18 June 2009 Volume 459 Number 7249, pp 889 - 1026
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EDITORIALS
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Animal farm: pig in the middle p889
The 2009 flu pandemic highlights the urgent need for an
independent international body for research into human
diseases that originate in animals.
doi:10.1038/459889a
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Coherent advocacy please pp889-890
Reactions to UK government changes are an example of how
researchers should not behave in a downturn.
doi:10.1038/459889b
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Degrees of knowledge p890
Technology is founded on precision measurements, and
scientists strive to make these ever more exact.
doi:10.1038/459890a
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RESEARCH HIGHLIGHTS
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Cell biology: A grey's anatomy p892
doi:10.1038/459892a
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Agriculture: No hectare spare p892
doi:10.1038/459892b
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Human evolution: Not so clean sweep p892
doi:10.1038/459892c
http://links.ealert.nature.com/ctt?kn=118&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Physiology: Pain's new path p892
doi:10.1038/459892d
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Plant genetics: Asexual Arabidopsis p892
doi:10.1038/459892e
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Immunology: Trouble for termites pp892-893
doi:10.1038/459892f
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Quantum mechanics: Do the wave-particle p893
doi:10.1038/459893a
http://links.ealert.nature.com/ctt?kn=76&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Chemistry: Don't be square p893
doi:10.1038/459893b
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Plant biology: Seeding expression p893
doi:10.1038/459893c
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Gene regulation: Just-in-time activation p893
doi:10.1038/459893d
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JOURNAL CLUB
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Journal club p893
Wolf-Dietrich Hardt
doi:10.1038/459893e
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NEWS
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Climate talks snarled up pp894-895
Two-pronged negotiations fail to bridge divide between nations.
Jeff Tollefson
doi:10.1038/459894a
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Patchy pig monitoring may hide flu threat pp894-895
Experts call for increased surveillance of animals.
Declan Butler
doi:10.1038/459894b
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Research parks feel the economic pinch pp896-897
Once lauded as incubators of high-tech jobs, science parks
find themselves struggling in the new financial environment.
Heidi Ledford
doi:10.1038/459896a
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Astronomers lose access to military data pp896-897
Satellite information on incoming meteors is blocked.
Geoff Brumfiel
doi:10.1038/459897a
http://links.ealert.nature.com/ctt?kn=125&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Venezuelan scientists speak out p898
University cuts are the latest in a series of government actions
that have researchers seeing red.
Anna Petherick
doi:10.1038/459898a
http://links.ealert.nature.com/ctt?kn=136&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Early man becomes early ape p899
Author withdraws claim that ancient jawbone is human ancestor.
Rex Dalton
doi:10.1038/459899a
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Italy outsources peer review to NIH p900
Some question whether grants should be decided in-country.
Richard Van Noorden
doi:10.1038/459900a
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Editor to quit over hoax open-access paper p901
doi:10.1038/459901a
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FDA gains the power to regulate tobacco products p901
doi:10.1038/459901b
http://links.ealert.nature.com/ctt?kn=74&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Japan's lunar orbiter ends mission with crash landing p901
doi:10.1038/459901c
http://links.ealert.nature.com/ctt?kn=102&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Artefact raiders charged after undercover operation p901
doi:10.1038/459901d
http://links.ealert.nature.com/ctt?kn=66&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
US revives FutureGen 'clean' coal plant p901
doi:10.1038/459901e
http://links.ealert.nature.com/ctt?kn=126&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Infrared scan reveals colourful past of the Parthenon p901
doi:10.1038/459901f
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Corrections p901
doi:10.1038/459901g
http://links.ealert.nature.com/ctt?kn=161&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
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NEWS FEATURES
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Metrology: The new and improved kelvin pp902-904
Metrologists are on a path to redefine the unit of temperature.
