April 2009 Volume 15 Number 4, pp 345 - 462
Visit Nature Medicine online to browse the journal.
Now available at http://links.ealert.nature.com/ctt?kn=132&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Please note that you need to be a subscriber to enjoy full text access to Nature Medicine online. To purchase a subscription, please visit:
http://links.ealert.nature.com/ctt?kn=148&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.com/ctt?kn=56&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
qPCR - Ready, Set, Done!
Easily and quickly quantify genes in cellular pathways and gene
families.
RealTime ready Focus Panels are pre-plated with gene-specific primers,
probes, controls and reference genes.
Just add master mix and sample cDNA.
More RealTime ready information is available here.
http://links.ealert.nature.com/ctt?kn=154&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
=====================================================================
=========================== ADVERTISEMENT ===========================
Future Medicine journals provide award-winning coverage of postgenomic
medicine.
For a huge FREE collection of cutting-edge articles taken from our ent
ire journal range, including Pharmacogenomics, Personalized Medicine,
Nanomedicine, Regenerative Medicine, Biomarkers in Medicine,
Immunotherapy and much more simply click here.
http://links.ealert.nature.com/ctt?kn=72&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
=====================================================================
=========================== ADVERTISEMENT ===========================
Job Opportunity:
The University of Wisconsin-Madison invites applications for a
DIRECTOR of the Wisconsin National Primate Research Center. The
ideal candidate will have an exemplary research record and have
an international reputation as a leader in his/her field.
To apply and for complete description, visit:
http://links.ealert.nature.com/ctt?kn=8&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Deadline: May 15, 2009
=====================================================================
=========================== ADVERTISEMENT ===========================
Nature Collections Malaria
Can the scourge of malaria be eradicated?
This collection highlights advances in the deployment of existing malaria-control tools and the basic science of malaria.
Access the collection free online for 3 months and request a sample copy at http://links.ealert.nature.com/ctt?kn=66&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0.
Produced with support from Special Programme for Research and Training in Tropical Diseases (TDR), Medicines for Malaria Venture(MMV) and GlaxoSmithKline
=====================================================================
=========================== ANNOUNCEMENT ===========================
Frontiers of clinical investigation-Metabolism
Metabolism 2009: From bench to bedside
We invite you to attend the 4th Annual Frontiers of Clinical Investigation Symposium. The meeting will explore innovative approaches to bridge laboratory investigation and clinical research in metabolism.
Visit the 4th Annual Frontiers of Clinical Investigation Symposium website today!
http://links.ealert.nature.com/ctt?kn=138&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
=====================================================================
----------------------
NATURE MEDICINE PODCAST
----------------------
Clioquinol's comeback
The podcast examines breakthroughs from the past month and investigates the return of a drug, clioquinol, which has a haunted past.
http://links.ealert.nature.com/ctt?kn=97&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
EDITORIAL
----------------------
Risky business p345
A recent US Supreme Court ruling places responsibility for the wording of drug labels on pharmaceutical companies. But the task of improving the communication of drug risks does not rest with the pharmaceutical industry alone.
doi:10.1038/nm0409-345
http://links.ealert.nature.com/ctt?kn=38&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
NEWS
----------------------
A stem cell ban is lifted, but some states see a heavy backlash p347
Kirsten Dorans
doi:10.1038/nm0409-347
http://links.ealert.nature.com/ctt?kn=161&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Five big ideas for nanotechnology p348
Jon Evans
doi:10.1038/nm0409-348
http://links.ealert.nature.com/ctt?kn=124&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Biosafety bungle leads to bird flu contamination p349
Cassandra Willyard
doi:10.1038/nm0409-349a
http://links.ealert.nature.com/ctt?kn=153&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Blueprint for autism research put forward p349
Virginia Hughes
doi:10.1038/nm0409-349b
http://links.ealert.nature.com/ctt?kn=73&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
US stimulus bill challenges biomedicine to deliver p350
Kirsten Dorans
doi:10.1038/nm0409-350a
http://links.ealert.nature.com/ctt?kn=78&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
New cancer research centers open in UK p350
Nayanah Siva
doi:10.1038/nm0409-350b
http://links.ealert.nature.com/ctt?kn=57&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Dutch seizure of drugs sparks outcry p350
Nayanah Siva
doi:10.1038/nm0409-350c
http://links.ealert.nature.com/ctt?kn=104&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
A vaccine based on conserved regions could prove radical p351
Kirsten Dorans
doi:10.1038/nm0409-351a
http://links.ealert.nature.com/ctt?kn=81&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Broad-acting HPV vaccines explored to fight cancer p351
Kirsten Dorans
doi:10.1038/nm0409-351b
http://links.ealert.nature.com/ctt?kn=42&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
News in brief pp352 - 353
doi:10.1038/nm0409-352
http://links.ealert.nature.com/ctt?kn=91&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Straight talk with ... Agnes Saint Raymond pp354 - 355
Agnes Saint Raymond has long advocated for children's health and worked with members of the European Parliament to draft and pass new legislation in 2006 to promote drug development in this area. She spoke with Genevive Bjorn about the future of medicines designed for youngsters.
