July 2009 Volume 10 Number 7, pp 667 - 793
Visit Nature Immunology online to browse the journal.
Now available at http://links.ealert.nature.com/ctt?kn=104&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Please note that you need to be a subscriber to enjoy full text
access to Nature Immunology online. To purchase a subscription,
please visit:
http://links.ealert.nature.com/ctt?kn=103&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.com/ctt?kn=45&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Introducing the special order BD LSRFortessa(TM) Cell Analyzer
Choose from 5 lasers, 30 detector positions, and 11 wavelengths to
detect up to 18 colors simultaneously. Measuring just 36" x 30",
it delivers all the power of the world's most flexible cell analyzer
in a benchtop footprint. For more information, click here or contact
your BD Biosciences representative today.
http://links.ealert.nature.com/ctt?kn=91&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
=====================================================================
=========================== ADVERTISEMENT ===========================
7-minute
western transfer
Yes, it's possible!
To learn how, visit:
http://links.ealert.nature.com/ctt?kn=52&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
=====================================================================
=========================== ADVERTISEMENT ===========================
Nature Reviews Microbiology
Poster on inhibition of the replicative cycle of hepatitis C virus
It is estimated that 170 million people are infected with the hepatitis C virus (HCV). Because current drugs against HCV have poor safety profiles and limited effectiveness, there is considerable interest in identifying specific inhibitors of HCV replication.
This poster summarizes the replicative cycle of HCV and the principal targets for specific antiviral agents that are currently being developed.
To download the poster, visit http://links.ealert.nature.com/ctt?kn=2&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0.
This poster is freely available thanks to support from Boehringer Ingelheim.
http://links.ealert.nature.com/ctt?kn=24&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
=====================================================================
----------------------
EDITORIAL
----------------------
Biotech bailout? p667
A rescue of some sort will be needed to save a large subset of the
US biotechnology industry.
doi:10.1038/ni0709-667
http://links.ealert.nature.com/ctt?kn=110&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
----------------------
MEETING REPORT
----------------------
NKT cells turn ten pp669 - 671
It has been 10 years since the first workshop on natural killer T
cells helped to launch a growth phase for this field of research.
Peter D Burrows, Mitchell Kronenberg and Masaru Taniguchi
doi:10.1038/ni0709-669
http://links.ealert.nature.com/ctt?kn=111&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
----------------------
COMMENTARY
----------------------
NIAID workshop on immunity to malaria: addressing immunological
challenges pp673 - 678
The US National Institute of Allergy and Infectious Diseases convened
a workshop of malaria investigators and immunologists to foster
collaborations and attract more immunologists into malaria research.
Discussions highlighted research gaps and underscored the incomplete
understanding of basic immune mechanisms that contribute to the
pathogenesis of or protection against malaria.
Alison Deckhut Augustine et al.
doi:10.1038/ni0709-673
http://links.ealert.nature.com/ctt?kn=26&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Basophils trump dendritic cells as APCs for TH2 responses
pp679 - 681
Dendritic cells are best known as antigen-presenting cells that
initiate adaptive immune responses. Three new papers suggest that
basophils initiate allergen- and helminth-driven CD4+ T helper type
2 responses by functioning as antigen-presenting cells in draining
lymph nodes.
Thomas A Wynn
doi:10.1038/ni0709-679
http://links.ealert.nature.com/ctt?kn=92&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
CSF-1R, DAP12 and beta-catenin: a menage a trois
pp681 - 683
DAP12-coupled receptors influence signals emanating from Toll-like
receptors, integrins and receptors for cytokines and growth factors.
New findings indicate that DAP12 also facilitates the ability of
CSF-1R, the receptor for M-CSF, to induce the stabilization and
nuclear translocation of beta-catenin.
Daniel W McVicar and Giorgio Trinchieri
doi:10.1038/ni0709-681
http://links.ealert.nature.com/ctt?kn=57&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
ASMase: the tailor of cytotoxic T cell granule exocytosis
pp683 - 685
Deficiency in acid sphingomyelinase causes lysosomal storage of
sphingomyelin, mediates resistance to stress-induced apoptosis and
alters susceptibility to certain infections. New work links acid
sphingomyelinase to the granule exocytosis of cytotoxic T cells.
Christian Bogdan
doi:10.1038/ni0709-683
http://links.ealert.nature.com/ctt?kn=117&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
A novel modifier of regulatory T cells pp685 - 686
The receptor for the lipid mediator sphingosine 1-phosphate is
critical for T cell trafficking. New data show that signaling
mediated by this receptor critically controls the development,
maintenance and suppressive activity of natural regulatory T
cells that express the transcription factor Foxp3.
Naganari Ohkura and Shimon Sakaguchi
doi:10.1038/ni0709-685
http://links.ealert.nature.com/ctt?kn=42&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
Research Highlights p687
doi:10.1038/ni0709-687
http://links.ealert.nature.com/ctt?kn=13&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
----------------------
REVIEW
----------------------
Foxp3+ regulatory T cells: differentiation, specification,
subphenotypes pp689 - 695
Markus Feuerer, Jonathan A Hill, Diane Mathis and Christophe Benoist
doi:10.1038/ni.1760
Abstract: http://links.ealert.nature.com/ctt?kn=109&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=113&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
----------------------
ARTICLES
----------------------
MHC class II-dependent basophil-CD4+ T cell interactions promote TH2
cytokine-dependent immunity pp697 - 705
Basophils act as effector cells in immunoglobulin E-mediated
hypersensitivity responses. Artis, Nakanishi and Medzhitov and
their colleagues report that basophils present antigen and induce
T helper type 2 responses to helminths, allergens and immunoglobulin
E immune complexes.