The freezing point of water will never be the same again,
finds Nicola Jones.
doi:10.1038/459902a
http://links.ealert.nature.com/ctt?kn=95&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Forestry: Planting the forest of the future pp906-908
While conservation biologists debate whether to move organisms
threatened by the warming climate, one forester in British
Columbia is already doing it. Emma Marris reports.
doi:10.1038/459906a
http://links.ealert.nature.com/ctt?kn=134&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
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CORRESPONDENCE
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OPINION
Global warming: why the 2[deg]C goal is a political delusion p909
David G. Victor
doi:10.1038/459909a
http://links.ealert.nature.com/ctt?kn=317&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Ancient ivory figurine deserves a more thoughtful label p909
Anna McDonnell
doi:10.1038/459909b
http://links.ealert.nature.com/ctt?kn=283&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
San Andreas array failure is only a temporary setback p909
Mark D. Zoback, William Ellsworth and Stephen Hickman
doi:10.1038/459909c
http://links.ealert.nature.com/ctt?kn=196&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
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ESSAY
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OPINION
The mystery ape of Pleistocene Asia pp910-911
Fossil finds of early humans in southeast Asia may actually be the
remains of an unknown ape. Russell Ciochon says that many
palaeoanthropologists -- including himself -- have been mistaken.
Russell L. Ciochon
doi:10.1038/459910a
http://links.ealert.nature.com/ctt?kn=274&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
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BOOKS AND ARTS
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OPINION
A fresh take on food pp912-913
A slew of publications examines our changing attitudes to the things
we eat, so what lies behind our need for mutant maize or locally
grown organic food, asks Jascha Hoffman?
Jascha Hoffman reviews An Edible History of Humanity by Tom Standage
doi:10.1038/459912a
http://links.ealert.nature.com/ctt?kn=260&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Q&A: Education from the ground up p913
When Alice Waters founded Chez Panisse restaurant in 1971, she used
fresh ingredients from local suppliers and sparked a culinary
revolution in Berkeley, California, that has spread worldwide. For
the past decade she has been taking that revolution into education.
Waters talks about teaching science in the garden, and the true
cost of a school lunch.
Jascha Hoffman reviews Edible Schoolyard: A Universal
Idea by Alice Waters
doi:10.1038/459913a
http://links.ealert.nature.com/ctt?kn=307&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Seeds of an edible city architecture pp914-915
Global warming and food shortages are renewing interest in urban
agriculture, finds John Whitfield.
John Whitfield reviews London Yields: Urban Agriculture by
doi:10.1038/459914a
http://links.ealert.nature.com/ctt?kn=194&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Sustainable fashion p915
Josie Glausiusz reviews Design for a Living World by
doi:10.1038/459915a
http://links.ealert.nature.com/ctt?kn=115&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
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NEWS AND VIEWS
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Organometallic chemistry: Charting the course of catalysis pp917-918
With palladium catalysts, chemists can manipulate ordinarily inert
carbon-hydrogen bonds to build useful molecules from simple building
blocks. How the catalysts guide this process has just become a bit
clearer.
Gregory L. Hamilton and F. Dean Toste
doi:10.1038/459917a
http://links.ealert.nature.com/ctt?kn=58&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Malaria: The gatekeeper revealed pp918-919
A molecular machine used by the malaria parasite to export its
protein armoury into the host cell has at last been identified,
providing researchers with a potentially invaluable therapeutic
target.
Sarah B. Reiff and Boris Striepen
doi:10.1038/459918a
http://links.ealert.nature.com/ctt?kn=19&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Biomechanics: Serpentine steps pp919-920
Combine theoretical modelling, friction measurements and observations
of serpentine slithering. Together, they show that snakes are in
effect just taking a walk even when moving at high speed.
Andrew J. Clark and Adam P. Summers
doi:10.1038/459919a
http://links.ealert.nature.com/ctt?kn=73&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Planetary science: Io's escape pp920-921
According to the latest study, our witnessing of the volcanic
splendour of Jupiter's moon Io might just be a lucky circumstance.
The odds are that the satellite will become quiescent on its
escape from orbital custody.