Genevive Bjorn
doi:10.1038/nm0409-354
http://links.ealert.nature.com/ctt?kn=121&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
NEWS FEATURE
----------------------
The curious case of clioquinol pp356 - 359
An indigestion drug blamed for a debilitating illness that affected thousands of people in the 1950s has been resurrected as a potential treatment for Alzheimer's disease. But not everyone is cheering for the drug, clioquinol, to make a comeback. Lauren Cahoon reports.
Lauren Cahoon
doi:10.1038/nm0409-356
http://links.ealert.nature.com/ctt?kn=23&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
BOOK REVIEW
----------------------
A new progressive era? p361
Scott H Podolsky reviews Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs by Melody Petersen
doi:10.1038/nm0409-361
http://links.ealert.nature.com/ctt?kn=152&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Choosing between GVHD and delayed engraftment pp363 - 364
Growth factors used to accelerate engraftment after hematopoietic cell transplantation can increase the severity of graft-versus-host disease. Experiments with mice examine how irradiation, used to prepare recipients for transplants, contributes to this problem (pages 436-441).
Paul J Martin
doi:10.1038/nm0409-363
http://links.ealert.nature.com/ctt?kn=149&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Neutrophil sandwiches injure the microcirculation pp364 - 366
Experiments in two mouse models of thromboinflammatory disease show how neutrophils stick to red blood cells and platelets[mdash]leading to reduced blood flow and damage to the microcirculation. Polarized expression of [alpha]M[beta]2 integrins on neutrophils helps set the process in motion (pages 384-391).
Mark R Looney and Michael A Matthay
doi:10.1038/nm0409-364
http://links.ealert.nature.com/ctt?kn=134&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Dust mites' dirty dealings in the lung pp366 - 367
Toll-like receptors on lung epithelia recognize allergens and help provoke asthma. The findings put new emphasis on innate immunity as a driver of allergic responses (pages 410-416).
Clare M Lloyd
doi:10.1038/nm0409-366
http://links.ealert.nature.com/ctt?kn=176&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Neuropeptide beckons cells that heal pp367 - 369
Experiments in rodents identify a factor that causes the release of multipotent cells into the circulation after injury. These cells contribute to tissue repair (pages 425-435).
Pamela Gehron Robey
doi:10.1038/nm0409-367
http://links.ealert.nature.com/ctt?kn=70&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
COMMUNITY CORNER
----------------------
Bone marrow transplant muffles HIV p371
doi:10.1038/nm0409-371
http://links.ealert.nature.com/ctt?kn=158&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
BETWEEN BEDSIDE AND BENCH
----------------------
Getting away from glucose
Type 2 diabetes is often viewed as a disorder of glucose metabolism. But many factors come into play in this condition, with obesity a prime risk factor and cardiovascular disease a major result. In Bedside to Bench, Babak Razani and Clay Semenkovich examine the linkages between diabetes and cardiovascular disease. They call for new research approaches in the wake of clinical trials showing that lowering glucose levels does not decrease cardiovascular events in people with type 2 diabetes. In Bench to Bedside, Steven Shoelson and Allison Goldfine examine how type 2 diabetes and other disorders can stem from obesity[mdash]and its effect on inflammation. These authors take a look at two recent studies showing how obesity perturbs inflammatory gene networks.
