June 2009 Volume 6 Number 6
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=========================== ADVERTISEMENT ===========================
UCSD Clinical and Translational Research Institute and Nature Medicine
present:
Frontiers of Clinical Investigation Symposium
Metabolism 2009: From Bench to Bedside
October 8-10, 2009
La Jolla, California, USA
The theme for this year's symposium explores innovative approaches to
bridge laboratory investigation to clinical research in metabolism.
Early Bird Deadline: September 8, 2009
Abstract Submission Deadline: August 21, 2009
For more information visit:
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EDITORIAL
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Keep your cool: burn calories
Stephen B. Hanauer
p315 | doi:10.1038/nrgastro.2009.88
http://links.ealert.nature.com/ctt?kn=30&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Ulcerative colitis: Appendicitis, but not appendectomy, reduces risk of
ulcerative colitis
p317 | doi:10.1038/nrgastro.2009.78
http://links.ealert.nature.com/ctt?kn=40&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
IBD: Diagnosis by proteasome pattern
p318 | doi:10.1038/nrgastro.2009.74
http://links.ealert.nature.com/ctt?kn=7&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
Esophageal cancer: Hot tea raises risk of cancer
p318 | doi:10.1038/nrgastro.2009.79
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Prediction of recurrent C. difficile infection
p319 | doi:10.1038/nrgastro.2009.73
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Liver: Dietary links to NAFLD in nonobese patients
p320 | doi:10.1038/nrgastro.2009.75
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Gastrointestinal stromal tumor: Adjuvant imatinib mesylate therapy
improves recurrence-free survival
p320 | doi:10.1038/nrgastro.2009.80
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NEWS AND VIEWS
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Pancreas: Alcoholic pancreatitis-it's the alcohol, stupid
Minoti V. Apte, Romano C. Pirola and Jeremy S. Wilson
p321 | doi:10.1038/nrgastro.2009.84
The management of alcoholic pancreatitis is mostly reactive; little is
done to prevent disease progression. It is time for physicians to pay
attention to the root cause of the condition-that is, alcohol-rather than
just responding to its effects. This article discusses an important paper
that describes the first prospective, randomized, controlled, clinical
trial to investigate the effect of brief interventions for alcohol abuse
on the progression of alcoholic pancreatitis.
http://links.ealert.nature.com/ctt?kn=47&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
Rectal cancer: The evolution of laparoscopy-what's next?
Heidi Nelson
p322 | doi:10.1038/nrgastro.2009.82
Despite advances in laparoscopic surgery for colorectal cancer, the role
of laparoscopic approaches for rectal cancer remains controversial. A
large, single-center study has now demonstrated the safety and feasibility
of laparoscopy for rectal cancer, which provides new incentives for
prospective clinical trials to rigorously test this surgical approach.
http://links.ealert.nature.com/ctt?kn=20&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
Motility: Prucalopride for chronic constipation
Gabrio Bassotti and Vincenzo Villanacci
p324 | doi:10.1038/nrgastro.2009.81
Many patients with chronic constipation have a poor quality of life and
are dissatisfied with laxative treatment. Findings from a multicenter,
randomized, placebo-controlled, phase III study have demonstrated the
beneficial effects of the 5-hydroxytryptamine 4 receptor agonist,
prucalopride, for chronic constipation and associated symptoms. This
drug represents the newest addition to the medical armamentarium for
this disorder.
http://links.ealert.nature.com/ctt?kn=62&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
Hepatitis C: New therapeutic strategies needed for advanced disease
Wolf P. Hofmann and Stefan Zeuzem
p325 | doi:10.1038/nrgastro.2009.63
Approximately 50% of patients with chronic hepatitis C fail to achieve
a sustained virological response to standard therapy with pegylated
interferon and ribavirin. Progression to advanced liver disease (which
may lead to hepatic decompensation, hepatocellular carcinoma, and death)
is common in these patients, but can low-dose pegylated interferon
maintenance therapy improve outcomes?
