Signaling Gateway - 6 March 2009
http://links.ealert.nature.com/ctt?kn=31&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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CANCER STEM CELLS: KILLING HEDGEHOG TO TREAT CML
Inhibition of the Hedgehog signaling pathway blocks chronic
myelogenous leukemia progression by depleting cancer stem cells.
Original research paper: Nature advance online publication,
25 January 2009
http://links.ealert.nature.com/ctt?kn=25&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
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Selected Updates
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CELL CYCLE: SIGNALLING TO WAIT
The sequential production of MAD2–CDC20 and BUBR1–CDC20 inhibitors
generates a cell-cycle-checkpoint signal that delays the onset of
anaphase until all chromosomes are properly attached to spindle
microtubules.
Original research paper: Dev. Cell 16, 105-117 (2009)
http://links.ealert.nature.com/ctt?kn=3&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
TUMORIGENESIS: DISCONNECTING HEDGEHOG FROM GLI
A non-canonical mode of KRAS-driven GLI target gene expression is
required for the survival of pancreatic ductal adenocarcinoma (PDAC)
cancer cells.
Original research paper: Genes Dev. 23, 24-36 (2009)
http://links.ealert.nature.com/ctt?kn=23&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
MOLECULAR NEUROSCIENCE: RIGHT TIME, RIGHT PLACE
The trafficking of AMPA-type glutamate receptors from the endoplasmic
reticulum (ER) to the plasma membrane is carefully regulated by
glutamate binding and actin dynamics.
Original research paper: J. Neurosci. 29, 303-312
(2009)
http://links.ealert.nature.com/ctt?kn=32&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=22&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
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Research Library
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THE RATE OF N-WASP EXCHANGE LIMITS THE EXTENT OF
ARP2/3-COMPLEX-DEPENDENT ACTIN-BASED MOTILITY
Nature 458, 87-91 (2009)
http://links.ealert.nature.com/ctt?kn=9&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
THE UBIQUITIN LIGASE CHIP ACTS AS AN UPSTREAM REGULATOR OF ONCOGENIC
PATHWAYS
Nature Cell Biology 11, 312-319 (2009)
http://links.ealert.nature.com/ctt?kn=12&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
REGULATION OF LYMPHOID VERSUS MYELOID FATE 'CHOICE' BY THE
TRANSCRIPTION FACTOR MEF2C
Nature Immunology 10, 289-296 (2009)
http://links.ealert.nature.com/ctt?kn=27&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
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Signaling News
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NATURE REVIEWS IMMUNOLOGY POSTER: CD4+ T-CELL DIVERSITY
http://links.ealert.nature.com/ctt?kn=16&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
After contact with antigen–presenting cells, naive CD4+ T cells begin
to differentiate towards one of several fates. Nature Reviews
Immunology presents a FREE poster that provides an overview of the
various cytokines, transcription factors and signaling pathways that
are associated with the differentiation, survival, function and
plasticity of CD4+ effector T cells.
http://links.ealert.nature.com/ctt?kn=16&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
More news
http://links.ealert.nature.com/ctt?kn=13&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
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Gateway Updates
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THE CELL MIGRATION GATEWAY - MARCH UPDATE
http://links.ealert.nature.com/ctt?kn=19&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's featured articles:
Calcium entry channels: The gates to metastasis
http://links.ealert.nature.com/ctt?kn=15&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
N-WASP turnover: The sting in the actin tail
http://links.ealert.nature.com/ctt?kn=29&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
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Job of the Week
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Postdoctoral positions
Employer: University of Texas Health Science Center at Houston
Location: Houston, Texas
http://links.ealert.nature.com/ctt?kn=8&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
Several postdoctoral positions are available to study the mechanisms
of muscle remodeling including skeletal muscle wasting, regeneration
and congestive heart failure. Cellular and molecular biology
techniques will be used to elucidate the signaling mechanisms that
mediate muscle adaptation to various forms of stress and disease.
More Jobs:
http://links.ealert.nature.com/ctt?kn=10&m=31839639&r=MTc2ODc4NDI0MAS2&b=2&j=NDYzMjM2NDkS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
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