Signaling Gateway - 8 May 2009
http://links.ealert.nature.com/ctt?kn=38&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=41&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
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In Signaling Update this week:
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Featured Article
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PROSTATE CANCER: A NEW COOPERATIVE LINK EMERGES
Misregulated expression of the transcription factor ERG cooperates
with loss of the PI(3)K pathway inhibitor PTEN to promote prostate
tumorigenesis.
Original research paper: Nature Genetics 41, 524-526 (2009)
http://links.ealert.nature.com/ctt?kn=14&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
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Molecule Pages
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GUANYLATE CYCLASE 2E
http://links.ealert.nature.com/ctt?kn=20&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
The retina-specific, membrane-bound guanylate cyclase 1 catalyzes the
synthesis of the intracellular messenger cyclic GMP in rod and cone
photoreceptor cells. The catalytic transformation of GTP to cyclic
GMP requires a dimeric state of the enzyme. A Ca2+ feedback-triggered
increase in guanylate cyclase activity restores the empty cyclic GMP
pool after illumination.
Also published this week:
Frs2 alpha
http://links.ealert.nature.com/ctt?kn=4&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
Frs2 beta
http://links.ealert.nature.com/ctt?kn=29&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=40&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
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Selected Updates
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CYTOSKELETON: JMY: ACTIN UP IN CELL MOTILITY
The p53 cofactor JMY promotes cell motility by combining the
nucleating activities of the actin-related protein 2/3 (Arp2/3)
complex and spire, which create branched actin filaments and
unbranched filaments, respectively.
Original research paper: Nature Cell Biology 11, 451-459 (2009)
http://links.ealert.nature.com/ctt?kn=6&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
METABOLISM: LESS IS MORE IS MUTATION DEPENDENT
In mice, mutational activation of the PI3K signaling pathway confers
resistance to the reduction in tumor growth induced by dietary
restriction.
Original research paper: Nature 458, 725-731 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
NEUROGENESIS: ASSISTED BIRTH WITH DISC1
DISC1 (disrupted in schizophrenia 1) regulates the proliferation of
both embryonic and adult neuronal progenitor cells by modulating
glycogen synthase kinase 3beta (GSK3beta)-beta-catenin signaling.
Original research paper: Cell 136, 1017-1031 (2009)
http://links.ealert.nature.com/ctt?kn=18&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=27&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
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Research Library
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SCAI ACTS AS A SUPPRESSOR OF CANCER CELL INVASION THROUGH THE
TRANSCRIPTIONAL CONTROL OF [beta]1-INTEGRIN
Nature Cell Biology 11, 557-568 (2009)
http://links.ealert.nature.com/ctt?kn=36&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
THE ENDOGENOUS INHIBITOR OF AKT, CTMP, IS CRITICAL TO
ISCHEMIA-INDUCED NEURONAL DEATH
Nature Neuroscience 12, 618-626 (2009)
http://links.ealert.nature.com/ctt?kn=23&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
MOLECULAR MIMICRY OF SUMO PROMOTES DNA REPAIR
Nature Structural & Molecular Biology 16, 509-516 (2009)
http://links.ealert.nature.com/ctt?kn=13&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
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Signaling News
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UK SCIENTISTS GET FUNDING BAN REPRIEVE
http://links.ealert.nature.com/ctt?kn=34&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
The UK Engineering and Physical Sciences Research Council (EPSRC) has
postponed and softened its proposal to bar serially unsuccessful
grant applicants from making funding bids for one year.
The restriction has been delayed to 1 April 2010, and barred
researchers will still be able to submit one application during the
year instead of being excluded outright
More news
http://links.ealert.nature.com/ctt?kn=26&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
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Gateway Updates
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LIPIDOMICS GATEWAY - MAY UPDATE
http://links.ealert.nature.com/ctt?kn=17&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
Nature Publishing Group is pleased to announce the launch of the
Lipidomics Gateway - a free, comprehensive website for researchers
interested in lipid biology.
This month's update features:
Macrolipophagy: Too much fat spoils the autophagic appetite
http://links.ealert.nature.com/ctt?kn=35&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
Endocytosis: The APPL of my PI3P eye
http://links.ealert.nature.com/ctt?kn=8&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
Fungal toxicity: Based in sphinganine
http://links.ealert.nature.com/ctt?kn=24&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
Sign up here to receive the monthly update alert for the
Lipidomics Gateway.
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Job of the Week
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Lecturer or Senior Lecturer position
Employer: St George's University of London
Location: London, United Kingdom
http://links.ealert.nature.com/ctt?kn=12&m=32897532&r=MTc2ODc4NDI0MAS2&b=2&j=NDg1NjM4NzAS1&mt=1&rt=0
A Lecturer/Senior Lecturer position is available at St George's,
University of London. The successful applicant will be expected to
undertake teaching duties that are related to undergraduate and
postgraduate anatomy, and to pursue a vigorous research program of
their own, preferentially in the area of cell signaling.
More Jobs:
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To advertise a job in this spot, please contact Naturejobs.
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