Jacqueline G Perrigoue et al.
doi:10.1038/ni.1740
Abstract: http://links.ealert.nature.com/ctt?kn=10&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=41&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Basophils contribute to TH2-IgE responses in vivo via IL-4 production
and presentation of peptide-MHC class II complexes to CD4+ T cells
pp706 - 712
Basophils act as effector cells in immunoglobulin E-mediated
hypersensitivity responses. Artis, Nakanishi and Medzhitov and
their colleagues report that basophils present antigen and induce
T helper type 2 responses to helminths, allergens and immunoglobulin
E immune complexes.
Tomohiro Yoshimoto et al.
doi:10.1038/ni.1737
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Basophils function as antigen-presenting cells for an
allergen-induced T helper type 2 response pp713 - 720
Basophils act as effector cells in immunoglobulin E-mediated
hypersensitivity responses. Artis, Nakanishi and Medzhitov and
their colleagues report that basophils present antigen and induce
T helper type 2 responses to helminths, allergens and immunoglobulin
E immune complexes.
Caroline L Sokol et al.
doi:10.1038/ni.1738
Abstract: http://links.ealert.nature.com/ctt?kn=90&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=51&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Structural and functional implications of the alternative complement
pathway C3 convertase stabilized by a staphylococcal inhibitor
pp721 - 727
Complement forms an ancient innate immune defense. Gros and
colleagues provide new insight into the interactions between
complement convertase C3b and its regulator factor H and with
the staphylococcal inhibitor SCIN.
Suzan H M Rooijakkers et al.
doi:10.1038/ni.1756
Abstract: http://links.ealert.nature.com/ctt?kn=99&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Structure of complement fragment C3b-factor H and implications for
host protection by complement regulators pp728 - 733
Complement forms an ancient innate immune defense. Gros and
colleagues provide new insight into the interactions between
complement convertase C3b and its regulator factor H and with
the staphylococcal inhibitor SCIN.
Jin Wu et al.
doi:10.1038/ni.1755
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Macrophage colony-stimulating factor induces the proliferation and
survival of macrophages via a pathway involving DAP12 and
beta-catenin pp734 - 743
Macrophage colony-stimulating factor (M-CSF) induces the
proliferation of mononuclear phagocytes, and DAP12 is needed
for their function. Colonna and colleagues show that DAP12 is
also needed for M-CSF-induced stabilization of beta-catenin.
Karel Otero et al.
doi:10.1038/ni.1744
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=30&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated
production of type I interferon pp744 - 752
E3 ubiquitin ligases are critical for innate and adaptive immunity.
Cao and colleagues show that the E3 ubiquitin ligase Nrdp inhibits
the production of proinflammatory cytokines while promoting the
release of interferon-beta in Toll-like receptor-triggered macrophages.
Chen Wang et al.
doi:10.1038/ni.1742
Abstract: http://links.ealert.nature.com/ctt?kn=82&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=55&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Immunological synapse formation inhibits, via NF-kappa B and FOXO1,
the apoptosis of dendritic cells pp753 - 760
Immunological synapses (IS) involving surface receptors form between
dendritic cells (DC) and T cells. Rodriguez-Fernandez and colleagues
show that IS-induced signals activate Akt and NF-kappa B and suppress
Foxo1 to promote DC survival.
Lorena Riol-Blanco et al.
doi:10.1038/ni.1750
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=18&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Acid sphingomyelinase is a key regulator of cytotoxic granule
secretion by primary T lymphocytes pp761 - 768
Granules containing perforin and granzymes are secreted from
cytotoxic T lymphocytes. Kronke and co-workers find that acid
sphingomyelase is needed for granule shrinkage just before
exocytosis in this process.
Jasmin Herz et al.
doi:10.1038/ni.1757
Abstract: http://links.ealert.nature.com/ctt?kn=76&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=98&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
The receptor S1P1 overrides regulatory T cell-mediated immune
suppression through Akt-mTOR pp769 - 777
Regulatory T cells (Treg cells) are necessary for maintaining
peripheral tolerance. Chi and colleagues show that the receptor
S1P1 negatively regulates thymic Treg cell production and blocks
Treg cell activity via an Akt-mTor pathway.
Guangwei Liu et al.
doi:10.1038/ni.1743
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=79&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Interleukin 17 acts in synergy with B cell-activating factor to
influence B cell biology and the pathophysiology of systemic lupus
erythematosus pp778 - 785
How interleukin 17 influences B cell biology is unclear.
Bonnefoy-Berard and colleagues find that interleukin 17 alone or
in combination with B cell-activating factor controls the survival,
proliferation of human B cells and their differentiation into
immunoglobulin-secreting cells.
Agnes Doreau et al.
doi:10.1038/ni.1741
Abstract: http://links.ealert.nature.com/ctt?kn=38&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=62&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Immune complex relay by subcapsular sinus macrophages and noncognate
B cells drives antibody affinity maturation pp786 - 793
Immune complexes are captured from lymph by subcapsular macrophages.
Cyster and colleagues show that an intricate relay shuttles antigen
into germinal centers to drive affinity maturation.
Tri Giang Phan et al.
doi:10.1038/ni.1745
Abstract: http://links.ealert.nature.com/ctt?kn=33&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=101&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
=====================================================================
You have been sent this Table of Contents Alert because you have
opted in to receive it. You can change or discontinue your e-mail
alerts at any time, by modifying your preferences on your nature.com
account at:
http://links.ealert.nature.com/ctt?kn=16&m=33429492&r=MTc2NTA4MDAwNgS2&b=2&j=NTE2Njc1MTAS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration
department:
registration@nature.com
For print subscription enquiries, please contact our subscription
department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2009 Nature Publishing Group
=====================================================================