Gerald Schubert
doi:10.1038/459920a
http://links.ealert.nature.com/ctt?kn=20&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Inflammation: Wound healing in zebrafish pp921-923
What is the first signal that directs the rapid influx of immune
cells to a wound to stave off potential infection? A study in
the zebrafish reveals an unusual but well-qualified candidate.
Paul Martin and Yi Feng
doi:10.1038/459921a
http://links.ealert.nature.com/ctt?kn=114&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Condensed-matter physics: Coupled vibrations pp923-924
Demonstrating that macroscopic objects can display quantum
behaviour, which is usually associated with the microscopic
world of atoms, is a long-standing goal in physics. That
goal is now within closer reach.
Pertti J. Hakonen and Mika A. Sillanpaa
doi:10.1038/459923a
http://links.ealert.nature.com/ctt?kn=217&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Cell biology: Beyond the prion principle pp924-925
It seems that many misfolded proteins can act like
prions -- spreading disease by imparting their misshapen
structure to normal cellular counterparts. But how common
are bona fide prions really?
Adriano Aguzzi
doi:10.1038/459924a
http://links.ealert.nature.com/ctt?kn=240&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Correction p925
doi:10.1038/459925a
http://links.ealert.nature.com/ctt?kn=139&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
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FEATURE
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Unlocking the secrets of the genome pp927-930
Despite the successes of genomics, little is known about how genetic
information produces complex organisms. A look at the crucial
functional elements of fly and worm genomes could change that.
Susan E. Celniker et al.
doi:10.1038/459927a
http://links.ealert.nature.com/ctt?kn=150&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
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REVIEW
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Emergence and pandemic potential of swine-origin H1N1 influenza virus p931
Gabriele Neumann, Takeshi Noda and Yoshihiro Kawaoka
doi:10.1038/nature08157
http://links.ealert.nature.com/ctt?kn=231&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
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ARTICLES
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A Jurassic ceratosaur from China helps clarify avian digital
homologies pp940-944
The bird hand is thought to derive from the second, third and fourth
digits of an ancestral five-digit hand. However, the three-fingered
hand of theropod dinosaurs, which are the closest extinct relatives
of birds, are thought to derive from the first, second and third
digits. The discovery of a small, primitive herbivorous theropod from
the Jurassic period of China with a stub of the first digit alongside
more developed second, third and fourth digits, sheds light on this
problem.
Xing Xu et al.
doi:10.1038/nature08124
Abstract: http://links.ealert.nature.com/ctt?kn=159&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=168&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
A newly discovered protein export machine in malaria parasites
pp945-949
Malaria parasites reside in vacuoles during intracellular infection
of erythrocytes and export many proteins into the host cell, a
process that is essential for the virulence and viability of
Plasmodium. Whereas transport across the parasite membrane is known
to rely on the secretory pathway, the transporter responsible for
the translocation of proteins across the vacuole membrane is now
identified.
Tania F. de Koning-Ward et al.
doi:10.1038/nature08104
Abstract: http://links.ealert.nature.com/ctt?kn=288&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=266&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
The Listeria transcriptional landscape from saprophytism to virulence
pp950-956
Listeria monocytogenes is responsible for severe food-borne infections.
The first global comparative transcriptome analysis of this species
reveals successive and coordinated global transcriptional changes
during infection and points to previously unknown regulatory
mechanisms in bacteria.
Alejandro Toledo-Arana et al.
doi:10.1038/nature08080
Abstract: http://links.ealert.nature.com/ctt?kn=185&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=263&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
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LETTERS
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Strong tidal dissipation in Io and Jupiter from astrometric
observations p957
The geological activity on Io, volcanically the most active body
in the Solar System, is thought to be the result of tides raised
by Jupiter, but it is not known whether the current tidal heat
production is sufficiently high to generate the observed surface
heat flow. Here, a determination of the tidal dissipation in Io
and Jupiter is reported; for Io, this is in good agreement with
the observed surface heat flow, whereas for Jupiter, dissipation
is found to be close to the upper bound of its average value
expected from the long-term evolution of the system.
