April 2009 Volume 7 Number 4
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This month's FEATURED article:
Principles of c-di-GMP signalling in bacteria
Regine Hengge
p263 | doi:10.1038/nrmicro2109
http://links.ealert.nature.com/ctt?kn=10&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
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In this issue
p251 | doi:10.1038/nrmicro2126
http://links.ealert.nature.com/ctt?kn=64&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Editorial: TerraGenome: a consortium for the sequencing of a soil metagenome
Timothy M. Vogel, Pascal Simonet, Janet K. Jansson, Penny R. Hirsch,
James M. Tiedje, Jan Dirk van Elsas, Mark J. Bailey, Renaud Nalin and
Laurent Philippot
p252 | doi:10.1038/nrmicro2119
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=47&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Innate immunity: Not-so-lucky 7 for West Nile virusus
p253 | doi:10.1038/nrmicro2124
http://links.ealert.nature.com/ctt?kn=46&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Environmental Microbiology: Marine phosphate stress is PhoX-rated
p254 | doi:10.1038/nrmicro2116
http://links.ealert.nature.com/ctt?kn=79&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
IN BRIEF
Techniques and applications | Fungal ecology | Bacterial pathogenesis
p254 | doi:10.1038/nrmicro2121
http://links.ealert.nature.com/ctt?kn=86&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Prions: Prions hijack the nanotube
p255 | doi:10.1038/nrmicro2117
http://links.ealert.nature.com/ctt?kn=58&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Plant Virology: Granule formation in early infection
p255 | doi:10.1038/nrmicro2118
http://links.ealert.nature.com/ctt?kn=62&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Bacterial transcription: Regulation by sigma factor mimicry
p256 | doi:10.1038/nrmicro2120
http://links.ealert.nature.com/ctt?kn=2&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Fungal Pathogenesis: Varying for virulence
p256 | doi:10.1038/nrmicro2125
http://links.ealert.nature.com/ctt?kn=45&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Functional Genomics: A malevolent matchmaker
p257 | doi:10.1038/nrmicro2127
http://links.ealert.nature.com/ctt?kn=22&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
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NEWS AND ANALYSIS
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GENOME WATCH
Sequencing the species pan-genome
Stephen Bentley
p258 | doi:10.1038/nrmicro2123
http://links.ealert.nature.com/ctt?kn=11&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
DISEASE WATCH
In the News
p260 | doi:10.1038/nrmicro2122
http://links.ealert.nature.com/ctt?kn=67&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
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REVIEWS
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Principles of c-di-GMP signalling in bacteria
Regine Hengge
p263 | doi:10.1038/nrmicro2109
Bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) was
recently identified as a second messenger in bacteria that regulates
a wide range of phenotypes, including biofilm formation and motility.
The discovery that the enzymes that make and break c-di-GMP are widespread
in the bacterial world highlighted their central importance in bacterial
physiology, but raised questions about the specificity of the signalling.
Regine Hengge describes the mechanisms and evolutionary variations of
c-di-GMP signalling.
Abstract: http://links.ealert.nature.com/ctt?kn=83&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Pathogenic neisseriae: surface modulation, pathogenesis and infection
control
Mumtaz Virji
p274 | doi:10.1038/nrmicro2097
Neisseria meningitidis and Neisseria gonorrhoeae share extensive genetic
and antigenic similarities but have distinct lifestyles and niche preferences.
In this Review, Mumtaz Virji examines the mechanisms underlying niche
establishment and the challenges posed by the rapidly modulated surface
structures of these bacteria to vaccine development.
Abstract: http://links.ealert.nature.com/ctt?kn=33&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=49&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Application of 'next-generation' sequencing technologies to microbial
genetics
Daniel MacLean, Jonathan D. G. Jones and David J. Studholme
p287 | doi:10.1038/nrmicro2088
New sequencing methods have enabled the assembly of whole microbial genomes
in a matter of days, greatly expanding the volume and scope of microbial
sequencing efforts. This article reviews the current capabilities of the
various high-throughput sequencing technologies and data analysis tools
in the context of their application to microbial genomics.
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
The role of predictive modelling in rationally re-engineering
biological systems
Tie Koide, Wyming Lee Pang and Nitin S. Baliga
p297 | doi:10.1038/nrmicro2107
Synthetic biology will provide the potential to redesign, or even build
from scratch, specialized organisms to carry out complex tasks. In this
Opinion article, Nitin Baliga and colleagues argue that to achieve the
integrated framework for such complex bioengineering, a convergence
of the fields of synthetic biology and systems biology will be required.
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
OPINION
Ten reasons to exclude viruses from the tree of life
David Moreira and Purificacion Lopez-Garcia
p306 | doi:10.1038/nrmicro2108
Viruses are widespread and come in many shapes and sizes. They play an
important part in the evolution of many species. But are they alive and
should they be included as part of the tree of life? Moreira and Lopez-Garcia
discuss ten reasons why they should be excluded.
Abstract: http://links.ealert.nature.com/ctt?kn=1&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
OPINION
Symbiotic use of pathogenic strategies: rhizobial protein secretion systems
William J. Deakin and William J. Broughton
p312 | doi:10.1038/nrmicro2091
Rhizobia are a diverse group of soil bacteria that induce the formation
of nitrogen-fixing nodules on the roots of legumes. In this Opinion article,
a group of proteins that are secreted by rhizobia, some of which have
homologues in bacterial pathogens, are used to support the hypothesis
that some pathogenic pathways have been co-opted by rhizobia for
symbiotic purposes.
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=31993738&r=MTc2NzM1ODUwNgS2&b=2&j=NDY1NTc4MTgS1&mt=1&rt=0
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