June 2009 Volume 10 Number 6
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present:
Frontiers of Clinical Investigation Symposium
Metabolism 2009: From Bench to Bedside
October 8-10, 2009
La Jolla, California, USA
The theme for this year's symposium explores innovative approaches to
bridge laboratory investigation to clinical research in metabolism.
Early Bird Deadline: September 8, 2009
Abstract Submission: Deadline: August 21, 2009
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Nature Reviews Molecular Cell Biology
Article Series on Chromatin Dynamics
In March 2009, Nature Reviews Molecular Cell Biology launched an
Article Series that focuses on recent breakthroughs in our understanding
of the mechanisms that govern the dynamic structural and spatial
organization of chromatin, thereby providing important insights into
gene regulation, DNA repair, development and epigenetic inheritance.
The series will run throughout 2009.
Follow the series today:
http://links.ealert.nature.com/ctt?kn=61&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
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This month's FEATURED article:
Physiological functions of the HECT family of ubiquitin ligases
Daniela Rotin and Sharad Kumar
p319 | doi:10.1038/nrm2690
http://links.ealert.nature.com/ctt?kn=38&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
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From the editors
p365 | doi:10.1038/nrm2706
http://links.ealert.nature.com/ctt?kn=87&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Chromatin: CENP-A on target
p367 | doi:10.1038/nrm2704
http://links.ealert.nature.com/ctt?kn=68&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
Protein degradation: Tipping the balance
p368 | doi:10.1038/nrm2701
http://links.ealert.nature.com/ctt?kn=23&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
Cell migration: Talin heads off
p368 | doi:10.1038/nrm2702
http://links.ealert.nature.com/ctt?kn=93&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
Plant cell biology: New receptors for ABA
p368 | doi:10.1038/nrm2703
http://links.ealert.nature.com/ctt?kn=55&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
IN BRIEF
Mitosis | Gene expression | Protein degradation | Polycomb
proteins
p369 | doi:10.1038/nrm2695
http://links.ealert.nature.com/ctt?kn=46&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
Protein degradation: Chain gang
p370 | doi:10.1038/nrm2691
http://links.ealert.nature.com/ctt?kn=82&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
TECHNOLOGY WATCH
Hunting phosphoproteins | See the force
p370 | doi:10.1038/nrm2705
http://links.ealert.nature.com/ctt?kn=1&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
Post-translational modification: Examining the Fic domain
p371 | doi:10.1038/nrm2696
http://links.ealert.nature.com/ctt?kn=37&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
DNA repair: Time to switch
p371 | doi:10.1038/nrm2700
http://links.ealert.nature.com/ctt?kn=94&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
Prions: Prying into prions
p372 | doi:10.1038/nrm2692
http://links.ealert.nature.com/ctt?kn=26&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
JOURNAL CLUB
Freedom versus constraint in protein function
p372 | doi:10.1038/nrm2697
http://links.ealert.nature.com/ctt?kn=59&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
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REVIEWS
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Chromatin remodelling beyond transcription: the INO80 and SWR1
complexes
Ashby J Morrison and Xuetong Shen
p373 | doi:10.1038/nrm2693
ATP-dependent chromatin-remodelling complexes are well-known regulators
of transcriptional processes. Interestingly, the INO80 and SWR1 complexes
also participate in a range of pathways that are involved in genome
maintenance, such as DNA repair, checkpoint regulation, DNA replication,
chromosome segregation and telomere stabilization.
Abstract: http://links.ealert.nature.com/ctt?kn=71&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
The ubiquitin-26S proteasome system at the nexus of plant biology
Richard D. Vierstra
p385 | doi:10.1038/nrm2688
The ubiquitin-26S proteasome system is one of the most pervasive pathways
of intracellular protein regulation in plants. It controls hormone
signalling, chromatin structure and transcription, tailoring morphogenesis,
responses to environmental challenges, self-recognition and the battle
between pathogens and their plant hosts.
Abstract: http://links.ealert.nature.com/ctt?kn=67&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=90&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
Physiological functions of the HECT family of ubiquitin ligases
Daniela Rotin and Sharad Kumar
p398 | doi:10.1038/nrm2690
Ubiquitylation targets proteins for degradation or other cellular fates.
The HECT enzymes are E3 ubiquitin ligases, which dictate the specificity
of ubiquitylation. HECTs regulate trafficking of many receptors, channels,
transporters and viral proteins. Their role in metazoans is becoming
clearer from in vivo studies.
Abstract: http://links.ealert.nature.com/ctt?kn=38&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=22&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
The second wave of synthetic biology: from modules to systems
Priscilla E. M. Purnick and Ron Weiss
p410 | doi:10.1038/nrm2698
Synthetic biology combines the investigative nature of biology with the
constructive nature of engineering. A 'first wave' in the field has led
to the creation of genetic devices and small modules that are constructed
from these devices. Now, a 'second wave' is required to develop effective
strategies for assembling devices and modules into intricate customizable
larger scale systems.
Abstract: http://links.ealert.nature.com/ctt?kn=17&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
It takes two to tango: regulation of G proteins by dimerization
Raphael Gasper, Simon Meyer, Katja Gotthardt, Minhajuddin Sirajuddin
and Alfred Wittinghofer
p423 | doi:10.1038/nrm2689
Guanine nucleotide-binding (G) proteins are regulated by GTPase-activating
proteins and guanine nucleotide-exchange factors. Another class of G
proteins is emerging that are regulated by homodimerization. The authors
propose that juxtaposition of the G domains of two monomers across the
GTP-binding sites activates the biological function of these proteins
nd the GTPase reaction.
Abstract: http://links.ealert.nature.com/ctt?kn=77&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
OPINION
RNA granules: post-transcriptional and epigenetic modulators of gene
expression
Paul Anderson and Nancy Kedersha
p430 | doi:10.1038/nrm2694
Compositionally and functionally distinct RNA granules are found in
the cytoplasm of somatic and germ cells. The components of most RNA
granules are in a dynamic equilibrium, thereby allowing rapid shifts
between the translation, storage and decay of RNAs.
Abstract: http://links.ealert.nature.com/ctt?kn=52&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=33136452&r=MTc2NzYzNjQ2NgS2&b=2&j=NDk5NTM2OTgS1&mt=1&rt=0
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