May 7 2009
Visit Nature Reports Stem Cells online.
Now available at http://links.ealert.nature.com/ctt?kn=15&m=32897699&r=MTc2NjM3NTc5MQS2&b=2&j=NDg1NjUzMzkS1&mt=1&rt=0
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OUR TOP STORIES
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Commentary
International stem cell environments: a world of difference
Stem-cell research represents a patchwork of patchworks. Understanding this can help the research community to manage it effectively.
http://links.ealert.nature.com/ctt?kn=19&m=32897699&r=MTc2NjM3NTc5MQS2&b=2&j=NDg1NjUzMzkS1&mt=1&rt=0
Features
What does reprogramming do?
Researchers grapple with the factors that make cells pluripotent
http://links.ealert.nature.com/ctt?kn=17&m=32897699&r=MTc2NjM3NTc5MQS2&b=2&j=NDg1NjUzMzkS1&mt=1&rt=0
A closer look at the single cell
Analyses of individual stem cells are gaining momentum, but technological barriers persist
http://links.ealert.nature.com/ctt?kn=10&m=32897699&r=MTc2NjM3NTc5MQS2&b=2&j=NDg1NjUzMzkS1&mt=1&rt=0
Meeting report
Caution and hope for the stem cell industry
Experts describe how to get through the valley of financial death and the FDA
http://links.ealert.nature.com/ctt?kn=1&m=32897699&r=MTc2NjM3NTc5MQS2&b=2&j=NDg1NjUzMzkS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Getting blood stem cells to the heart
Improving engraftment increases survival in a mouse model
Zaruba, M-M. et al. Cell Stem Cell 4, 313-323 (2009).
http://links.ealert.nature.com/ctt?kn=21&m=32897699&r=MTc2NjM3NTc5MQS2&b=2&j=NDg1NjUzMzkS1&mt=1&rt=0
What makes a cancer stem cell?
What can cultured balls of cells say about the origin of cancer stem cells?
Liu, Y. et al. Cell Stem Cell 4, 336-347 (2009).
http://links.ealert.nature.com/ctt?kn=20&m=32897699&r=MTc2NjM3NTc5MQS2&b=2&j=NDg1NjUzMzkS1&mt=1&rt=0
MicroRNAs boost reprogramming, boot out cMyc
MicroRNAs, along with other transcription factors, produce homogenous iPS cell colonies from mouse fibroblasts
Judson, R. L., Babia, J. E., Venere, M. & Blelloch, R. Nature Biotechnol. advance online publication, doi:10.1038/nbt.1535 (12 April 2009).
http://links.ealert.nature.com/ctt?kn=16&m=32897699&r=MTc2NjM3NTc5MQS2&b=2&j=NDg1NjUzMzkS1&mt=1&rt=0
Connecting Oct4 to chromatin
An RNAi screen finds a protein complex that keeps pluripotency genes open for transcription
Ding, L. et al. Cell Stem Cell doi:10.1016/j.stem.2009.03.009 (published online 2 April 2009).
http://links.ealert.nature.com/ctt?kn=9&m=32897699&r=MTc2NjM3NTc5MQS2&b=2&j=NDg1NjUzMzkS1&mt=1&rt=0
Reprogramming to pluripotency without genetic engineering
Researchers make iPS cells without inserting DNA
Zhou, H. et al. Cell Stem Cell doi:10.1016/j.stem.2009.04.005 (published online 23 April 2009).
http://links.ealert.nature.com/ctt?kn=2&m=32897699&r=MTc2NjM3NTc5MQS2&b=2&j=NDg1NjUzMzkS1&mt=1&rt=0
Cloned embryos can't fool a womb
The endometrium can differentiate between embryos generated by various technologies
Bauersachs, S. et al. Proc. Natl Acad. Sci. USA doi:10.1073/pnas.0811841106 (published online 7 April 2009).
Mansouri-Attia, N. et al. Proc. Natl Acad. Sci. USA doi:10.1073/pnas.0812722106 (published online 7 April 2009).
http://links.ealert.nature.com/ctt?kn=7&m=32897699&r=MTc2NjM3NTc5MQS2&b=2&j=NDg1NjUzMzkS1&mt=1&rt=0
A recipe for heart cells from amnion
Two transcription factors and a chromatin remodeller help make mouse cardiomyocytes
Takeuchi, J. K. & Bruneau, B. G. Nature advance online publication, doi:10.1038/nature08039 (26 April 2009).
http://links.ealert.nature.com/ctt?kn=5&m=32897699&r=MTc2NjM3NTc5MQS2&b=2&j=NDg1NjUzMzkS1&mt=1&rt=0
New tool for finding reprogramming human cells
Genetic vector is off in differentiated cells, on in stem cells
Hotta, A. et al. Nature Methods 6, 370-376 (2009).
http://links.ealert.nature.com/ctt?kn=13&m=32897699&r=MTc2NjM3NTc5MQS2&b=2&j=NDg1NjUzMzkS1&mt=1&rt=0
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