May 2009 Volume 23 Number 5, pp 829 - 1017
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EDITORIAL
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The rewards and challenges of array-based karyotyping for clinical
oncology applications
J M Hagenkord and C C Chang
Abstract: http://links.ealert.nature.com/ctt?kn=5&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
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REVIEW
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The complete evaluation of erythrocytosis: congenital and acquired
M M Patnaik and A Tefferi
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=125&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
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ORIGINAL ARTICLES
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FIP1L1-PDGFR[alpha] D842V, a novel panresistant mutant, emerging
after treatment of FIP1L1-PDGFR[alpha] T674I eosinophilic leukemia
with single agent sorafenib
E Lierman, L Michaux, E Beullens, P Pierre, P Marynen,
J Cools and P Vandenberghe
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
MPLW515L mutation in acute megakaryoblastic leukaemia
K Hussein, O Bock, K Theophile, K Schulz-Bischof, A Porwit,
J Schlue, D Jonigk and H Kreipe
Abstract: http://links.ealert.nature.com/ctt?kn=72&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
A new molecular network comprising PU.1, interferon regulatory factor
proteins and miR-342 stimulates ATRA-mediated granulocytic
differentiation of acute promyelocytic leukemia cells
M L De Marchis, M Ballarino, B Salvatori, M C Puzzolo, I Bozzoni
and A Fatica
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=25&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Strong association of the HLA-DP6 supertype with childhood leukaemia
is due to a single allele, DPB1*0601
G M Taylor, A Hussain, V Verhage, P D Thompson, W D Fergusson,
G Watkins, T Lightfoot, C J Harrison and J M Birch
Abstract: http://links.ealert.nature.com/ctt?kn=134&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Chromosome 14 copy number-dependent IGH gene rearrangement patterns
in high hyperdiploid childhood B-cell precursor ALL: implications
for leukemia biology and minimal residual disease analysis
E Csinady, V H J van der Velden, R Joas, S Fischer, J F de Vries,
H B Beverloo, M Konig, U Potschger, J J M van Dongen, G Mann,
O A Haas and E R Panzer-Grumayer
Abstract: http://links.ealert.nature.com/ctt?kn=15&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
In situ analysis of the antigen-processing machinery in acute myeloid
leukaemic blasts by tissue microarray
S Hoves, M Aigner, C Pfeiffer, M Laumer, E C Obermann and A Mackensen
Abstract: http://links.ealert.nature.com/ctt?kn=21&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=29&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Erythroid precursors from patients with low-risk myelodysplasia
demonstrate ultrastructural features of enhanced autophagy of
mitochondria
E J Houwerzijl, H-Wd Pol, N R Blom, J J L van der Want, JThM de Wolf
and E Vellenga
Abstract: http://links.ealert.nature.com/ctt?kn=102&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
The hematopoietic stem cell in chronic phase CML is characterized
by a transcriptional profile resembling normal myeloid progenitor
cells and reflecting loss of quiescence
I Bruns, A Czibere, J C Fischer, F Roels, R-P Cadeddu, S Buest,
D Bruennert, A N Huenerlituerkoglu, N H Stoecklein, R Singh,
L F Zerbini, M Jager, G Kobbe, N Gattermann, R Kronenwett,
B Brors and R Haas
Abstract: http://links.ealert.nature.com/ctt?kn=76&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=133&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Frequent TET2 mutations in systemic mastocytosis: clinical,
KITD816V and FIP1L1-PDGFRA correlates
A Tefferi, R L Levine, K-H Lim, O Abdel-Wahab, T L Lasho, J Patel,
C M Finke, A Mullally, C-Y Li, A Pardanani and D G Gilliland
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=47&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
TET2 mutations and their clinical correlates in polycythemia vera,