Valery Lainey, Jean-Eudes Arlot, Ozgur Karatekin & Tim Van Hoolst
doi:10.1038/nature08108
Abstract: http://links.ealert.nature.com/ctt?kn=189&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=309&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Nanomechanical measurements of a superconducting qubit pp960-964
Fabricating tiny mechanical structures where the vibrational motion
is purely quantum mechanical is a long-standing goal in physics,
and a parallel goal is the development of a scheme for observing
and controlling such tiny motions. By coupling a tiny mechanical
resonator to a superconducting two-level quantum system (qubit),
the state of the superconducting qubit can be measured through its
influence on the vibrations of the resonator, a demonstration of
nanomechanical read-out of quantum interference.
M. D. LaHaye et al.
doi:10.1038/nature08093
Abstract: http://links.ealert.nature.com/ctt?kn=195&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=276&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Peierls distortion as a route to high thermoelectric performance in
In4Se3-[delta] crystals pp965-968
Thermoelectric materials, which can convert heat into electricity,
are of great interest for energy sustainability. The problem is the
low efficiency of these materials, quantified by a coefficient, ZT,
which for mid-temperature materials is usually around 1. The
realization of a material, In4Se3-[delta], which achieves the ZT
value of 1.48 at 705 K, could open up a new avenue in the research
to generate high ZT materials.
Jong-Soo Rhyee et al.
doi:10.1038/nature08088
Abstract: http://links.ealert.nature.com/ctt?kn=176&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=156&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Increased seasonality through the Eocene to Oligocene transition in
northern high latitudes pp969-973
About 33.5 million years ago, at the Eocene-Oligocene transition,
the Earth's climate switched from greenhouse to icehouse conditions.
The analysis of terrestrial spore and pollen evidence deposited in
ocean sediments in the Norwegian-Greenland Sea now reveals that
cold-month mean temperatures declined by about 5 [deg]C prior to
the Eocene-Oligocene transition and that seasonality increased.
James S. Eldrett, David R. Greenwood, Ian C. Harding and Matthew Huber
doi:10.1038/nature08069
Abstract: http://links.ealert.nature.com/ctt?kn=151&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=243&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Creep cavitation can establish a dynamic granular fluid pump in
ductile shear zones pp974-977
Fluid migration in the middle crust is difficult to explain--the
environment is considered too hot for a dynamic fracture-sustained
permeability, as in the upper crust, and fluid pathways are
generally too deformed to be controlled by equilibrium wetting
angles that apply to hotter, deeper environments. Here, synchroton
X-ray tomography and scanning electron microscopy observations are
used to formulate a model for fluid migration in shear zones which
may explain fluid transfer through the middle crust.
F. Fusseis et al.
doi:10.1038/nature08051
Abstract: http://links.ealert.nature.com/ctt?kn=212&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=48&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Colorado Plateau magmatism and uplift by warming of heterogeneous
lithosphere pp978-982
There has been a long-standing debate about the forces that drove
uplift of the low-relief and tectonically-stable Colorado plateau,
which experienced about 2 km of rock uplift without significant
internal deformation. Warming of the thicker, more iron-depleted
Colorado plateau lithosphere over 35-40 million years--following
removal of the Farallon plate from beneath North America--is now
proposed to be the primary mechanism for driving rock uplift.
Mousumi Roy, Thomas H. Jordan and Joel Pederson
doi:10.1038/nature08052
Abstract: http://links.ealert.nature.com/ctt?kn=215&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Adaptation and the evolution of parasite virulence in a connected
world pp983-986
The evolution of lowered virulence in spatially structured
populations with limited dispersal has been suggested to be an
example of adaptation at the group level. The extension of previous
models now shows that the effect of dispersal can be understood
within the framework of inclusive fitness theory, demonstrating
that reduced virulence could be due to individual-level adaptation
by the parasite.