http://links.ealert.nature.com/ctt?kn=39&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
Surgery: Neoadjuvant chemoradiation and sphincter preservation
Vincenzo Valentini and Francesco Cellini
p327 | doi:10.1038/nrgastro.2009.83
The benefit of preoperative combined chemotherapy and radiotherapy to
perform sphincter-preserving surgery for patients with locally advanced
distal rectal cancer is not supported by findings from randomized,
controlled trials. These findings have, however, now been questioned
by a study that supports the prospect of a tailored surgical approach
to rectal-cancer treatment on the basis of tumor behavior after
neoadjuvant treatment.
http://links.ealert.nature.com/ctt?kn=37&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
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REVIEWS
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Management of gastric polyps: a pathology-based guide for gastroenterologists
Susanne W. Carmack, Robert M. Genta, David Y. Graham and Gregory Y. Lauwers
Published online: 07 May 2009
p331 | doi:10.1038/nrgastro.2009.70
Appropriate clinical and pathological evaluation is crucial for the
diagnosis and management of gastric polyps and polypoid lesions. This
Review discusses the endoscopic characteristics, histopathology,
pathogenesis and management of polyps and common polypoid lesions in
the stomach, and provides a practical guide for gastroenterologists.
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
Actions and therapeutic pathways of ghrelin for gastrointestinal disorders
Michael Camilleri, Athanasios Papathanasopoulos and Suwebatu T. Odunsi
Published online: 12 May 2009
p343 | doi:10.1038/nrgastro.2009.72
Ghrelin is an orexigenic hormone that acts to increase food intake and
fat deposition, and at high doses, can modulate gastric motility. This
Review addresses the actions of ghrelin in gastrointestinal systems.
Studies that have investigated the role of ghrelin receptor agonists
and antagonists for the treatment of gastrointestinal motility disorders
and obesity are also discussed.
Abstract: http://links.ealert.nature.com/ctt?kn=66&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
Capsule endoscopy: progress update and challenges ahead
Andrea Moglia, Arianna Menciassi, Paolo Dario and Alfred Cuschieri
Published online: 12 May 2009
p353 | doi:10.1038/nrgastro.2009.69
Advances in complementary metal oxide semiconductor technology have
enabled the development of capsule endoscopy, a diagnostic technique that
involves ingestion of a pill-sized camera that collects and relays still
images of the tissues lining the gastrointestinal tract. Moglia and
colleagues review the literature on the use of different capsule endoscopy
devices for the inspection of the small bowel, esophagus and colon, and
discuss the potential future applications and developments of this technology.
Abstract: http://links.ealert.nature.com/ctt?kn=5&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
A guide for the diagnosis and management of gastrointestinal stromal cell tumors
Paul S. Sepe and William R. Brugge
Published online: 14 April 2009
p363 | doi:10.1038/nrgastro.2009.43
Gastrointestinal stromal cell tumors (GISTs) always have a degree of
malignant potential, and, increasingly, they are diagnosed only on
routine endoscopy. Sepe and Brugge provide a gastroenterologist's guide
for GIST diagnosis and assessment of malignant potential. The authors of
this Review also propose an algorithm for the treatment of localized
GISTs that is especially useful for the management of incidentally
diagnosed tumors.
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=9&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
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CASE STUDY
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Treatment of chronic hepatitis C in a slow responder: a case for extended
therapy
Paul J. Gaglio
p372 | doi:10.1038/nrgastro.2009.65
This article considers the case of a 49-year-old man who presented with
fatigue and poor concentration. He was diagnosed with HCV genotype 1
infection and started on a 48-week course of pegylated interferon
[alpha]2b plus ribavirin. Despite initial reductions in his serum
HCV-RNA levels, HCV-RNA remained detectable at week 12; however, it was
undetectable by week 24. The patient was classified as a slow responder
and therapy was extended to 72 weeks.
Abstract: http://links.ealert.nature.com/ctt?kn=60&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=49&m=33351455&r=MTc2OTYyOTQ2MwS2&b=2&j=NTA4MTA0MDMS1&mt=1&rt=0
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