May 2009 Volume 89 Number 5, pp 486 - 607
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Laboratory Investigation appoints its sixth Editor-in-Chief:
Gene P. Siegal, M.D., Ph.D.
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Dr. Siegal serves as Director of Anatomic Pathology at the University of
Alabama at Birmingham and is a world authority on bone tumors.
With newly appointed Senior Associate Editors Drs. Brian Rubin and Robert W.
Hardy, and Catherine Ketcham continuing as Managing Editor, Dr. Siegal is
committed to building upon Laboratory Investigation's strong standing as one
of the top ranked experimental pathology journals.
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Laboratory Investigation presents: Pathobiology in Focus
Innovative...Incisive...Thought-provoking
Pathobiology in Focus is a FREE and highly popular series on seminal advances
across the spectrum of disease pathogenesis, incorporating high-quality artwork
and powerpoint slides with concise articles. View the latest PIF online at
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INSIDE LAB INVEST
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Inside Lab Invest
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PATHOBIOLOGY IN FOCUS
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Mechanisms of parenchymal injury and signaling pathways in ectatic ducts of chronic
pancreatitis: implications for pancreatic carcinogenesis
Umesh K Bhanot and Peter Moller
Abstract: http://links.ealert.nature.com/ctt?kn=58&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
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RESEARCH ARTICLES
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Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins,
fiber cell apoptosis and cataract formation in the mouse lens
Maneesh Mailankot, Magdalena M Staniszewska, Heather Butler, Moonkyung H Caprara,
Scott Howell, Benlian Wang, Catherine Doller, Lixing W Reneker and Ram H Nagaraj
Abstract: http://links.ealert.nature.com/ctt?kn=52&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
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Tenofovir renal toxicity targets mitochondria of renal proximal tubules
James J Kohler, Seyed H Hosseini, Amy Hoying-Brandt, Elgin Green, David M Johnson,
Rodney Russ, Dung Tran, C Michael Raper, Robert Santoianni and William Lewis
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
Interstitial fibrosis and microvascular disease of the heart in uremia: amelioration
by a calcimimetic
Nadezda Koleganova, Grzegorz Piecha, Eberhard Ritz, Raffi Bekeredjian, Peter Schirmacher,
Claus Peter Schmitt and Marie-Luise Gross
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
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NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and
invasion through Rac1 in colon carcinoma cells
Limei Hu, Walter Hittelman, Tao Lu, Ping Ji, Ralph Arlinghaus, Ilya Shmulevich,
Stanley R Hamilton and Wei Zhang
Abstract: http://links.ealert.nature.com/ctt?kn=15&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
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Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and
laboratory-based study
Eizo Watanabe, Jared T Muenzer, William G Hawkins, Christopher G Davis, David J Dixon,
Jonathan E McDunn, Daniel J Brackett, Megan R Lerner, Paul E Swanson and Richard S Hotchkiss
Abstract: http://links.ealert.nature.com/ctt?kn=5&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
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Expression of stem cell factor and its receptor c-Kit during the development of intrahepatic
cholangiocarcinoma
Tumen Mansuroglu, Pierluigi Ramadori, Jozsef Dudas, Ihtzaz Malik, Kristoff Hammerich,
Laszlo Fuzesi and Giuliano Ramadori
Abstract: http://links.ealert.nature.com/ctt?kn=34&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
Hypoxia influences linearly patterned programmed cell necrosis and tumor blood supply
patterns formation in melanoma
Shiwu Zhang, Man Li, Danfang Zhang, Shaoyan Xu, Xiaoyu Wang, Zhiyong Liu, Xiulan Zhao and Baocun Sun
Abstract: http://links.ealert.nature.com/ctt?kn=47&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
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TECHNICAL REPORTS
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Increased expression of metastasis-related genes in hypoxic cells sorted from cervical and
lymph nodal xenograft tumors
Naz Chaudary and Richard P Hill
Abstract: http://links.ealert.nature.com/ctt?kn=38&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=70&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues
Angela B Y Hui, Wei Shi, Paul C Boutros, Naomi Miller, Melania Pintilie, Tony Fyles,
David McCready, Derek Wong, Kate Gerster, Igor Jurisica, Linda Z Penn and Fei-Fei Liu
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=32615352&r=MTc2Mjk0MzQ4MgS2&b=2&j=NDgwODg3NzAS1&mt=1&rt=0
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CORRIGENDUM
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PPAR-[gamma] agonist attenuates renal interstitial fibrosis and inflammation through
reduction of TGF-[beta]
Toru Kawai, Takao Masaki, Shigehiro Doi, Tetsuji Arakawa, Yukio Yokoyama, Toshiki Doi,
Nobuoki Kohno and Noriaki Yorioka
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