June 2009 Volume 16 Number 6, pp 707 - 826
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Special Issue on Gene Therapy for Chronic Pain
Guest Editors: Joseph Glorioso and David Fink
Volume 16 Number 4
Chronic pain is a significant medical problem. Recent studies suggest
that employing gene transfer to release neuroactive peptides at target
ed sites in the pain pathway may be an effective means to reduce pain,
while avoiding off-target side effects that limit pharmacologic treat
ment. This issue surveys results from preclinical animal studies using
several different vector technologies, and describes the first clinic
al trial of gene transfer for the treatment of pain using an HSV-based
vector that began enrolling patients in December 2008.
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NEWS AND COMMENTARY
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Gene therapy for cardiomyocytes, a heart beat away
S W J McPhee and R J Samulski
http://links.ealert.nature.com/ctt?kn=69&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
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REVIEW
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Progress and prospects: Biological properties and technological advances
of herpes simplex virus type 1-based amplicon vectors
A L Epstein
Abstract: http://links.ealert.nature.com/ctt?kn=67&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
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ORIGINAL ARTICLES
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Repeated, but not single, VEGF gene transfer affords protection against
ischemic muscle lesions in rabbits with hindlimb ischemia
F D Olea, G Vera Janavel, L Cuniberti, G Yannarelli, P Cabeza Meckert,
J Cors, L Valdivieso, G Lev, O Mendiz, A Bercovich, M Criscuolo, C Melo,
R Laguens and A Crottogini
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
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Indoleamine 2,3-dioxygenase attenuates inhibitor development in gene-
therapy-treated hemophilia A mice
L Liu, H Liu, C Mah and B S Fletcher
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
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Discrepancies between the fate of myoblast xenograft in mouse leg muscle
and NMR label persistency after loading with Gd-DTPA or SPIOs
C Baligand, K Vauchez, M Fiszman, J-T Vilquin and P G Carlier
Abstract: http://links.ealert.nature.com/ctt?kn=24&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
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Widespread biochemical correction of murine mucopolysaccharidosis type VII
pathology by liver hydrodynamic plasmid delivery
M Richard, A Arfi, J Seguin, C Gandolphe and D Scherman
Abstract: http://links.ealert.nature.com/ctt?kn=35&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
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Apolipoprotein A-I and lecithin:cholesterol acyltransferase transfer induce
cholesterol unloading in complex atherosclerotic lesions
E Van Craeyveld, J Lievens, F Jacobs, Y Feng, J Snoeys and B De Geest
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
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Purification of recombinant baculoviruses for gene therapy using membrane
processes
T Vicente, C Peixoto, M J T Carrondo and P M Alves
Abstract: http://links.ealert.nature.com/ctt?kn=42&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
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Noncarrier naked antigen-specific DNA vaccine generates potent antigen-
specific immunologic responses and antitumor effects
C-A Chen, M-C Chang, W-Z Sun, Y-L Chen, Y-C Chiang, C-Y Hsieh, S M Chen,
P-N Hsiao and W-F Cheng
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
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High-titer lentiviral vectors stimulate fetal calf serum-specific human
CD4 T-cell responses: implications in human gene therapy
L Bao, H Guo, X Huang, S Tammana, M Wong, R S McIvor and X Zhou
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
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Genetically engineered Newcastle disease virus for malignant melanoma
therapy
D Zamarin, A Vigil, K Kelly, A Garcia-Sastre and Y Fong
Abstract: http://links.ealert.nature.com/ctt?kn=72&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
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Development of inducible EIAV-based lentiviral vector packaging and
producer cell lines
H J Stewart, M A Leroux-Carlucci, C J M Sion, K A Mitrophanous and P A
Radcliffe
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=20&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
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SHORT COMMUNICATIONS
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Real-time monitoring of cell transplantation in mouse dystrophic muscles
by a secreted alkaline phosphatase reporter gene
X Gerard, L Vignaud, S Charles, C Pinset, D Scherman, A Kichler and
D Israeli
Abstract: http://links.ealert.nature.com/ctt?kn=10&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
In vivo assessment of mutations in OTC for dominant-negative effects
following rAAV2/8-mediated gene delivery to the mouse liver
S L Ginn, S C Cunningham, M Zheng, A Spinoulas, K H Carpenter and I E
Alexander
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
Validation of oligonucleotide-mediated gene editing
P Disterer, J P Simons and J S Owen
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=49&m=33400111&r=MTc2MTA1MzIyNwS2&b=2&j=NTEyNjE1NzAS1&mt=1&rt=0
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Nature Reviews Goes Clinical!
In April 2009, Nature Clinical Practice Rheumatology
was completely redesigned and became Nature Reviews
Rheumatology, bringing all the qualities of the
top-ranked* life science review series to the
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*2007 Journal Citation Report (Thomson Reuters, 2008)
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