Getting away from glucose: stop sugarcoating diabetes pp372 - 373
Babak Razani and Clay F Semenkovich
doi:10.1038/nm0409-372
http://links.ealert.nature.com/ctt?kn=174&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Getting away from glucose: fanning the flames of obesity-induced inflammation pp373 - 374
Steven E Shoelson and Allison B Goldfine
doi:10.1038/nm0409-373
http://links.ealert.nature.com/ctt?kn=2&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
Research Highlights p375
doi:10.1038/nm0409-375
http://links.ealert.nature.com/ctt?kn=93&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
BRIEF COMMUNICATIONS
----------------------
Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury pp377 - 379
The neurotoxic A[beta] peptide is produced after traumatic brain injury. Mark P. Burns and his colleagues show that inhibiting the enzymes involved in A[beta] production can block the neuron death and neurological dysfunction that occurs after traumatic brain injury.
David J Loane et al.
doi:10.1038/nm.1940
Abstract: http://links.ealert.nature.com/ctt?kn=82&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=94&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans pp380 - 383
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome that is often difficult to treat. Hiroshi Watanabe and coworkers now show that flecainide, an approved drug known to inhibit sodium channels, is able to target the underlying cause of CPVT by inhibiting calcium release through the ryanodine receptor. Flecainide prevented arrhythmia in a mouse model of CPVT and was also effective when tested in two individuals with CPVT.
Hiroshi Watanabe et al.
doi:10.1038/nm.1942
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
ARTICLES
----------------------
Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury pp384 - 391
Signaling between endothelial and blood cell types controls inflammatory and thrombotic responses. Andres Hidalgo and his coworkers now uncover a signaling mechanism by which the endothelium, acting on adherent leukocytes, promotes the capture of platelets or red blood cells by those leukocytes, contributing to pathology in mouse models of two very different types of disease[mdash]transfusion-related acute lung injury and sickle cell disease(pages 364-366).
Andres Hidalgo et al.
doi:10.1038/nm.1939
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors pp392 - 400
Inhibitors of [alpha]v[beta]3 and [alpha]v[beta]5 integrins have previously been shown to inhibit tumor angiogenesis and growth and have entered human clinical trials. Andrew Reynolds and his coworkers now show that low (nanomolar) concentrations of these inhibitors can unexpectedly promote VEGF-dependent tumor angiogenesis and growth in vivo. Such effects could compromise the anticancer efficacy of these agents in humans.
Andrew R Reynolds et al.
doi:10.1038/nm.1941
Abstract: http://links.ealert.nature.com/ctt?kn=19&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity pp401 - 409
Bali Pulendran and his colleagues explore ways that signaling through different pathogen receptors can program dendritic cells (DCs) to orchestrate inflammatory or tolerogenic immune responses. The yeast component zymosan triggers signaling through both Toll-like receptor 2 (TLR2) and the C-type lectin dectin-1. In the absence of TLR2, zymosan induces proinflammatory responses through dectin-1. But TLR2 triggering induces DCs to form the vitamin A-metabolizing enzyme Raldh2. The DCs can then form retinoic acid that acts in an autocrine manner on the DCs, programming them for the induction of regulatory T cell responses.
Santhakumar Manicassamy et al.
doi:10.1038/nm.1925
Abstract: http://links.ealert.nature.com/ctt?kn=63&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells pp410 - 416
House dust mite allergen (HDM) is a potent trigger of airway inflammation. Dendritic cells (DCs) and lung epithelial cells both express the pathogen receptor TLR4, which senses lipopolysaccharide contaminating the allergen. Bart Lambrecht and his colleagues show that TLR4 on the epithelial cells, not the DCs, is the primary sensor of HDM. TLR4 on these lung structural cells is required for recruitment of DCs and the induction of allergic inflammation in response to HDM (pages 366-367).
Hamida Hammad et al.
doi:10.1038/nm.1946
Abstract: http://links.ealert.nature.com/ctt?kn=164&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=116&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis pp417 - 424
Kurt Redlich and his colleagues show that estrogen deficiency results in increased numbers of preosteoclast progenitor cells in the bones of mice. But they also find that lack of CCR2 in these future bone-resorbing cells prevents their maturation and thus protects the mice from osteoporosis, suggesting a future target for therapy in humans.
