Signaling Gateway - 15 May 2009
http://links.ealert.nature.com/ctt?kn=35&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=27&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
HEMATOPOIETIC STEM CELLS: HOME TO MARROW
The heterotrimeric G protein Galphas subunit is required for the
ability of primitive hematopoietic cells to home to and engraft the
bone marrow.
Original research paper: Nature 459, 103-107 (2009)
http://links.ealert.nature.com/ctt?kn=13&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
------------------------
Molecule Pages
------------------------
S100a13
http://links.ealert.nature.com/ctt?kn=21&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
S100A13, a small calcium-binding protein, is expressed in many types
of cells and tissues. S100A13 is spontaneously released from the
cells through a Golgi-independent mechanism. It forms
copper-dependent complexes with fibroblast growth factor 1 (FGF1)
and interleukin-1alpha (IL-1alpha), and participates in stress-induced
non-classical export of these proteins. Upregulation of S100A13
expression is observed in astrocytic gliomas and lung carcinomas.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=5&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
-------------------
Selected Updates
-------------------
APOPTOSIS: DODGING DEATH
Apoptosis-stimulating protein of p53 2 (ASPP2, also known as TP53BP2)
functions as a haploinsufficient tumor suppressor by enhancing
pro-apoptotic programs and affecting the response to DNA damage.
Original research paper: Proc. Natl Acad. Sci. USA 106,
4390-4395 (2009)
http://links.ealert.nature.com/ctt?kn=28&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
PLANT DEVELOPMENT: PATERNAL CONTROL REGULATES DIVISION
In plants, a kinase provided by the sperm cells mediates the timing
of zygote elongation and the first division.
Original research paper: Science 323, 1485-1488 (2009)
http://links.ealert.nature.com/ctt?kn=37&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
ANTICANCER DRUGS: COMPARTMENTAL SOLUTION
Targeting heat shock protein 90 (HSP90) antagonists specifically to
mitochondria can markedly increase their anticancer activity in mice.
Original research paper: J. Clin. Invest. 119, 454-464 (2009)
http://links.ealert.nature.com/ctt?kn=6&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=30&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
------------------------
Research Library
------------------------
TALIN PHOSPHORYLATION BY CDK5 REGULATES SMURF1-MEDIATED TALIN HEAD
UBIQUITYLATION AND CELL MIGRATION
Nature Cell Biology 11, 624-630 (2009)
http://links.ealert.nature.com/ctt?kn=31&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
HISTONE H2AX IS INTEGRAL TO HYPOXIA-DRIVEN NEOVASCULARIZATION
Nature Medicine 15, 553-558 (2009)
http://links.ealert.nature.com/ctt?kn=22&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
THE TRANSCRIPTIONAL NETWORK THAT CONTROLS GROWTH ARREST AND
DIFFERENTIATION IN A HUMAN MYELOID LEUKEMIA CELL LINE
Nature Genetics 41, 553-562 (2009)
http://links.ealert.nature.com/ctt?kn=32&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
------------------------
Signaling News
------------------------
HOW THALIDOMIDE MAKES ITS MARK
http://links.ealert.nature.com/ctt?kn=26&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
More than 50 years after the drug thalidomide hit the market as a
remedy for nausea in pregnant women, researchers have now shown that
the drug's ability to block the development of new blood vessels may
be behind the deformed limbs of children born to women who took
thalidomide early in pregnancy. The finding could contribute to the
development of a similar compound that does not have the same
ill-effects.
More news
http://links.ealert.nature.com/ctt?kn=25&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
-------------------------
Gateway Updates
-------------------------
PSI-NATURE STRUCTURAL GENOMICS KNOWLEDGEBASE - MAY UPDATE
http://links.ealert.nature.com/ctt?kn=36&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
The Structural Genomics Knowledgebase is a free portal to research
data and other resources from the Protein Structure Initiative for
structural biologists to keep informed of the latest developments
in their field. This month's update features the following articles:
Controlling p53
http://links.ealert.nature.com/ctt?kn=12&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
Model proteins in your lunch break
http://links.ealert.nature.com/ctt?kn=20&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
Mitotic checkpoint control
http://links.ealert.nature.com/ctt?kn=2&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
Sign up to receive monthly updates from the PSI-Nature Structural
Genomics Knowledgebase.
http://links.ealert.nature.com/ctt?kn=29&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
-----------------------------
Job of the Week
-----------------------------
Joint Industry/Academic Postdoctoral Position
Employer: Wake Forest University School of Medicine
Location: Winston-Salem, North Carolina, USA
http://links.ealert.nature.com/ctt?kn=11&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
A postdoctoral position is available in the Department of
Neurobiology to study the molecular and cellular signaling cascades
in the brain that regulate ion channel expression and function.
The position is jointly sponsored by industry with the opportunity
for significant collaboration on a number of cutting edge projects,
including epilepsy, alcohol abuse and visual neurophysiology.
More Jobs:
http://links.ealert.nature.com/ctt?kn=3&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=23&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://links.ealert.nature.com/ctt?kn=7&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://links.ealert.nature.com/ctt?kn=34&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
For further technical assistance or any other enquiries, please click here:
http://links.ealert.nature.com/ctt?kn=1&m=32958549&r=MTc2ODc4NDI0MAS2&b=2&j=NDk1NDg2NTgS1&mt=1&rt=0
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2009 Nature Publishing Group
---------------------------------------------------------------------