Geoff Wild, Andy Gardner and Stuart A. West
doi:10.1038/nature08071
Abstract: http://links.ealert.nature.com/ctt?kn=241&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=262&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Copy number variation at 1q21.1 associated with neuroblastoma
pp987-991
Copy number variations (CNVs) and single nucleotide polymorphisms
(SNPs) are two important potential sources of phenotypic variation
in humans; however, only SNPs have been associated with cancer.
Here, a CNV at 1q21.1 is shown to be associated with neuroblastoma,
and a transcript within this CNV, NBPF23, is implicated in early
tumorigenesis of the disease.
Sharon J. Diskin et al.
doi:10.1038/nature08035
Abstract: http://links.ealert.nature.com/ctt?kn=174&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=105&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Identification of the pollen self-incompatibility determinant in
Papaver rhoeas pp992-995
Self-incompatibility is an important mechanism used in many species
to prevent inbreeding by ensuring rejection of 'self' pollen. The
cloning of three alleles of a highly polymorphic pollen-expressed
gene, PrpS (Papaver rhoeas pollen S), now provides evidence that it
encodes the pollen S locus determinant and adds to our knowledge of
the evolution of cell-cell recognition systems.
Michael J. Wheeler et al.
doi:10.1038/nature08027
Abstract: http://links.ealert.nature.com/ctt?kn=135&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=183&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
A tissue-scale gradient of hydrogen peroxide mediates rapid wound
detection in zebrafish pp996-999
In animals, within minutes of wounding, leukocytes are recruited to
the site of injury across distances of hundreds of micrometres. Early
leukocyte recruitment after injury is now shown to be driven by the
establishment of an H2O2 gradient from the epithelium to the
vasculature in zebrafish.
Philipp Niethammer, Clemens Grabher, A. Thomas Look and
Timothy J. Mitchison
doi:10.1038/nature08119
Abstract: http://links.ealert.nature.com/ctt?kn=137&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=106&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
CCR7 signalling as an essential regulator of CNS infiltration in
T-cell leukaemia pp1000-1004
T-cell acute lymphoblastic leukaemia (T-ALL) patients are at an
increased risk of central nervous system (CNS) relapse, and yet,
despite its clinical importance, little is known about the mechanism
of leukaemic cell infiltration of the CNS. Here, using T-ALL animal
modelling and gene-expression profiling, the chemokine receptor CCR7
is shown to be the essential adhesion signal required for the
targeting of leukaemic T cells into the CNS.
Silvia Buonamici et al.
doi:10.1038/nature08020
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Genes that mediate breast cancer metastasis to the brain pp1005-1009
Little is known about the mechanisms by which breast cancer cells
metastasize to the brain. By performing gene expression analysis
on cells that preferentially infiltrate the brain it has now been
possible to identify three genes that are involved in this process,
two of which--COX2 and HBEGF--have previously been shown to mediate
breast cancer metastasis to the lung.
Paula D. Bos et al.
doi:10.1038/nature08021
Abstract: http://links.ealert.nature.com/ctt?kn=284&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
The RNA-binding protein KSRP promotes the biogenesis of a subset of
microRNAs pp1010-1014
MicroRNAs (miRNAs) have a role in down-regulating gene expression,
and the levels of specific miRNAs are important for correct embryonic
development; however, the mechanisms by which this is regulated are
unknown. The splicing regulatory protein, KSRP, is now found to
regulate the precursor processing of a subset of miRNAs, and its
disruption leads to effects on proliferation, differentiation and
apoptosis.
Michele Trabucchi et al.
doi:10.1038/nature08025
Abstract: http://links.ealert.nature.com/ctt?kn=291&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=242&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Structure and mechanism of a bacterial light-regulated cyclic
nucleotide phosphodiesterase pp1015-1018
Although structures of single-domain BLUF proteins--a photoreceptor
protein domain that senses blue light--have been determined, there
have been no reports of the structure of a BLUF protein containing
a functional output domain; for this reason, the mechanism of light
activation has remained enigmatic. The first biochemical, structural
and mechanistic characterization of a full-length, active
photoreceptor containing a BLUF sensor domain and a
phosphodiesterase EAL output domain is now reported.
