTc2NzM1ODUwNgS2&b=2&j=NTE1MjIwMTMS1&mt=1&rt=0
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