Nikolaus B Binder et al.
doi:10.1038/nm.1945
Abstract: http://links.ealert.nature.com/ctt?kn=171&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=86&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
A new role of substance P as an injury-inducible messenger for mobilization of CD29+ stromal-like cells pp425 - 435
New factors in wound healing are sorely needed. Here Youngsook Son and colleagues identify substance P, a small neuropeptide, as one such factor that seems to work by mobilizing stromal-like cells to the site of wounding, accelerating the healing process (pages 367-369).
Hyun Sook Hong et al.
doi:10.1038/nm.1909
Abstract: http://links.ealert.nature.com/ctt?kn=65&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=169&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
LETTERS
----------------------
Induction of natural killer T cell-dependent alloreactivity by administration of granulocyte colony-stimulating factor after bone marrow transplantation pp436 - 441
Granulocyte colony-stimulating factor (G-CSF) is used to accelerate neutrophil engraftment in bone marrow transplant (BMT) recipients to reduce bacterial infections but may also enhance the risk of graft-versus-host disease (GVHD). Morris et al. now show that total body irradiation increases the expression of the G-CSF receptor on recipient dendritic cells, resulting in the activation of donor natural killer T cells and enhanced GVHD when G-CSF is administered shortly after BMT (pages 363-364).
Edward S Morris et al.
doi:10.1038/nm.1948
Abstract: http://links.ealert.nature.com/ctt?kn=130&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=18&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding pp442 - 446
One way to reduce obesity is to alter fat absorption from the diet. Here Robert Farese, Jr. and his colleagues identify MGAT2 as a potential therapeutic target for doing so. The enzyme is mostly expressed in the gut of humans and mice, and its genetic deletion in mice results in slower kinetics of fat absorption[mdash]more of the fat is burned and less is stored, offering protection from diet-induced obesity.
Chi-Liang Eric Yen et al.
doi:10.1038/nm.1937
Abstract: http://links.ealert.nature.com/ctt?kn=100&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=128&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
TECHNICAL REPORTS
----------------------
Molecular therapy of obesity and diabetes by a physiological autoregulatory approach pp447 - 454
Lei Cao et al.
doi:10.1038/nm.1933
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=1&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Bioluminescence imaging of myeloperoxidase activity in vivo pp455 - 461
Shimon Gross et al.
doi:10.1038/nm.1886
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=84&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
CORRIGENDA
----------------------
Corrigendum: VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis p462
Betty YFY Tam et al.
doi:10.1038/nm0409-462a
http://links.ealert.nature.com/ctt?kn=127&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Corrigendum: Bone marrow stromal cells attenuate sepsis via prostaglandin E2-dependent reprogramming of host macrophages to increase their interleukin-10 production p462
Krisztian Nemeth et al.
doi:10.1038/nm0409-462b
http://links.ealert.nature.com/ctt?kn=111&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Corrigendum: The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases p462
Kevin J Whitehead et al.
doi:10.1038/nm0409-462c
http://links.ealert.nature.com/ctt?kn=16&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
Corrigendum: Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. p462
Scott G Hansen et al.
doi:10.1038/nm0409-462d
http://links.ealert.nature.com/ctt?kn=92&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
----------------------
ERRATUM
----------------------
Erratum: Straight talk with...Mac Cowell and Jason Bobe p462
Prashant Nair
doi:10.1038/nm0409-462e
http://links.ealert.nature.com/ctt?kn=44&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Nature Immunology
FOCUS ON IMMUNE SIGNALING CROSS-TALK
Nature Immunology presents a series of specially commissioned articles that focus on the molecular basis for and biological consequences of the interplay among signaling pathways. The web focus also includes highlights of recent research findings and several short comments-written by experts-providing in-depth insight into specific signaling cross-talk points.
For more information, visit www.nature.com/ni/focus/crosstalk
=====================================================================
You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=24&m=32251026&r=MTc2NTQyNDEzOQS2&b=2&j=NDcxNTYzNjYS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2009 Nature Publishing Group
=====================================================================