Thomas R. M. Barends et al.
doi:10.1038/nature07966
Abstract: http://links.ealert.nature.com/ctt?kn=252&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=206&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
News
Women at the top p1021
US academies track women's success along the academic pipeline.
Hannah Hoag
doi:10.1038/nj7249-1021a
http://links.ealert.nature.com/ctt?kn=270&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Postdoc journal
Befriending rejection p1021
Being rebuffed can be a source of strength.
Sam Walcott
doi:10.1038/nj7249-1021b
http://links.ealert.nature.com/ctt?kn=92&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
In Brief
Biosafety training p1021
University-based biosafety training programme expands.
doi:10.1038/nj7249-1021c
http://links.ealert.nature.com/ctt?kn=213&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
In Brief
Science for physicians p1021
Pre-med and medical-school curricula need defined science
competencies.
doi:10.1038/nj7249-1021d
http://links.ealert.nature.com/ctt?kn=310&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
In Brief
Venezuela science boost p1021
Venezuelan government announces grant to research universities.
doi:10.1038/nj7249-1021e
http://links.ealert.nature.com/ctt?kn=227&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Careers and Recruitment
Texas-sized challenge p1022
Houston's Texas Medical Center is a biomedical behemoth. But it's
not immune to the souring economy, as Gene Russo finds out.
Gene Russo
doi:10.1038/nj7249-1022a
http://links.ealert.nature.com/ctt?kn=211&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
----------------------
FUTURES
----------------------
Totipotent p1026
Caught in a trap.
Catherine Krahe
doi:10.1038/4591026a
http://links.ealert.nature.com/ctt?kn=171&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
17 June 2009
The pluripotency factor Oct4 interacts with Ctcf and also controls
X-chromosome pairing and counting
Mary E. Donohoe et al.
doi:10.1038/nature08098
Abstract: http://links.ealert.nature.com/ctt?kn=191&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=191&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Unlimited multistability in multisite phosphorylation systems
Matthew Thomson and Jeremy Gunawardena
doi:10.1038/nature08102
Abstract: http://links.ealert.nature.com/ctt?kn=269&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=269&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Adaptive prediction of environmental changes by microorganisms
Amir Mitchell et al.
doi:10.1038/nature08112
Abstract: http://links.ealert.nature.com/ctt?kn=226&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=226&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
Sung Wook Chi, Julie B. Zang, Aldo Mele and Robert B. Darnell
doi:10.1038/nature08170
Abstract: http://links.ealert.nature.com/ctt?kn=289&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=289&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Macrophage elastase kills bacteria within murine macrophages
A. McGarry Houghton et al.
doi:10.1038/nature08181
Abstract: http://links.ealert.nature.com/ctt?kn=97&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=97&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
14 June 2009
Emergence and pandemic potential of swine-origin H1N1 influenza virus
Gabriele Neumann, Takeshi Noda and Yoshihiro Kawaoka
doi:10.1038/nature08157
Abstract: http://links.ealert.nature.com/ctt?kn=256&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
CD14 regulates the dendritic cell life cycle after LPS exposure through
NFAT activation
Ivan Zanoni et al.
doi:10.1038/nature08118
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=62&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
CCR3 is a target for age-related macular degeneration diagnosis and
therapy
Atsunobu Takeda et al.
doi:10.1038/nature08151
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=49&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Distinctive chromatin in human sperm packages genes for embryo
development
Saher Sue Hammoud et al.
doi:10.1038/nature08162
Abstract: http://links.ealert.nature.com/ctt?kn=39&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=33425712&r=MjA1NTkxMDA2MAS2&b=2&j=NTE2MDQ0NTYS1&mt=1&rt=0
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