Volume 100 Number 8
Published online 14 April 2009 (1213 - 1368)
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British Journal of Cancer publishes high quality original papers and reviews
that make a significant contribution to increasing understanding of the causes
of cancer and to improving the treatment and survival of patients.
Visit the journal online at http://links.ealert.nature.com/ctt?kn=63&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
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British Journal of Cancer has an impact factor 4.635*
*2007 Journal Citation Report (Thomson Reuters, 2008)
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MINIREVIEWS
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Methodological approaches in application of synthetic lethality screening towards anticancer therapy
D Canaani
Abstract: http://links.ealert.nature.com/ctt?kn=38&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Prognostic markers in cancer: the evolution of evidence from single studies to meta-analysis, and beyond
R D Riley, W Sauerbrei and D G Altman
Abstract: http://links.ealert.nature.com/ctt?kn=103&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=22&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
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CLINICAL STUDIES
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Comparison of a guaiac and an immunochemical faecal occult blood test for the detection of colonic lesions according to lesion type and location
L Guittet, V Bouvier, N Mariotte, J P Vallee, R Levillain, J Tichet and G Launoy
Abstract: http://links.ealert.nature.com/ctt?kn=73&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancer
L H Moyes, E F Leitch, R F McKee, J H Anderson, P G Horgan and D C McMillan
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
The impact of healthcare costs in the last year of life and in all life years gained on the cost-effectiveness of cancer screening
I M C M de Kok, J J Polder, J D F Habbema, L-M Berkers, W J Meerding, M Rebolj and M van Ballegooijen
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
A phase I study of extended dosing with lomeguatrib with temozolomide in patients with advanced melanoma
R F Kefford, N P B Thomas, P G Corrie, C Palmer, E Abdi, D Kotasek, J Beith, M Ranson, P Mortimer, A J Watson, G P Margison and M R Middleton
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
O6-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib
A J Watson, M R Middleton, G McGown, M Thorncroft, M Ranson, P Hersey, G McArthur, I D Davis, D Thomson, J Beith, A Haydon, R Kefford, P Lorigan, P Mortimer, A Sabharwal, O Hayward and G P Margison
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=108&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
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TRANSLATIONAL THERAPEUTICS
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Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma
D Yoshikawa, H Ojima, A Kokubu, T Ochiya, S Kasai, S Hirohashi and T Shibata
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=30&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Activity of a novel, dual PI3-kinase//mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts
P Cao, S-M Maira, C Garcia-Echeverria and D W Hedley
Abstract: http://links.ealert.nature.com/ctt?kn=88&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=70&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
The presence of circulating total DNA and methylated genes is associated with circulating tumour cells in blood from breast cancer patients
I Van der Auwera, H J Elst, S J Van Laere, H Maes, P Huget, P van Dam, E A Van Marck, P B Vermeulen and L Y Dirix
Abstract: http://links.ealert.nature.com/ctt?kn=47&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=80&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Intra-tumoural extra-cellular pH: a useful parameter of response to chemotherapy in syngeneic tumour lines
D Lindner and D Raghavan
Abstract: http://links.ealert.nature.com/ctt?kn=50&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
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MOLECULAR DIAGNOSTICS
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An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET)
H A Rogers, S Miller, J Lowe, M-A Brundler, B Coyle and R G Grundy
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=96&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Differential tissue-specific protein markers of vaginal carcinoma
K Hellman, A A Alaiya, S Becker, M Lomnytska, K Schedvins, W Steinberg, A-C Hellstrom, S Andersson, U Hellman and G Auer
Abstract: http://links.ealert.nature.com/ctt?kn=51&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=86&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts
K Huhtinen, P Suvitie, J Hiissa, J Junnila, J Huvila, H Kujari, M Setala, P Harkki, J Jalkanen, J Fraser, J Makinen, A Auranen, M Poutanen and A Perheentupa
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=102&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers
Y Hirata, N Ogasawara, M Sasaki, T Mizushima, T Shimura, T Mizoshita, Y Mori, E Kubota, T Wada, S Tanida, H Kataoka, T Kamiya, S Higashiyama and T Joh
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=55&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
TP53 mutations predict disease control in metastatic colorectal cancer treated with cetuximab-based chemotherapy
A Oden-Gangloff, F Di Fiore, F Bibeau, A Lamy, G Bougeard, F Charbonnier, F Blanchard, D Tougeron, M Ychou, F Boissiere, F Le Pessot, J-C Sabourin, J-J Tuech, P Michel and T Frebourg
Abstract: http://links.ealert.nature.com/ctt?kn=16&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=40&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
DNA copy number loss and allelic imbalance at 2p16 in lung cancer associated with asbestos exposure
E Kettunen, M Aavikko, P Nymark, S Ruosaari, H Wikman, E Vanhala, K Salmenkivi, R Pirinen, A Karjalainen, E Kuosma and S Anttila
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
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GENETICS AND GENOMICS
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Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
T Pabst, M Eyholzer, J Fos and B U Mueller
Abstract: http://links.ealert.nature.com/ctt?kn=2&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
The BAG-1 cochaperone is a negative regulator of p73-dependent transcription
X-H Wang, D O'Connor, M Brimmell and G Packham
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=19&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Common genetic variability in ESR1 and EGF in relation to endometrial cancer risk and survival
K Einarsdottir, H Darabi, K Czene, Y Li, Y L Low, Y Q Li, C Bonnard, S Wedren, E T Liu, P Hall, J Liu and K Humphreys
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
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LETTERS TO THE EDITOR
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CD133 expression in different stages of gastric adenocarcinoma
M Boegl and C Prinz
http://links.ealert.nature.com/ctt?kn=20&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
Reply: CD133 expression in different stages of gastric adenocarcinoma
L M Smith, A Nesterova, M C Ryan, S Duniho, M Jonas, M Anderson, M K Sutherland, K L Van Orden, P A Moore, S M Ruben and P J Carter
http://links.ealert.nature.com/ctt?kn=42&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
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CORRIGENDUM
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Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatin//5-fluorouracil as first-line chemotherapy
L Pare, E Marcuello, A Altes, E del Rio, L Sedano, J Salazar, A Cortes, A Barnadas and M Baiget
http://links.ealert.nature.com/ctt?kn=104&m=32273627&r=MTc2MDAwMTgxNgS2&b=2&j=NDc0Mjc2MTgS1&mt=1&rt=0
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