essential thrombocythemia and myelofibrosis
A Tefferi, A Pardanani, K-H Lim, O Abdel-Wahab, T L Lasho, J Patel,
N Gangat, C M Finke, S Schwager, A Mullally, C-Y Li, C A Hanson,
R Mesa, O Bernard, F Delhommeau, W Vainchenker, D G Gilliland
and R L Levine
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=45&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
A phase I/II study of rituximab and etanercept in patients with
chronic lymphocytic leukemia and small lymphocytic lymphoma
J A Woyach, T S Lin, M S Lucas, N Heerema, M E Moran, C Cheney,
D M Lucas, L Wei, M A Caligiuri and J C Byrd
Abstract: http://links.ealert.nature.com/ctt?kn=100&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=80&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Molecular evidence for EBV and CMV persistence in a subset of
patients with chronic lymphocytic leukemia expressing stereotyped
IGHV4-34 B-cell receptors
E Kostareli, A Hadzidimitriou, N Stavroyianni, N Darzentas,
A Athanasiadou, M Gounari, V Bikos, A Agathagelidis, T Touloumenidou,
I Zorbas, A Kouvatsi, N Laoutaris, A Fassas, A Anagnostopoulos,
C Belessi and K Stamatopoulos
Abstract: http://links.ealert.nature.com/ctt?kn=70&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=108&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Human mesenchymal stem cells inhibit cancer cell proliferation
by secreting DKK-1
Y Zhu, Z Sun, Q Han, L Liao, J Wang, C Bian, J Li, X Yan,
Y Liu, C Shao and R C Zhao
Abstract: http://links.ealert.nature.com/ctt?kn=119&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=22&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
AML with translocation t(8;16)(p11;p13) demonstrates unique
cytomorphological, cytogenetic, molecular and prognostic features
T Haferlach, A Kohlmann, H-U Klein, C Ruckert, M Dugas, P M Williams,
W Kern, S Schnittger, U Bacher, H Loffler and C Haferlach
Abstract: http://links.ealert.nature.com/ctt?kn=36&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Quantification of fusion transcript reveals a subgroup with distinct
biological properties and predicts relapse in BCR/ABL-positive ALL:
implications for residual disease monitoring
M Zaliova, E Fronkova, K Krejcikova, K Muzikova, E Mejstrikova,
J Stary, J Trka and J Zuna
Abstract: http://links.ealert.nature.com/ctt?kn=1&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=4&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
The novel immunosuppressive enzyme IL4I1 is expressed by neoplastic
cells of several B-cell lymphomas and by tumor-associated macrophages
A Carbonnelle-Puscian, C Copie-Bergman, M Baia, N Martin-Garcia,
Y Allory, C Haioun, A Cremades, I Abd-Alsamad, J-P Farcet, P Gaulard,
F Castellano and V Molinier-Frenkel
Abstract: http://links.ealert.nature.com/ctt?kn=82&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=122&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Preclinical activity of P276-00, a novel small-molecule cyclin-dependent
kinase inhibitor in the therapy of multiple myeloma
N Raje, T Hideshima, S Mukherjee, M Raab, S Vallet, S Chhetri,
D Cirstea, S Pozzi, C Mitsiades, M Rooney, T Kiziltepe, K Podar,
Y Okawa, H Ikeda, R Carrasco, P G Richardson, D Chauhan, N C Munshi,
S Sharma, H Parikh, B Chabner, D Scadden and K C Anderson
Abstract: http://links.ealert.nature.com/ctt?kn=88&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=37&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
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LETTERS TO THE EDITOR
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Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene,
predisposes to 6-MP related toxicities in childhood ALL patients
N Karas-Kuzelicki, J Jazbec, M Milek and I Mlinaric-Rascan
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Caspase-independent type III PCD: a new means to modulate cell
death in chronic lymphocytic leukemia
H Merle-Beral, S Barbier, G Roue, M Bras, M Sarfati and S A Susin
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=13&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Hematolymphoid neoplasms: World Health Organization versus rest
of the world
