Signaling Gateway - 13 March 2009
http://links.ealert.nature.com/ctt?kn=32&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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CALCIUM SIGNALING: INSP3 HOSTS A RECEPTOR GET-TOGETHER
The sensitivity of InsP3 receptors is modulated by InsP3-mediated
receptor clustering.
Original research paper: Nature advance online publication,
25 February 2009
http://links.ealert.nature.com/ctt?kn=26&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
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Molecule Pages
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Vrk2
http://links.ealert.nature.com/ctt?kn=4&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
VRK2 (vaccinia-related kinase 2) is a member of the casein kinase I
subgroup in the human kinome. The VRK2 gene expresses two isoforms,
which differ in their subcellular location, but seem to have the same
substrate specificity in vitro. Both VRK2A (full-length; 508 amino
acids) and VRK2B (397 amino acids) have intrinsic autophosphorylation
activity and are able to phosphorylate p53 and the amino terminus of
the BAF (barrier to autointegration factor) protein.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=24&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
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Selected Updates
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CELL SIGNALLING: NEMO KEEPS IT STRAIGHT
NF-kappaB-essential modulator (NEMO) is modified by a
head-to-tail-linked linear polyubiquitin chain, which promotes
activation of the canonical NF-kappaB pathway.
Original research paper: Nature Cell Biol. 11, 123-132 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
TUMOUR IMMUNOLOGY: MULTI-TASKING BY STAT3
Three reports now show that STAT3 activity in tumor cells promotes
cytokine-induced tumor growth, whereas STAT3 activity in immune cells
in the tumor microenvironment modulates cytokine production to
inhibit tumor-specific immune responses.
Original research paper: Cancer Cell 15, 91-102 (2009)
http://links.ealert.nature.com/ctt?kn=23&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
SIGNALLING: PINNING DOWN NOTCH ACTIVATION
The prolyl isomerase PIN1 is an activator of Notch signaling in
breast cancer, and inhibiting both NOTCH1 and PIN1 in a breast cancer
xenograft mouse model causes synergistic inhibition of tumor growth.
Original research paper: Nature Cell Biol. 11, 133-142 (2009)
http://links.ealert.nature.com/ctt?kn=27&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=16&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
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Research Library
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CHROMATIN SIGNATURE REVEALS OVER A THOUSAND HIGHLY CONSERVED LARGE
NON-CODING RNAs IN MAMMALS
Nature 458, 223-227 (2009)
http://links.ealert.nature.com/ctt?kn=28&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
A POINT MUTATION IN KINDLIN3 ABLATES ACTIVATION OF THREE INTEGRIN
SUBFAMILIES IN HUMANS
Nature Medicine 15, 313-318 (2009)
http://links.ealert.nature.com/ctt?kn=34&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
HIGHLY EFFICIENT NEURAL CONVERSION OF HUMAN ES AND iPS CELLS BY DUAL
INHIBITION OF SMAD SIGNALING
Nature Biotechnology 27, 275-280 (2009)
http://links.ealert.nature.com/ctt?kn=2&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
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Signaling News
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NATURE REVIEWS MOLECULAR CELL BIOLOGY POSTER: PRODUCTION AND ACTIONS
OF SMALL RNAs
http://links.ealert.nature.com/ctt?kn=10&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
Recent progress in cloning, deep sequencing and bioinformatics have
revealed an astounding landscape of small RNAs. At least three
classes of small RNA can be distinguished in eukaryotes: microRNAs,
endogenous small interfering RNAs and Piwi-interacting RNAs.
This FREE poster depicts our current understanding of the processing
pathways of eukaryotic small RNAs and their possible mechanisms of
action.
http://links.ealert.nature.com/ctt?kn=31&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
More news
http://links.ealert.nature.com/ctt?kn=22&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - MARCH UPDATE
http://links.ealert.nature.com/ctt?kn=12&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and
bioinformaticians to explore, visualize and mine signaling events.
Recently added pathways include:
Regulation of retinoblastoma protein
http://links.ealert.nature.com/ctt?kn=29&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
E-cadherin signaling in the nascent adherens junction
http://links.ealert.nature.com/ctt?kn=19&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
Sign up here to receive the monthly update alert for the
NCI-Nature Pathway Interaction Database.
http://links.ealert.nature.com/ctt?kn=17&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
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Job of the Week
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Computational Biology and Bioinformatics Scientists
Employer: Pacific Northwest National Laboratory
Location: Richland, Washington, USA
http://links.ealert.nature.com/ctt?kn=9&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
Two positions are available in the Computational Biology and
Bioinformatics Group at the PNNL. The computational biology scientist
will develop a strong network inference and modeling research program
focused on the predictive understanding of biological systems.
The bioinformatics scientist will analyze and interpret proteomics
and microarray data to reconstruct signaling networks, and integrate
project and public data sources in support of network inference
studies.
More Jobs:
http://links.ealert.nature.com/ctt?kn=11&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=20&m=31961774&r=MTc2ODc4NDI0MAS2&b=2&j=NDY1MDQ0NDUS1&mt=1&rt=0
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