June 2009 Volume 7 Number 6
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This month's FEATURED article:
Making the cut: central roles of intramembrane proteolysis in pathogenic
microorganisms
Sinisa Urban
p411 | doi:10.1038/nrmicro2130
http://links.ealert.nature.com/ctt?kn=62&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
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In this issue
p401 | doi:10.1038/nrmicro2160
http://links.ealert.nature.com/ctt?kn=17&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Editorial: The price of a pandemic
p402 | doi:10.1038/nrmicro2162
Article: http://links.ealert.nature.com/ctt?kn=54&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Biofilms: Building biofilms with DNA
p403 | doi:10.1038/nrmicro2158
http://links.ealert.nature.com/ctt?kn=19&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Viral pathogenesis: Bovine factors aid foot and mouth
p404 | doi:10.1038/nrmicro2152
http://links.ealert.nature.com/ctt?kn=36&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
IN BRIEF
Parasitology | Symbiosis | Vaccines
p404 | doi:10.1038/nrmicro2155
http://links.ealert.nature.com/ctt?kn=97&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Cellular microbiology: Examining the Fic domain
p405 | doi:10.1038/nrmicro2157
http://links.ealert.nature.com/ctt?kn=3&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Fungal pathogenesis: Hsp90 turns up the heat on Candida
p405 | doi:10.1038/nrmicro2159
http://links.ealert.nature.com/ctt?kn=83&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Gene expression: Structure versus codon bias
p406 | doi:10.1038/nrmicro2153
http://links.ealert.nature.com/ctt?kn=80&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Type IV secretion: A sprouting interest in Bartonella
p406 | doi:10.1038/nrmicro2156
http://links.ealert.nature.com/ctt?kn=60&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Bacterial physiology: Sugar-coating friendly bacteria
p407 | doi:10.1038/nrmicro2151
http://links.ealert.nature.com/ctt?kn=82&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
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NEWS AND ANALYSIS
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GENOME WATCH
Genome watch: What a scorcher!
Ana M. Cerdeno-Tarraga
p408 | doi:10.1038/nrmicro2154
http://links.ealert.nature.com/ctt?kn=22&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
DISEASE WATCH
In the News
p410 | doi:10.1038/nrmicro2161
http://links.ealert.nature.com/ctt?kn=94&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
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REVIEWS
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Making the cut: central roles of intramembrane proteolysis in pathogenic
microorganisms
Sinisa Urban
p411 | doi:10.1038/nrmicro2130
Cleavage of membrane proteins by intramembrane proteases can release
effector domains that carry out a range of cellular functions. In higher
eukaryotes, the functions of such proteases are well characterized.
However, the importance of such proteases in unicellular organisms is
only recently being appreciated. In this article, Sin Urban reviews
the recent advances in our understanding of how intramembrane proteases
play pivotal parts in a range of pathogenic microorganisms.
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Roles of galectins in infection
Gerardo R. Vasta
p424 | doi:10.1038/nrmicro2146
Galectins are important for recognition of carbohydrate ligands during
embryogenesis, development and immune regulation. In addition, recent
work has shown that galectins also function as receptors for glycans
expressed on the surface of potentially pathogenic microorganisms.
In this Review, Gerardo Vasta discusses the roles of galectins in host
immunity and how pathogens have evolved to evade or subvert galectin-mediated
immune responses.
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Coronaviruses post-SARS: update on replication and pathogenesis
Stanley Perlman and Jason Netland
p439 | doi:10.1038/nrmicro2147
Coronaviruses gained prominence during the SARS outbreaks of 2002-2003,
but there are many different coronaviruses that infect humans and animals.
Perlman and Netland describe the biology of the coronaviruses, including
their replication, host immune response and interspecies transmission.
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=85&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
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ANALYSIS
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Microbial growth in the polar oceans - role of temperature and potential
impact of climate change
David L. Kirchman, Xose Anxelu G. Moran and Hugh Ducklow
p451 | doi:10.1038/nrmicro2115
In this Analysis, Kirchman and colleagues compare microbial processes in
the western Arctic Ocean and other polar waters with low-latitude oceans
to attempt to understand the role of heterotrophic bacteria in oceanic
biogeochemical cycles. This may further our understanding of the changes
that could occur as these waters warm.
Abstract: http://links.ealert.nature.com/ctt?kn=2&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
Drug interactions and the evolution of antibiotic resistance
Pamela J. Yeh, Matthew J. Hegreness, Aviva Presser Aiden and Roy Kishony
p460 | doi:10.1038/nrmicro2133
Using large-scale, systems biology approaches, we can now systematically
map synergistic and antagonistic interactions between drugs. Consequently,
drug antagonism is providing us with insight into the functions and
relatedness of cellular components, mechanisms of drug action and novel
ways to inhibit the evolution of antibiotic resistance.
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=71&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
OPINION
Is the high virulence of HIV-1 an unfortunate coincidence of primate
lentiviral evolution?
Frank Kirchhoff
p467 | doi:10.1038/nrmicro2111
The pathogenesis of HIV-1 is markedly different to that of most simian
immunodeficiency viruses (SIVs). Frank Kirchhoff proposes a model in which
the presence of vpu in HIV-1 and a small number of SIV strains allowed
changes in the Nef proteins that contribute to these differences.
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=76&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
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CORRESPONDENCE
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Correspondence: Antioxidants used by Deinococcus radiodurans and
implications for antioxidant drug discovery
Hong-Yu Zhang, Xue-Juan Li, Na Gao and Ling-Ling Chen
p476 | doi:10.1038/nrmicro2073-c1
http://links.ealert.nature.com/ctt?kn=93&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
Correspondence: Deinococcus prospects
Michael J. Daly
p476 | doi:10.1038/nrmicro2073-c2
http://links.ealert.nature.com/ctt?kn=48&m=32949673&r=MTc2NzM1ODUwNgS2&b=2&j=NDk1MzMyNzYS1&mt=1&rt=0
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