S Gujral
Abstract: http://links.ealert.nature.com/ctt?kn=42&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=57&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Investigation of C/EBP[alpha] function in human (versus murine)
myelopoiesis provides novel insight into the impact of CEBPA
mutations in acute myelogenous leukemia (AML)
B Niebuhr, G B Iwanski, M Schwieger, S Roscher, C Stocking
and J Cammenga
Abstract: http://links.ealert.nature.com/ctt?kn=35&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Early in vivo changes of the transcriptome in Philadelphia
chromosome-positive CD34+ cells from patients with chronic
myelogenous leukaemia following imatinib therapy
D Bruennert, A Czibere, I Bruns, R Kronenwett, N Gattermann,
R Haas and F Neumann
Abstract: http://links.ealert.nature.com/ctt?kn=105&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=113&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Involvement of Tis11b, an AU-rich binding protein, in
induction of apoptosis by rituximab in B cell chronic
lymphocytic leukemia cells
M Baou, A Jewell, A Muthurania, R G Wickremasinghe, K L Yong,
R Carr, P Marsh and J J Murphy
Abstract: http://links.ealert.nature.com/ctt?kn=79&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=130&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
MLL/AF-4 leukemic cells recruit new blood vessels but do
not incorporate into capillaries in culture or in a
NOD/SCID xenograft model
Z Hu, X-M Li, M L Jorgensen and W B Slayton
Abstract: http://links.ealert.nature.com/ctt?kn=121&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=92&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Therapeutic concentrations of dasatinib inhibit in vitro
osteoclastogenesis
K Vandyke, A L Dewar, A N Farrugia, S Fitter, L Bik To,
T P Hughes and A C W Zannettino
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=65&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Molecular profile of CD34+ stem/progenitor cells according
to JAK2V617F mutation status in essential thrombocythemia
L Catani, R Zini, D Sollazzo, E Ottaviani, A M Vannucchi,
S Ferrari, M Baccarani, N Vianelli, R M Lemoli and R Manfredini
Abstract: http://links.ealert.nature.com/ctt?kn=38&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Exclusion of ABCB8 and ABCB10 as cancer candidate genes
in acute myeloid leukemia
L Tang, S M Bergevoet, L E Franssen, T de Witte, J H Jansen,
R A P Raymakers and B A van der Reijden
Abstract: http://links.ealert.nature.com/ctt?kn=83&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
A second NOTCH1 chromosome rearrangement: t(9;14)(q34.3;q11.2)
in T-cell neoplasia
S Suzuki, S Nagel, B Schneider, S Chen, M Kaufmann, K Uozumi,
N Arima, H G Drexler and R A F MacLeod
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=116&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Nuclear entrapment of BCR-ABL by combining imatinib mesylate
with leptomycin B does not eliminate CD34+ chronic myeloid
leukaemia cells
E K Allan, A Hamilton, S Hatziieremia, P Zhou, H G Jorgensen,
P Vigneri and T L Holyoake
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
No evidence of frequent association of the JAK2 V617F mutation
with acute myocardial infarction in young patients
M Politou, C Zoi, I J Dahabreh, L Rallidis, A Gialeraki,
D Loukopoulos and K Zoi
Abstract: http://links.ealert.nature.com/ctt?kn=127&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Dexamethasone and the risk for adrenal suppression in multiple
myeloma
A C Ng, S K Kumar, S J Russell, S V Rajkumar and M T Drake
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=128&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Atypical 11q deletions identified by array CGH may be missed
by FISH panels for prognostic markers in chronic
lymphocytic leukemia
S R Gunn, M K Hibbard, S H Ismail, M Lowery-Nordberg,
C H M Mellink, D W Bahler, L V Abruzzo, E L Enriquez,
M E Gorre, M S Mohammed and R S Robetorye
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=40&m=32919053&r=MTc2MzIyNTA1NQS2&b=2&j=NDk0NTg3NzAS1&mt=1&rt=0
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